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Species | Lisa M RimszaSummaryAffiliation: University of Arizona Country: USA Publications
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Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma MolecularLisa M Rimsza
Department of Pathology, College of Medicine, University of Arizona, 1501 N Campbell Ave, PO Box 245043, Tucson, AZ 85724 5043, USA
Blood 103:4251-8. 2004..8% versus 11.0%; P =.001), supporting the hypothesis that loss of tumor immunosurveillance has a devastating effect on patient outcome in DLBCL...
Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletionsLisa M Rimsza
Department of Pathology, University of Arizona, Tucson, AZ 85724 5043, USA
Blood 107:1101-7. 2006..Large deletions of the MHCII locus are uncommon in non-IP-DLBCL, implicating altered transcription as the operative mechanism for decreased expression...- HLA-DR protein status predicts survival in patients with diffuse large B-cell lymphoma treated on the MACOP-B chemotherapy regimenLisa M Rimsza
Department of Pathology, University of Arizona, Tucson, AZ 85724, USA
Leuk Lymphoma 48:542-6. 2007..023). A Cox multivariate model established both IPI (P = 0.031) and HLA-DR (P = 0.04) as independent predictors of OS. This is the first demonstration of the prognostic relevance of HLA-DR in a uniformly treated DLBCL patient group... - Benign B-cell precursors (hematogones) are the predominant lymphoid population in the bone marrow of preterm infantsLisa M Rimsza
Department of Pathology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
Biol Neonate 86:247-53. 2004..These findings are pertinent for the interpretation of BM and peripheral blood samples in this age group as survival improves and diagnostic samples become more common... - Endothelial stimulation by small lymphocytic lymphoma correlates with secreted levels of basic fibroblastic growth factorLisa Rimsza
Department of Pathology, Immunology and Laboratory Medicine, Division of Hematopathology, University of Florida, Gainesville, FL, USA
Br J Haematol 120:753-8. 2003..Our results indicate that bFGF is probably the primary mediator responsible for increased angiogenesis in involved nodes. These findings may be pertinent to future investigation into the mechanisms of increased angiogenesis in SLL... 
Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOPLisa M Rimsza
Department of Pathology, University of Arizona, Tucson, USA
Blood 112:3425-33. 2008....- Accurate classification of diffuse large B-cell lymphoma into germinal center and activated B-cell subtypes using a nuclease protection assay on formalin-fixed, paraffin-embedded tissuesLisa M Rimsza
Department of Pathology, University of Arizona High ThroughPut Genomics Arizona Cancer Center, Tucson, Arizona 85724, USA
Clin Cancer Res 17:3727-32. 2011..This approach is quantifiable, applicable to FFPE tissues with no technical failures, and has potential for significant impact on DLBCL research and clinical trial development... - Loss of major histocompatibility class II gene and protein expression in primary mediastinal large B-cell lymphoma is highly coordinated and related to poor patient survivalRobin A Roberts
Department of Pathology, University of Arizona, Tucson, AZ 85724-5043, USA
Blood 108:311-8. 2006..Although overall survival was better, survival of the lowest 10% of MHC II expressers was similarly poor in DLBCL and PMBCL. MHC II expression may define a therapeutic target in both these diseases... - A phase 2 trial of standard-dose cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) and rituximab plus bevacizumab for patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: SWOG 0515Alison T Stopeck
University of Arizona Cancer Center, Tucson, AZ, USA
Blood 120:1210-7. 2012..This study is registered at www.clinicaltrials.gov as #NCT00121199... - Effects of hypoxia on megakaryocyte progenitors obtained from the umbilical cord blood of term and preterm neonatesMatthew A Saxonhouse
Department of Pediatrics, University of Florida, Gainesville, 32610 0296, USA
Biol Neonate 89:104-8. 2006..We hypothesized that decreased Mk production is the result of a direct inhibitory effect of hypoxia on the proliferation of Mk progenitors, or a hypoxia-induced change in the fetal hematopoietic environment... - Phase II study of rituximab plus three cycles of CHOP and involved-field radiotherapy for patients with limited-stage aggressive B-cell lymphoma: Southwest Oncology Group study 0014Daniel O Persky
Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
J Clin Oncol 26:2258-63. 2008.... - Effects of sepsis on neonatal thrombopoiesisRachel E Brown
Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
Pediatr Res 64:399-404. 2008..In addition, our findings suggest that different factors, likely including level of illness and/or specific platelet or bacterial products, can down-regulate the magnitude of the thrombopoietic response... - Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy aloneDaniel O Persky
Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
Haematologica 97:937-42. 2012..We examined this association in the context of anti-CD20 monoclonal antibody combined with chemotherapy, as compared to chemotherapy alone, in follicular lymphoma patients treated on SWOG clinical trials... - Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B-cell lymphoma into germinal center B-cell and nongerminal center B-cell subtypes correlates with gene expression profile and patient survivalChadwick F Haarer
Department of Pathology, University of Arizona, Tucson, AZ, USA
Arch Pathol Lab Med 130:1819-24. 2006.... - Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytesKaren M Pastos
Shands Cancer Center, University of Florida, Gainesville, FL, USA
Blood 108:3360-2. 2006..1 ng/mL) inhibited their maturation. This is the first evidence that human neonatal and adult MKs have substantially different biologic responses to Tpo and potentially to other cytokines... - A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosisMargaret E Tome
Department of Pathology, University of Arizona, Tucson, 85724, USA
Blood 106:3594-601. 2005..The data suggest that the patients with the worst prognosis combine a decrease in antioxidant defense enzyme expression with an increase in thioredoxin system function (the redox signature score)... - A phase II trial of single agent bevacizumab in patients with relapsed, aggressive non-Hodgkin lymphoma: Southwest oncology group study S0108Alison T Stopeck
Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
Leuk Lymphoma 50:728-35. 2009..Clinical trials combining active chemotherapy regimens with VEGF targeted agents are currently in progress... - Differences between newborn and adult mice in their response to immune thrombocytopeniaZhongbo Hu
Department of Pediatrics, University of Florida, Gainesville, FL, USA
Neonatology 98:100-8. 2010..Sick neonates frequently develop severe thrombocytopenia... - Reticulated platelet percentages in term and preterm neonatesMatthew A Saxonhouse
Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, P O Box 100296, Gainesville, FL 32610 0296, USA
J Pediatr Hematol Oncol 26:797-802. 2004..The authors aimed to determine whether their reticulated platelet percentage (RP%) analysis technique was suitable for use in term and preterm neonates and to characterize RP% values among nonthrombocytopenic neonates... - Severe thrombocytopenia in a neonate with congenital HIV infectionPatrick Tighe
Department of Pediatrics, University of Florida, Gainesville 32610, USA
J Pediatr 146:408-13. 2005 - Partial plasma cell differentiation as a mechanism of lost major histocompatibility complex class II expression in diffuse large B-cell lymphomaSarah T Wilkinson
Department of Pathology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5043, USA
Blood 119:1459-67. 2012..Our observations provide a possible unifying concept that may contribute to the poor outcome reported in all MHC II(-) B-cell tumors... - Natural killer-like T-cell lymphoma of the parotid in a patient infected with human immunodeficiency virusDennis B Cornfield
Department of Pathology, University of Florida College of Medicine, Gainesville, USA
Arch Pathol Lab Med 126:738-41. 2002..After 2 separate chemotherapy regimens, the patient achieved clinical remission for 1(1/2) years; he then developed progressive pulmonary lesions and died... - Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesisChristof Dame
Department of Pediatrics, University of Florida, Gainesville 32610 0296, USA
Br J Haematol 119:510-5. 2002.... - Megakaryocyte size and concentration in the bone marrow of thrombocytopenic and nonthrombocytopenic neonatesMartha C Sola Visner
Department of Pediatrics, University of Florida, Gainesville, FL 32611, USA
Pediatr Res 61:479-84. 2007..001). This was not observed among thrombocytopenic neonates, suggesting a developmental limitation in their ability to increase megakaryocyte size... - Quantitative nuclease protection assay in paraffin-embedded tissue replicates prognostic microarray gene expression in diffuse large-B-cell lymphomaRobin A Roberts
Department of Pathology, University of Arizona, Tucson, AZ 85724 5043, USA
Lab Invest 87:979-97. 2007..While this technique cannot replace GEP for discovery, it indicates that expression differences identified by GEP can be replicated on a platform applicable to archived FFPE samples... - A strategy for full interrogation of prognostic gene expression patterns: exploring the biology of diffuse large B cell lymphomaLisa M Rimsza
Department of Pathology, University of Arizona, Tucson, Arizona, United States of America
PLoS ONE 6:e22267. 2011..We sought to determine whether examining multiple cut-points might be a more powerful technique to investigate the association of gene expression with outcome... - Effects of anoxia on megakaryocyte progenitors derived from cord blood CD34pos cellsMatthew A Saxonhouse
Department of Pediatrics, University of Florida, Gainesville, FL, USA
Eur J Haematol 71:359-65. 2003..The thrombocytopenia in some cases is the result of disseminated intravascular coagulation, but that mechanism fails to account for all, perhaps the majority, of cases... - A neonate with severe thrombocytopenia and radio-ulnar synostosisMartha C Sola
Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
J Perinatol 24:528-30. 2004..This entity can be distinguished from the TAR syndrome (thrombocytopenia and absent radii) by the distinctive orthopedic issues, different underlying genetic mutations, and a more worrisome prognosis for CAMT than for TAR... - Regulating the suppressors: helpful or harmful?Lisa Rimsza
Department of Pathology, University of Arizona, Tucson, Arizona, USA
Leuk Lymphoma 49:179-80. 2008 - Diffuse aggressive histologies of non-hodgkin lymphoma: treatment and biology of limited diseaseThomas P Miller
Department of Medicine, and Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
Semin Hematol 43:207-12. 2006.... - CD58 expression decreases as nonmalignant B cells mature in bone marrow and is frequently overexpressed in adult and pediatric precursor B-cell acute lymphoblastic leukemiaRonald V Lee
Department of Pathology, University of Florida, Gainesville, USA
Am J Clin Pathol 123:119-24. 2005..These findings support the potential usefulness of CD58 expression in the diagnosis and monitoring of precursor B-ALL, but only when blasts express high levels of CD58... - Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphomaChristopher J Stasik
Department of Pathology, University of Arizona, 1501 N Campbell Avenue, PO Box 245043, Tucson, AZ 85724 5043, USA
Haematologica 95:597-603. 2010..However, the presence of increased MYC gene copy number and/or polysomy of chromosome 8 have not been previously described... - Developmental differences in megakaryocyte size in infants and childrenDeborah A Fuchs
Department of Pathology, Box 5403, 1501 N Campbell Ave, Tucson, AZ 85724, USA
Am J Clin Pathol 138:140-5. 2012..These observations have direct implications for the evaluation of bone marrow megakaryocytes in young children... - Umbilical cord blood produces small megakaryocytes after transplantationMark Ignatz
Department of Pediatrics, University of Florida, Gainesville, Florida, USA
Biol Blood Marrow Transplant 13:145-50. 2007..For the first time, we demonstrate that the attainment of adult size in CB-derived megakaryocytes is delayed after human CB transplantation... - Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cellsSandeep S Dave
National Cancer Institute, NIH, Bethesda, MD 20892, USA
N Engl J Med 351:2159-69. 2004..CONCLUSIONS: The length of survival among patients with follicular lymphoma correlates with the molecular features of nonmalignant immune cells present in the tumor at diagnosis... - Molecular diagnosis of Burkitt's lymphomaSandeep S Dave
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
N Engl J Med 354:2431-42. 2006..CONCLUSIONS: Gene-expression profiling is an accurate, quantitative method for distinguishing Burkitt's lymphoma from diffuse large-B-cell lymphoma... - Follicular lymphoma intratumoral CD4+CD25+GITR+ regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8+CD25- and CD4+CD25- T cellsShannon P Hilchey
James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Immunol 178:4051-61. 2007..Lastly, we demonstrate that inhibition of TGF-beta signaling partially restores FLN T cell proliferation suggesting a mechanistic role for TGF-beta in FLN T(R)-mediated suppression... - Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathwaysGeorg Lenz
Metabolism Branch, Biometric Research Branch, Center for Information Technology, and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:13520-5. 2008..Together, these data provide genetic evidence that the DLBCL subtypes are distinct diseases that use different oncogenic pathways... - Frequent occurrence of deletions in primary mediastinal B-cell lymphomaLindsey R Kimm
Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
Genes Chromosomes Cancer 46:1090-7. 2007..We conclude that consistent losses are present in the PMBCL genome. Given the similar frequency of losses to that of segmental gains of DNA, they are likely to play an important role in the pathogenesis of PMBCL... - Pseudothrombocytopenia in a preterm neonateRobert D Christensen
Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine and All Children s Hospital, St Petersburg, Florida, USA
Pediatrics 114:273-5. 2004.... - AML, angiogenesis, and prognostic variablesLisa M Rimsza
Blood 100:1517-8. 2002