Genomes and Genes
Affiliation: University of Texas
- Neuregulins: primary or secondary signals for the control of synapse-specific gene expressionMendell Rimer
Section of Neurobiology, Institute for Cell and Molecular Biology, and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
J Neurocytol 32:665-75. 2003..In addition, I briefly present new evidence that raise the possibility that Nrgs encoded by the ngr-1 -related gene nrg-2 might have a role controlling AChR expression...
- Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4Mendell Rimer
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, NYU Medical School, New York, NY 10016, USA
Mol Cell Neurosci 26:271-81. 2004..Thus, Neuregulin-2 is a candidate for a signal that regulates synaptic differentiation...
- Neuregulin-1 immunoglobulin-like domain mutant mice: clozapine sensitivity and impaired latent inhibitionMendell Rimer
Section of Neurobiology, University of Texas at Austin, Austin, TX 78712 0248, USA
Neuroreport 16:271-5. 2005..These results suggest that Ig-Nrg-1's contribute to some - but not all - aspects of the schizophrenia-like phenotype of nrg-1 mutants, and further support nrg-1 as a candidate gene for schizophrenia...
- Neuregulins at the neuromuscular synapse: past, present, and futureMendell Rimer
Section of Neurobiology, Institute for Neuroscience and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712 0248, USA
J Neurosci Res 85:1827-33. 2007..Finally, I also suggest that neuregulin signaling may have an important role to play in mediating the response of adult terminal Schwann cells to denervation...
- Evidence for muscle-dependent neuromuscular synaptic site determination in mammalsVita M Vock
Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712, USA
J Neurosci 28:3123-30. 2008..This, and not the nerve, seems primarily responsible for the widely distributed pattern of synapses in our experimental animals...
- Schwann cell-derived neuregulin-2alpha can function as a cell-attached activator of muscle acetylcholine receptor expressionOlga N Ponomareva
Section of Neurobiology, University of Texas, Austin, Texas, USA
Glia 54:630-7. 2006..They also raise the possibility that Schwann cell-derived Nrg-2 could activate ErbB receptors on the synaptic sarcolemma and that this could account, at least in part, for the Nrg-mediated regulation of AChR expression...
- Induction of neuregulin signaling in mouse schwann cells in vivo mimics responses to denervationChristopher R Hayworth
Section of Neurobiology and Institute for Neuroscience, University of Texas, Austin, Texas 78712, USA
J Neurosci 26:6873-84. 2006..These findings show that the responses of SCs in muscle to denervation can be explained by induction of an autocrine/paracrine neuregulin signaling cascade suggested by previous molecular studies...
- Muscles in a mouse model of spinal muscular atrophy show profound defects in neuromuscular development even in the absence of failure in neuromuscular transmission or loss of motor neuronsYoung Il Lee
Section of Molecular Cell and Developmental Biology, The University of Texas, Austin, TX 78712, USA
Dev Biol 356:432-44. 2011..Thus, if SMA in this particular mouse is a disease of motor neurons, it can act in a manner that does not result in their death or disconnection from their targets but nonetheless alters many aspects of neuromuscular development...
- Defective neuromuscular synaptogenesis in mice expressing constitutively active ErbB2 in skeletal muscle fibersOlga N Ponomareva
Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712 0248, USA
Mol Cell Neurosci 31:334-45. 2006..Thus, a gain-of-function manipulation of ErbB2 signaling pathways renders an agrin-deficient-like phenotype that uncouples MuSK and AChR tyrosine phosphorylation...
- Regulation of the intermediate filament protein nestin at rodent neuromuscular junctions by innervation and activityHyuno Kang
Section of Neurobiology, Institute of Neuroscience, University of Texas, Austin, Texas 78712, USA
J Neurosci 27:5948-57. 2007..Nestin antibodies and GFP driven by nestin promoter elements serve as excellent markers for the reactive state of SCs. Vital imaging of GFP shows that SCs grow a dynamic set of processes after denervation...