WILLIAM RICKESummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Steroid hormones and carcinogenesis of the prostate: the role of estrogensWilliam A Ricke
Department of Urology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
Differentiation 75:871-82. 2007..Answers to these questions will further our understanding of the mechanisms of estrogen/ER signaling and will serve as a basis for chemopreventive and/or chemotherapeutic strategies for prostate cancer...- Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signalingWilliam A Ricke
Department of Urology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
FASEB J 22:1512-20. 2008..This mouse model provides a means to examine genetic gain and loss of function and determine the efficacy of therapeutics on prostatic carcinogenesis... 
Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptorChun Te Wu
George Whipple Laboratory for Cancer Research, Departments of Pathology and Urology, University of Rochester, Rochester, NY 14620, USA
Proc Natl Acad Sci U S A 104:12679-84. 2007..These data support the hypothesis that epithelial AR controls prostate growth by suppressing epithelial proliferation in the mature gland...- Androgen receptor is a tumor suppressor and proliferator in prostate cancerYuanjie Niu
George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14620, USA
Proc Natl Acad Sci U S A 105:12182-7. 2008..Collectively, our understanding of these opposing roles of prostatic AR may revolutionize the way we combat prostate cancer, and allow the development of new and better therapies by targeting only the proliferative role of AR... - Steroid hormones stimulate human prostate cancer progression and metastasisWilliam A Ricke
Department of Anatomy, University of California, San Francisco, CA 94143, USA
Int J Cancer 118:2123-31. 2006..Use of mUGM in this system will allow future studies to utilize the power of mouse genetics to identify paracrine factors involved in human prostatic carcinogenesis... - Role of the stromal microenvironment in carcinogenesis of the prostateGerald R Cunha
Department of Anatomy, University of California, San Francisco, CA 94143, USA
Int J Cancer 107:1-10. 2003..Thus, the stromal microenvironment is a critical determinant of benign versus malignant growth... - Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonistJennifer E Mersereau
Department of Obstetrics, Gynecology and Reproductive Sciences and Center for Reproductive Sciences, Cellular and Molecular Pharmacology, University of California, San Francisco, CA, United States
Mol Cell Endocrinol 283:49-57. 2008..In a mouse xenograph model, liquiritigenin did not stimulate uterine size or tumorigenesis of MCF-7 breast cancer cells. Our results demonstrate that some plants contain highly selective estrogens for ERbeta...
Research Grants
- Stromal androgen receptors mediated human prostate Cancer progressionWILLIAM RICKE; Fiscal Year: 2007..These experiments will provide key insight into the prevention of human PRCA and lead to a better understanding of the mechanisms of androgen action in human prostate carcinogenesis. ..
- Stromal androgen receptors mediated human prostate Cancer progressionWILLIAM RICKE; Fiscal Year: 2009..These experiments will provide key insight into the prevention of human PRCA and lead to a better understanding of the mechanisms of androgen action in human prostate carcinogenesis. ..