Neil J Risch

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
  2. pmc Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
    Joshua W Knowles
    Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    BMC Med Genet 9:23. 2008
  3. pmc Ancestry-related assortative mating in Latino populations
    Neil Risch
    Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Genome Biol 10:R132. 2009
  4. pmc Intragenic Cis and Trans modification of genetic susceptibility in DYT1 torsion dystonia
    Neil J Risch
    Institute for Human Genetics, University of California at San Francisco, San Francisco, CA 94143, USA
    Am J Hum Genet 80:1188-93. 2007
  5. pmc Dissecting complex diseases in complex populations: asthma in latino americans
    Shweta Choudhry
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2911, USA
    Proc Am Thorac Soc 4:226-33. 2007
  6. pmc Ancestry-environment interactions and asthma risk among Puerto Ricans
    Shweta Choudhry
    University of California, San Francisco, San Francisco, CA 94143 2911, USA
    Am J Respir Crit Care Med 174:1088-93. 2006
  7. pmc Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region
    Shweta Choudhry
    Institute for Human Genetics, University of California, San Francisco, CA, USA
    Hum Genet 123:455-68. 2008
  8. pmc Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study
    Ronnie Sebro
    Institute for Human Genetics, University of California San Francisco, San Francisco, California 94143 0794, USA
    Genet Epidemiol 34:674-9. 2010
  9. doi request reprint Differentiating population stratification from genotyping error using family data
    Ronnie Sebro
    Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Suite S965, San Francisco, CA 94143, USA
    Ann Hum Genet 76:42-52. 2012
  10. ncbi request reprint Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics
    Keyan Salari
    Department of Medicine, University of California, San Francisco, California 94143 1732, USA
    Genet Epidemiol 29:76-86. 2005

Collaborators

Detail Information

Publications19

  1. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
    ..To focus on African ancestry, we reduced the data to include only those genotypes in each African American determined statistically to be African in origin...
  2. pmc Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
    Joshua W Knowles
    Division of Cardiovascular Medicine, Falk Cardiovascular Research Building, Stanford University School of Medicine, Stanford, CA 94305 5406, USA
    BMC Med Genet 9:23. 2008
    ..We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically significant CAD in the Atherosclerotic Disease, VAscular FuNction, & Geneti C Epidemiology (ADVANCE) study...
  3. pmc Ancestry-related assortative mating in Latino populations
    Neil Risch
    Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Genome Biol 10:R132. 2009
    ..While spouse correlations have been documented for numerous traits, no prior studies have assessed assortative mating for genetic ancestry in admixed populations...
  4. pmc Intragenic Cis and Trans modification of genetic susceptibility in DYT1 torsion dystonia
    Neil J Risch
    Institute for Human Genetics, University of California at San Francisco, San Francisco, CA 94143, USA
    Am J Hum Genet 80:1188-93. 2007
    ..Our findings establish, for the first time, a clinically relevant gene modifier of DYT1...
  5. pmc Dissecting complex diseases in complex populations: asthma in latino americans
    Shweta Choudhry
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2911, USA
    Proc Am Thorac Soc 4:226-33. 2007
    ....
  6. pmc Ancestry-environment interactions and asthma risk among Puerto Ricans
    Shweta Choudhry
    University of California, San Francisco, San Francisco, CA 94143 2911, USA
    Am J Respir Crit Care Med 174:1088-93. 2006
    ..We hypothesized that, in this admixed population, the association between SES and asthma may interact with genetic ancestry...
  7. pmc Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region
    Shweta Choudhry
    Institute for Human Genetics, University of California, San Francisco, CA, USA
    Hum Genet 123:455-68. 2008
    ..3 region. Our results provide strong evidence that the previously linked 5q23 region is associated with asthma in Puerto Ricans. The detection of causative variants in this region will require fine mapping and functional validation...
  8. pmc Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study
    Ronnie Sebro
    Institute for Human Genetics, University of California San Francisco, San Francisco, California 94143 0794, USA
    Genet Epidemiol 34:674-9. 2010
    ..This nonrandom mating likely affects genetic structure seen more generally in the North American population of European descent today, and decreases the rate of decay of linkage disequilibrium for ancestrally informative markers...
  9. doi request reprint Differentiating population stratification from genotyping error using family data
    Ronnie Sebro
    Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Suite S965, San Francisco, CA 94143, USA
    Ann Hum Genet 76:42-52. 2012
    ..We simulate data based on several models of genotyping error in previously published literature, and show how this method could be used in practice to assist in differentiating population stratification from systematic genotyping error...
  10. ncbi request reprint Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics
    Keyan Salari
    Department of Medicine, University of California, San Francisco, California 94143 1732, USA
    Genet Epidemiol 29:76-86. 2005
    ..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation...
  11. pmc Admixture mapping of quantitative trait loci for blood lipids in African-Americans
    Analabha Basu
    Institute for Human Genetics, University of California San Francisco, 513 Parnassus Avenue, Room 901F HSW, San Francisco, CA 94143, USA
    Hum Mol Genet 18:2091-8. 2009
    ..The identified regions provide locations for follow-up studies of genetic variants underlying lipid variation in African-Americans and possibly other populations...
  12. pmc Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 76:268-75. 2005
    ..S. population. Implications of this genetic structure for case-control association studies are discussed...
  13. pmc Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene
    Gary A Heiman
    Department of Epidemiology of Joseph L Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Am J Med Genet B Neuropsychiatr Genet 144:361-4. 2007
    ..We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia...
  14. ncbi request reprint A genome-wide scan in forty large pedigrees with multiple sclerosis
    Cristen J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 52:955-62. 2007
    ..30. The inability to find significant linkage in these highly penetrant families suggests that linkage is not the optimal tool for dissecting the inheritance of MS...
  15. pmc Recent genetic selection in the ancestral admixture of Puerto Ricans
    Hua Tang
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
    Am J Hum Genet 81:626-33. 2007
    ..Two of these regions harbor genes for olfactory receptors. Interestingly, all three regions exhibit deficiencies in the European-ancestry proportion...
  16. ncbi request reprint Estimation of individual admixture: analytical and study design considerations
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Epidemiol 28:289-301. 2005
    ..g., simulations) not possible by Bayesian methods. Our simulation results demonstrate that inclusion of ancestral populations or their surrogates in the analysis is required by any method of IA estimation to obtain reasonable results...
  17. pmc Tree-structured supervised learning and the genetics of hypertension
    Jing Huang
    Affymetrix Inc, 3380 Central Expressway, Santa Clara, CA 95051, USA
    Proc Natl Acad Sci U S A 101:10529-34. 2004
    ..FlexTree and Logic Regression appear better than the others in terms of Bayes risk. However, the differences are not significant in the usual statistical sense...
  18. ncbi request reprint Immunology: hepatitis A virus link to atopic disease
    Jennifer J McIntire
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305 5208, USA
    Nature 425:576. 2003
  19. ncbi request reprint Candidate-gene approaches for studying complex genetic traits: practical considerations
    Holly K Tabor
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Nat Rev Genet 3:391-7. 2002
    ..We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation...