C R Rinaldo

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc MicroRNA regulation and its effects on cellular transcriptome in human immunodeficiency virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts
    Karolina Duskova
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 425 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    BMC Infect Dis 13:250. 2013
  2. pmc Dendritic cell-based human immunodeficiency virus vaccine
    C R Rinaldo
    Department of Infectious Diseases, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Intern Med 265:138-58. 2009
  3. pmc Passive immunization against poliomyelitis: the Hammon gamma globulin field trials, 1951-1953
    Charles R Rinaldo
    Department of Infectious Diseases, University of Pittsburgh Graduate School of Public Health, School of Public Health, PA 15261, USA
    Am J Public Health 95:790-9. 2005
  4. ncbi request reprint Virus infection of dendritic cells: portal for host invasion and host defense
    Charles R Rinaldo
    Department of Infectious Diseases and Microbiology and Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Trends Microbiol 12:337-45. 2004
  5. ncbi request reprint Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens
    C R Rinaldo
    Deptartment of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Infect Dis 179:329-36. 1999
  6. pmc Anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1-infected patients with advanced immunodeficiency
    C R Rinaldo
    Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    J Virol 74:4127-38. 2000
  7. pmc High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors
    P Gupta
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, and Veterans Affairs Medical Center, Pennsylvania, USA
    J Virol 71:6271-5. 1997
  8. ncbi request reprint Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins
    Q J Wang
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Blood 97:2366-73. 2001
  9. pmc Processing and presentation of exogenous HLA class I peptides by dendritic cells from human immunodeficiency virus type 1-infected persons
    Xiao li Huang
    University of Pittsburgh Graduate School of Public Health, 130 DeSoto St, Pittsburgh, PA 15261, USA
    J Virol 79:3052-62. 2005
  10. doi request reprint Maturation of dendritic cells for enhanced activation of anti-HIV-1 CD8(+) T cell immunity
    Xiao li Huang
    Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Leukoc Biol 83:1530-40. 2008

Research Grants

  1. Dendritic Cell-Based Immunotherapy for HIV Infection
    Charles Rinaldo; Fiscal Year: 2006
  2. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles Rinaldo; Fiscal Year: 2007
  3. MULTICENTER AIDS COHORT STUDY
    Charles Rinaldo; Fiscal Year: 2007
  4. ANTI-HIV T CELL RESPONSES DURING ANTIVIRAL DRUG THERAPY
    Charles Rinaldo; Fiscal Year: 2007
  5. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles Rinaldo; Fiscal Year: 2006
  6. CYTOTOXIC T CELL RESPONSES TO HHV8
    Charles Rinaldo; Fiscal Year: 2002
  7. ANTIHIV T CELL RESPONSES DURING ANTIVIRAL DRUG THERAPY
    Charles Rinaldo; Fiscal Year: 1999
  8. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles Rinaldo; Fiscal Year: 2003
  9. ANTI-HIV T CELL RESPONSES DURING ANTIVIRAL DRUG THERAPY
    Charles Rinaldo; Fiscal Year: 2003
  10. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2010

Detail Information

Publications57

  1. pmc MicroRNA regulation and its effects on cellular transcriptome in human immunodeficiency virus-1 (HIV-1) infected individuals with distinct viral load and CD4 cell counts
    Karolina Duskova
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 425 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    BMC Infect Dis 13:250. 2013
    ....
  2. pmc Dendritic cell-based human immunodeficiency virus vaccine
    C R Rinaldo
    Department of Infectious Diseases, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Intern Med 265:138-58. 2009
    ..The objective is to define a safe and effective strategy for enhancing control of HIV infection in patients undergoing antiretroviral therapy...
  3. pmc Passive immunization against poliomyelitis: the Hammon gamma globulin field trials, 1951-1953
    Charles R Rinaldo
    Department of Infectious Diseases, University of Pittsburgh Graduate School of Public Health, School of Public Health, PA 15261, USA
    Am J Public Health 95:790-9. 2005
    ..This study provided the first evidence that antibodies to poliovirus could prevent the disease in humans...
  4. ncbi request reprint Virus infection of dendritic cells: portal for host invasion and host defense
    Charles R Rinaldo
    Department of Infectious Diseases and Microbiology and Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Trends Microbiol 12:337-45. 2004
    ..Engineering of DCs with various forms of viral immunogens and co-treatment with cytokines and chemokines is being used as an immunotherapy for HIV-1 and other viral infections...
  5. ncbi request reprint Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens
    C R Rinaldo
    Deptartment of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Infect Dis 179:329-36. 1999
    ..Prolonged indinavir-zidovudine-lamivudine treatment has significant but incomplete enhancing effects on CD4 T cell reactivity, which could be important in host control of microbial and persistent HIV-1 infections...
  6. pmc Anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1-infected patients with advanced immunodeficiency
    C R Rinaldo
    Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    J Virol 74:4127-38. 2000
    ..These results indicate that new strategies will be needed to target residual, immunocompetent HIV-1-specific CD8(+) T cells to enhance the effectiveness of antiretroviral therapy in patients with advanced immunodeficiency...
  7. pmc High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors
    P Gupta
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, and Veterans Affairs Medical Center, Pennsylvania, USA
    J Virol 71:6271-5. 1997
    ..These findings have important implications for the biology of sexual transmission of HIV-1 and its potential reduction by antiretroviral therapy...
  8. ncbi request reprint Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins
    Q J Wang
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Blood 97:2366-73. 2001
    ..CD8(+) T-cell responses to HHV-8 decreased by 2 to 3 years after primary infection. This antiviral T-cell response may control initial HHV-8 infection and prevent development of disease...
  9. pmc Processing and presentation of exogenous HLA class I peptides by dendritic cells from human immunodeficiency virus type 1-infected persons
    Xiao li Huang
    University of Pittsburgh Graduate School of Public Health, 130 DeSoto St, Pittsburgh, PA 15261, USA
    J Virol 79:3052-62. 2005
    ..This conclusion supports the use of DCs loaded with synthetic peptides in immunotherapy of HIV-1 infection...
  10. doi request reprint Maturation of dendritic cells for enhanced activation of anti-HIV-1 CD8(+) T cell immunity
    Xiao li Huang
    Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Leukoc Biol 83:1530-40. 2008
    ..Thus, DC from HIV-1-infected subjects can be engineered with CD40L or a poly(I:C)-cytokine combination for enhancing CD8(+) T cell responses to HIV-1, which has potential applications in HIV-1 immunotherapy...
  11. pmc Dendritic cell function during chronic hepatitis C virus and human immunodeficiency virus type 1 infection
    Zheng Fan
    Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Vaccine Immunol 14:1127-37. 2007
    ..DCs from these infected subjects have a normal capacity to stimulate CD4+ T cells. The functional effectiveness of DCs derived from HCV-infected individuals provides a rationale for the DC-based immunotherapy of chronic HCV infection...
  12. pmc Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape
    Biswanath Majumder
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, USA
    J Virol 79:7990-8003. 2005
    ..Taken together, these results indicate that HIV-1 Vpr may in part be responsible for HIV-1 immune evasion by inhibiting the maturation of costimulatory molecules and cytokines essential for immune activation...
  13. pmc Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individuals
    Nancy C Connolly
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Vaccine Immunol 15:284-92. 2008
    ..DC vaccination was safe, was feasible, and showed promise of immunogenicity in ART-treated, HIV-1-positive individuals. Additional studies of DC immunization strategies for HIV-1 infection are warranted...
  14. pmc Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, 604 Parran Hall, 130 De Soto St, Pittsburgh, PA 15261, USA
    J Virol 82:4793-806. 2008
    ..Thus, the expression of DC-SIGN is essential for productive HHV-8 infection of and replication in B cells...
  15. pmc DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS Pathog 2:e70. 2006
    ..Transmission of HIV-1 from B cells to T cells through this DC-SIGN pathway could be important in the pathogenesis of HIV-1 infection...
  16. ncbi request reprint Levels of antigen processing machinery components in dendritic cells generated for vaccination of HIV-1+ subjects
    Nancy Connolly
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    AIDS 21:1683-92. 2007
    ....
  17. ncbi request reprint DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages
    Giovanna Rappocciolo
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Immunol 176:1741-9. 2006
    ..We propose that DC-SIGN serves as a portal for immune dysfunction and oncogenesis caused by HHV-8 infection...
  18. pmc Herpesvirus infections in organ transplant recipients
    Frank J Jenkins
    Department of Pathology and Infectious Diseases, University of Pittsburgh School of Medicine, Graduate School of Public Health, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261, USA
    Clin Diagn Lab Immunol 10:1-7. 2003
  19. ncbi request reprint Proinflammatory cytokines in HIV disease-a review and rationale for new therapeutic approaches
    Nancy C Connolly
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    AIDS Rev 7:168-80. 2005
    ..This review presents what is known about the dysregulation of proinflammatory cytokines in HIV-1 infection, highlighting newly available immune-based therapies that could augment antiretroviral drug therapies...
  20. pmc Multiple T-cell responses to human immunodeficiency virus type 1 are enhanced by dendritic cells
    Xiao li Huang
    Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Clin Vaccine Immunol 16:1504-16. 2009
    ..These results indicate that DC can enhance multiple types of HIV-1-specific T-cell functions...
  21. pmc Primary human immunodeficiency virus type 1-specific CD8+ T-cell responses induced by myeloid dendritic cells
    Bonnie A Colleton
    Graduate School of Public Health1 and School of Medicine, 2 University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 83:6288-99. 2009
    ..Thus, three major types of blood and tissue myeloid DC targeted by HIV-1, i.e., moDC, LC, and idDC, can prime multispecific, polyfunctional CD8(+) T-cell responses to HIV-1 and other viral antigens...
  22. ncbi request reprint Priming of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cell responses by dendritic cells loaded with HIV-1 proteins
    Xiao li Huang
    Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    J Infect Dis 187:315-9. 2003
    ..Whole HIV-1 protein in liposome may be an effective immunogen for HIV-1 vaccine protocols...
  23. ncbi request reprint CD8+ T-cell immunity to HIV infection
    Paolo Piazza
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, 425 Parran Hall, Pittsburgh, PA 15261, USA
    Clin Lab Med 22:773-97. 2002
    ..Knowledge of HIV-1-specific T-cell immunity and its role in protection from HIV-1 infection and disease must continue to expand until the goal of complete control of HIV-1 infection is accomplished...
  24. ncbi request reprint A phase I study of ampligen in human immunodeficiency virus-infected subjects
    J A Armstrong
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania
    J Infect Dis 166:717-22. 1992
    ..This effect of ampligen and the fact that it has been shown to act synergistically with zidovudine against HIV in vitro suggest that the combination might be tried clinically in patients...
  25. ncbi request reprint Identification of an HLA A*0201-restricted CD8(+) T-cell epitope for the glycoprotein B homolog of human herpesvirus 8
    Qiong J Wang
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Blood 99:3360-6. 2002
    ..This epitope may be important in control of HHV-8 infection by CD8(+) T cells...
  26. pmc Comparison of immunologic assays for detecting immune responses in HIV immunotherapeutic studies: AIDS Clinical Trials Group Trial A5181
    Bernard J C Macatangay
    Division of Infectious Diseases HIV AIDS Unit, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Vaccine Immunol 17:1452-9. 2010
    ..These studies highlight complexities of immunologic monitoring of T-cell responses in multisite clinical trials in HIV infection and outline considerations for optimizing these efforts...
  27. ncbi request reprint Activation of HIV type 1 specific cytotoxic T lymphocytes from semen by HIV type 1 antigen-presenting dendritic cells and IL-12
    Xiao li Huang
    Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    AIDS Res Hum Retroviruses 22:93-8. 2006
    ..The DC-T cell system can serve as a model for immunotherapy of HIV-1 infection in the local genital tract as well as systemic blood circulation...
  28. pmc Production of a dendritic cell-based vaccine containing inactivated autologous virus for therapy of patients with chronic human immunodeficiency virus type 1 infection
    Theresa L Whiteside
    Department of Pathology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    Clin Vaccine Immunol 16:233-40. 2009
    ..bb-ind-13137)...
  29. ncbi request reprint Treating HIV-1 infection with dendritic cells
    Nancy C Connolly
    University of Pittsburgh, School of Medicine and Graduate School of Public Health, 204 Craft Avenue, B501, Pittsburgh, PA 15213, USA
    Curr Opin Mol Ther 9:353-63. 2007
    ..This review focuses on HIV-1-DC interactions, the impact of these on DC therapeutics for the treatment of HIV-1-infected individuals and the current status of DC-based therapeutic vaccines for HIV-1 infection...
  30. pmc Induction of anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) and CD4(+) T-cell reactivity by dendritic cells loaded with HIV-1 X4-infected apoptotic cells
    Xiao Qing Zhao
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 76:3007-14. 2002
    ..This may be an important mechanism of HIV-1 immunogenicity and provides a strategy for immunotherapy of HIV-1-infected patients on combination antiretroviral therapy...
  31. pmc Restoration of anti-human immunodeficiency virus type 1 (HIV-1) responses in CD8+ T cells from late-stage patients on prolonged antiretroviral therapy by stimulation in vitro with HIV-1 protein-loaded dendritic cells
    Z Fan
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Virol 75:4413-9. 2001
    ..This suggests that dendritic cells from HIV-1-infected persons can be engineered to evoke stronger anti-HIV-1 CD8+ T-cell reactivity as a strategy to augment antiretroviral therapy...
  32. pmc Cytokine production by human herpesvirus 8-infected dendritic cells
    Heather R Hensler
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Gen Virol 90:79-83. 2009
    ..These results suggest an intentional skewing of cytokine production in HHV-8-infected DCs towards induction of a Th2 response...
  33. pmc CD27 and CD57 expression reveals atypical differentiation of human immunodeficiency virus type 1-specific memory CD8+ T cells
    Aki Hoji
    Department of Infectious Diseases, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Vaccine Immunol 14:74-80. 2007
    ..This lack of normal CD8+ T-cell differentiation could contribute to the failure of cellular immune control of HIV-1 infection...
  34. pmc Human CD8+ T cells specific for influenza A virus M1 display broad expression of maturation-associated phenotypic markers and chemokine receptors
    Aki Hoji
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Immunology 115:239-45. 2005
    ..A phenotypic profile based on these observations showed that there are both immature and mature memory CD8+ T cells specific for FluA...
  35. ncbi request reprint Minimization of genetic distances by the consensus, ancestral, and center-of-tree (COT) sequences for HIV-1 variants within an infected individual and the design of reagents to test immune reactivity
    Girish S Kesturu
    Thomas E Starzl Transplantation Institute, Department of Surgery, School of Medicine, University of Pittsburgh, PA 15261, USA
    Virology 348:437-48. 2006
    ..COT or CON sequences derived from autologous virus samplings may be useful for increasing the sensitivity of assessments of immune reactivity against HIV...
  36. pmc Prevalence of chlamydia and gonorrhoea among a population of men who have sex with men
    R L Cook
    University of Pittsburgh, PA 15213, USA
    Sex Transm Infect 78:190-3. 2002
    ....
  37. ncbi request reprint Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection
    Chenglong Liu
    School of Public Health, University of California, Los Angeles, CA 90095, USA
    J Infect Dis 187:1404-10. 2003
    ..In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34-23.10; P=.018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28-3.84; P=.005) were associated with resistance...
  38. ncbi request reprint Successful outcome of human metapneumovirus (hMPV) pneumonia in a lung transplant recipient treated with intravenous ribavirin
    Kashif Raza
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 26:862-4. 2007
    ..We report a case of hMPV pneumonia in a lung transplant recipient presenting with respiratory failure and sepsis syndrome. hMPV was diagnosed by polymerase chain reaction, and treated with intravenous ribavirin with a successful outcome...
  39. ncbi request reprint Lack of associations between HLA class II alleles and resistance to HIV-1 infection among white, non-Hispanic homosexual men
    Chenglong Liu
    School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    J Acquir Immune Defic Syndr 37:1313-7. 2004
    ..Other genetic factors in the HLA class II-TAP region of the major histocompatibility complex might be involved...
  40. pmc Vascular risk factors, HIV serostatus, and cognitive dysfunction in gay and bisexual men
    J T Becker
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 73:1292-9. 2009
    ..The purpose of this study was to evaluate the relationship between cognitive performance, risk factors for cardiovascular and cerebrovascular disease (CVD), and HIV infection in the era of highly active antiretroviral therapy...
  41. doi request reprint Relationship of cytomegalovirus load assessed by real-time PCR to pp65 antigenemia in organ transplant recipients
    Sonali K Sanghavi
    Clinical Virology Laboratory, University of Pittsburgh Medical Center, United States
    J Clin Virol 42:335-42. 2008
    ..Cytomegalovirus (CMV) infection in immunocompromised patients can lead to viremia associated with morbidity and mortality. Monitoring of viral loads in blood is critical for initiating and monitoring antiviral treatment...
  42. ncbi request reprint Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection
    Janis V Giorgi
    UCLA School of Medicine and Center for AIDS Research, Los Angeles, California 90095 1475, USA
    J Acquir Immune Defic Syndr 29:346-55. 2002
    ....
  43. ncbi request reprint Development and implementation of a direct detection, quantitation and validation system for class I MHC self-peptide epitopes
    Jon A Weidanz
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    J Immunol Methods 318:47-58. 2007
    ..We therefore demonstrate the successful development and implementation of an integrated discovery and validation technology system for direct identification and confirmation of class I MHC-peptide epitopes on cells...
  44. ncbi request reprint When to initiate highly active antiretroviral therapy: a cohort approach
    Linda Ahdieh-Grant
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 157:738-46. 2003
    ..Furthermore, results suggest a potential threshold for HAART initiation in the neighborhood of 275 cells/microl...
  45. ncbi request reprint Effect of highly active antiretroviral therapy on multiple AIDS-defining illnesses among male HIV seroconverters
    Lauren E Cain
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street E7640, Baltimore, MD 21205, USA
    Am J Epidemiol 163:310-5. 2006
    ..34 (95% CI: 0.25, 0.45) relative to the reference calendar period. HAART protects against initial and subsequent AIDS-defining illnesses, whose inclusion in analysis markedly increased the precision of the estimated hazard ratio...
  46. ncbi request reprint Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 193:698-702. 2006
    ..5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals; P=.0291). These findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1...
  47. ncbi request reprint Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL response
    June Kan-Mitchell
    Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 176:6690-701. 2006
    ..This study suggests that agonist sequences can replace aberrantly immunogenic native epitopes for the rational design of vaccines targeting HIV-1...
  48. ncbi request reprint Prognostic value of HIV-1 RNA, CD4 cell count, and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1 infection
    John W Mellors
    JAMA 297:2349-50. 2007
  49. ncbi request reprint Estimating the benefit of an HIV-1 vaccine that reduces viral load set point
    Swati B Gupta
    Merck Research Laboratories, West Point, PA, USA
    J Infect Dis 195:546-50. 2007
    ..5-1.25 log(10) copies/mL lower than the reference group. By quantifying the anticipated clinical benefits associated with a reduction in viral set point, these findings support the use of virologic end points in HIV-1 vaccine trials...
  50. ncbi request reprint Prospective study of attitudinal and relationship predictors of sexual risk in the multicenter AIDS cohort study
    David G Ostrow
    David Ostrow and Associates, Chicago MACS Howard Brown Health Center and Northwestern University School of Medicine, 5455 N Sheridan Rd, Suite 1207, Chicago, IL 60640, USA
    AIDS Behav 12:127-38. 2008
    ..We conclude that HIV prevention efforts should target modifiable attitudes (reduced concern about HIV and safer sex fatigue) and increases in sexual risk-taking of MSM, particularly among HIV+ men having sex with serodiscordant partners...
  51. pmc Induction of mucosal protection against primary, heterologous simian immunodeficiency virus by a DNA vaccine
    Deborah Heydenburg Fuller
    PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
    J Virol 76:3309-17. 2002
    ..These results support further development of a DNA vaccine for protection against HIV...
  52. pmc Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS
    Ping An
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, Maryland, United States of America
    PLoS Pathog 3:e88. 2007
    ..These results implicate regulatory PPIA polymorphisms as a component of genetic susceptibility to HIV-1 infection or disease progression, affirming the important role of PPIA in HIV-1 pathogenesis...
  53. ncbi request reprint Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype
    Elizabeth Crabb Breen
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Clin Immunol 109:119-29. 2003
    ..009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter -592 C/C genotype are associated with development of AIDS lymphoma...
  54. ncbi request reprint Impact of inversion of the CD4/CD8 ratio on the natural history of HIV-1 infection
    Joseph B Margolick
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 42:620-6. 2006
    ..HIV-1 infection is characterized by an inverted CD4/CD8 T-cell ratio, but the distribution of inversions over time after seroconversion and whether delay of inversion is associated with a favorable prognosis are not known...
  55. pmc Effect of tuberculosis on the survival of HIV-infected men in a country with low tuberculosis incidence
    Hugo Lopez-Gatell
    Directorate of Epidemiology, Ministry of Health, Mexico, Mexico
    AIDS 22:1869-73. 2008
    ..2-4.7). Results underscore the importance of avoiding TB by using preventive interventions such as treatment of latent TB infection, particularly in populations with a large prevalence of HIV/TB co-infected individuals...
  56. doi request reprint Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study
    Gypsyamber D'Souza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 48:491-9. 2008
    ..To examine the incidence and risk factors for anal cancer in a multicenter cohort of human immunodeficiency virus (HIV) positive and HIV-negative men who have sex with men followed between 1984 and 2006 (Multicenter AIDS Cohort Study)...
  57. pmc Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Virol 81:12382-93. 2007
    ....

Research Grants30

  1. Dendritic Cell-Based Immunotherapy for HIV Infection
    Charles Rinaldo; Fiscal Year: 2006
    ..We believe that this novel immunotherapy strategy ideally fulfills the intent of the NIAID Integrated Preclinical/Clinical Program. ..
  2. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles Rinaldo; Fiscal Year: 2007
    ..This is important for development of therapies and prophylactic vaccines for HHV-8 infection. ..
  3. MULTICENTER AIDS COHORT STUDY
    Charles Rinaldo; Fiscal Year: 2007
    ..abstract_text> ..
  4. ANTI-HIV T CELL RESPONSES DURING ANTIVIRAL DRUG THERAPY
    Charles Rinaldo; Fiscal Year: 2007
    ..We propose that this DC-apoptotic cell model may be an ideal immunogen that contains all antigenic forms of HIV-1 and can be a vehicle for therapeutic immunization. ..
  5. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles Rinaldo; Fiscal Year: 2006
    ..This is important for development of therapies and prophylactic vaccines for HHV-8 infection. ..
  6. CYTOTOXIC T CELL RESPONSES TO HHV8
    Charles Rinaldo; Fiscal Year: 2002
    ..Such information is also important for understanding the immune correlates of protection against HHV-8 infection as the basis for development of therapeutic regimens and prophylatic vaccines ..
  7. ANTIHIV T CELL RESPONSES DURING ANTIVIRAL DRUG THERAPY
    Charles Rinaldo; Fiscal Year: 1999
    ....
  8. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles Rinaldo; Fiscal Year: 2003
    ..This is important for development of therapies and prophylactic vaccines for HHV-8 infection. ..
  9. ANTI-HIV T CELL RESPONSES DURING ANTIVIRAL DRUG THERAPY
    Charles Rinaldo; Fiscal Year: 2003
    ..We believe that these new, novel antigen delivery systems and processing methods will be highly efficient at inducing a broad spectrum of anti-HIV-1 T cell responses in ART patients. ..
  10. CYTOTOXIC T CELL RESPONSES TO HHV-8
    Charles R Rinaldo; Fiscal Year: 2010
    ..This study will provide important information on CD8 T cell immunity during HHV-8 infection for development of adequate treatment and prevention strategies for HHV-8 related cancers. ..