April L Risinger

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation
    April L Risinger
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Cancer 13:41. 2014
  2. pmc The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability
    April L Risinger
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, TX, United States
    Cancer Lett 307:104-11. 2011
  3. doi request reprint The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions
    April L Risinger
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States
    J Nat Prod 76:1923-9. 2013
  4. pmc Identification and biological activities of new taccalonolide microtubule stabilizers
    Jiangnan Peng
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Med Chem 54:6117-24. 2011
  5. ncbi request reprint Structure-activity relationships of retro-dihydrochalcones isolated from Tacca sp
    Jiangnan Peng
    Department of Pharmacology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States
    J Nat Prod 76:2189-94. 2013
  6. pmc Hydrolysis reactions of the taccalonolides reveal structure-activity relationships
    Jing Li
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229, United States
    J Nat Prod 76:1369-75. 2013
  7. pmc Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel
    April L Risinger
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA
    Cell Cycle 10:2162-71. 2011
  8. pmc Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers
    Jing Li
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Am Chem Soc 133:19064-7. 2011
  9. pmc Taccalonolides: Novel microtubule stabilizers with clinical potential
    April L Risinger
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, United States
    Cancer Lett 291:14-9. 2010
  10. pmc Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri
    Jiangnan Peng
    Department of Pharmacology and Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Nat Prod 73:1590-2. 2010

Detail Information

Publications12

  1. ncbi request reprint The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation
    April L Risinger
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Cancer 13:41. 2014
    ..At slightly higher concentrations, these agents cause the formation of multiple mitotic asters with distinct morphologies elicited by different microtubule stabilizers...
  2. pmc The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability
    April L Risinger
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, TX, United States
    Cancer Lett 307:104-11. 2011
    ..These studies suggest that diverse antimitotic agents, including the taccalonolides, may have utility in chemoradiotherapy...
  3. doi request reprint The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions
    April L Risinger
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States
    J Nat Prod 76:1923-9. 2013
    ....
  4. pmc Identification and biological activities of new taccalonolide microtubule stabilizers
    Jiangnan Peng
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Med Chem 54:6117-24. 2011
    ..In vivo antitumor evaluations of taccalonolides A, E, and N show that each of these molecules has in vivo antitumor activity...
  5. ncbi request reprint Structure-activity relationships of retro-dihydrochalcones isolated from Tacca sp
    Jiangnan Peng
    Department of Pharmacology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States
    J Nat Prod 76:2189-94. 2013
    ..The isolation and biological characterization of several retro-dihydrochalcones facilitated preliminary structure-activity relationships for this compound class concerning its antiproliferative and microtubule depolymerizing activities. ..
  6. pmc Hydrolysis reactions of the taccalonolides reveal structure-activity relationships
    Jing Li
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229, United States
    J Nat Prod 76:1369-75. 2013
    ..Biological assays were performed on each of the purified taccalonolides, which allowed for increased refinement of the structure-activity relationship of this class of compounds. ..
  7. pmc Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel
    April L Risinger
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, USA
    Cell Cycle 10:2162-71. 2011
    ....
  8. pmc Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers
    Jing Li
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Am Chem Soc 133:19064-7. 2011
    ..The potencies of taccalonolides AF and AJ and their direct interaction with tubulin, together with the previous excellent in vivo antitumor activity of this class, reveal the potential of the taccalonolides as new anticancer agents...
  9. pmc Taccalonolides: Novel microtubule stabilizers with clinical potential
    April L Risinger
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, United States
    Cancer Lett 291:14-9. 2010
    ..We also discuss the challenges in formulation and supply that will need to be solved before the taccalonolides can become candidates for clinical development...
  10. pmc Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri
    Jiangnan Peng
    Department of Pharmacology and Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Nat Prod 73:1590-2. 2010
    ..Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC(50) values of 4.1, 3.9, 4.7, and 6.3 μM, respectively...
  11. pmc Microtubule dynamics as a target in oncology
    April L Risinger
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Cancer Treat Rev 35:255-61. 2009
    ..We also offer a frank discussion of which microtubule-targeting agents are amenable to further development based on their availability, efficacy and toxic profile...
  12. pmc The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms
    April L Risinger
    Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Cancer Res 68:8881-8. 2008
    ....