E Ridgway

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Update in thyroidology
    E Chester Ridgway
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 92:3755-61. 2007
  2. ncbi request reprint MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes
    David F Gordon
    Division of Endocrinology, Department of Medicine, University of Colorado Health Sciences Center Fitzsimons, Mail Stop 8106, P O Box 6511, Aurora, Colorado 80049, USA
    Mol Endocrinol 20:1073-89. 2006
  3. ncbi request reprint Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter
    D F Gordon
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 272:24339-47. 1997
  4. ncbi request reprint Management practices among primary care physicians and thyroid specialists in the care of hypothyroid patients
    M T McDermott
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    Thyroid 11:757-64. 2001
  5. ncbi request reprint Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors
    M T McDermott
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
    Pituitary 2:217-24. 1999
  6. ncbi request reprint The effect of thyroid hormone and a long-acting somatostatin analogue on TtT-97 murine thyrotropic tumors
    W W Woodmansee
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
    Thyroid 10:533-41. 2000
  7. ncbi request reprint Cloning of the mouse somatostatin receptor subtype 5 gene: promoter structure and function
    D F Gordon
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    Endocrinology 140:5598-608. 1999
  8. ncbi request reprint An upstream regulator of the glycoprotein hormone alpha-subunit gene mediates pituitary cell type activation and repression by different mechanisms
    W M Wood
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 274:15526-32. 1999
  9. ncbi request reprint Activation of the glycoprotein hormone alpha-subunit gene promoter in thyrotropes
    V D Sarapura
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Mol Cell Endocrinol 146:77-86. 1998
  10. ncbi request reprint Growth arrest of thyrotropic tumors by thyroid hormone is correlated with novel changes in Wnt-10A
    Janice M Kerr
    University of Colorado Health Sciences Center, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, MS8106, P O Box 6511 Denver, CO 80262, USA
    Mol Cell Endocrinol 238:57-67. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Update in thyroidology
    E Chester Ridgway
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 92:3755-61. 2007
    ..The new molecular understanding of thyroid cancer causation is now opening a new therapeutic frontier as drugs are developed that modulate the MAPK pathway...
  2. ncbi request reprint MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes
    David F Gordon
    Division of Endocrinology, Department of Medicine, University of Colorado Health Sciences Center Fitzsimons, Mail Stop 8106, P O Box 6511, Aurora, Colorado 80049, USA
    Mol Endocrinol 20:1073-89. 2006
    ..Thus, the TSHbeta gene is maximally activated by a combination of three thyrotrope transcription factors that act via both protein-DNA and protein-protein interactions...
  3. ncbi request reprint Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter
    D F Gordon
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 272:24339-47. 1997
    ..In summary, these data demonstrate functional synergy and physical interaction between homeobox and zinc finger factors and provide insights into the transcriptional mechanisms of thyrotrope-specific gene expression...
  4. ncbi request reprint Management practices among primary care physicians and thyroid specialists in the care of hypothyroid patients
    M T McDermott
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    Thyroid 11:757-64. 2001
    ..5-5.0 microU/mL. In conclusion, the current practice patterns of PCPs and ATA members that were elicited in this survey differ significantly in regard to the evaluation and management of hypothyroidism...
  5. ncbi request reprint Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors
    M T McDermott
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
    Pituitary 2:217-24. 1999
    ..Combined analysis of hormone and transcription factor mRNA in pituitary tumor tissue may therefore be a more meaningful approach to pituitary tumor characterization...
  6. ncbi request reprint The effect of thyroid hormone and a long-acting somatostatin analogue on TtT-97 murine thyrotropic tumors
    W W Woodmansee
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver 80262, USA
    Thyroid 10:533-41. 2000
    ..These data suggest an important interaction between the somatostatinergic system and thyroid hormone in the regulation of thyrotrope cell structure and function...
  7. ncbi request reprint Cloning of the mouse somatostatin receptor subtype 5 gene: promoter structure and function
    D F Gordon
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    Endocrinology 140:5598-608. 1999
    ..Cloning of the sst5 gene will facilitate the mapping of basal and regulated responses at the transcriptional level...
  8. ncbi request reprint An upstream regulator of the glycoprotein hormone alpha-subunit gene mediates pituitary cell type activation and repression by different mechanisms
    W M Wood
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 274:15526-32. 1999
    ....
  9. ncbi request reprint Activation of the glycoprotein hormone alpha-subunit gene promoter in thyrotropes
    V D Sarapura
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Mol Cell Endocrinol 146:77-86. 1998
    ..This analysis provides basic information important to identify common and unique factors contributing to the cell-specific expression of the alpha-subunit gene...
  10. ncbi request reprint Growth arrest of thyrotropic tumors by thyroid hormone is correlated with novel changes in Wnt-10A
    Janice M Kerr
    University of Colorado Health Sciences Center, Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, MS8106, P O Box 6511 Denver, CO 80262, USA
    Mol Cell Endocrinol 238:57-67. 2005
    ..We conclude that treatment of thyrotropic TtT-97 tumors with T3 resulted in the decreased expression of Wnt-10A, and that thyroid hormone may inhibit growth via cyclin A regulation...
  11. ncbi request reprint The proliferative status of thyrotropes is dependent on modulation of specific cell cycle regulators by thyroid hormone
    Whitney W Woodmansee
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Endocrinology 147:272-82. 2006
    ..These processes are reversed when TH is withdrawn, resulting in an increase in the fraction of S-phase cells...
  12. ncbi request reprint A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal
    Pamela R Schroeder
    Johns Hopkins Medical Institutions, Division of Endocrinology and Metabolism, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 91:878-84. 2006
    ..Levothyroxine (L-T4) withdrawal for thyroglobulin measurement and whole body scanning increases these tests' sensitivities but causes hypothyroidism. Recombinant human TSH (rhTSH) enables testing without L-T4 withdrawal...
  13. ncbi request reprint Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism
    Marcelo A Christoffolete
    Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 147:1735-43. 2006
    ..These results resolve the apparent paradox between the homeostatic regulation of D2 and its role in mediating the critical mechanism by which T(4) triggers the TSH-negative feedback...
  14. ncbi request reprint Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes
    Virginia D Sarapura
    Department of Medicine, Division of Endocrinology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Pituitary 9:11-8. 2006
    ..The overall similarity between the two tumor types renders the alphaSUnull tumor as a suitable thyrotropic tumor model...
  15. ncbi request reprint The management of subclinical hyperthyroidism by thyroid specialists
    Michael T McDermott
    Division of Endocrinology, Metabolism and Diabetes, and Division of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80010, USA
    Thyroid 13:1133-9. 2003
    ..In the absence of adequate evidence-based guidelines, it is hoped that this survey of expert opinions may provide useful guidance for physicians providing care for patients with subclinical hyperthyroidism...
  16. ncbi request reprint Congenital isolated central hypothyroidism caused by a "hot spot" mutation in the thyrotropin-beta gene
    Michael T McDermott
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Thyroid 12:1141-6. 2002
    ..quot;..
  17. ncbi request reprint Domains of Pit-1 required for transcriptional synergy with GATA-2 on the TSH beta gene
    David F Gordon
    Department of Medicine, University of Colorado Health Sciences Center, Box B151, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Mol Cell Endocrinol 196:53-66. 2002
    ..Thus multiple domains of Pit-1 are required for full synergy with GATA-2 and sequences between the two binding sites contribute to co-occupancy with both factors on the proximal TSH beta promoter...
  18. ncbi request reprint Mutational analysis of the mouse somatostatin receptor type 5 gene promoter
    Whitney W Woodmansee
    Division of Endocrinology, University of Colorado Health Sciences Center, Denver, Colorado 80262
    Endocrinology 143:2268-76. 2002
    ..The region between -67 and -47 appears to contain a nucleotide sequence critical for basal transcriptional regulation of the mouse sst5 gene in pituitary cells...
  19. ncbi request reprint Clinical comparison of whole-body radioiodine scan and serum thyroglobulin after stimulation with recombinant human thyrotropin
    Bryan R Haugen
    Department of Medicine, Division of Endocrinology, University of Colorado Health Sciences Center, Denver, USA
    Thyroid 12:37-43. 2002
    ..In our practice, an rhTSH-stimulated Tg greater than 4-5 ng/mL often resulted in further evaluation, while a Tg less than 4 ng/mL rarely resulted in further immediate evaluation...
  20. ncbi request reprint Early gene expression changes preceding thyroid hormone-induced involution of a thyrotrope tumor
    William M Wood
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 143:347-59. 2002
    ..These include repression of specific growth factor and receptors and cell cycle genes as well as induction of other factors associated with growth arrest and apoptosis...
  21. ncbi request reprint Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial
    Andrew R Hoffman
    Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, California 94304, USA
    J Clin Endocrinol Metab 89:2048-56. 2004
    ..GH treatment was generally well tolerated. Subjects with AGHD should receive individualized GH therapy to maintain IGF-I between the mean value and +2 SD and improve body composition and cardiovascular risk factors...
  22. ncbi request reprint Thyroid-stimulating-hormone concentrations and risk of hypothyroidism
    Jeffrey James Glasheen
    Lancet 360:2082-3. 2002
  23. ncbi request reprint Mapping of an autoimmunity susceptibility locus (AIS1) to chromosome 1p31.3-p32.2
    Asem Alkhateeb
    Human Medical Genetics Program, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, B161, Denver, CO 80262, USA
    Hum Mol Genet 11:661-7. 2002
    ....
  24. ncbi request reprint Thoughts on prevention of thyroid disease in the United States
    David S Cooper
    Division of Endocrinology, Sinai Hospital of Baltimore, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Thyroid 12:925-9. 2002
    ..Together, these data suggest that the notion of preventive medicine in the United States should be expanded to include thyroid disease as a target for secondary and tertiary intervention...

Research Grants50

  1. ALTERATION OF T3 RECEPTORS IN ALPHA PITUITARY TUMOR
    E Ridgway; Fiscal Year: 2001
    ....
  2. REGULATION OF TSH SUBUNIT GENE EXPRESSION
    E Ridgway; Fiscal Year: 1991
    ..These studies will provide fundamental information on TSH regulation that is directly applicable to other pituitary hormone genes...
  3. THYROTROPIN BETA SUBUNIT GENE TRANSCRIPTION FACTORS
    E Ridgway; Fiscal Year: 2002
    ..These studies will provide new fundamental knowledge on the structural interactions between different classes of transcription factors and the impact of these interactions on normal physiology. ..
  4. Training Program in Diabetes, Endocriniology and Metabolism
    ELI RIDGWAY; Fiscal Year: 2007
    ..Twenty of 24 are still doing research. Overall, this outstanding training environment and excellent record of accomplishment justify continued support of the TPDEM at UCDHSC. ..
  5. Thyrotrope Proliferation by Thyroid Hormone
    ELI RIDGWAY; Fiscal Year: 2006
    ..At their conclusion, these studies will develop a body of knowledge that would be directly applicable to the broad field of cell hyperplasia and neoplasia. ..
  6. THYROTROPIN BETA SUBUNIT GENE TRANSCRIPTION FACTORS
    ELI RIDGWAY; Fiscal Year: 2006
    ..These studies will provide new fundamental knowledge on the structural interactions between multiple classes of transcription factors and the impact of these interactions on normal physiology. ..
  7. ANTERIOR PITUITARY ALPHA SUBUNIT GENE ACTIVATION
    E Ridgway; Fiscal Year: 2003
    ..These studies will provide new fundamental knowledge that will impact our understanding of physiological and pathological pituitary alpha-subunit expression. ..
  8. THYROTROPIN BETA SUBUNIT GENE TRANSCRIPTION FACTORS
    E Ridgway; Fiscal Year: 2003
    ..These studies will provide new fundamental knowledge on the structural interactions between multiple classes of transcription factors and the impact of these interactions on normal physiology. ..
  9. ALTERATION OF T3 RECEPTORS IN A PITUITARY TUMOR
    E Ridgway; Fiscal Year: 1993
    ..Knowledge gained on thyroid hormone regulation of this tumor's growth and alpha-subunit production will contribute substantive information on thyroid hormone action as it relates to differentiated and undifferentiated cellular functions...
  10. ABNORMAL GENE EXPRESSION IN A MURINE A-SUBUNIT SECRETING
    E Ridgway; Fiscal Year: 1990
    ..Knowledge gained on the regulation of this tumor's alpha-subunit production may contribute substantive information on pathogenetic mechanisms as well as the treatment of human pituitary and non-pituitary neoplasms...