R M Richardson

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    Stereotact Funct Neurosurg 89:141-51. 2011
  2. ncbi Surgical repositioning of misplaced subthalamic electrodes in Parkinson's disease: location of effective and ineffective leads
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 87:297-303. 2009
  3. ncbi Future applications: gene therapy
    R M Richardson
    Laboratory for Molecular Therapeutics, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
    Neurosurg Clin N Am 20:205-10. 2009
  4. ncbi T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery
    R Mark Richardson
    Laboratory of Molecular Therapeutics, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    Neurosurgery 69:154-63; discussion 163. 2011
  5. ncbi Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 63:629-442; dicussion 642-4. 2008
  6. ncbi Developing cell transplantation for temporal lobe epilepsy
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Neurosurg Focus 24:E17. 2008
  7. ncbi Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells
    R Mark Richardson
    Department of Neurosurgery, Medical College of Virginia, Hospitals, Virginia Commonwealth University, VA, USA
    Neurosci Lett 421:168-72. 2007
  8. ncbi Neurogenesis after traumatic brain injury
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143 0112, USA
    Neurosurg Clin N Am 18:169-81, xi. 2007
  9. ncbi Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograft
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143, USA
    J Neurol Neurosurg Psychiatry 82:266-71. 2011
  10. ncbi Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline
    R Mark Richardson
    Department of Neurosurgery, Medical College of Virginia Hospitals, Virginia Commonwealth University Health System, P O Box 980631, Richmond, VA 23298, USA
    Brain Res 1032:11-22. 2005

Collaborators

Detail Information

Publications18

  1. ncbi Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    Stereotact Funct Neurosurg 89:141-51. 2011
    ..The targeting accuracy of this delivery system and the performance of the infusion cannula were validated in nonhuman primates...
  2. ncbi Surgical repositioning of misplaced subthalamic electrodes in Parkinson's disease: location of effective and ineffective leads
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 87:297-303. 2009
    ..These results are contrasted with findings in other studies demonstrating optimal lead placement in STN border zones or neighboring white-matter tracts...
  3. ncbi Future applications: gene therapy
    R M Richardson
    Laboratory for Molecular Therapeutics, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
    Neurosurg Clin N Am 20:205-10. 2009
    ....
  4. ncbi T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery
    R Mark Richardson
    Laboratory of Molecular Therapeutics, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    Neurosurgery 69:154-63; discussion 163. 2011
    ..The use of T2 MRI in RCD is less developed. In addition, the effect of flushing a dead-space volume on subsequent distribution of a therapeutic agent is not known...
  5. ncbi Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 63:629-442; dicussion 642-4. 2008
    ..The authors review data obtained from primate models that form the basis for ongoing clinical trials to consider how new preclinical models should be developed to answer questions that arise from experimental clinical data...
  6. ncbi Developing cell transplantation for temporal lobe epilepsy
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Neurosurg Focus 24:E17. 2008
    ..These issues are reviewed, with a focus on those factors most likely to influence clinically applicable results...
  7. ncbi Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells
    R Mark Richardson
    Department of Neurosurgery, Medical College of Virginia, Hospitals, Virginia Commonwealth University, VA, USA
    Neurosci Lett 421:168-72. 2007
    ....
  8. ncbi Neurogenesis after traumatic brain injury
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143 0112, USA
    Neurosurg Clin N Am 18:169-81, xi. 2007
    ..Additionally, there is some evidence for local activation of latent neural progenitor cells in the injured neocortex itself. Each of these themes is discussed, with emphasis on the possibility of future therapeutic intervention...
  9. ncbi Pallidal neuronal discharge in Parkinson's disease following intraputamenal fetal mesencephalic allograft
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143, USA
    J Neurol Neurosurg Psychiatry 82:266-71. 2011
    ....
  10. ncbi Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline
    R Mark Richardson
    Department of Neurosurgery, Medical College of Virginia Hospitals, Virginia Commonwealth University Health System, P O Box 980631, Richmond, VA 23298, USA
    Brain Res 1032:11-22. 2005
    ..These results suggest that although neither the normal nor the deafferented striatum alone support the neuronal differentiation of transplanted adult SEZ NPCs, grafts maintaining a progenitor phenotype may produce a therapeutic benefit...
  11. ncbi Isolation of neuronal progenitor cells from the adult human neocortex
    R M Richardson
    Department of Neurosurgery, Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond, Virginia, USA
    Acta Neurochir (Wien) 148:773-7. 2006
    ..The reliability of harvesting neuronal progenitor cells (NPCs) from the adult human neocortex has not been established, with respect to preparing autologous cell cultures for transplantation in stroke and traumatic brain injured patients...
  12. ncbi Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders
    E Aguilar Salegio
    Department of Neurosurgery, University of California San Francisco, 94103, USA
    Hum Gene Ther 21:1093-103. 2010
    ..We found that enzymatic augmentation in brainstem, thalamic, cortical, as well subcortical areas provided convincing evidence that much of the large NHP brain can be transduced with as few as three injection sites...
  13. ncbi Magnetic resonance imaging of implanted deep brain stimulators: experience in a large series
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Stereotact Funct Neurosurg 86:92-100. 2008
    ..This series strongly suggests that the 0.1 W/kg recommendation for SAR may be unnecessarily low for the prevention of MRI-related adverse events...
  14. ncbi Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements
    Massimo S Fiandaca
    Movement Disorders Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    J Neurosci Methods 196:124-30. 2011
    ....
  15. ncbi Heterotypic neuronal differentiation of adult subependymal zone neuronal progenitor cells transplanted to the adult hippocampus
    R Mark Richardson
    Department of Neurosurgery, Virginia Commonwealth University Health System, PO Box 980631, Richmond, VA 23298, USA
    Mol Cell Neurosci 28:674-82. 2005
    ..These novel results indicate that in vitro expanded adult SEZ NPCs are capable of heterotypic neuronal differentiation in a neurogenic region of the adult brain...
  16. ncbi Stem cell biology in traumatic brain injury: effects of injury and strategies for repair
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, California, USA
    J Neurosurg 112:1125-38. 2010
    ..Each strategy is discussed with an emphasis on highlighting the progress and limiting factors relevant to the development of clinical trials of cellular replacement therapy for severe TBI in humans...
  17. ncbi Progress in cerebral transplantation of expanded neuronal stem cells
    R Mark Richardson
    Department of Neurosurgery, Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond, Virginia 23221, USA
    J Neurosurg 100:659-71. 2004
    ..Understanding the mechanisms responsible for this may lead to similar success with less studied adult neuronal progenitor cells, which offer the potential for autologous NSC transplantation with less risk of tumorigenesis...
  18. ncbi Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors
    Xiaomin Su
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103, USA
    Mol Ther 18:1490-5. 2010
    ..Our data support the use of Gd and MRI to monitor AAV2 infusion via CED and to predict the distribution of GDNF protein after AAV2-GDNF administration...