Research Topics
Species | Michael R RickelsSummaryAffiliation: University of Pennsylvania Country: USA Publications
| Collaborators
|
Detail Information
Publications
Recovery of endocrine function after islet and pancreas transplantationMichael R Rickels
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Institute for Diabetes, Obesity, and Metabolism, 12 134 Translational Research Center, Philadelphia, PA 19104, USA
Curr Diab Rep 12:587-96. 2012....- Effect of glucagon-like peptide-1 on beta- and alpha-cell function in isolated islet and whole pancreas transplant recipientsMichael R Rickels
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
J Clin Endocrinol Metab 94:181-9. 2009..Glucose-dependent insulin secretion is often impaired after islet transplantation where reduced beta-cell secretory capacity indicates a low functional beta-cell mass... 
Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantationMichael R Rickels
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
Transplantation 84:1357-60. 2007..02). Also, the measures of beta-cell secretory capacity were highly correlated (n=7, r2=0.98, P<0.0001). These results support the use of AIR(arg) as a surrogate indicator of beta-cell secretory capacity in islet transplantation...- Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacityMichael R Rickels
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6149, USA
J Clin Endocrinol Metab 92:2410-4. 2007..The majority of islet transplant recipients experience a gradual decline in islet graft function, but the identification of islet-specific immune responses remains uncommon... - {beta}-Cell secretory capacity and demand in recipients of islet, pancreas, and kidney transplantsMichael R Rickels
University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
J Clin Endocrinol Metab 95:1238-46. 2010..control groups. Conclusions: Impaired beta-cell secretory capacity in islet transplantation is best explained by a low engrafted beta-cell mass and not by a deleterious effect of tacrolimus... - Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipientsMichael R Rickels
University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
J Clin Endocrinol Metab 92:873-9. 2007..Islet transplantation can ameliorate occurrences of hypoglycemia in these patients... - Insulin sensitivity, glucose effectiveness, and free fatty acid dynamics after human islet transplantation for type 1 diabetesMichael R Rickels
University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
J Clin Endocrinol Metab 91:2138-44. 2006..Islet transplantation results in impaired insulin secretion, but whether defects in insulin sensitivity contribute to impaired glucose disposal after islet transplantation under modern immunosuppression is not known... - Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetesMichael R Rickels
Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
Diabetes 54:3205-11. 2005..01). These results suggest that after islet transplantation and in response to insulin-induced hypoglycemia, endogenous insulin secretion is appropriately suppressed and glucagon secretion may be partially restored... - Experimental endotoxemia induces adipose inflammation and insulin resistance in humansNehal N Mehta
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes 59:172-81. 2010..This study sought to explore potential mechanisms of inflammatory-induced IR in humans with a focus on adipose tissue... - Insulin sensitivity, food intake, and cravings with premenstrual syndrome: a pilot studyKimberly K Trout
University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA
J Womens Health (Larchmt) 17:657-65. 2008..The objective of this pilot study was to evaluate possible differences in insulin sensitivity, food intake, and cravings between the follicular and luteal phases of the menstrual cycle in women with premenstrual syndrome (PMS)... - {beta}-Cell function following human islet transplantation for type 1 diabetesMichael R Rickels
University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, Metabolism, 778 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6149, USA
Diabetes 54:100-6. 2005..Because AR(max) provides an estimate of the functional beta-cell mass, these results suggest that a low engrafted beta-cell mass may account for the functional defects observed after islet transplantation... - Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant modelChengyang Liu
Division of Transplantation, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104 5160, USA
Endocrinology 153:1673-83. 2012.... - A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trialNehal N Mehta
Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
J Transl Med 10:124. 2012.... - Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trialShrita M Patel
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 94:2161-6. 2010..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women... - Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot studyKimberly K Trout
University of Pennsylvania School of Nursing, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes Technol Ther 9:176-82. 2007..This pilot study's objective was to evaluate possible differences in insulin sensitivity between follicular and luteal phases in women with type 1 diabetes... - Analysis of B cell subsets following pancreatic islet cell transplantation in a patient with type 1 diabetes by cytometric fingerprintingDebora R Sekiguchi
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol Methods 363:233-44. 2011.... - B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primatesChengyang Liu
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nat Med 13:1295-8. 2007..Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy... - Innate immunity modulates adipokines in humansPaul D Anderson
Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
J Clin Endocrinol Metab 92:2272-9. 2007..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis... - Narrative review: effect of bariatric surgery on type 2 diabetes mellitusMarion L Vetter
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Ann Intern Med 150:94-103. 2009..This review discusses the various bariatric procedures and how they alter the enteroinsular axis. Familiarity with these effects can help physicians decide among the different surgical procedures and avoid postoperative hypoglycemia... - RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetesAnil K Panigrahi
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Exp Med 205:2985-94. 2008..Low RS rearrangement levels are also observed in human subjects with SLE or T1D... 
Severe insulin resistance and hypertriglyceridemia after childhood total body irradiationSarah E Mayson
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Endocr Pract 19:51-8. 2013....- Assessment of anxiety and depression in primary care: value of a four-item questionnaireMichael R Rickels
Mood and Anxiety Disorders Section, Department of PsychiatryUniversity of Pennsylvania School of Medicine, 3535 Market St, Philadelphia, PA 19104 3309, USA
J Am Osteopath Assoc 109:216-9. 2009..However, such survey tools are typically lengthy and are therefore not used often in primary care... - Cabergoline decreases somatotroph adenoma size: a case reportMichael R Rickels
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6149, USA
Pituitary 7:107-10. 2004..This demonstration, plus the ease of oral administration, suggests that it would be worthwhile to study systematically the effect of cabergoline on the size of somatotroph macroadenomas...