R Mark Richardson

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Mol Ther 19:1048-57. 2011
  2. pmc Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum
    Waldy San Sebastián
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103, USA
    Hum Gene Ther 23:210-7. 2012
  3. doi T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery
    R Mark Richardson
    Laboratory of Molecular Therapeutics, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    Neurosurgery 69:154-63; discussion 163. 2011
  4. pmc Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements
    Massimo S Fiandaca
    Movement Disorders Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    J Neurosci Methods 196:124-30. 2011
  5. pmc An optimized system for interventional magnetic resonance imaging-guided stereotactic surgery: preliminary evaluation of targeting accuracy
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 70:95-103; discussion 103. 2012
  6. doi Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics
    Dali Yin
    Department of Neurosurgery, University of California, San Francisco, California 94103, USA
    J Neurosurg 113:240-8. 2010
  7. pmc Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain
    Ernesto A Salegio
    Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94103, USA
    Hum Gene Ther 23:891-902. 2012
  8. doi Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease
    Francisco Valles
    Movement Disorder Research Program, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94103, USA
    Neurosurgery 67:1377-85. 2010
  9. pmc Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    Stereotact Funct Neurosurg 89:141-51. 2011
  10. pmc Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors
    Xiaomin Su
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103, USA
    Mol Ther 18:1490-5. 2010

Collaborators

Detail Information

Publications17

  1. pmc Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Mol Ther 19:1048-57. 2011
    ..The results elucidate the necessary parameters for achieving widespread GDNF expression in the putamenal motor area and afferent substantia nigra of PD patients...
  2. pmc Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum
    Waldy San Sebastián
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103, USA
    Hum Gene Ther 23:210-7. 2012
    ..Our data indicate that this approach directed accurate cannula placement and effective vector distribution without inducing any untoward effects in nonhuman primates infused with a high dose of AAV2-hAADC...
  3. doi T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery
    R Mark Richardson
    Laboratory of Molecular Therapeutics, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    Neurosurgery 69:154-63; discussion 163. 2011
    ..The use of T2 MRI in RCD is less developed. In addition, the effect of flushing a dead-space volume on subsequent distribution of a therapeutic agent is not known...
  4. pmc Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements
    Massimo S Fiandaca
    Movement Disorders Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    J Neurosci Methods 196:124-30. 2011
    ....
  5. pmc An optimized system for interventional magnetic resonance imaging-guided stereotactic surgery: preliminary evaluation of targeting accuracy
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 70:95-103; discussion 103. 2012
    ..A novel system (SurgiVision ClearPoint) consisting of an aiming device (SMARTFrame) and software has been developed specifically for interventional MRI, including deep brain stimulation...
  6. doi Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics
    Dali Yin
    Department of Neurosurgery, University of California, San Francisco, California 94103, USA
    J Neurosurg 113:240-8. 2010
    ....
  7. pmc Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain
    Ernesto A Salegio
    Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94103, USA
    Hum Gene Ther 23:891-902. 2012
    ..This study defines dose-dependent and dose-independent toxicities of AAV2-hASM in the naive primate brain, and reveals potential challenges in the design of a clinical trial...
  8. doi Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease
    Francisco Valles
    Movement Disorder Research Program, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94103, USA
    Neurosurgery 67:1377-85. 2010
    ....
  9. pmc Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    Stereotact Funct Neurosurg 89:141-51. 2011
    ..The targeting accuracy of this delivery system and the performance of the infusion cannula were validated in nonhuman primates...
  10. pmc Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors
    Xiaomin Su
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103, USA
    Mol Ther 18:1490-5. 2010
    ..Our data support the use of Gd and MRI to monitor AAV2 infusion via CED and to predict the distribution of GDNF protein after AAV2-GDNF administration...
  11. doi Incidence and management of venous air embolisms during awake deep brain stimulation surgery in a large clinical series
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 89:76-82. 2011
    ..The diagnosis and management of VAE in patients undergoing awake deep brain stimulation (DBS) lead implantation in the sitting position are underreported...
  12. doi Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograft
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143, USA
    J Neurol Neurosurg Psychiatry 82:266-71. 2011
    ....
  13. doi Surgical repositioning of misplaced subthalamic electrodes in Parkinson's disease: location of effective and ineffective leads
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 87:297-303. 2009
    ..These results are contrasted with findings in other studies demonstrating optimal lead placement in STN border zones or neighboring white-matter tracts...
  14. ncbi Magnetic resonance imaging of implanted deep brain stimulators: experience in a large series
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Stereotact Funct Neurosurg 86:92-100. 2008
    ..This series strongly suggests that the 0.1 W/kg recommendation for SAR may be unnecessarily low for the prevention of MRI-related adverse events...
  15. doi Delayed acute spinal cord injury following intracranial gunshot trauma: case report
    Jason S Cheng
    Department of Neurological Surgery, University of California, San Francisco, CA, USA
    J Neurosurg 116:921-5. 2012
    ..Consideration for craniotomy and bullet retrieval should be given to large bullets lying in the CSF spaces of the posterior fossa as they pose risk for acute spinal cord injury...
  16. doi Stem cell biology in traumatic brain injury: effects of injury and strategies for repair
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, California, USA
    J Neurosurg 112:1125-38. 2010
    ..Each strategy is discussed with an emphasis on highlighting the progress and limiting factors relevant to the development of clinical trials of cellular replacement therapy for severe TBI in humans...
  17. doi Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 63:629-442; dicussion 642-4. 2008
    ..The authors review data obtained from primate models that form the basis for ongoing clinical trials to consider how new preclinical models should be developed to answer questions that arise from experimental clinical data...