B Ribalet

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Regulation of cloned ATP-sensitive K channels by phosphorylation, MgADP, and phosphatidylinositol bisphosphate (PIP(2)): a study of channel rundown and reactivation
    B Ribalet
    Department of Physiology, Cardiovascular Research Laboratory, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, USA
    J Gen Physiol 116:391-410. 2000
  2. pmc Regulation of cloned ATP-sensitive K channels by adenine nucleotides and sulfonylureas: interactions between SUR1 and positively charged domains on Kir6.2
    S A John
    UCLA Cardiovascular Research Laboratory, Division of Cardiology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    J Gen Physiol 118:391-405. 2001
  3. pmc Hexokinase-mitochondrial interactions regulate glucose metabolism differentially in adult and neonatal cardiac myocytes
    Guillaume Calmettes
    UCLA Cardiovascular Research Laboratory, 2 Department of Medicine Cardiology, and 3 Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095
    J Gen Physiol 142:425-36. 2013
  4. pmc Subcellular localization of hexokinases I and II directs the metabolic fate of glucose
    Scott John
    UCLA Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e17674. 2011
  5. pmc Molecular basis for Kir6.2 channel inhibition by adenine nucleotides
    Bernard Ribalet
    UCLA Cardiovascular Research Laboratory, Department of Physiology, University of California Los Angeles School of Medicine, 90095, USA
    Biophys J 84:266-76. 2003
  6. pmc ATP-sensitive K+ channels: regulation of bursting by the sulphonylurea receptor, PIP2 and regions of Kir6.2
    Bernard Ribalet
    University of California Los Angeles Cardiovascular Research Laboratory, 90095, USA
    J Physiol 571:303-17. 2006
  7. pmc The sulphonylurea receptor SUR1 regulates ATP-sensitive mouse Kir6.2 K+ channels linked to the green fluorescent protein in human embryonic kidney cells (HEK 293)
    S A John
    UCLA Cardiovascular Research Laboratory, Department of Medicine Cardiology, UCLA School of Medicine 90095, USA
    J Physiol 510:333-45. 1998
  8. pmc Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2
    Scott A John
    UCLA Cardiovascular Research Laboratory, Department of Physiology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Physiol 552:23-34. 2003
  9. pmc Regulation of gating by negative charges in the cytoplasmic pore in the Kir2.1 channel
    Lai Hua Xie
    Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine at UCLA, 675 Young Drive South, MRL 3645, Los Angeles, CA 90095, USA
    J Physiol 561:159-68. 2004
  10. ncbi request reprint Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands
    Lai Hua Xie
    Cardiovascular Research Laboratory, Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Prog Biophys Mol Biol 94:320-35. 2007

Collaborators

Detail Information

Publications16

  1. pmc Regulation of cloned ATP-sensitive K channels by phosphorylation, MgADP, and phosphatidylinositol bisphosphate (PIP(2)): a study of channel rundown and reactivation
    B Ribalet
    Department of Physiology, Cardiovascular Research Laboratory, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, USA
    J Gen Physiol 116:391-410. 2000
    ..2 and/or SUR1 is required for functional coupling. In summary, short-term regulation of Kir6.2+SUR1 channels involves MgADP, while long-term regulation requires PIP(2) and phosphorylation...
  2. pmc Regulation of cloned ATP-sensitive K channels by adenine nucleotides and sulfonylureas: interactions between SUR1 and positively charged domains on Kir6.2
    S A John
    UCLA Cardiovascular Research Laboratory, Division of Cardiology, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    J Gen Physiol 118:391-405. 2001
    ..2 in the absence of ATP. The region delimited by R301 and R314 is not involved in the interaction with NBF1 or NBF2, but confers additional PIP2 sensitivity...
  3. pmc Hexokinase-mitochondrial interactions regulate glucose metabolism differentially in adult and neonatal cardiac myocytes
    Guillaume Calmettes
    UCLA Cardiovascular Research Laboratory, 2 Department of Medicine Cardiology, and 3 Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095
    J Gen Physiol 142:425-36. 2013
    ..In conclusion, differential interactions of HKI and HKII with mitochondria underlie the different metabolic profiles of ARVM and NRVM, accounting for the markedly increased glycolytic activity of NRVM. ..
  4. pmc Subcellular localization of hexokinases I and II directs the metabolic fate of glucose
    Scott John
    UCLA Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e17674. 2011
    ....
  5. pmc Molecular basis for Kir6.2 channel inhibition by adenine nucleotides
    Bernard Ribalet
    UCLA Cardiovascular Research Laboratory, Department of Physiology, University of California Los Angeles School of Medicine, 90095, USA
    Biophys J 84:266-76. 2003
    ..Based on these results a structural scheme is proposed, which includes features of other recently published models...
  6. pmc ATP-sensitive K+ channels: regulation of bursting by the sulphonylurea receptor, PIP2 and regions of Kir6.2
    Bernard Ribalet
    University of California Los Angeles Cardiovascular Research Laboratory, 90095, USA
    J Physiol 571:303-17. 2006
    ..In conjunction with this PIP2-dependent process, SUR1 also regulates channel activity via a PIP2-independent, but MgADP-dependent process...
  7. pmc The sulphonylurea receptor SUR1 regulates ATP-sensitive mouse Kir6.2 K+ channels linked to the green fluorescent protein in human embryonic kidney cells (HEK 293)
    S A John
    UCLA Cardiovascular Research Laboratory, Department of Medicine Cardiology, UCLA School of Medicine 90095, USA
    J Physiol 510:333-45. 1998
    ..In addition, SUR1 promotes uniform insertion of Kir6.2-C-GFP into the plasma membrane and a 35-fold increase in channel activity, suggesting that SUR1 facilitates protein trafficking of Kir6.2 into the plasma membrane...
  8. pmc Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2
    Scott A John
    UCLA Cardiovascular Research Laboratory, Department of Physiology, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Physiol 552:23-34. 2003
    ..Binding of the alpha phosphate group of ATP to R201 then stabilizes the closed state. R50 on the N-terminus controls ATP binding by facilitating the interaction of the beta phosphate group of ATP with K185 to destabilize the open state...
  9. pmc Regulation of gating by negative charges in the cytoplasmic pore in the Kir2.1 channel
    Lai Hua Xie
    Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine at UCLA, 675 Young Drive South, MRL 3645, Los Angeles, CA 90095, USA
    J Physiol 561:159-68. 2004
    ..1 channels. By suppressing fast gating, these negative charges facilitate polyamine block and unblock, which may be their physiologically important role...
  10. ncbi request reprint Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands
    Lai Hua Xie
    Cardiovascular Research Laboratory, Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Prog Biophys Mol Biol 94:320-35. 2007
    ..Recent studies have demonstrated that PIP(2) acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP(2) and co-factors modulate channel activities in each subfamily of the Kir channels...
  11. pmc Phosphatidylinositol-4,5-bisphosphate (PIP2) regulation of strong inward rectifier Kir2.1 channels: multilevel positive cooperativity
    Lai Hua Xie
    Cardiovascular Research Laboratory, Rm 3645 MRL Building, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Physiol 586:1833-48. 2008
    ..Interaction with additional subunits exerts positive cooperativity at multiple levels to further enhance channel availability and promote the fully open state...
  12. pmc ATP sensitivity of ATP-sensitive K+ channels: role of the gamma phosphate group of ATP and the R50 residue of mouse Kir6.2
    Scott A John
    UCLA Cardiovascular Research Laboratory, Department of Medicine Cardiology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Physiol 568:931-40. 2005
    ..Based on these results, we propose that a phosphate group or a negative charge at position 50 initiates channel closure by destabilizing the electrostatic interactions between negative phosphate groups of PIP2 and residues such as R54...
  13. ncbi request reprint Regulation of the ATP-sensitive K channel Kir6.2 by ATP and PIP(2)
    Bernard Ribalet
    UCLA Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Mol Cell Cardiol 39:71-7. 2005
    ..These residues include R54 in the N-terminus and R176, R177 and R206 in the C-terminus. Thus, the binding domains of ATP and PIP(2) in the N- and C-termini do not appear to overlap...
  14. ncbi request reprint Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor
    Scott A John
    UCLA Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pflugers Arch 456:307-22. 2008
    ..Basal glucose level also increased with elevated temperatures. Experiments performed with C2C12 cells demonstrated a shift from fast glucose uptake to slow glucose uptake in the absence of insulin during differentiation...
  15. pmc The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels
    Sonal Srikanth
    Department of Physiology, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 285:5066-75. 2010
    ..These results along with recent reports support a model in which the N terminus and the selectivity filter of Orai1 as well as STIM1 act in concert to regulate the movement of the intracellular loop and evoke fast inactivation...
  16. pmc Long polyamines act as cofactors in PIP2 activation of inward rectifier potassium (Kir2.1) channels
    Lai Hua Xie
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    J Gen Physiol 126:541-9. 2005
    ..Sustained pore block by polyamines was neither sufficient nor necessary for this effect. We conclude that long polyamines serve a dual role as both blockers and coactivators (with PIP2) of Kir2.1 channels...