Sharon A Riddler
Affiliation: University of Pittsburgh
- Coadministration of indinavir and nelfinavir in human immunodeficiency virus type 1-infected adults: safety, pharmacokinetics, and antiretroviral activitySharon A Riddler
University of Pittsburgh, Pennsylvania, USA
Antimicrob Agents Chemother 46:3877-82. 2002..The combination of IDV and NFV was generally well tolerated and resulted in sustained virologic suppression with 45% of the subjects having an HIV-1 RNA level in plasma of <400 copies/ml at week 72 (intent-to-treat)...
- Impact of HIV infection and HAART on serum lipids in menSharon A Riddler
University of Pittsburgh, Pittsburgh, PA, USA
JAMA 289:2978-82. 2003....
- Class-sparing regimens for initial treatment of HIV-1 infectionSharon A Riddler
University of Pittsburgh, Pittsburgh, USA
N Engl J Med 358:2095-106. 2008..The alternative regimen of lopinavir-ritonavir plus efavirenz may prevent toxic effects associated with NRTIs...
- Antiretroviral therapy is associated with an atherogenic lipoprotein phenotype among HIV-1-infected men in the Multicenter AIDS Cohort StudySharon A Riddler
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Acquir Immune Defic Syndr 48:281-8. 2008..Alterations in serum lipids and an increased risk of myocardial infarction have been associated with HIV-1 infection and its treatment...
- Production of a dendritic cell-based vaccine containing inactivated autologous virus for therapy of patients with chronic human immunodeficiency virus type 1 infectionTheresa L Whiteside
Department of Pathology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
Clin Vaccine Immunol 16:233-40. 2009..bb-ind-13137)...
- Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individualsNancy C Connolly
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Clin Vaccine Immunol 15:284-92. 2008..DC vaccination was safe, was feasible, and showed promise of immunogenicity in ART-treated, HIV-1-positive individuals. Additional studies of DC immunization strategies for HIV-1 infection are warranted...
- CD4⁺CD73⁺ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppressionPatrick J Schuler
Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
AIDS 27:1545-55. 2013..The role of the adenosine (ADO) suppression pathway, specifically CD39-expressing and CD73-expressing CD4⁺ T cells in HIV-1 infection is unclear...
- Regulatory T cell suppression of Gag-specific CD8 T cell polyfunctional response after therapeutic vaccination of HIV-1-infected patients on ARTBernard J C Macatangay
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 5:e9852. 2010..The Treg suppressive effect masked an increase in the vaccine-induced anti-HIV-1-specific polyfunctional response. The role of Treg should be considered in immunotherapeutic trials of HIV-1 infection...
- A randomized study of antiviral medication switch at lower- versus higher-switch thresholds: AIDS Clinical Trials Group Study A5115Sharon A Riddler
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Antivir Ther 12:531-41. 2007..Clinical stability has been observed with continued antiretroviral therapy (ART) in the setting of partial virological suppression. The optimal time to switch treatment in patients with low but detectable HIV-1 RNA is not known...
- Failure of initial therapy with two nucleosides and efavirenz is not associated with early emergence of mutations in the C-terminus of HIV-1 reverse transcriptaseJessica H Brehm
Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
J Acquir Immune Defic Syndr 56:344-8. 2011..001; M184I/V, P = 0.016). Selection of mutations in C-terminal domains of RT is not common with early failure of efavirenz-containing regimens...
- Proinflammatory cytokines in HIV disease-a review and rationale for new therapeutic approachesNancy C Connolly
University of Pittsburgh, Pittsburgh, PA 15213, USA
AIDS Rev 7:168-80. 2005..This review presents what is known about the dysregulation of proinflammatory cytokines in HIV-1 infection, highlighting newly available immune-based therapies that could augment antiretroviral drug therapies...
- Recovery of replication-competent HIV type 1-infected circulating monocytes from individuals receiving antiretroviral therapySharon M Harrold
Department of Pathology, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
AIDS Res Hum Retroviruses 18:427-34. 2002..These studies demonstrate that HIV-infected individuals on ART with breakthrough viremia have significantly higher levels of circulating infected monocytes, the precursors of tissue macrophages...
- Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapyStephen J Gange
Department of Epidemiology and Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
AIDS 17:119-21. 2003
- Rapid declines in total lymphocyte counts and hemoglobin concentration prior to AIDS among HIV-1-infected menBryan Lau
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
AIDS 17:2035-44. 2003..To describe temporal patterns in total lymphocyte count (TLC) and hemoglobin (Hgb) concentration during HIV infection and relate these patterns to changes in other markers and to clinical disease...
- Anthropometrics and examiner-reported body habitus abnormalities in the multicenter AIDS cohort studyFrank J Palella
Northwestern University, Feinberg School of Medicine, Div of Infectious Diseases, Chicago, Illinois 60611, USA
Clin Infect Dis 38:903-7. 2004....
- Interruption and discontinuation of highly active antiretroviral therapy in the multicenter AIDS cohort studyXiuhong Li
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Acquir Immune Defic Syndr 38:320-8. 2005..Identify the determinants and consequences of interrupting and discontinuing highly active antiretroviral therapy (HAART) among a population-based cohort of HIV-infected men...
- Plasma HIV-1 RNA dynamics in antiretroviral-naive subjects receiving either triple-nucleoside or efavirenz-containing regimens: ACTG A5166sDaniel R Kuritzkes
Section of Retroviral Therapeutics, Brigham and Women s Hospital, Cambridge, MA 02139, USA
J Infect Dis 195:1169-76. 2007..We sought to compare clearance rates of plasma human immunodeficiency virus type 1 (HIV-1) RNA in men and women starting triple-nucleoside-based versus efavirenz (EFV)-based regimens...
- Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort StudyTodd T Brown
Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
AIDS 19:1375-83. 2005..To estimate insulin resistance and its relationship to antiretroviral therapy (ART) in a cohort of HIV-infected persons with comparison to HIV-seronegative controls...
- Association between highly active antiretroviral therapy and hypertension in a large cohort of men followed from 1984 to 2003Eric C Seaberg
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
AIDS 19:953-60. 2005..UO1-AI-35041: To examine the impact of HIV infection and highly active antiretroviral therapy on systolic and diastolic hypertension...
- Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort studyTodd T Brown
Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
Arch Intern Med 165:1179-84. 2005..The risk of diabetes mellitus (DM) in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) has not been well defined...
- Use of total lymphocyte count and hemoglobin concentration for monitoring progression of HIV infectionBryan Lau
Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 39:620-5. 2005..Prior research has demonstrated rapid declines in total lymphocyte count (TLC) and hemoglobin levels before AIDS, but the prognostic accuracy of these declines has not been examined prospectively...