Mercedes Rincon

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 206:69-78. 2009
  2. pmc Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis
    Gustavo Carbone
    Department of Medicine, Division of Rheumatology, University of Vermont, Burlington, VT 05405, USA
    Int J Biol Sci 9:279-88. 2013
  3. pmc Non-classical p38 map kinase functions: cell cycle checkpoints and survival
    Tina M Thornton
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, Vermont 05405 0068, USA
    Int J Biol Sci 5:44-51. 2009
  4. pmc Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung
    O Dienz
    Department of Medicine Immunobiology, The University of Vermont, Burlington, Vermont, USA
    Mucosal Immunol 5:258-66. 2012
  5. pmc Role of IL-6 in asthma and other inflammatory pulmonary diseases
    Mercedes Rincon
    Department of Medicine, Immunobiology Division, University of Vermont, Burlington, VT 05405, USA
    Int J Biol Sci 8:1281-90. 2012
  6. doi request reprint Interleukin-6: from an inflammatory marker to a target for inflammatory diseases
    Mercedes Rincon
    Department of Medicine Immunobiology, University of Vermont, Burlington, VT 05405, USA
    Trends Immunol 33:571-7. 2012
  7. doi request reprint Regulation of the immune response by stress-activated protein kinases
    Mercedes Rincon
    Immunology Program, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Immunol Rev 228:212-24. 2009
  8. ncbi request reprint Inhibition of NFAT specifically in T cells prevents allergic pulmonary inflammation
    Sean Diehl
    Immunobiology Program, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 172:3597-603. 2004
  9. pmc Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells
    Wendy A Neveu
    Division of Immunobiology, Department of Medicine, Vermont Lung Center, University of Vermont College of Medicine, Burlington, USA
    Am J Respir Cell Mol Biol 45:1133-41. 2011
  10. pmc Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    Jenna B Allard
    Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
    Eur J Immunol 39:776-88. 2009

Research Grants

  1. P53 and cell cycle checkpoint by p38 MAP kinase
    Mercedes Rincon; Fiscal Year: 2007
  2. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2009
  3. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2001
  4. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2003
  5. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2004
  6. P53 and cell cycle checkpoint by p38 MAP kinase
    Mercedes Rincon; Fiscal Year: 2006
  7. P53 and cell cycle checkpoint by p38 MAP kinase
    Mercedes Rincon; Fiscal Year: 2003
  8. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2002
  9. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2010

Collaborators

Detail Information

Publications50

  1. pmc The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 206:69-78. 2009
    ..Thus, IL-6 promotes antibody production by promoting the B cell helper capabilities of CD4(+) T cells through increased IL-21 production. IL-6 could therefore be a potential coadjuvant to enhance humoral immunity...
  2. pmc Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis
    Gustavo Carbone
    Department of Medicine, Division of Rheumatology, University of Vermont, Burlington, VT 05405, USA
    Int J Biol Sci 9:279-88. 2013
    ..Thus, IL-6 contributes to the presence of IgG4-specific anti-CCP autoantibodies in RA patients, likely through its effect on IL-21 production by CD4 T cells, and IL-6R blockade down-regulates this pathway...
  3. pmc Non-classical p38 map kinase functions: cell cycle checkpoints and survival
    Tina M Thornton
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, Vermont 05405 0068, USA
    Int J Biol Sci 5:44-51. 2009
    ..It is important to recognize these less appreciated functions of p38 MAPK when considering the potential use of pharmacological inhibitors of p38 MAPK in therapeutic treatments for disease...
  4. pmc Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung
    O Dienz
    Department of Medicine Immunobiology, The University of Vermont, Burlington, Vermont, USA
    Mucosal Immunol 5:258-66. 2012
    ..Genetic or environmental factors that impair IL-6 production or signaling could increase mortality to influenza virus infection...
  5. pmc Role of IL-6 in asthma and other inflammatory pulmonary diseases
    Mercedes Rincon
    Department of Medicine, Immunobiology Division, University of Vermont, Burlington, VT 05405, USA
    Int J Biol Sci 8:1281-90. 2012
    ..Here, we provide an overview of the studies in mouse models and human patients that provide support for the involvement of IL-6 in lung diseases...
  6. doi request reprint Interleukin-6: from an inflammatory marker to a target for inflammatory diseases
    Mercedes Rincon
    Department of Medicine Immunobiology, University of Vermont, Burlington, VT 05405, USA
    Trends Immunol 33:571-7. 2012
    ..I will summarize the results from the recent clinical studies using IL-6 receptor blockade, and describe potential mechanisms by which IL-6 can contribute to the progression of inflammatory diseases...
  7. doi request reprint Regulation of the immune response by stress-activated protein kinases
    Mercedes Rincon
    Immunology Program, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Immunol Rev 228:212-24. 2009
    ....
  8. ncbi request reprint Inhibition of NFAT specifically in T cells prevents allergic pulmonary inflammation
    Sean Diehl
    Immunobiology Program, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 172:3597-603. 2004
    ..We, therefore, conclude that activation of NFAT in CD4+ T cells is required for the development of a Th2 immune response in vivo and allergic airway inflammation...
  9. pmc Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells
    Wendy A Neveu
    Division of Immunobiology, Department of Medicine, Vermont Lung Center, University of Vermont College of Medicine, Burlington, USA
    Am J Respir Cell Mol Biol 45:1133-41. 2011
    ..Thus, β-glucans may constitute a common determinant of the fungal and plant-derived allergens responsible for some of the pathological features in allergic asthma...
  10. pmc Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    Jenna B Allard
    Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
    Eur J Immunol 39:776-88. 2009
    ..Thus, different types of microbial products within the airway can alter the host's adaptive immune response and potentially impact the development of allergic airway disease to environmental fungal antigens...
  11. pmc IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program
    Viswas K Nagaleekar
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Immunol 181:8315-22. 2008
    ..Thus, IP(3)Rs play a key role in the activation and differentiation of CD4 T cells. The immunosuppressive effect of pharmacological blockers of these receptors may be complicated by promoting the development of inflammatory CD4 T cells...
  12. pmc Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 180:7471-9. 2008
    ..These data are the first to demonstrate that structural polymorphisms influencing cell surface expression of a G protein-coupled receptor in T cells regulates immune functions and autoimmune disease susceptibility...
  13. pmc IL-6 is required for airway mucus production induced by inhaled fungal allergens
    Wendy A Neveu
    Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, VT 05405, USA
    J Immunol 183:1732-8. 2009
    ..Thus, IL-6 is a key regulator of specific hallmark features of allergic airway inflammation and it could be a potential target for pulmonary diseases that are associated with goblet cell metaplasia and mucus hypersecretion...
  14. pmc Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 104:7175-80. 2007
    ..Thus, the accumulation of NFATc1 and NFATc2 in memory CD4+ T cells represents a previously uncharacterized regulatory mechanism for the induction of early gene expression after antigen stimulation...
  15. ncbi request reprint JNK and p38 MAP kinases in CD4+ and CD8+ T cells
    Mercedes Rincon
    Immunobiology Program, Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    Immunol Rev 192:131-42. 2003
    ..It is therefore important to consider the specific function of these kinases in each T cell population when pharmacological inhibitors of JNK and p38 MAP kinases are used for therapeutic purposes to control the immune response...
  16. pmc Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis
    Rajkumar Noubade
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT, USA
    Blood 118:3290-300. 2011
    ..Thus, mechanisms other than the regulation of gene expression also contribute to Th17 cell effector functions and, potentially, to the pathogenesis of other Th17 cell-mediated diseases...
  17. pmc Nuclear localization of p38 MAPK in response to DNA damage
    C David Wood
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, 05405, USA
    Int J Biol Sci 5:428-37. 2009
    ..The selective nuclear accumulation of p38 MAPK in response to DNA damage could be a mechanism to facilitate the phosphorylation of p38 MAPK nuclear targets for the induction of a G2/M cell cycle checkpoint and DNA repair...
  18. pmc Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expression
    Ketki M Hatle
    Department of Medicine Immunobiology Program, Given Medical Building D 305, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
    Mol Cell Biol 27:2952-66. 2007
    ..Thus, MCJ is required in these cells to prevent c-Jun-mediated expression of ABCB1 and maintain drug response...
  19. pmc Effects of acute and chronic low density lipoprotein exposure on neutrophil function
    Tatsiana Palvinskaya
    Department of Medicine, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Pulm Pharmacol Ther 26:405-11. 2013
    ..Together these findings suggest that chronic hypercholesterolemia impairs neutrophil functional responses, and these defects may be in part due to protracted signaling responses to LDL and its oxidized forms...
  20. pmc Translational control of NKT cell cytokine production by p38 MAPK
    Viswas K Nagaleekar
    Division of Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 186:4140-6. 2011
    ..Thus, in addition to gene expression, translational regulation by p38 MAPK could be a novel mechanism that contributes to the overall production of cytokine by NKT cells...
  21. pmc Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells
    Eva M Briso
    Department of Medicine Immunobiology Program, University of Vermont, Burlington VT 05405, USA
    J Immunol 180:7102-6. 2008
    ..Production of sIL-6R by autoreactive CD4 T cells may contribute to their role in the development of autoimmune disease by conferring IL-6-responsiveness to cells lacking IL-6R such as synoviocytes...
  22. pmc Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation
    Tina M Thornton
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405 0068, USA
    Science 320:667-70. 2008
    ..Activation of beta-catenin-mediated signaling through GSK3beta inhibition provides a potential mechanism for p38 MAPK-mediated survival in specific tissues...
  23. pmc Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    J Clin Invest 117:3507-18. 2007
    ..These data suggest that the presence of H1R in CD4+ T cells and its interaction with histamine regulates early TCR signals that lead to Th1 differentiation and autoimmune disease...
  24. ncbi request reprint Regulation of p38 MAP kinase in CD4+ lymphocytes by infliximab therapy in patients with rheumatoid arthritis
    Bruce E Garfield
    University of Vermont, Department of Medicine, Rheumatology Division, Burlington, VT 05405, USA
    Clin Immunol 116:101-7. 2005
    ..The selective effect of anti-TNFalpha therapy on the p38 MAP kinase signaling pathway of CD4+ T cells in patients with RA suggests that prolonged benefit with these agents may be mediated by their effect on CD4+ T cells...
  25. pmc Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos
    Christopher B Manning
    Environmental Pathology Program, University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 38:618-26. 2008
    ..These results suggest a critical role of MEK1 signaling in epithelial cell proliferation and lung remodeling after toxic injury...
  26. pmc Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation
    Sean Diehl
    Immunobiology Program, Department of Medicine, Given Medical Building, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 196:39-49. 2002
    ..Regulation of NFATc2 expression and NFAT transcriptional activity represents a novel pathway by which IL-6 can modulate gene expression...
  27. pmc p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells
    Nicholas Farley
    Department of Medicine Immunobiology Program, Given Medical Building D305, University of Vermont, Burlington, VT 05405, USA
    Mol Cell Biol 26:2118-29. 2006
    ..Therefore, the activation of p38 MAPK is a critical link between Fas and the mitochondrial death pathway and is required for the Fas-induced apoptosis of CD8+ T cells...
  28. pmc The effects of IL-6 on CD4 T cell responses
    Oliver Dienz
    Department of Medicine Immunobiology Program, Given Medical Building D305, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Clin Immunol 130:27-33. 2009
    ..This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases...
  29. pmc Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells
    Dimitry N Krementsov
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT
    Ann Neurol 75:50-66. 2014
    ..Investigators have described p38 mitogen-activated protein kinase (MAPK) as a key regulator of inflammatory responses in autoimmunity, but its role in the sexual dimorphism in MS or MS models remains unexplored...
  30. ncbi request reprint The two faces of IL-6 on Th1/Th2 differentiation
    Sean Diehl
    Immunobiology Program, Department of Medicine, University of Vermont, Given Medical Building D305, Burlington, VT 05405, USA
    Mol Immunol 39:531-6. 2002
    ..Since IL-6 is abundantly produced by APC, it is a likely source of early Th1/Th2 control during CD4(+) T cell activation. Thus, by using two independent molecular mechanisms, IL-6 plays a dual role in Th1/Th2 differentiation...
  31. pmc MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations
    Ketki M Hatle
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Mol Cell Biol 33:2302-14. 2013
    ..Impaired expression or loss of MCJ expression may therefore result in a "rapid" metabolism that mitigates the consequences of metabolic disorders...
  32. pmc Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice
    Arti Shukla
    Department of Pathology, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
    Am J Pathol 170:140-51. 2007
    ..These results also implicate targeted interruption of PKC-delta as a potential therapeutic option in asbestos-induced lung diseases...
  33. pmc Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function
    Wendy A Neveu
    Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont 05405, USA
    Respir Res 11:28. 2010
    ..Classically IL-6 has been viewed as an inflammatory marker, along with TNFalpha and IL-1beta, rather than as regulatory cytokine...
  34. pmc Polymorphisms in the CD1d promoter that regulate CD1d gene expression are associated with impaired NKT cell development
    Zachary D Borg
    Department of Surgery, University of Vermont College of Medicine, Burlington, VT 05405
    J Immunol 192:189-99. 2014
    ..Taken together, these results provide new insight into the control of CD1d gene expression, and they have implications for the evolution of CD1d and type I NKT cells. ..
  35. pmc Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint
    Gustavo Pedraza-Alva
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    EMBO J 25:763-73. 2006
    ..We propose that p38 MAP kinase is activated by V(D)J-mediated DSBs and induces a p53-mediated G2/M checkpoint to allow DNA repair and prevent cellular transformation...
  36. ncbi request reprint Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3
    Wenfang Wu
    Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Biol Chem 281:10682-90. 2006
    ..Our findings reveal a new post-transcriptional regulation of NFATc2 that operates, not only during apoptosis, but also in non-apoptotic effector T cells...
  37. pmc Acute inflammation induced by the biopsy of mouse mammary tumors promotes the development of metastasis
    Julia Hobson
    Division of Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Breast Cancer Res Treat 139:391-401. 2013
    ....
  38. pmc The emerging role of p38 mitogen-activated protein kinase in multiple sclerosis and its models
    Dimitry N Krementsov
    Department of Medicine, Immunobiology Program, University of Vermont, Burlington, Vermont, USA
    Mol Cell Biol 33:3728-34. 2013
    ....
  39. doi request reprint Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice
    Meagan Goodwin
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Stem Cells 29:1137-48. 2011
    ..Promotion of a Th1 phenotype in antigen-specific CD4 T lymphocytes by BMSCs is sufficient to inhibit Th2-mediated allergic airways inflammation through an IFNγ-dependent process...
  40. ncbi request reprint Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator
    Jenna B Allard
    Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 177:5186-94. 2006
    ..The Th2 bias of CD4+ T cells in the absence of functional CFTR correlates with elevated nuclear levels of NFAT. Thus, CFTR is important to maintain the Th1/Th2 balance in CD4+ T cells...
  41. ncbi request reprint Cyclin D-1, interleukin-6, HER-2/neu, transforming growth factor receptor-II and prediction of relapse in women with early stage, hormone receptor-positive breast cancer treated with tamoxifen
    Hyman B Muss
    Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Breast J 13:337-45. 2007
    ..In this trial, HER-2 and CD1 proved of borderline significance as predictive factors for recurrence on tamoxifen. An SVM model that included all clinical and biologic variables correctly predicted relapse in >75% of patients...
  42. ncbi request reprint Sonoporation, anti-cancer drug and antibody delivery using ultrasound
    Junru Wu
    Department of Physics, University of Vermont, Burlington, VT 05405, USA
    Ultrasonics 44:e21-5. 2006
    ..When goat anti-rabbit IgG was delivered, the efficiencies were 78.60+/-3.60% (control baseline was 1.60+/-0.00%) and 57.50+/-4.23% (control baseline was 11.30+/-0.81%) respectively for Jurkat cells and PBMC...
  43. ncbi request reprint Attenuation of neointimal vascular smooth muscle cellularity in atheroma by plasminogen activator inhibitor type 1 (PAI-1)
    David J Schneider
    University of Vermont, Colchester Research Facility, 208 S Park Drive, Colchester, VT 05446, USA
    J Histochem Cytochem 52:1091-9. 2004
    ..03). Accordingly, increased expression of PAI-1 protein by VSMCs reduces their migration in vitro and their contribution to neointimal cellularity in vivo...
  44. pmc Animal models of asthma
    Jason H T Bates
    Vermont Lung Center and Center for Immunology and Infectious Disease, University of Vermont College of Medicine, HSRF 228, 149 Beaumont Ave, Burlington, VT 05405 0075, USA
    Am J Physiol Lung Cell Mol Physiol 297:L401-10. 2009
    ....
  45. pmc c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation
    Dietrich Conze
    Section of Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 195:811-23. 2002
    ..Thus, JNK1 and JNK2 play different roles during CD8(+) T cell activation and these roles differ from those in CD4(+) T cells...
  46. pmc The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury
    Niki D Ubags
    1Department of Medicine, University of Vermont College of Medicine, Burlington, VT 2Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands 3Department of Medical Protein Research, Ghent University, Ghent, Belgium 4Department of Medicine, National Jewish Health, Denver, CO 5Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico 6Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 7Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA
    Crit Care Med 42:e143-51. 2014
    ..We hypothesized that pulmonary leptin contributes directly to the development of pulmonary neutrophilia during pneumonia and acute lung injury...
  47. ncbi request reprint Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: results of cancer and leukemia group B trial 159806
    Mercedes Rincon
    Vermont Cancer Center, University of Vermont, Burlington, VT, USA
    Breast Cancer Res Treat 100:301-8. 2006
    ..IHC expression of IL-6 and PGP levels in tumor cells is not a predictive marker for response to paclitaxel in women with metastatic breast cancer...
  48. pmc Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury
    Lauren L Kordonowy
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 47:120-7. 2012
    ..ALI is attenuated in obese mice, and this blunted response is in part attributable to an obesity-associated abnormal neutrophil chemoattractant response...
  49. pmc Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Biol Chem 283:20579-89. 2008
    ..Thus, the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform...

Research Grants12

  1. P53 and cell cycle checkpoint by p38 MAP kinase
    Mercedes Rincon; Fiscal Year: 2007
    ..pre-TcR provides survival signals during the cell cycle checkpoint of CD25+CD44 - thymocytes to prevent death of these cells while DNA repairs takes place. ..
  2. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2009
    ..In addition, genetic mutations that may affect this pathway could determine a relatively higher susceptibility to develop T cell malignancies. ..
  3. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2001
    ..abstract_text> ..
  4. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2003
    ..abstract_text> ..
  5. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2004
    ..abstract_text> ..
  6. P53 and cell cycle checkpoint by p38 MAP kinase
    Mercedes Rincon; Fiscal Year: 2006
    ..pre-TcR provides survival signals during the cell cycle checkpoint of CD25+CD44 - thymocytes to prevent death of these cells while DNA repairs takes place. ..
  7. P53 and cell cycle checkpoint by p38 MAP kinase
    Mercedes Rincon; Fiscal Year: 2003
    ..pre-TcR provides survival signals during the cell cycle checkpoint of CD25+CD44 - thymocytes to prevent death of these cells while DNA repairs takes place. ..
  8. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2002
    ..abstract_text> ..
  9. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2010
    ..In addition, genetic mutations that may affect this pathway could determine a relatively higher susceptibility to develop T cell malignancies. ..