Research Topics
| Joel RichterSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Publications
Regulation of cap-dependent translation by eIF4E inhibitory proteinsJoel D Richter
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 433:477-80. 2005..The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation...
Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon developmentAndrew C Lin
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
Neural Dev 4:8. 2009..Control of poly(A) tail length by cytoplasmic polyadenylation element (CPE) binding protein 1 (CPEB1) is a conserved mechanism for mRNA-specific translational regulation that could be involved in regulating translation in axons...- Development. The message is in the translationJ D Richter
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 293:60-2. 2001 - Think globally, translate locally: what mitotic spindles and neuronal synapses have in commonJ D Richter
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Biotech 4, Room 330, 377 Plantation Street, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 98:7069-71. 2001..Therefore, CPEB-controlled local translation may influence such seemingly disparate processes as the cell cycle and synaptic plasticity... - Selective translation of mRNAs at synapsesJoel D Richter
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Curr Opin Neurobiol 12:300-4. 2002..Such mechanisms may be inferred from those operating in early development and in cognitive disease... 
Making synaptic plasticity and memory last: mechanisms of translational regulationJoel D Richter
Program in Molecular Medicine University of Massachusetts Medical School Worcester, Massachusetts 01605, USA
Genes Dev 23:1-11. 2009..Here, we review recent studies that reflect the importance and challenges of investigating the role of mRNA translation in synaptic plasticity and memory formation...- CPEB: a life in translationJoel D Richter
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Trends Biochem Sci 32:279-85. 2007..These observations underscore the growing complexities of CPEB involvement in cell function... - Translational control in oocyte developmentJoel D Richter
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
Cold Spring Harb Perspect Biol 3:a002758. 2011.... - Translational control of synaptic plasticityJoel D Richter
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Biochem Soc Trans 38:1527-30. 2010..In the present paper, I review some salient features of translational control of synaptic plasticity... - CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell divisionI Groisman
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
Cell 103:435-47. 2000..These data suggest that CPEB-regulated mRNA translation is important for the integrity of the mitotic apparatus and for cell division... - Translational control by CPEB: a means to the endR Mendez
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Nat Rev Mol Cell Biol 2:521-9. 2001..What are the features and functions of this multifaceted protein?.. - CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapsesL Wu
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
Neuron 21:1129-39. 1998..In the intact brain, visual experience induces alpha-CaMKII mRNA polyadenylation and translation, suggesting that this process likely occurs at synapses... - Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complexR Mendez
Department of Molecular Genetics and Microbiology University of Massachusetts Medical School, Worcester, MA 01655, USA
Mol Cell 6:1253-9. 2000..These results demonstrate that the molecular function of Eg2-phosphorylated CPEB is to recruit CPSF into an active cytoplasmic polyadenylation complex... - Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNAR Mendez
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester 01655, USA
Nature 404:302-7. 2000..In addition, we show that this selective, early phosphorylation of CPEB is catalysed by Eg2, a member of the Aurora family of serine/threonine protein kinases... - Translational control in vertebrate developmentC H de Moor
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
Int Rev Cytol 203:567-608. 2001..This review discusses examples of translational control and their relevance for developmental regulation... - Maskin is a CPEB-associated factor that transiently interacts with elF-4EB Stebbins-Boaz
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
Mol Cell 4:1017-27. 1999..The dissolution of this complex may result in the binding of elF-4E to elF-4G and the translational activation of CPE-containing mRNAs... - Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout miceJ Tay
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
Dev Cell 1:201-13. 2001..Synaptonemal complexes were not detected in these animals. CPEB therefore controls germ cell differentiation by regulating the formation of the synaptonemal complex... - CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytesR Hodgman
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Development 128:2815-22. 2001..These data indicate that cytoplasmic polyadenylation in mouse oocytes is mediated by IAK1/Eg2-catalyzed phosphorylation of CPEB... - CPEB control of NF-kappaB nuclear localization and interleukin-6 production mediates cellular senescenceRachel Groppo
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cell Biol 31:2707-14. 2011..Thus, CPEB deficiency not only increases IL-6 production but also renders the cell incapable of a senescence-promoting response... - Cytoplasmic polyadenylation in development and beyondJ D Richter
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Microbiol Mol Biol Rev 63:446-56. 1999..Finally, there may be multiple mechanisms by which polyadenylation promotes translation. Important questions yet to be answered in the field of cytoplasmic polyadenylation are addressed... - Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylationJong Heon Kim
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mol Cell 24:173-83. 2006..However, because PARN is more active than Gld2, the poly(A) tail is short. When oocytes mature, CPEB phosphorylation causes PARN to be expelled from the ribonucleoprotein complex, which allows Gld2 to elongate poly(A) by default... - CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progressionQuiping Cao
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, Massachusetts 01605, USA
Nat Struct Mol Biol 13:1128-34. 2006..These phosphorylation events control the Maskin-eIF4E interaction and, as a result, translation of cyclin B1 mRNA. Cell cycle progression requires this Maskin-mediated translational regulation... - CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNAYi Shuian Huang
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
EMBO J 25:4865-76. 2006..These results indicate that CPEB3 is a sequence-specific translational regulatory protein... - Analysis of mRNA translation in cultured hippocampal neuronsYi Shuian Huang
Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Methods Enzymol 431:143-62. 2007..2006); here, we describe the experimental details of our methods, which could be used for any RNA binding protein... - RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePABJong Heon Kim
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 21:2571-9. 2007..Subsequent ePAB binding to the poly(A) tail is necessary to protect the homopolymer from degradation by deadenylating enzymes. Poly(A)-bound ePAB also interacts with eIF4G, which instigates translation initiation of CPEB-bound mRNAs... - Breaking the code of polyadenylation-induced translationJoel D Richter
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Cell 132:335-7. 2008..In this issue, Piqué et al. (2008) explore the interplay of these elements to elucidate a combinatorial code that predicts the timing of polyadenylation and translation of maternal mRNAs... - Translational unmasking of Emi2 directs cytostatic factor arrest in meiosis IIJeffrey J Tung
Genentech, Inc, South San Francisco, California, USA
Cell Cycle 6:725-31. 2007..Our results demonstrate that cytoplasmic polyadenylation and translational unmasking of Emi2 directs meiosis II-specific CSF arrest... - A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampusN Ruth Zearfoss
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Neurosci 28:8502-9. 2008..These results indicate that CPEB-1 control of c-Jun mRNA translation regulates GH gene expression and resulting downstream signaling events (e.g., synaptic plasticity) in the mouse hippocampus... - Control of cellular senescence by CPEBIrina Groisman
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 20:2701-12. 2006..Thus, CPEB appears to act as a translational repressor protein to control myc translation and resulting cellular senescence... - Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding proteinMi Young Jung
Program in Molecular Medicine, University of Massachusetts Medical School, Suite 204, 373 Plantation St, Worcester MA 01605, USA
Mol Cell Biol 26:4277-87. 2006..These data suggest that Ngd guides neural development by regulating the translation of CPE-containing mRNAs... - Reduced extinction of hippocampal-dependent memories in CPEB knockout miceJoanne Berger-Sweeney
Department of Biology, Wellesley College, Wellesley, Massachusetts 02481, USA
Learn Mem 13:4-7. 2006..14% of hippocampal genes have an altered expression in the CPEB knockout mouse. These data suggest that CPEB-dependent local protein synthesis may be an important cellular mechanism underlying extinction of hippocampal-dependent memories... - Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destructionRaul Mendez
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
EMBO J 21:1833-44. 2002..CPEB destruction is also necessary for mitosis in the early embryo. These data indicate that a change in the CPEB:CPE ratio is necessary to activate mRNAs at metaphase I and drive the cells' entry into metaphase II... - N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapsesYi Shuian Huang
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
EMBO J 21:2139-48. 2002..These data demonstrate a remarkable conservation of the regulatory machinery that controls signal-induced mRNA translation, and elucidates an axis connecting the NMDA receptor to localized protein synthesis at synapses... - Translational control of the embryonic cell cycleIrina Groisman
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605, USA
Cell 109:473-83. 2002..Mammalian cells also display a cell cycle-dependent cytoplasmic polyadenylation, suggesting that translational control by polyadenylation might be a general feature of mitosis in animal cells... - Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturationQuiping Cao
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
EMBO J 21:3852-62. 2002..These results suggest a molecular mechanism by which CPE- containing mRNA is activated in early development... - Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translationJoyce Tay
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Genes Dev 17:1457-62. 2003..The temporal control of CPEB phosphorylation suggests a mechanism in which CPE-containing mRNA translation is stimulated at pachytene and metaphase I... - Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3Madathia Sarkissian
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 18:48-61. 2004..These results suggest that the progesterone and insulin stimulate maturation by inhibiting GSK-3, which allows Aurora A activation and CPEB-mediated translation... - Regulation of local mRNA translationYi-Shuian Huang
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 204, Worcester, MA 01605, USA
Curr Opin Cell Biol 16:308-13. 2004..The importance of local translation cannot be overstated, for, depending on the species or cell type, it is required for cell division, establishment of mating type, development and memory formation... - Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 geneJuan M Alarcon
College of Physicians and Surgeons of Columbia University, Columbia University, New York, New York 10032, USA
Learn Mem 11:318-27. 2004..These data suggest that CPEB-1 contributes in the translational control of mRNAs that is critical only for some selected forms of LTP and LTD... - Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylationDaron C Barnard
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 119:641-51. 2004..The identification of these factors has broad implications for biological process that employ polyadenylation-regulated translation, such as gametogenesis, cell cycle progression, and synaptic plasticity... - Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activationKiran Padmanabhan
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 20:199-209. 2006..These results demonstrate that a reversible Pum2 interaction controls RINGO/Spy mRNA translation and, as a result, CPEB-mediated cytoplasmic polyadenylation... - Differential phosphorylation controls Maskin association with eukaryotic translation initiation factor 4E and localization on the mitotic apparatusDaron C Barnard
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
Mol Cell Biol 25:7605-15. 2005..These results show that Maskin activity and localization is controlled by differential phosphorylation... - Activity-dependent polyadenylation in neuronsLing Du
University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
RNA 11:1340-7. 2005..These studies show that many mRNAs undergo activity-dependent polyadenylation in neurons and that this process coincides with increased translation in the synapto-dendritic compartment... - Human let-7a miRNA blocks protein production on actively translating polyribosomesStephanie Nottrott
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Suite 204, Worcester, Massachusetts 01605, USA
Nat Struct Mol Biol 13:1108-14. 2006..These data indicate that let-7a miRNA inhibits actively translating polyribosomes. Nascent polypeptide coimmunoprecipitation experiments further suggest that let-7a miRNA interferes with the accumulation of growing polypeptides... - Facilitation of dendritic mRNA transport by CPEBYi Shuian Huang
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 17:638-53. 2003..These results suggest a mechanism whereby CPE-containing mRNAs can be transported to dendrites in a translationally dormant form, but activated at synapses in response to NMDA receptor stimulation... - Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translationQuiping Cao
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
Mol Cell Biol 25:10930-9. 2005..These data demonstrate a link between cytoplasmic polyadenylation and membrane association and implicate APP family member proteins as anchors for localized mRNA polyadenylation and translation... - CPEB controls oocyte growth and follicle development in the mouseWaldemar J Racki
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Development 133:4527-37. 2006..Finally, several phenotypes, i.e. progressive oocyte loss and infertility, elicited by the knockdown of CPEB in oocytes resemble those of the human premature ovarian failure syndrome... - Synapses go nucle(ol)arJoel D Richter
Nat Neurosci 10:399-400. 2007 - Think you know how miRNAs work? Think againJoel D Richter
Nat Struct Mol Biol 15:334-6. 2008
Research Grants
- CPEB and Cell SenescenceJoel Richter; Fiscal Year: 2007..This proposal focuses on new molecules that regulate cell senescence. Because this process is strongly linked to cancer and ageing, it clearly has important implications for human health. ..
- TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENTJoel Richter; Fiscal Year: 2007..The importance of CPEB3 for oocytedevelopment will be assessed. The proposed experiments will examine the molecular basis of oocyte development, and thus are relevant to human health especially human reproduction. ..
- RNA Localization 2006Joel Richter; Fiscal Year: 2007..The cross-disciplinary nature of this meeting will be attractive to molecular, cellular, developmental, and neurobiological scientists. ..
- POLYADENYLATION AND TRANSLATIONAL CONTROLJoel Richter; Fiscal Year: 2009..In particular, we will examine RNA processing and translational control. Because of the fundamental nature of this work, it has important implications for fertility, neurodegeneration, and cancer. ..
- CPEB and Cell SenescenceJoel Richter; Fiscal Year: 2009..This proposal focuses on new molecules that regulate cell senescence. Because this process is strongly linked to cancer and ageing, it clearly has important implications for human health. ..
- POLYADENYLATION AND TRANSLATIONAL CONTROLJoel Richter; Fiscal Year: 2009..Finally, an upstream event that is necessary for CPEB-mediated polyadenylation is the translational activation of RINGO/Spy mRNA, which encodes an atypical cyclin B1-like protein. Pumilio is the ..
- POLYADENYLATION AND TRANSLATIONAL CONTROLJoel D Richter; Fiscal Year: 2010..In particular, we will examine RNA processing and translational control. Because of the fundamental nature of this work, it has important implications for fertility, neurodegeneration, and cancer. ..
- CELL BIOLOGY OF DEVELOPMENTJoel Richter; Fiscal Year: 2007....
- POLYADENYLATION AND TRANSLATIONAL CONTROLJoel Richter; Fiscal Year: 2007..Therefore, mechanistic studies of polyadenylation-induced translation are likely to have important implications for human health. ..
- POLYADENYLATION AND TRANSLATIONAL CONTROLJoel Richter; Fiscal Year: 1999....
- TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENTJoel Richter; Fiscal Year: 2001..Finally, an mRNA that is deadenylated and stored in a dormant form in mouse oocytes undergoes prior CPE-mediated deadenylation. The possible role of mCPEB in the process will be assessed. ..
- POLYADENYLATION AND TRANSLATIONAL CONTROLJoel Richter; Fiscal Year: 2003..The mechanism responsible for, and the biological significance of, this localization will be investigated. ..
- CPEB and Cell SenescenceJoel D Richter; Fiscal Year: 2010..This proposal focuses on new molecules that regulate cell senescence. Because this process is strongly linked to cancer and ageing, it clearly has important implications for human health. ..