Research Topics
Genomes and Genes
| Mercedes RinconSummaryAffiliation: University of Vermont Country: USA Publications
Research Grants
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Detail Information
Publications
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cellsOliver Dienz
Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
J Exp Med 206:69-78. 2009..Thus, IL-6 promotes antibody production by promoting the B cell helper capabilities of CD4(+) T cells through increased IL-21 production. IL-6 could therefore be a potential coadjuvant to enhance humoral immunity...- Role of IL-6 in asthma and other inflammatory pulmonary diseasesMercedes Rincon
Department of Medicine, Immunobiology Division, University of Vermont, Burlington, VT 05405, USA
Int J Biol Sci 8:1281-90. 2012..Here, we provide an overview of the studies in mouse models and human patients that provide support for the involvement of IL-6 in lung diseases... 
Interleukin-6: from an inflammatory marker to a target for inflammatory diseasesMercedes Rincon
Department of Medicine Immunobiology, University of Vermont, Burlington, VT 05405, USA
Trends Immunol 33:571-7. 2012..I will summarize the results from the recent clinical studies using IL-6 receptor blockade, and describe potential mechanisms by which IL-6 can contribute to the progression of inflammatory diseases...- Regulation of the immune response by stress-activated protein kinasesMercedes Rincon
Immunology Program, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
Immunol Rev 228:212-24. 2009.... - Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cellsWendy A Neveu
Division of Immunobiology, Department of Medicine, Vermont Lung Center, University of Vermont College of Medicine, Burlington, USA
Am J Respir Cell Mol Biol 45:1133-41. 2011..Thus, β-glucans may constitute a common determinant of the fungal and plant-derived allergens responsible for some of the pathological features in allergic asthma... - Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial productsJenna B Allard
Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
Eur J Immunol 39:776-88. 2009..Thus, different types of microbial products within the airway can alter the host's adaptive immune response and potentially impact the development of allergic airway disease to environmental fungal antigens... - IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine programViswas K Nagaleekar
Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
J Immunol 181:8315-22. 2008..Thus, IP(3)Rs play a key role in the activation and differentiation of CD4 T cells. The immunosuppressive effect of pharmacological blockers of these receptors may be complicated by promoting the development of inflammatory CD4 T cells... - Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expressionRajkumar Noubade
Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Immunol 180:7471-9. 2008..These data are the first to demonstrate that structural polymorphisms influencing cell surface expression of a G protein-coupled receptor in T cells regulates immune functions and autoimmune disease susceptibility... - Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitisRajkumar Noubade
Department of Medicine, Immunobiology Program, University of Vermont, Burlington, VT, USA
Blood 118:3290-300. 2011..Thus, mechanisms other than the regulation of gene expression also contribute to Th17 cell effector functions and, potentially, to the pathogenesis of other Th17 cell-mediated diseases... - Translational control of NKT cell cytokine production by p38 MAPKViswas K Nagaleekar
Division of Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Immunol 186:4140-6. 2011..Thus, in addition to gene expression, translational regulation by p38 MAPK could be a novel mechanism that contributes to the overall production of cytokine by NKT cells... - Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cellsOliver Dienz
Department of Medicine Immunobiology Program, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
Proc Natl Acad Sci U S A 104:7175-80. 2007..Thus, the accumulation of NFATc1 and NFATc2 in memory CD4+ T cells represents a previously uncharacterized regulatory mechanism for the induction of early gene expression after antigen stimulation... - Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestosChristopher B Manning
Environmental Pathology Program, University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue, Burlington, VT 05405, USA
Am J Respir Cell Mol Biol 38:618-26. 2008..These results suggest a critical role of MEK1 signaling in epithelial cell proliferation and lung remodeling after toxic injury... - Nuclear localization of p38 MAPK in response to DNA damageC David Wood
Department of Medicine Immunobiology Program, University of Vermont, Burlington, 05405, USA
Int J Biol Sci 5:428-37. 2009..The selective nuclear accumulation of p38 MAPK in response to DNA damage could be a mechanism to facilitate the phosphorylation of p38 MAPK nuclear targets for the induction of a G2/M cell cycle checkpoint and DNA repair... - Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in miceRajkumar Noubade
Department of Medicine, University of Vermont, Burlington, Vermont, USA
J Clin Invest 117:3507-18. 2007..These data suggest that the presence of H1R in CD4+ T cells and its interaction with histamine regulates early TCR signals that lead to Th1 differentiation and autoimmune disease... - IL-6 is required for airway mucus production induced by inhaled fungal allergensWendy A Neveu
Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, VT 05405, USA
J Immunol 183:1732-8. 2009..Thus, IL-6 is a key regulator of specific hallmark features of allergic airway inflammation and it could be a potential target for pulmonary diseases that are associated with goblet cell metaplasia and mucus hypersecretion... - Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivationTina M Thornton
Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405 0068, USA
Science 320:667-70. 2008..Activation of beta-catenin-mediated signaling through GSK3beta inhibition provides a potential mechanism for p38 MAPK-mediated survival in specific tissues... - Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cellsEva M Briso
Department of Medicine Immunobiology Program, University of Vermont, Burlington VT 05405, USA
J Immunol 180:7102-6. 2008..Production of sIL-6R by autoreactive CD4 T cells may contribute to their role in the development of autoimmune disease by conferring IL-6-responsiveness to cells lacking IL-6R such as synoviocytes... - p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cellsNicholas Farley
Department of Medicine Immunobiology Program, Given Medical Building D305, University of Vermont, Burlington, VT 05405, USA
Mol Cell Biol 26:2118-29. 2006..Therefore, the activation of p38 MAPK is a critical link between Fas and the mitochondrial death pathway and is required for the Fas-induced apoptosis of CD8+ T cells... - Methylation-controlled J protein promotes c-Jun degradation to prevent ABCB1 transporter expressionKetki M Hatle
Department of Medicine Immunobiology Program, Given Medical Building D 305, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
Mol Cell Biol 27:2952-66. 2007..Thus, MCJ is required in these cells to prevent c-Jun-mediated expression of ABCB1 and maintain drug response... - Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout miceArti Shukla
Department of Pathology, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
Am J Pathol 170:140-51. 2007..These results also implicate targeted interruption of PKC-delta as a potential therapeutic option in asbestos-induced lung diseases... - Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway functionWendy A Neveu
Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont 05405, USA
Respir Res 11:28. 2010..Classically IL-6 has been viewed as an inflammatory marker, along with TNFalpha and IL-1beta, rather than as regulatory cytokine... 
JNK and p38 MAP kinases in CD4+ and CD8+ T cellsMercedes Rincon
Immunobiology Program, Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
Immunol Rev 192:131-42. 2003..It is therefore important to consider the specific function of these kinases in each T cell population when pharmacological inhibitors of JNK and p38 MAP kinases are used for therapeutic purposes to control the immune response...- The two faces of IL-6 on Th1/Th2 differentiationSean Diehl
Immunobiology Program, Department of Medicine, University of Vermont, Given Medical Building D305, Burlington, VT 05405, USA
Mol Immunol 39:531-6. 2002..Since IL-6 is abundantly produced by APC, it is a likely source of early Th1/Th2 control during CD4(+) T cell activation. Thus, by using two independent molecular mechanisms, IL-6 plays a dual role in Th1/Th2 differentiation... - The effects of IL-6 on CD4 T cell responsesOliver Dienz
Department of Medicine Immunobiology Program, Given Medical Building D305, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
Clin Immunol 130:27-33. 2009..This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases... - Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in miceMeagan Goodwin
Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
Stem Cells 29:1137-48. 2011..Promotion of a Th1 phenotype in antigen-specific CD4 T lymphocytes by BMSCs is sufficient to inhibit Th2-mediated allergic airways inflammation through an IFNγ-dependent process... - Non-classical p38 map kinase functions: cell cycle checkpoints and survivalTina M Thornton
Department of Medicine Immunobiology Program, University of Vermont, Burlington, Vermont 05405 0068, USA
Int J Biol Sci 5:44-51. 2009..It is important to recognize these less appreciated functions of p38 MAPK when considering the potential use of pharmacological inhibitors of p38 MAPK in therapeutic treatments for disease... - Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpointGustavo Pedraza-Alva
Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
EMBO J 25:763-73. 2006..We propose that p38 MAP kinase is activated by V(D)J-mediated DSBs and induces a p53-mediated G2/M checkpoint to allow DNA repair and prevent cellular transformation... - Sonoporation, anti-cancer drug and antibody delivery using ultrasoundJunru Wu
Department of Physics, University of Vermont, Burlington, VT 05405, USA
Ultrasonics 44:e21-5. 2006..When goat anti-rabbit IgG was delivered, the efficiencies were 78.60+/-3.60% (control baseline was 1.60+/-0.00%) and 57.50+/-4.23% (control baseline was 11.30+/-0.81%) respectively for Jurkat cells and PBMC... - Animal models of asthmaJason H T Bates
Vermont Lung Center and Center for Immunology and Infectious Disease, University of Vermont College of Medicine, HSRF 228, 149 Beaumont Ave, Burlington, VT 05405 0075, USA
Am J Physiol Lung Cell Mol Physiol 297:L401-10. 2009.... - Cyclin D-1, interleukin-6, HER-2/neu, transforming growth factor receptor-II and prediction of relapse in women with early stage, hormone receptor-positive breast cancer treated with tamoxifenHyman B Muss
Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 05401, USA
Breast J 13:337-45. 2007..In this trial, HER-2 and CD1 proved of borderline significance as predictive factors for recurrence on tamoxifen. An SVM model that included all clinical and biologic variables correctly predicted relapse in >75% of patients... - Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulatorJenna B Allard
Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Immunol 177:5186-94. 2006..The Th2 bias of CD4+ T cells in the absence of functional CFTR correlates with elevated nuclear levels of NFAT. Thus, CFTR is important to maintain the Th1/Th2 balance in CD4+ T cells... - c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activationDietrich Conze
Section of Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Exp Med 195:811-23. 2002..Thus, JNK1 and JNK2 play different roles during CD8(+) T cell activation and these roles differ from those in CD4(+) T cells... - Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3Wenfang Wu
Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Biol Chem 281:10682-90. 2006..Our findings reveal a new post-transcriptional regulation of NFATc2 that operates, not only during apoptosis, but also in non-apoptotic effector T cells... - Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injuryLauren L Kordonowy
Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Respir Cell Mol Biol 47:120-7. 2012..ALI is attenuated in obese mice, and this blunted response is in part attributable to an obesity-associated abnormal neutrophil chemoattractant response... - Attenuation of neointimal vascular smooth muscle cellularity in atheroma by plasminogen activator inhibitor type 1 (PAI-1)David J Schneider
University of Vermont, Colchester Research Facility, 208 S Park Drive, Colchester, VT 05446, USA
J Histochem Cytochem 52:1091-9. 2004..03). Accordingly, increased expression of PAI-1 protein by VSMCs reduces their migration in vitro and their contribution to neointimal cellularity in vivo... - Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backboneSusan Lowey
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
J Biol Chem 283:20579-89. 2008..Thus, the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform... - Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritisGustavo Carbone
Department of Medicine, Division of Rheumatology, University of Vermont, Burlington, VT 05405, USA
Int J Biol Sci 9:279-88. 2013..Thus, IL-6 contributes to the presence of IgG4-specific anti-CCP autoantibodies in RA patients, likely through its effect on IL-21 production by CD4 T cells, and IL-6R blockade down-regulates this pathway... - Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiationSean Diehl
Immunobiology Program, Department of Medicine, Given Medical Building, University of Vermont, Burlington, VT 05405, USA
J Exp Med 196:39-49. 2002..Regulation of NFATc2 expression and NFAT transcriptional activity represents a novel pathway by which IL-6 can modulate gene expression... - Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: results of cancer and leukemia group B trial 159806Mercedes Rincon
Vermont Cancer Center, University of Vermont, Burlington, VT, USA
Breast Cancer Res Treat 100:301-8. 2006..IHC expression of IL-6 and PGP levels in tumor cells is not a predictive marker for response to paclitaxel in women with metastatic breast cancer...
Research Grants
- p38 MAP kinase in early thymocyte developmentMercedes Rincon; Fiscal Year: 2009..In addition, genetic mutations that may affect this pathway could determine a relatively higher susceptibility to develop T cell malignancies. ..
- P53 and cell cycle checkpoint by p38 MAP kinaseMercedes Rincon; Fiscal Year: 2007..pre-TcR provides survival signals during the cell cycle checkpoint of CD25+CD44 - thymocytes to prevent death of these cells while DNA repairs takes place. ..
- P53 and cell cycle checkpoint by p38 MAP kinaseMercedes Rincon; Fiscal Year: 2006..pre-TcR provides survival signals during the cell cycle checkpoint of CD25+CD44 - thymocytes to prevent death of these cells while DNA repairs takes place. ..
- Lung epithelium-derived IL-6 in CD4+ T cell immune resp*Mercedes Rincon; Fiscal Year: 2004..abstract_text> ..
- P53 and cell cycle checkpoint by p38 MAP kinaseMercedes Rincon; Fiscal Year: 2003..pre-TcR provides survival signals during the cell cycle checkpoint of CD25+CD44 - thymocytes to prevent death of these cells while DNA repairs takes place. ..
- p38 MAP kinase in early thymocyte developmentMercedes Rincon; Fiscal Year: 2010..In addition, genetic mutations that may affect this pathway could determine a relatively higher susceptibility to develop T cell malignancies. ..