Research Topics
Genomes and GenesSpecies | Eric K RichfieldSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Selective loss of striatal preprotachykinin neurons in a phenocopy of Huntington's diseaseEric K Richfield
Department of Pathology and Laboratory Medicine and Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Mov Disord 17:327-32. 2002..This case demonstrates the existence of one type of striatal lesion that may produce a clinical picture similar to HD, and raises the possibility of a rare hereditary disease that mimics HD...- The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthoodRuth Reeves
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Toxicol Appl Pharmacol 200:54-63. 2004..These results indicate for the first time that TDF may be considered an environmental risk factor for developmental dopaminergic neurotoxicity... - A fetal risk factor for Parkinson's diseaseBrian K Barlow
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Dev Neurosci 26:11-23. 2004..This study implicates a role for developmental neurotoxicant exposure in the induction of neurodegenerative disorders such as PD... - Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotypeMona Thiruchelvam
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Neurotoxicology 23:621-33. 2002.... - Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefonRuth Reeves
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pharmacol Biochem Behav 76:315-26. 2003..Thus, TDF exposure may serve as an environmental risk factor for DA system dysfunctions... - Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic miceEric K Richfield
Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
Exp Neurol 175:35-48. 2002..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers... - Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamatesBrian K Barlow
Department of Pathology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Neurochem 85:1075-86. 2003..These results suggest that selective dithiocarbamates may alter the kinetics of different endogenous and exogenous compounds to enhance their neurotoxicity... - Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotypeMona Thiruchelvam
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Eur J Neurosci 18:589-600. 2003..Collectively, these data demonstrate enhanced sensitivity of the ageing nigrostriatal dopamine pathway to these pesticides, particularly paraquat + maneb, resulting in irreversible and progressive neurotoxicity... - Reporter gene transfer induces apoptosis in primary cortical neuronsEric R Detrait
Center for Aging and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, New York 14642, USA
Mol Ther 5:723-30. 2002..This work underscores the need for careful design of gene expression constructs. Moreover, in studies where cell injury or toxicity is being evaluated, their use should be carefully considered... - Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotypeMona Thiruchelvam
Department of Biochemistry, and Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
J Biol Chem 280:22530-9. 2005.... 
Developmental pesticide models of the Parkinson disease phenotypeDeborah A Cory-Slechta
Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 07920, USA
Environ Health Perspect 113:1263-70. 2005..As such, this hypothesis presents a biologic strategy for identifying potentially significant neurotoxic mixtures for hazard identification in future studies...- Developmental pesticide exposures and the Parkinson's disease phenotypeDeborah A Cory-Slechta
Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA
Birth Defects Res A Clin Mol Teratol 73:136-9. 2005..In addition, they demonstrate the fact that silent neurotoxicity produced by developmental insults can be unmasked by challenges later during life as well as the potential for cumulative neurotoxicity over the life span... - Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteinsPerry J Blackshear
Laboratory of Neurobiology, Office of Clinical Research, National Institute of Environmental Health Sciences, North Carolina 27709, USA
Biol Reprod 73:297-307. 2005..Its presumed role in placental physiology may be unique to rodents or murine rodents, but this role may be subsumed by other family members in nonrodents... - The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorderBrian K Barlow
MD PhD Program, Graduate Program in Neuroscience, UMDNJ RWJMS and Rutgers, USA
Reprod Toxicol 23:457-70. 2007..Additionally, challenges in studying the neurodevelopmental basis of neurodegeneration experimentally and epidemiologically are presented...