Neil J Risch
Affiliation: University of California
- Characterizing the admixed African ancestry of African AmericansFouad Zakharia
Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Genome Biol 10:R141. 2009..To focus on African ancestry, we reduced the data to include only those genotypes in each African American determined statistically to be African in origin...
- Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CADJoshua W Knowles
Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
BMC Med Genet 9:23. 2008..We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically significant CAD in the Atherosclerotic Disease, VAscular FuNction, & Geneti C Epidemiology (ADVANCE) study...
- Ancestry-related assortative mating in Latino populationsNeil Risch
Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Genome Biol 10:R132. 2009..While spouse correlations have been documented for numerous traits, no prior studies have assessed assortative mating for genetic ancestry in admixed populations...
- Intragenic Cis and Trans modification of genetic susceptibility in DYT1 torsion dystoniaNeil J Risch
Institute for Human Genetics, University of California at San Francisco, San Francisco, CA 94143, USA
Am J Hum Genet 80:1188-93. 2007..Our findings establish, for the first time, a clinically relevant gene modifier of DYT1...
- Dissecting complex diseases in complex populations: asthma in latino americansShweta Choudhry
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2911, USA
Proc Am Thorac Soc 4:226-33. 2007....
- Ancestry-environment interactions and asthma risk among Puerto RicansShweta Choudhry
University of California, San Francisco, San Francisco, CA 94143-2911, USA
Am J Respir Crit Care Med 174:1088-93. 2006..CONCLUSIONS: The observed interaction may help to explain the unique pattern of risk for asthma in Puerto Ricans and the lack of association with SES observed in previous studies when not accounting for varying proportions of ancestry...
- Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 regionShweta Choudhry
Institute for Human Genetics, University of California, San Francisco, CA, USA
Hum Genet 123:455-68. 2008..3 region. Our results provide strong evidence that the previously linked 5q23 region is associated with asthma in Puerto Ricans. The detection of causative variants in this region will require fine mapping and functional validation...
- Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart studyRonnie Sebro
Institute for Human Genetics, University of California San Francisco, San Francisco, California 94143 0794, USA
Genet Epidemiol 34:674-9. 2010..This nonrandom mating likely affects genetic structure seen more generally in the North American population of European descent today, and decreases the rate of decay of linkage disequilibrium for ancestrally informative markers...
- Differentiating population stratification from genotyping error using family dataRonnie Sebro
Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Suite S965, San Francisco, CA 94143, USA
Ann Hum Genet 76:42-52. 2012..We simulate data based on several models of genotyping error in previously published literature, and show how this method could be used in practice to assist in differentiating population stratification from systematic genotyping error...
- Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmaticsKeyan Salari
Department of Medicine, University of California, San Francisco, California 94143-1732, USA
Genet Epidemiol 29:76-86. 2005..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation...
- Admixture mapping of quantitative trait loci for blood lipids in African-AmericansAnalabha Basu
Institute for Human Genetics, University of California San Francisco, 513 Parnassus Avenue, Room 901F HSW, San Francisco, CA 94143, USA
Hum Mol Genet 18:2091-8. 2009..The identified regions provide locations for follow-up studies of genetic variants underlying lipid variation in African-Americans and possibly other populations...
- Genetic structure, self-identified race/ethnicity, and confounding in case-control association studiesHua Tang
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Am J Hum Genet 76:268-75. 2005..S. population. Implications of this genetic structure for case-control association studies are discussed...
- Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia geneGary A Heiman
Department of Epidemiology of Joseph L Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Am J Med Genet B Neuropsychiatr Genet 144:361-4. 2007..We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia...
- A genome-wide scan in forty large pedigrees with multiple sclerosisCristen J Willer
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
J Hum Genet 52:955-62. 2007..30. The inability to find significant linkage in these highly penetrant families suggests that linkage is not the optimal tool for dissecting the inheritance of MS...
- Recent genetic selection in the ancestral admixture of Puerto RicansHua Tang
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
Am J Hum Genet 81:626-33. 2007..Two of these regions harbor genes for olfactory receptors. Interestingly, all three regions exhibit deficiencies in the European-ancestry proportion...
- Estimation of individual admixture: analytical and study design considerationsHua Tang
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genet Epidemiol 28:289-301. 2005..g., simulations) not possible by Bayesian methods. Our simulation results demonstrate that inclusion of ancestral populations or their surrogates in the analysis is required by any method of IA estimation to obtain reasonable results...
- Tree-structured supervised learning and the genetics of hypertensionJing Huang
Affymetrix Inc, 3380 Central Expressway, Santa Clara, CA 95051, USA
Proc Natl Acad Sci U S A 101:10529-34. 2004..FlexTree and Logic Regression appear better than the others in terms of Bayes risk. However, the differences are not significant in the usual statistical sense...
- Immunology: hepatitis A virus link to atopic diseaseJennifer J McIntire
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA
Nature 425:576. 2003
- Candidate-gene approaches for studying complex genetic traits: practical considerationsHolly K Tabor
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305-5120, USA
Nat Rev Genet 3:391-7. 2002..We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation...