Lisa M Rimsza

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Molecular
    Lisa M Rimsza
    Department of Pathology, College of Medicine, University of Arizona, 1501 N Campbell Ave, PO Box 245043, Tucson, AZ 85724 5043, USA
    Blood 103:4251-8. 2004
  2. ncbi request reprint HLA-DR protein status predicts survival in patients with diffuse large B-cell lymphoma treated on the MACOP-B chemotherapy regimen
    Lisa M Rimsza
    Department of Pathology, University of Arizona, Tucson, AZ 85724, USA
    Leuk Lymphoma 48:542-6. 2007
  3. ncbi request reprint Endothelial stimulation by small lymphocytic lymphoma correlates with secreted levels of basic fibroblastic growth factor
    Lisa Rimsza
    Department of Pathology, Immunology and Laboratory Medicine, Division of Hematopathology, University of Florida, Gainesville, FL, USA
    Br J Haematol 120:753-8. 2003
  4. pmc Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions
    Lisa M Rimsza
    Department of Pathology, University of Arizona, Tucson, AZ 85724 5043, USA
    Blood 107:1101-7. 2006
  5. ncbi request reprint Benign B-cell precursors (hematogones) are the predominant lymphoid population in the bone marrow of preterm infants
    Lisa M Rimsza
    Department of Pathology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Biol Neonate 86:247-53. 2004
  6. doi request reprint Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP
    Lisa M Rimsza
    Department of Pathology, University of Arizona, Tucson, USA
    Blood 112:3425-33. 2008
  7. pmc Accurate classification of diffuse large B-cell lymphoma into germinal center and activated B-cell subtypes using a nuclease protection assay on formalin-fixed, paraffin-embedded tissues
    Lisa M Rimsza
    Department of Pathology, University of Arizona High ThroughPut Genomics Arizona Cancer Center, Tucson, Arizona 85724, USA
    Clin Cancer Res 17:3727-32. 2011
  8. pmc Loss of major histocompatibility class II gene and protein expression in primary mediastinal large B-cell lymphoma is highly coordinated and related to poor patient survival
    Robin A Roberts
    Department of Pathology, University of Arizona, Tucson, AZ 85724 5043, USA
    Blood 108:311-8. 2006
  9. pmc A phase 2 trial of standard-dose cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) and rituximab plus bevacizumab for patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: SWOG 0515
    Alison T Stopeck
    University of Arizona Cancer Center, Tucson, AZ, USA
    Blood 120:1210-7. 2012
  10. ncbi request reprint Effects of hypoxia on megakaryocyte progenitors obtained from the umbilical cord blood of term and preterm neonates
    Matthew A Saxonhouse
    Department of Pediatrics, University of Florida, Gainesville, 32610 0296, USA
    Biol Neonate 89:104-8. 2006

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Molecular
    Lisa M Rimsza
    Department of Pathology, College of Medicine, University of Arizona, 1501 N Campbell Ave, PO Box 245043, Tucson, AZ 85724 5043, USA
    Blood 103:4251-8. 2004
    ..8% versus 11.0%; P =.001), supporting the hypothesis that loss of tumor immunosurveillance has a devastating effect on patient outcome in DLBCL...
  2. ncbi request reprint HLA-DR protein status predicts survival in patients with diffuse large B-cell lymphoma treated on the MACOP-B chemotherapy regimen
    Lisa M Rimsza
    Department of Pathology, University of Arizona, Tucson, AZ 85724, USA
    Leuk Lymphoma 48:542-6. 2007
    ..023). A Cox multivariate model established both IPI (P = 0.031) and HLA-DR (P = 0.04) as independent predictors of OS. This is the first demonstration of the prognostic relevance of HLA-DR in a uniformly treated DLBCL patient group...
  3. ncbi request reprint Endothelial stimulation by small lymphocytic lymphoma correlates with secreted levels of basic fibroblastic growth factor
    Lisa Rimsza
    Department of Pathology, Immunology and Laboratory Medicine, Division of Hematopathology, University of Florida, Gainesville, FL, USA
    Br J Haematol 120:753-8. 2003
    ..Our results indicate that bFGF is probably the primary mediator responsible for increased angiogenesis in involved nodes. These findings may be pertinent to future investigation into the mechanisms of increased angiogenesis in SLL...
  4. pmc Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions
    Lisa M Rimsza
    Department of Pathology, University of Arizona, Tucson, AZ 85724 5043, USA
    Blood 107:1101-7. 2006
    ..Large deletions of the MHCII locus are uncommon in non-IP-DLBCL, implicating altered transcription as the operative mechanism for decreased expression...
  5. ncbi request reprint Benign B-cell precursors (hematogones) are the predominant lymphoid population in the bone marrow of preterm infants
    Lisa M Rimsza
    Department of Pathology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Biol Neonate 86:247-53. 2004
    ..These findings are pertinent for the interpretation of BM and peripheral blood samples in this age group as survival improves and diagnostic samples become more common...
  6. doi request reprint Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP
    Lisa M Rimsza
    Department of Pathology, University of Arizona, Tucson, USA
    Blood 112:3425-33. 2008
    ....
  7. pmc Accurate classification of diffuse large B-cell lymphoma into germinal center and activated B-cell subtypes using a nuclease protection assay on formalin-fixed, paraffin-embedded tissues
    Lisa M Rimsza
    Department of Pathology, University of Arizona High ThroughPut Genomics Arizona Cancer Center, Tucson, Arizona 85724, USA
    Clin Cancer Res 17:3727-32. 2011
    ..This approach is quantifiable, applicable to FFPE tissues with no technical failures, and has potential for significant impact on DLBCL research and clinical trial development...
  8. pmc Loss of major histocompatibility class II gene and protein expression in primary mediastinal large B-cell lymphoma is highly coordinated and related to poor patient survival
    Robin A Roberts
    Department of Pathology, University of Arizona, Tucson, AZ 85724 5043, USA
    Blood 108:311-8. 2006
    ..Although overall survival was better, survival of the lowest 10% of MHC II expressers was similarly poor in DLBCL and PMBCL. MHC II expression may define a therapeutic target in both these diseases...
  9. pmc A phase 2 trial of standard-dose cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) and rituximab plus bevacizumab for patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: SWOG 0515
    Alison T Stopeck
    University of Arizona Cancer Center, Tucson, AZ, USA
    Blood 120:1210-7. 2012
    ..This study is registered at www.clinicaltrials.gov as #NCT00121199...
  10. ncbi request reprint Effects of hypoxia on megakaryocyte progenitors obtained from the umbilical cord blood of term and preterm neonates
    Matthew A Saxonhouse
    Department of Pediatrics, University of Florida, Gainesville, 32610 0296, USA
    Biol Neonate 89:104-8. 2006
    ..We hypothesized that decreased Mk production is the result of a direct inhibitory effect of hypoxia on the proliferation of Mk progenitors, or a hypoxia-induced change in the fetal hematopoietic environment...
  11. doi request reprint Phase II study of rituximab plus three cycles of CHOP and involved-field radiotherapy for patients with limited-stage aggressive B-cell lymphoma: Southwest Oncology Group study 0014
    Daniel O Persky
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    J Clin Oncol 26:2258-63. 2008
    ....
  12. doi request reprint Effects of sepsis on neonatal thrombopoiesis
    Rachel E Brown
    Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    Pediatr Res 64:399-404. 2008
    ..In addition, our findings suggest that different factors, likely including level of illness and/or specific platelet or bacterial products, can down-regulate the magnitude of the thrombopoietic response...
  13. pmc Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone
    Daniel O Persky
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Haematologica 97:937-42. 2012
    ..We examined this association in the context of anti-CD20 monoclonal antibody combined with chemotherapy, as compared to chemotherapy alone, in follicular lymphoma patients treated on SWOG clinical trials...
  14. ncbi request reprint Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B-cell lymphoma into germinal center B-cell and nongerminal center B-cell subtypes correlates with gene expression profile and patient survival
    Chadwick F Haarer
    Department of Pathology, University of Arizona, Tucson, AZ, USA
    Arch Pathol Lab Med 130:1819-24. 2006
    ....
  15. pmc Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes
    Karen M Pastos
    Shands Cancer Center, University of Florida, Gainesville, FL, USA
    Blood 108:3360-2. 2006
    ..1 ng/mL) inhibited their maturation. This is the first evidence that human neonatal and adult MKs have substantially different biologic responses to Tpo and potentially to other cytokines...
  16. pmc Differences between newborn and adult mice in their response to immune thrombocytopenia
    Zhongbo Hu
    Department of Pediatrics, University of Florida, Gainesville, FL, USA
    Neonatology 98:100-8. 2010
    ..Sick neonates frequently develop severe thrombocytopenia...
  17. pmc A phase II trial of single agent bevacizumab in patients with relapsed, aggressive non-Hodgkin lymphoma: Southwest oncology group study S0108
    Alison T Stopeck
    Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Leuk Lymphoma 50:728-35. 2009
    ..Clinical trials combining active chemotherapy regimens with VEGF targeted agents are currently in progress...
  18. ncbi request reprint Reticulated platelet percentages in term and preterm neonates
    Matthew A Saxonhouse
    Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, P O Box 100296, Gainesville, FL 32610 0296, USA
    J Pediatr Hematol Oncol 26:797-802. 2004
    ..The authors aimed to determine whether their reticulated platelet percentage (RP%) analysis technique was suitable for use in term and preterm neonates and to characterize RP% values among nonthrombocytopenic neonates...
  19. ncbi request reprint Severe thrombocytopenia in a neonate with congenital HIV infection
    Patrick Tighe
    Department of Pediatrics, University of Florida, Gainesville 32610, USA
    J Pediatr 146:408-13. 2005
  20. pmc A redox signature score identifies diffuse large B-cell lymphoma patients with a poor prognosis
    Margaret E Tome
    Department of Pathology, University of Arizona, Tucson, 85724, USA
    Blood 106:3594-601. 2005
    ..The data suggest that the patients with the worst prognosis combine a decrease in antioxidant defense enzyme expression with an increase in thioredoxin system function (the redox signature score)...
  21. doi request reprint Developmental differences in megakaryocyte size in infants and children
    Deborah A Fuchs
    Department of Pathology, Box 5403, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Am J Clin Pathol 138:140-5. 2012
    ..These observations have direct implications for the evaluation of bone marrow megakaryocytes in young children...
  22. pmc Partial plasma cell differentiation as a mechanism of lost major histocompatibility complex class II expression in diffuse large B-cell lymphoma
    Sarah T Wilkinson
    Department of Pathology, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724 5043, USA
    Blood 119:1459-67. 2012
    ..Our observations provide a possible unifying concept that may contribute to the poor outcome reported in all MHC II(-) B-cell tumors...
  23. ncbi request reprint Natural killer-like T-cell lymphoma of the parotid in a patient infected with human immunodeficiency virus
    Dennis B Cornfield
    Department of Pathology, University of Florida College of Medicine, Gainesville, USA
    Arch Pathol Lab Med 126:738-41. 2002
    ..After 2 separate chemotherapy regimens, the patient achieved clinical remission for 1(1/2) years; he then developed progressive pulmonary lesions and died...
  24. ncbi request reprint Quantitative nuclease protection assay in paraffin-embedded tissue replicates prognostic microarray gene expression in diffuse large-B-cell lymphoma
    Robin A Roberts
    Department of Pathology, University of Arizona, Tucson, AZ 85724 5043, USA
    Lab Invest 87:979-97. 2007
    ..While this technique cannot replace GEP for discovery, it indicates that expression differences identified by GEP can be replicated on a platform applicable to archived FFPE samples...
  25. ncbi request reprint Megakaryocyte size and concentration in the bone marrow of thrombocytopenic and nonthrombocytopenic neonates
    Martha C Sola-Visner
    Department of Pediatrics, University of Florida, Gainesville, FL 32611, USA
    Pediatr Res 61:479-84. 2007
    ..001). This was not observed among thrombocytopenic neonates, suggesting a developmental limitation in their ability to increase megakaryocyte size...
  26. ncbi request reprint Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis
    Christof Dame
    Department of Pediatrics, University of Florida, Gainesville 32610 0296, USA
    Br J Haematol 119:510-5. 2002
    ....
  27. ncbi request reprint Effects of anoxia on megakaryocyte progenitors derived from cord blood CD34pos cells
    Matthew A Saxonhouse
    Department of Pediatrics, University of Florida, Gainesville, FL, USA
    Eur J Haematol 71:359-65. 2003
    ..The thrombocytopenia in some cases is the result of disseminated intravascular coagulation, but that mechanism fails to account for all, perhaps the majority, of cases...
  28. pmc A strategy for full interrogation of prognostic gene expression patterns: exploring the biology of diffuse large B cell lymphoma
    Lisa M Rimsza
    Department of Pathology, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 6:e22267. 2011
    ..We sought to determine whether examining multiple cut-points might be a more powerful technique to investigate the association of gene expression with outcome...
  29. ncbi request reprint A neonate with severe thrombocytopenia and radio-ulnar synostosis
    Martha C Sola
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
    J Perinatol 24:528-30. 2004
    ..This entity can be distinguished from the TAR syndrome (thrombocytopenia and absent radii) by the distinctive orthopedic issues, different underlying genetic mutations, and a more worrisome prognosis for CAMT than for TAR...
  30. ncbi request reprint Regulating the suppressors: helpful or harmful?
    Lisa Rimsza
    Department of Pathology, University of Arizona, Tucson, Arizona, USA
    Leuk Lymphoma 49:179-80. 2008
  31. ncbi request reprint Diffuse aggressive histologies of non-hodgkin lymphoma: treatment and biology of limited disease
    Thomas P Miller
    Department of Medicine, and Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Semin Hematol 43:207-12. 2006
    ....
  32. pmc Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma
    Christopher J Stasik
    Department of Pathology, University of Arizona, 1501 N Campbell Avenue, PO Box 245043, Tucson, AZ 85724 5043, USA
    Haematologica 95:597-603. 2010
    ..However, the presence of increased MYC gene copy number and/or polysomy of chromosome 8 have not been previously described...
  33. ncbi request reprint CD58 expression decreases as nonmalignant B cells mature in bone marrow and is frequently overexpressed in adult and pediatric precursor B-cell acute lymphoblastic leukemia
    Ronald V Lee
    Department of Pathology, University of Florida, Gainesville, USA
    Am J Clin Pathol 123:119-24. 2005
    ..These findings support the potential usefulness of CD58 expression in the diagnosis and monitoring of precursor B-ALL, but only when blasts express high levels of CD58...
  34. pmc The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies
    Kristy Lee
    Department of Pathology, University of Arizona, Tucson, AZ 85724, USA
    Free Radic Biol Med 60:157-67. 2013
    ..Our findings suggest that ATN-224's dual targeting of SOD1 and CcOX is a promising approach for treatment of hematological malignancies either as an adjuvant or as a single agent...
  35. ncbi request reprint Umbilical cord blood produces small megakaryocytes after transplantation
    Mark Ignatz
    Department of Pediatrics, University of Florida, Gainesville, Florida, USA
    Biol Blood Marrow Transplant 13:145-50. 2007
    ..For the first time, we demonstrate that the attainment of adult size in CB-derived megakaryocytes is delayed after human CB transplantation...
  36. ncbi request reprint Molecular diagnosis of Burkitt's lymphoma
    Sandeep S Dave
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 354:2431-42. 2006
    ..We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma...
  37. ncbi request reprint Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
    Sandeep S Dave
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    N Engl J Med 351:2159-69. 2004
    ..We used gene-expression profiles of tumor-biopsy specimens obtained at diagnosis to develop a molecular predictor of the length of survival...
  38. ncbi request reprint Frequent occurrence of deletions in primary mediastinal B-cell lymphoma
    Lindsey R Kimm
    Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    Genes Chromosomes Cancer 46:1090-7. 2007
    ..We conclude that consistent losses are present in the PMBCL genome. Given the similar frequency of losses to that of segmental gains of DNA, they are likely to play an important role in the pathogenesis of PMBCL...
  39. ncbi request reprint Follicular lymphoma intratumoral CD4+CD25+GITR+ regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8+CD25- and CD4+CD25- T cells
    Shannon P Hilchey
    James P Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:4051-61. 2007
    ..Lastly, we demonstrate that inhibition of TGF-beta signaling partially restores FLN T cell proliferation suggesting a mechanistic role for TGF-beta in FLN T(R)-mediated suppression...
  40. ncbi request reprint Pseudothrombocytopenia in a preterm neonate
    Robert D Christensen
    Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine and All Children s Hospital, St Petersburg, Florida, USA
    Pediatrics 114:273-5. 2004
    ....
  41. ncbi request reprint AML, angiogenesis, and prognostic variables
    Lisa M Rimsza
    Blood 100:1517-8. 2002
  42. pmc Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
    Georg Lenz
    Metabolism Branch, Biometric Research Branch, Center for Information Technology, and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:13520-5. 2008
    ..Together, these data provide genetic evidence that the DLBCL subtypes are distinct diseases that use different oncogenic pathways...