Austen F Riggs

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi A globin in every cell?
    Austen F Riggs
    Section of Neurobiology, School of Biological Sciences, University of Texas, Austin, TX 78712 0252, USA
    Proc Natl Acad Sci U S A 103:2469-70. 2006
  2. ncbi Stoichiometry of subunits and heme content of hemoglobin from the earthworm Lumbricus terrestris
    H Zhu
    Department of Zoology, University of Texas, Austin, Texas 78712 1064, USA
    J Biol Chem 271:29999-30006. 1996
  3. ncbi Assembly of the gigantic hemoglobin of the earthworm Lumbricus terrestris. Roles of subunit equilibria, non-globin linker chains, and valence of the heme iron
    H Zhu
    Department of Zoology, University of Texas, Austin, Texas 78712 1064, USA
    J Biol Chem 271:30007-21. 1996
  4. ncbi Self-association, cooperativity and supercooperativity of oxygen binding by hemoglobins
    A F Riggs
    Department of Zoology, University of Texas, Austin, TX 78712, USA
    J Exp Biol 201:1073-84. 1998
  5. ncbi Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli
    Olga Abramczyk
    Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, TX 78712, USA
    Protein Expr Purif 79:237-44. 2011
  6. ncbi Activated ERK2 is a monomer in vitro with or without divalent cations and when complexed to the cytoplasmic scaffold PEA-15
    Tamer S Kaoud
    Division of Medicinal Chemistry, University of Texas, Austin, TX 78712, USA
    Biochemistry 50:4568-78. 2011
  7. ncbi Linker chains of the gigantic hemoglobin of the earthworm Lumbricus terrestris: primary structures of linkers L2, L3, and L4 and analysis of the connectivity of the disulfide bonds in linker L1
    Wen-Yen Kao
    Institute of Cellular and Molecular Biology, Section of Neurobiology, School of Biological Sciences, University of Texas, Austin, Texas, USA
    Proteins 63:174-87. 2006
  8. ncbi Indefinite noncooperative self-association of chicken deoxy hemoglobin D
    Mitra S Rana
    Section of Neurobiology, School of Biological Sciences, University of Texas, Austin, Texas 78712 0252, USA
    Proteins 79:1499-512. 2011
  9. ncbi Component D of chicken hemoglobin and the hemoglobin of the embryonic Tammar wallaby (Macropus eugenii) self-associate upon deoxygenation: Effect on oxygen binding
    Mitra S Rana
    Section of Neurobiology, School of Biologicalu Sciences, University of Texas, Austin, Texas 78712 0252, USA
    Proteins 70:553-61. 2008
  10. ncbi Apparent specific volume of human hemoglobin: effect of ligand state and contribution of heme
    Edward DeMoll
    Section of Neurobiology, School of Biological Sciences, Institute of Molecular and Cell Biology, and Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    Anal Biochem 363:196-203. 2007

Collaborators

  • John S Olson
  • Thomas A Gorr
  • Sunbae Lee
  • Brian T Chait
  • Alexey G Ryazanov
  • George Georgiou
  • Ezra Daniel
  • Jun Qin
  • T L Vandergon
  • Paola Ascenzi
  • Mitra S Rana
  • Olga Abramczyk
  • Kevin N Dalby
  • Ashwini K Devkota
  • Tamer S Kaoud
  • Silvia A Arredondo
  • Edward DeMoll
  • James E Knapp
  • Wen-Yen Kao
  • Kari A Callaway
  • H Zhu
  • Alessandra Pesce
  • Clint D J Tavares
  • Benjamin E Turk
  • Bulent Ozpolat
  • Mark E Girvin
  • Mangalika Warthaka
  • Richard Harris
  • Hiram F Gilbert
  • Tiffany F Chen
  • Robert A B Holland
  • J E Knapp
  • David J Cox
  • Kenzo Fushitani
  • Mark A Rainey
  • Claire K Riggs
  • Sandra S Smith
  • Q Xie
  • Sylvia Dewilde
  • Martino Bolognesi
  • Pengchi Deng
  • Eva Geuens
  • Karin Nienhaus
  • Marco Nardini
  • G Ulrich Nienhaus
  • Luc Moens
  • Angela Hale
  • S R Ernst
  • M A Oliveira
  • M L Hackert
  • K Linse
  • Y Nozaki
  • D W Ownby
  • C K Riggs
  • M Hargrove
  • N J Nolasco
  • J K Stoops
  • S S Smith

Detail Information

Publications16

  1. ncbi A globin in every cell?
    Austen F Riggs
    Section of Neurobiology, School of Biological Sciences, University of Texas, Austin, TX 78712 0252, USA
    Proc Natl Acad Sci U S A 103:2469-70. 2006
  2. ncbi Stoichiometry of subunits and heme content of hemoglobin from the earthworm Lumbricus terrestris
    H Zhu
    Department of Zoology, University of Texas, Austin, Texas 78712 1064, USA
    J Biol Chem 271:29999-30006. 1996
    ..Measurement of the rate of hemin loss from oxidized L. terrestris Hb shows that high rates of loss can account for values of heme content significantly below 2.9% (or 0.26% iron)...
  3. ncbi Assembly of the gigantic hemoglobin of the earthworm Lumbricus terrestris. Roles of subunit equilibria, non-globin linker chains, and valence of the heme iron
    H Zhu
    Department of Zoology, University of Texas, Austin, Texas 78712 1064, USA
    J Biol Chem 271:30007-21. 1996
    ..These experiments indicate that oxidation causes the Hb to shed subunits. The observations provide an explanation for the wide variations in the molecular mass of L. terrestris Hb that have been observed previously...
  4. ncbi Self-association, cooperativity and supercooperativity of oxygen binding by hemoglobins
    A F Riggs
    Department of Zoology, University of Texas, Austin, TX 78712, USA
    J Exp Biol 201:1073-84. 1998
    ..The increased cooperativity should result in an increase in the amount of O2 delivered to the tissues and should be especially valuable for avian flight muscles...
  5. ncbi Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli
    Olga Abramczyk
    Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, TX 78712, USA
    Protein Expr Purif 79:237-44. 2011
    ..Light scattering shows that eEF-2K is a monomer of ∼85 kDa. In vitro kinetic analysis confirmed that recombinant human eEF-2K is able to phosphorylate wheat germ eEF-2 with kinetic parameters comparable to the mammalian enzyme...
  6. ncbi Activated ERK2 is a monomer in vitro with or without divalent cations and when complexed to the cytoplasmic scaffold PEA-15
    Tamer S Kaoud
    Division of Medicinal Chemistry, University of Texas, Austin, TX 78712, USA
    Biochemistry 50:4568-78. 2011
    ..Our data provide strong evidence that ERK2 is monomeric under physiological conditions. Analysis of the same ERK2 construct with the nonphysiological His(6) tag shows substantial dimerization under the same ionic conditions...
  7. ncbi Linker chains of the gigantic hemoglobin of the earthworm Lumbricus terrestris: primary structures of linkers L2, L3, and L4 and analysis of the connectivity of the disulfide bonds in linker L1
    Wen-Yen Kao
    Institute of Cellular and Molecular Biology, Section of Neurobiology, School of Biological Sciences, University of Texas, Austin, Texas, USA
    Proteins 63:174-87. 2006
    ..Similar Asp-Asp-His repeats have been found in a protein homologous to superoxide dismutase in the hemolymph of certain mussels. These repeats may function as metal-binding sites...
  8. ncbi Indefinite noncooperative self-association of chicken deoxy hemoglobin D
    Mitra S Rana
    Section of Neurobiology, School of Biological Sciences, University of Texas, Austin, Texas 78712 0252, USA
    Proteins 79:1499-512. 2011
    ..Residue glutamate 138 has previously been proposed to influence intertetramer interactions. Our results with recombinant Hb D show that Glu138 plays no role in deoxy Hb D intertetramer interactions...
  9. ncbi Component D of chicken hemoglobin and the hemoglobin of the embryonic Tammar wallaby (Macropus eugenii) self-associate upon deoxygenation: Effect on oxygen binding
    Mitra S Rana
    Section of Neurobiology, School of Biologicalu Sciences, University of Texas, Austin, Texas 78712 0252, USA
    Proteins 70:553-61. 2008
    ..0, sedimentation velocity measurements provide clear evidence for deoxygenation-dependent self-association...
  10. ncbi Apparent specific volume of human hemoglobin: effect of ligand state and contribution of heme
    Edward DeMoll
    Section of Neurobiology, School of Biological Sciences, Institute of Molecular and Cell Biology, and Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    Anal Biochem 363:196-203. 2007
    ..The contribution can be estimated from the difference between the measured volume of each molecular species and that calculated from the amino acid composition...
  11. ncbi Properties and regulation of a transiently assembled ERK2.Ets-1 signaling complex
    Kari A Callaway
    Graduate Program in Biochemistry, University of Texas, Austin, Texas 78712 0252, USA
    Biochemistry 45:13719-33. 2006
    ..Displacement of EtsDelta138 from ERK2 by the peptide N-AKLSFQFPS-C derived from Elk-1 shows that EtsDelta138 communicates with the F-recruitment site of ERK2 also...
  12. ncbi The mini-hemoglobins in neural and body wall tissue of the nemertean worm, Cerebratulus lacteus
    T L Vandergon
    Department of Zoology, University of Texas, Austin, Texas 78712 1064, USA
    J Biol Chem 273:16998-7011. 1998
    ..Calculations suggest that the Hb can function as an O2 store capable of extending neuronal activity in an anoxic environment for 5-30 min...
  13. ncbi Role of dimerization in the catalytic properties of the Escherichia coli disulfide isomerase DsbC
    Silvia A Arredondo
    Department of Chemical Engineering, School of Biological Sciences, University of Texas, Austin, Texas 78712, USA
    J Biol Chem 284:23972-9. 2009
    ..Our results reveal that two catalytic domains in DsbC are not essential for disulfide bond isomerization and that a determining feature in isomerization is the availability of a substrate binding domain...
  14. ncbi The structural and functional analysis of the hemoglobin D component from chicken
    J E Knapp
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    J Biol Chem 274:6411-20. 1999
    ..This hydrophobic patch is a promising candidate for a tetramer-tetramer interface that could regulate oxygen binding via the distal histidine...
  15. ncbi Yeast flavohemoglobin is an ancient protein related to globins and a reductase family
    H Zhu
    Department of Zoology, University of Texas, Austin 78712
    Proc Natl Acad Sci U S A 89:5015-9. 1992
    ..8 billion years, the estimated time of divergence of prokaryotes and eukaryotes provided that cross-species gene transfer has not occurred...
  16. ncbi Thr-E11 regulates O2 affinity in Cerebratulus lacteus mini-hemoglobin
    Alessandra Pesce
    Department of Physics-INFM and Center for Excellence in Biomedical Research, University of Genova, Via Dodecaneso 33, 16146 Genova, Italy
    J Biol Chem 279:33662-72. 2004
    ....