Adam I Riker

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Immunotherapy as part of a multidisciplinary approach to melanoma treatment
    Adam I Riker
    Cutaneous Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Front Biosci 11:1-14. 2006
  2. ncbi request reprint Cutaneous melanoma: methods of biopsy and definitive surgical excision
    Adam I Riker
    Cutaneous Oncology Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, 33612, USA
    Dermatol Ther 18:387-93. 2005
  3. pmc Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma
    Adil I Daud
    Cutaneous Oncology and Experimental Therapeutics Programs, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    J Clin Oncol 26:5896-903. 2008
  4. pmc Comparative methodologies of regulatory T cell depletion in a murine melanoma model
    Norimasa Matsushita
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SRB 23244, Tampa, Florida 33612, United States
    J Immunol Methods 333:167-79. 2008
  5. doi request reprint Full-thickness grafts procured from skin overlying the sentinel lymph node basin; reconstruction of primary cutaneous malignancy excision defects
    James M Lewis
    Department of Oncologic Sciences, University of South Florida, Tampa, FL, USA
    Ann Surg Oncol 15:1733-40. 2008
  6. ncbi request reprint Activated stat-3 in melanoma
    Jane L Messina
    Pathology Service, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 15:196-201. 2008
  7. doi request reprint Phenotypic and functional analysis of dendritic cells and clinical outcome in patients with high-risk melanoma treated with adjuvant granulocyte macrophage colony-stimulating factor
    Adil I Daud
    H Lee Moffitt Cancer Center, Tampa, FL, USA
    J Clin Oncol 26:3235-41. 2008
  8. ncbi request reprint Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma
    Subhra Mohapatra
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute and the University of South Florida Medical Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cancer Res 5:145-51. 2007
  9. ncbi request reprint Sentinel node biopsy for thin melanomas: which patients should be considered?
    Christopher A Puleo
    Cutaneous Oncology Division, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 12:230-5. 2005
  10. ncbi request reprint Down-regulation of pro-apoptotic genes is an early event in the progression of malignant melanoma
    Eric H Jensen
    Department of Interdisciplinary Oncology, Cutaneous Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Stabile Research Building, Room 22043, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Ann Surg Oncol 14:1416-23. 2007

Detail Information

Publications21

  1. ncbi request reprint Immunotherapy as part of a multidisciplinary approach to melanoma treatment
    Adam I Riker
    Cutaneous Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Front Biosci 11:1-14. 2006
    ..This in turn will provide us with new insight and direction as we design the next generation of vaccines for patients with advanced cancer and in particular melanoma...
  2. ncbi request reprint Cutaneous melanoma: methods of biopsy and definitive surgical excision
    Adam I Riker
    Cutaneous Oncology Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, 33612, USA
    Dermatol Ther 18:387-93. 2005
    ..The present authors review current recommendations for excision margins for the primary tumor, usefulness of lymphoscintigraphy, timing of definitive surgical excision, and issues unique for head and neck melanoma...
  3. pmc Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma
    Adil I Daud
    Cutaneous Oncology and Experimental Therapeutics Programs, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    J Clin Oncol 26:5896-903. 2008
    ..In vivo electroporation, in preclinical models, significantly enhances gene transfer efficiency while retaining the safety advantages of plasmid DNA...
  4. pmc Comparative methodologies of regulatory T cell depletion in a murine melanoma model
    Norimasa Matsushita
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, SRB 23244, Tampa, Florida 33612, United States
    J Immunol Methods 333:167-79. 2008
    ..We therefore conclude that PC61 administration was the most effective method of reducing Tregs in a murine melanoma model in addition to providing evidence of a synergistic effect when combined with DC-based immunotherapy...
  5. doi request reprint Full-thickness grafts procured from skin overlying the sentinel lymph node basin; reconstruction of primary cutaneous malignancy excision defects
    James M Lewis
    Department of Oncologic Sciences, University of South Florida, Tampa, FL, USA
    Ann Surg Oncol 15:1733-40. 2008
    ..However, the potential for implantation of malignant cells transferred from the nodal basin to the primary site, resulting in increased perigraft recurrence rates with the FTSG technique, has not been evaluated...
  6. ncbi request reprint Activated stat-3 in melanoma
    Jane L Messina
    Pathology Service, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 15:196-201. 2008
    ..We examined the expression of phosphorylated Stat-3 (pStat-3), activated Stat-1 (pStat-1) and interferon alpha receptor subunit 1(IFNAR-1) in human melanocytic neoplasms...
  7. doi request reprint Phenotypic and functional analysis of dendritic cells and clinical outcome in patients with high-risk melanoma treated with adjuvant granulocyte macrophage colony-stimulating factor
    Adil I Daud
    H Lee Moffitt Cancer Center, Tampa, FL, USA
    J Clin Oncol 26:3235-41. 2008
    ..We hypothesized that GM-CSF-stimulated DC differentiation may result in clinical benefit in patients with high-risk melanoma...
  8. ncbi request reprint Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma
    Subhra Mohapatra
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute and the University of South Florida Medical Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cancer Res 5:145-51. 2007
    ..The results of this study show that roscovitine has the potential to inhibit the differentiation and invasion of metastatic melanoma and may be useful as a therapy for the treatment of patients with metastatic melanoma...
  9. ncbi request reprint Sentinel node biopsy for thin melanomas: which patients should be considered?
    Christopher A Puleo
    Cutaneous Oncology Division, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 12:230-5. 2005
    ..Currently available prognostic factors are limited in their ability to reliably discriminate which patients will manifest regional nodal metastasis and would be identified early through sentinel node biopsy...
  10. ncbi request reprint Down-regulation of pro-apoptotic genes is an early event in the progression of malignant melanoma
    Eric H Jensen
    Department of Interdisciplinary Oncology, Cutaneous Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Stabile Research Building, Room 22043, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Ann Surg Oncol 14:1416-23. 2007
    ..We used cDNA microarray to evaluate pro-apoptotic gene expression comparing normal skin to melanoma (thin and thick), nodal disease and distant metastases...
  11. ncbi request reprint Current surgical management of melanoma
    Adam I Riker
    Surgical Oncology Services and Associate Professor of Surgery, University of South Alabama Mitchell Cancer Institute, Cutaneous Oncology Program, 307 North University Blvd, MSB 2015, Mobile, Alabama 36688, USA
    Expert Rev Anticancer Ther 6:1569-83. 2006
    ..This review will also discuss what we have learned from past clinical trials and address several issues with regards to where we are going in the future...
  12. ncbi request reprint Immunostimulatory effects of CpG-ODN upon dendritic cell-based immunotherapy in a murine melanoma model
    Shari Pilon-Thomas
    Division of Cutaneous Oncology and the Immunology and Immunotherapy Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    J Immunother 29:381-7. 2006
    ..These experiments provide evidence that combined immunization with both antigen-pulsed DC and the immunoadjuvant, CpG, can lead to tumor regression and long-term survival in a murine B16 melanoma model...
  13. doi request reprint Significance of sentinel lymph node micrometastases in human breast cancer
    Charles E Cox
    Department of Surgery, Comprehensive Breast Cancer Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Am Coll Surg 206:261-8. 2008
    ..The objective of our study was to review the impact of micrometastatic carcinoma detected by SLN biopsy...
  14. ncbi request reprint Isolation and culture of melanoma cell lines
    Adam I Riker
    Lee Moffittt Cancer Canter and Research Institute, Tampa, FL, USA
    Methods Mol Med 88:93-9. 2004
  15. ncbi request reprint Immunotherapy of melanoma: a critical review of current concepts and future strategies
    Adam I Riker
    University of South Alabama Mitchell Cancer Institute, 307 North University Blvd, MSB 2015, Mobile, Alabama 36688, USA
    Expert Opin Biol Ther 7:345-58. 2007
    ..This review summarizes the recent results of novel immunotherapeutic regimens and focuses on cutting-edge modalities of treatment that encompass new lines of thinking in the war against cancer and, in particular, melanoma...
  16. ncbi request reprint Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: a multi-institutional study
    Sandra L Wong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Ann Surg Oncol 13:809-16. 2006
    ..This multi-institutional study was undertaken to characterize patterns of failure and survival rates in these patients and to compare results with those of positive-SLN patients who underwent CLND...
  17. doi request reprint Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling
    SuHu Liu
    Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA
    Pigment Cell Melanoma Res 21:545-58. 2008
    ....
  18. ncbi request reprint The impact of genomics in understanding human melanoma progression and metastasis
    Suping Ren
    Surgical Oncology Program, University of South Alabama Mitchell Cancer Institute, Mobile, AL 36688, USA
    Cancer Control 15:202-15. 2008
    ..The examination of the phenotypic and (epi)genetic changes in cutaneous melanoma has identified several genes deemed central to the development and progression of melanoma...
  19. pmc Identification of a mutated fibronectin as a tumor antigen recognized by CD4+ T cells: its role in extracellular matrix formation and tumor metastasis
    Helen Y Wang
    The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Exp Med 195:1397-406. 2002
    ....
  20. ncbi request reprint Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter region
    Lawrence S Stennett
    Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA
    Pigment Cell Res 17:525-32. 2004
    ..The current study provides insight into transcriptional regulation of the PMel17 and CDK2 genes, important to identify strategies for modulating expression of gp100 and CDK2 proteins by melanoma cells...
  21. pmc Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells
    I Caroline Le Poole
    Department of Pathology, Skin Oncology Research Program, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Bldg 112, Rm 303, 2160 S 1st Ave, Maywood, IL 60153, USA
    Am J Pathol 160:521-8. 2002
    ..Reduced MART-1 expression was frequently observed in adjacent tumor cells. Consequently, IFN-gamma may enhance inflammatory responses yet hamper effective recognition of melanoma cells...