B A Rikke

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    Exp Gerontol 45:691-701. 2010
  2. ncbi Physiological genetics of dietary restriction: uncoupling the body temperature and body weight responses
    Brad A Rikke
    Institute for Behavioral Genetics, Campus Box 447, Univ of Colorado, Boulder, CO 80309 0447, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1522-7. 2007
  3. ncbi Murine weight loss exhibits significant genetic variation during dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Physiol Genomics 27:122-30. 2006
  4. ncbi Lower body temperature as a potential mechanism of life extension in homeotherms
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, CO 80309 0447, USA
    Exp Gerontol 39:927-30. 2004
  5. ncbi Quantitative trait Loci specifying the response of body temperature to dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, USA
    J Gerontol A Biol Sci Med Sci 59:118-25. 2004
  6. ncbi Strain variation in the response of body temperature to dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder 80309 0447, USA
    Mech Ageing Dev 124:663-78. 2003
  7. ncbi No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics
    B A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 25:171-6. 2001
  8. ncbi Paralogy and orthology of tyrosine kinases that can extend the life span of Caenorhabditis elegans
    B A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Mol Biol Evol 17:671-83. 2000
  9. ncbi Murine albino-deletion complex: high-resolution microsatellite map and genetically anchored YAC framework map
    B A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Genetics 147:787-99. 1997
  10. ncbi Early life predictors of old-age life expectancy
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    Sci Aging Knowledge Environ 2004:pe21. 2004

Collaborators

Detail Information

Publications13

  1. ncbi Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    Exp Gerontol 45:691-701. 2010
    ..We present a metabolic model in which the anti-aging effects of DR are consistent with the ability to efficiently utilize dietary resources...
  2. ncbi Physiological genetics of dietary restriction: uncoupling the body temperature and body weight responses
    Brad A Rikke
    Institute for Behavioral Genetics, Campus Box 447, Univ of Colorado, Boulder, CO 80309 0447, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1522-7. 2007
    ..These results also suggest that murine genetic variation may be useful for uncoupling many more responses to DR...
  3. ncbi Murine weight loss exhibits significant genetic variation during dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
    Physiol Genomics 27:122-30. 2006
    ..The genetic variation also implies the existence of genes that would be novel therapeutic targets, distinct from genes affecting AL body weight or body fat, for enhancing (or mitigating) weight loss during food restriction...
  4. ncbi Lower body temperature as a potential mechanism of life extension in homeotherms
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, CO 80309 0447, USA
    Exp Gerontol 39:927-30. 2004
    ..These discoveries suggest that we can now extend the studies of Dr Walford to critically test whether lower body temperature can prolong the life span of mammals...
  5. ncbi Quantitative trait Loci specifying the response of body temperature to dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, USA
    J Gerontol A Biol Sci Med Sci 59:118-25. 2004
    ..Importantly, the genes underlying such QTLs would be causal factors affecting these responses and could be identified by positional cloning...
  6. ncbi Strain variation in the response of body temperature to dietary restriction
    Brad A Rikke
    Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder 80309 0447, USA
    Mech Ageing Dev 124:663-78. 2003
    ..The variation in strain mean T(b) was also present in the absence of torpor. This strain variation could be used to critically test whether lower T(b) is a covariate of life extension during DR...
  7. ncbi No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics
    B A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 25:171-6. 2001
    ..In addition, albinism is associated with altered brain development that could have pleiotropic effects on behavior. Therefore, in this study, we asked whether albinism affects sedative-hypnotic sensitivity...
  8. ncbi Paralogy and orthology of tyrosine kinases that can extend the life span of Caenorhabditis elegans
    B A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Mol Biol Evol 17:671-83. 2000
    ....
  9. ncbi Murine albino-deletion complex: high-resolution microsatellite map and genetically anchored YAC framework map
    B A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Genetics 147:787-99. 1997
    ....
  10. ncbi Early life predictors of old-age life expectancy
    Brad A Rikke
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    Sci Aging Knowledge Environ 2004:pe21. 2004
    ..Each measure appears to be an index of largely separate parameters that affect the course of aging. This article summarizes the results, discusses implications, mentions caveats, and suggests future studies...
  11. ncbi Thermoregulation in mice exhibits genetic variability early in senescence
    Patrick Gonzales
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Age (Dordr) 32:31-7. 2010
    ..004). Such variation is potentially a powerful tool for determining the cause of thermoregulatory loss with age and whether this loss predicts senescence changes later in life, including the force of mortality...
  12. ncbi Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis
    Robert W Williams
    Portland Alcohol Research Center, Oregon Health Sciences University, 97239, USA
    Mamm Genome 15:637-47. 2004
    ..Thus, the LXS panel provides a powerful new resource for mapping complex traits across many systems and disciplines and should prove to be of great utility in modeling the genetics of complex diseases in human populations...
  13. ncbi A microarray analysis of potential genes underlying the neurosensitivity of mice to propofol
    Damon A Lowes
    Academic Unit of Anesthesia and Intensive Care, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Anesth Analg 101:697-704, table of contents. 2005
    ....