Peter Rice

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection
    Sunita Gulati
    Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 9:e1003559. 2013
  2. ncbi request reprint Gonococcal arthritis (disseminated gonococcal infection)
    Peter A Rice
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building LRB, Room 321, Worcester, MA 01605, USA
    Infect Dis Clin North Am 19:853-61. 2005
  3. ncbi request reprint Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasion
    Jutamas Ngampasutadol
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 180:3426-35. 2008
  4. pmc Defining targets for complement components C4b and C3b on the pathogenic neisseriae
    Lisa A Lewis
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 370I, 364 Plantation Street, Worcester, MA 01605, USA
    Infect Immun 76:339-50. 2008
  5. ncbi request reprint Molecular characterization of the interaction between porins of Neisseria gonorrhoeae and C4b-binding protein
    Hanna Jarva
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, University of Lund, Malmo, Sweden
    J Immunol 179:540-7. 2007
  6. pmc Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistance
    Sanjay Ram
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 322, 364 Plantation Street, Worcester, MA 01605, USA
    Infect Immun 75:4071-81. 2007
  7. ncbi request reprint Factor H binding and function in sialylated pathogenic neisseriae is influenced by gonococcal, but not meningococcal, porin
    Guillermo Madico
    Evans Biomedical Research Center, Boston University Medical Center, Boston, MA 02118, USA
    J Immunol 178:4489-97. 2007
  8. pmc Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection
    Jutamas Ngampasutadol
    Section of Infectious Diseases, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:17142-7. 2005
  9. pmc Enhanced factor H binding to sialylated Gonococci is restricted to the sialylated lacto-N-neotetraose lipooligosaccharide species: implications for serum resistance and evidence for a bifunctional lipooligosaccharide sialyltransferase in Gonococci
    Sunita Gulati
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Infect Immun 73:7390-7. 2005
  10. ncbi request reprint Regulation of the mannan-binding lectin pathway of complement on Neisseria gonorrhoeae by C1-inhibitor and alpha 2-macroglobulin
    Sunita Gulati
    Section of Infectious Diseases and Hematology Oncology, Evans Biomedical Research Center, Boston University Medical Center, Boston, MA 02118, USA
    J Immunol 168:4078-86. 2002

Collaborators

Detail Information

Publications19

  1. pmc Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection
    Sunita Gulati
    Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 9:e1003559. 2013
    ..043). The OS epitope defined by mAb 2C7 may represent an effective vaccine target against gonorrhea, which is rapidly becoming incurable with currently available antibiotics. ..
  2. ncbi request reprint Gonococcal arthritis (disseminated gonococcal infection)
    Peter A Rice
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building LRB, Room 321, Worcester, MA 01605, USA
    Infect Dis Clin North Am 19:853-61. 2005
    ....
  3. ncbi request reprint Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasion
    Jutamas Ngampasutadol
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 180:3426-35. 2008
    ..Our findings may help to improve animal models for gonorrhea while also having implications in the choice of complement sources to evaluate neisserial vaccine candidates...
  4. pmc Defining targets for complement components C4b and C3b on the pathogenic neisseriae
    Lisa A Lewis
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 370I, 364 Plantation Street, Worcester, MA 01605, USA
    Infect Immun 76:339-50. 2008
    ..The binding of C3b and C4b to Opa provides a rationale for the recovery of predominantly "transparent" (Opa-negative) neisserial isolates from persons with invasive disease, where the bacteria encounter high levels of complement...
  5. ncbi request reprint Molecular characterization of the interaction between porins of Neisseria gonorrhoeae and C4b-binding protein
    Hanna Jarva
    Department of Laboratory Medicine, Division of Medical Protein Chemistry, University of Lund, Malmo, Sweden
    J Immunol 179:540-7. 2007
    ..Only those recombinant mutant C4BPs that bound to bacteria rescued them from 100% killing by rhesus serum, thereby providing a functional correlate for the binding studies and highlighting C4BP function in gonococcal serum resistance...
  6. pmc Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistance
    Sanjay Ram
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building, Room 322, 364 Plantation Street, Worcester, MA 01605, USA
    Infect Immun 75:4071-81. 2007
    ..This study provides mechanistic insights into how HepI LOS substitutions affect the serum resistance of N. gonorrhoeae...
  7. ncbi request reprint Factor H binding and function in sialylated pathogenic neisseriae is influenced by gonococcal, but not meningococcal, porin
    Guillermo Madico
    Evans Biomedical Research Center, Boston University Medical Center, Boston, MA 02118, USA
    J Immunol 178:4489-97. 2007
    ..Our data highlight the different mechanisms used by these two related species to evade complement...
  8. pmc Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection
    Jutamas Ngampasutadol
    Section of Infectious Diseases, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:17142-7. 2005
    ..Our findings may lead to the development of better animal models for gonorrhea and may also have implications in the choice of complement sources to evaluate neisserial vaccine candidates...
  9. pmc Enhanced factor H binding to sialylated Gonococci is restricted to the sialylated lacto-N-neotetraose lipooligosaccharide species: implications for serum resistance and evidence for a bifunctional lipooligosaccharide sialyltransferase in Gonococci
    Sunita Gulati
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Infect Immun 73:7390-7. 2005
    ..Thus, serum resistance mediated by sialylation of gonococcal L1 and LNT LOS occurs by different mechanisms, and specificity of factor H binding to sialylated gonococci is restricted to the LNT LOS species...
  10. ncbi request reprint Regulation of the mannan-binding lectin pathway of complement on Neisseria gonorrhoeae by C1-inhibitor and alpha 2-macroglobulin
    Sunita Gulati
    Section of Infectious Diseases and Hematology Oncology, Evans Biomedical Research Center, Boston University Medical Center, Boston, MA 02118, USA
    J Immunol 168:4078-86. 2002
    ..Our studies indicate that MBL does not participate in complement activation on N. gonorrhoeae in the presence of "complete" serum that contains C1-inhibitor and alpha(2)-macroglobulin...
  11. pmc Implications of phase variation of a gene (pgtA) encoding a pilin galactosyl transferase in gonococcal pathogenesis
    Asesh Banerjee
    Department of Biology, The Catholic University of America, Washington, DC 20064, USA
    J Exp Med 196:147-62. 2002
    ..In contrast, for the vast majority (20 out of 28) of GC isolated from uncomplicated gonorrhea (UG) patients, pgtA lacked the poly-G. These results indicate that Pv of pgtA is likely to be involved in the conversion of UG to DGI...
  12. ncbi request reprint Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity
    Sanjay Ram
    Section of Infectious Diseases, Evans Biomedical Research Center, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 278:50853-62. 2003
    ....
  13. pmc por Variable-region typing by DNA probe hybridization is broadly applicable to epidemiologic studies of Neisseria gonorrhoeae
    Margaret C Bash
    Division of Bacterial, Parasitic and Allergenic Products, HFM 428, Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, MD 20852, USA
    J Clin Microbiol 43:1522-30. 2005
    ..por VR typing is a molecular tool that appears to have broad applicability. This method can be adapted to a wide range of technologies from simple hybridization to microarray and may allow for typing from noncultured clinical specimens...
  14. pmc Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women
    Sarika Agarwal
    Department of Medicine, Section of Molecular Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Bacteriol 190:3129-39. 2008
    ..Microarray analysis of specimens obtained from female subjects with uncomplicated gonococcal infection corroborated our in vitro findings and point toward a key role of gonococcal Fur- and iron-regulated genes in gonococcal disease...
  15. ncbi request reprint Polymerase chain reaction to diagnose infective endocarditis: will it replace blood cultures?
    Peter A Rice
    Circulation 111:1352-4. 2005
  16. pmc The gonococcal Fur-regulated tbpA and tbpB genes are expressed during natural mucosal gonococcal infection
    Sarika Agarwal
    Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, 650 Albany Street, Room 637, Boston, Massachusetts 02118, USA
    Infect Immun 73:4281-7. 2005
    ..These results indicate that gonococcal iron- and Fur-regulated tbpA and tbpB genes are expressed in gonococcal infection and that male subjects with mucosal gonococcal infections exhibit antibodies to these proteins...
  17. pmc Binding of vitronectin by the Moraxella catarrhalis UspA2 protein interferes with late stages of the complement cascade
    Ahmed S Attia
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9048, USA
    Infect Immun 74:1597-611. 2006
    ..These results indicate that binding of vitronectin by UspA2 is involved in the serum resistance of M. catarrhalis; this represents the first example of vitronectin-mediated serum resistance on a microbe...
  18. pmc Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions
    Edith Porter
    Department of Biological Sciences, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA
    Infect Immun 73:4823-33. 2005
    ....
  19. ncbi request reprint Characterization of a peptide vaccine candidate mimicking an oligosaccharide epitope of Neisseria gonorrhoeae and resultant immune responses and function
    Jutamas Ngampasutadol
    Section of Infectious Diseases, Department of Medicine, Evans Biomedical Research Center EBRC, Boston University Medical Center, Boston, MA 02118, USA
    Vaccine 24:157-70. 2006
    ..These data indicate that a peptide can mimic an oligosaccharide epitope and may form the basis for the development of a vaccine candidate for human immunization against N. gonorrhoeae...

Research Grants16

  1. STRUCTURAL DETERMINATION OF NEISSERIA GONORRHOEAE OLIGOSACCHARIDES FROM ISOLATES
    Peter Rice; Fiscal Year: 1999
    ..In addition, these findings will contribute to the development of effective diagnosis and therapies of human trichomoniasis. ..
  2. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 1999
    ..The resultant strains will be characterized for: i) the ability to sialylate (endogenously or in the presence of exogenous CMP-NANA), ii) their serum sensitivity in bactericidal assays, and iii) their LOS structure. ..
  3. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2007
    ..abstract_text> ..
  4. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2003
    ..The resultant strains will be characterized for: i) the ability to sialylate (endogenously or in the presence of exogenous CMP-NANA), ii) their serum sensitivity in bactericidal assays, and iii) their LOS structure. ..
  5. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2002
    ..The resultant strains will be characterized for: i) the ability to sialylate (endogenously or in the presence of exogenous CMP-NANA), ii) their serum sensitivity in bactericidal assays, and iii) their LOS structure. ..
  6. STRUCTURAL DETERMINATION OF NEISSERIA GONORRHOEAE OLIGOSACCHARIDES FROM ISOLATES
    Peter Rice; Fiscal Year: 2001
    ..In addition, these findings will contribute to the development of effective diagnosis and therapies of human trichomoniasis. ..
  7. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2001
    ..The resultant strains will be characterized for: i) the ability to sialylate (endogenously or in the presence of exogenous CMP-NANA), ii) their serum sensitivity in bactericidal assays, and iii) their LOS structure. ..
  8. STRUCTURAL DETERMINATION OF NEISSERIA GONORRHOEAE OLIGOSACCHARIDES FROM ISOLATES
    Peter Rice; Fiscal Year: 2000
    ..In addition, these findings will contribute to the development of effective diagnosis and therapies of human trichomoniasis. ..
  9. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 2000
    ..The resultant strains will be characterized for: i) the ability to sialylate (endogenously or in the presence of exogenous CMP-NANA), ii) their serum sensitivity in bactericidal assays, and iii) their LOS structure. ..
  10. IMMUNOLOGY OF INFECTION WITH NEISSERIA GONORRHOEAE
    Peter Rice; Fiscal Year: 1993
    ....