Michael R Rickels

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures
    Michael R Rickels
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Am J Physiol Endocrinol Metab 306:E1217-24. 2014
  2. pmc Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes
    Michael R Rickels
    MD, MS, Perelman School of Medicine at the University of Pennsylvania, 12 134 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104
    J Clin Endocrinol Metab 98:E1780-5. 2013
  3. pmc Improvement in β-cell secretory capacity after human islet transplantation according to the CIT07 protocol
    Michael R Rickels
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes 62:2890-7. 2013
  4. pmc Recovery of endocrine function after islet and pancreas transplantation
    Michael R Rickels
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Institute for Diabetes, Obesity, and Metabolism, 12 134 Translational Research Center, Philadelphia, PA 19104, USA
    Curr Diab Rep 12:587-96. 2012
  5. ncbi request reprint Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients
    Michael R Rickels
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 92:873-9. 2007
  6. ncbi request reprint Insulin sensitivity, glucose effectiveness, and free fatty acid dynamics after human islet transplantation for type 1 diabetes
    Michael R Rickels
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 91:2138-44. 2006
  7. ncbi request reprint Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes
    Michael R Rickels
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    Diabetes 54:3205-11. 2005
  8. ncbi request reprint Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity
    Michael R Rickels
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 92:2410-4. 2007
  9. pmc {beta}-Cell secretory capacity and demand in recipients of islet, pancreas, and kidney transplants
    Michael R Rickels
    University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 95:1238-46. 2010
  10. ncbi request reprint Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation
    Michael R Rickels
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    Transplantation 84:1357-60. 2007

Collaborators

Detail Information

Publications31

  1. pmc Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures
    Michael R Rickels
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Am J Physiol Endocrinol Metab 306:E1217-24. 2014
    ..That the minimal model SIC is highly correlated to the clamp-derived measures indicates that the FSIGT is an appropriate methodology for the determination of insulin sensitivity in T1D and following islet transplantation. ..
  2. pmc Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes
    Michael R Rickels
    MD, MS, Perelman School of Medicine at the University of Pennsylvania, 12 134 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania 19104
    J Clin Endocrinol Metab 98:E1780-5. 2013
    ..However, current immunosuppression regimens containing tacrolimus and sirolimus have been shown to induce insulin resistance in rodents...
  3. pmc Improvement in β-cell secretory capacity after human islet transplantation according to the CIT07 protocol
    Michael R Rickels
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes 62:2890-7. 2013
    ....
  4. pmc Recovery of endocrine function after islet and pancreas transplantation
    Michael R Rickels
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Institute for Diabetes, Obesity, and Metabolism, 12 134 Translational Research Center, Philadelphia, PA 19104, USA
    Curr Diab Rep 12:587-96. 2012
    ....
  5. ncbi request reprint Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipients
    Michael R Rickels
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 92:873-9. 2007
    ..Islet transplantation can ameliorate occurrences of hypoglycemia in these patients...
  6. ncbi request reprint Insulin sensitivity, glucose effectiveness, and free fatty acid dynamics after human islet transplantation for type 1 diabetes
    Michael R Rickels
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 778 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 91:2138-44. 2006
    ..Islet transplantation results in impaired insulin secretion, but whether defects in insulin sensitivity contribute to impaired glucose disposal after islet transplantation under modern immunosuppression is not known...
  7. ncbi request reprint Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes
    Michael R Rickels
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    Diabetes 54:3205-11. 2005
    ..01). These results suggest that after islet transplantation and in response to insulin-induced hypoglycemia, endogenous insulin secretion is appropriately suppressed and glucagon secretion may be partially restored...
  8. ncbi request reprint Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity
    Michael R Rickels
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 92:2410-4. 2007
    ..The majority of islet transplant recipients experience a gradual decline in islet graft function, but the identification of islet-specific immune responses remains uncommon...
  9. pmc {beta}-Cell secretory capacity and demand in recipients of islet, pancreas, and kidney transplants
    Michael R Rickels
    University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 95:1238-46. 2010
    ..control groups. Conclusions: Impaired beta-cell secretory capacity in islet transplantation is best explained by a low engrafted beta-cell mass and not by a deleterious effect of tacrolimus...
  10. ncbi request reprint Acute insulin responses to glucose and arginine as predictors of beta-cell secretory capacity in human islet transplantation
    Michael R Rickels
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    Transplantation 84:1357-60. 2007
    ..02). Also, the measures of beta-cell secretory capacity were highly correlated (n=7, r2=0.98, P<0.0001). These results support the use of AIR(arg) as a surrogate indicator of beta-cell secretory capacity in islet transplantation...
  11. pmc Effect of glucagon-like peptide-1 on beta- and alpha-cell function in isolated islet and whole pancreas transplant recipients
    Michael R Rickels
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Endocrinol Metab 94:181-9. 2009
    ..Glucose-dependent insulin secretion is often impaired after islet transplantation where reduced beta-cell secretory capacity indicates a low functional beta-cell mass...
  12. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
    ..This study sought to explore potential mechanisms of inflammatory-induced IR in humans with a focus on adipose tissue...
  13. pmc Metabolic function of a suboptimal transplanted islet mass in nonhuman primates on rapamycin monotherapy
    Scott A Soleimanpour
    Islet and Autoimmunity Branch, NIDDK, NIH, Bethesda, MD, USA
    Cell Transplant 21:1297-304. 2012
    ..Furthermore, improved glycemic control achieved via islet transplantation over the diabetic state might be attained, in part, via reduced glucagon secretion...
  14. pmc Insulin sensitivity, food intake, and cravings with premenstrual syndrome: a pilot study
    Kimberly K Trout
    University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA
    J Womens Health (Larchmt) 17:657-65. 2008
    ..The objective of this pilot study was to evaluate possible differences in insulin sensitivity, food intake, and cravings between the follicular and luteal phases of the menstrual cycle in women with premenstrual syndrome (PMS)...
  15. pmc Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model
    Chengyang Liu
    Division of Transplantation, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104 5160, USA
    Endocrinology 153:1673-83. 2012
    ....
  16. ncbi request reprint {beta}-Cell function following human islet transplantation for type 1 diabetes
    Michael R Rickels
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes, Metabolism, 778 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 6149, USA
    Diabetes 54:100-6. 2005
    ..Because AR(max) provides an estimate of the functional beta-cell mass, these results suggest that a low engrafted beta-cell mass may account for the functional defects observed after islet transplantation...
  17. pmc Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 94:2161-6. 2010
    ..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women...
  18. ncbi request reprint Severe insulin resistance and hypertriglyceridemia after childhood total body irradiation
    Sarah E Mayson
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Endocr Pract 19:51-8. 2013
    ....
  19. pmc A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial
    Nehal N Mehta
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Transl Med 10:124. 2012
    ....
  20. ncbi request reprint Menstrual cycle effects on insulin sensitivity in women with type 1 diabetes: a pilot study
    Kimberly K Trout
    University of Pennsylvania School of Nursing, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Technol Ther 9:176-82. 2007
    ..This pilot study's objective was to evaluate possible differences in insulin sensitivity between follicular and luteal phases in women with type 1 diabetes...
  21. pmc Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012
    Michael R Rickels
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 15213, USA
    Pancreatology 13:336-42. 2013
    ..Diabetes and glucose intolerance are common complications of chronic pancreatitis, yet clinical guidance on their detection, classification, and management is lacking...
  22. pmc Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease
    Karen L Teff
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Diabetes 62:3232-40. 2013
    ....
  23. pmc Analysis of B cell subsets following pancreatic islet cell transplantation in a patient with type 1 diabetes by cytometric fingerprinting
    Debora R Sekiguchi
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol Methods 363:233-44. 2011
    ....
  24. ncbi request reprint B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
    Chengyang Liu
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Med 13:1295-8. 2007
    ..Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy...
  25. pmc Personalized cytomic assessment of vascular health: Evaluation of the vascular health profile in diabetes mellitus
    Nicholas Kurtzman
    Department of Pathology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Cytometry B Clin Cytom 84:255-66. 2013
    ..CF enabled discovery of a unique pattern, involving both MPs and CPCs and generated a personalized signature of vascular health, the vascular health profile (VHP)...
  26. pmc Improvement in outcomes of clinical islet transplantation: 1999-2010
    Franca B Barton
    The EMMES Corporation, Rockville, MD, USA
    Diabetes Care 35:1436-45. 2012
    ..To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010...
  27. ncbi request reprint Innate immunity modulates adipokines in humans
    Paul D Anderson
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Endocrinol Metab 92:2272-9. 2007
    ..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...
  28. ncbi request reprint Narrative review: effect of bariatric surgery on type 2 diabetes mellitus
    Marion L Vetter
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann Intern Med 150:94-103. 2009
    ..This review discusses the various bariatric procedures and how they alter the enteroinsular axis. Familiarity with these effects can help physicians decide among the different surgical procedures and avoid postoperative hypoglycemia...
  29. pmc RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes
    Anil K Panigrahi
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 205:2985-94. 2008
    ..Low RS rearrangement levels are also observed in human subjects with SLE or T1D...
  30. ncbi request reprint Assessment of anxiety and depression in primary care: value of a four-item questionnaire
    Michael R Rickels
    Mood and Anxiety Disorders Section, Department of PsychiatryUniversity of Pennsylvania School of Medicine, 3535 Market St, Philadelphia, PA 19104 3309, USA
    J Am Osteopath Assoc 109:216-9. 2009
    ..However, such survey tools are typically lengthy and are therefore not used often in primary care...
  31. ncbi request reprint Cabergoline decreases somatotroph adenoma size: a case report
    Michael R Rickels
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    Pituitary 7:107-10. 2004
    ..This demonstration, plus the ease of oral administration, suggests that it would be worthwhile to study systematically the effect of cabergoline on the size of somatotroph macroadenomas...