NICHOLAS R RHIND

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress
    Chaitali Dutta
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 4:e6944. 2009
  2. pmc DNA replication timing
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cold Spring Harb Perspect Biol 5:a010132. 2013
  3. pmc Genome-wide identification and characterization of replication origins by deep sequencing
    Jia Xu
    Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Genome Biol 13:R27. 2012
  4. ncbi DNA Replication Timing
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cold Spring Harb Perspect Med 3:1-26. 2013
  5. pmc Comparative functional genomics of the fission yeasts
    Nicholas Rhind
    Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Science 332:930-6. 2011
  6. pmc Reconciling stochastic origin firing with defined replication timing
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Chromosome Res 18:35-43. 2010
  7. pmc The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint
    Nicholas Willis
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genetics 184:887-97. 2010
  8. pmc Regulation of DNA replication by the S-phase DNA damage checkpoint
    Nicholas Willis
    Biochemistry and Molecular Pharmacology, University on Massachusetts Medical School, Worcester MA 01605, USA
    Cell Div 4:13. 2009
  9. pmc Changing of the guard: how ATM hands off DNA double-strand break signaling to ATR
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mol Cell 33:672-4. 2009
  10. pmc An intrinsic checkpoint model for regulation of replication origins
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell Cycle 7:2619-20. 2008

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress
    Chaitali Dutta
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 4:e6944. 2009
    ..These results demonstrate the general importance of checkpoint regulation of G1/S transcription in response to replicative stress and elucidate the specific roles of Mik1 and Mrc1 in the checkpoint...
  2. pmc DNA replication timing
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cold Spring Harb Perspect Biol 5:a010132. 2013
    ..Whether these patterns have inherent biological functions or simply reflect higher-order genome structure is an open question. ..
  3. pmc Genome-wide identification and characterization of replication origins by deep sequencing
    Jia Xu
    Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Genome Biol 13:R27. 2012
    ..DNA replication initiates at distinct origins in eukaryotic genomes, but the genomic features that define these sites are not well understood...
  4. ncbi DNA Replication Timing
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cold Spring Harb Perspect Med 3:1-26. 2013
    ..Whether these patterns have inherent biological functions or simply reflect higher-order genome structure is an open question...
  5. pmc Comparative functional genomics of the fission yeasts
    Nicholas Rhind
    Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Science 332:930-6. 2011
    ..These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade...
  6. pmc Reconciling stochastic origin firing with defined replication timing
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Chromosome Res 18:35-43. 2010
    ..In addition, we propose biochemically plausible mechanisms for these criteria and point out how stochastic and defined origin firing can be experimentally distinguished in population experiments...
  7. pmc The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint
    Nicholas Willis
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genetics 184:887-97. 2010
    ..Genetic interactions between MRN and Rhp51, the fission yeast Rad51 homolog, lead us to suggest that MRN participates in checkpoint-dependent replication slowing through negative regulation of recombination...
  8. pmc Regulation of DNA replication by the S-phase DNA damage checkpoint
    Nicholas Willis
    Biochemistry and Molecular Pharmacology, University on Massachusetts Medical School, Worcester MA 01605, USA
    Cell Div 4:13. 2009
    ....
  9. pmc Changing of the guard: how ATM hands off DNA double-strand break signaling to ATR
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mol Cell 33:672-4. 2009
    ....
  10. pmc An intrinsic checkpoint model for regulation of replication origins
    Nicholas Rhind
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell Cycle 7:2619-20. 2008
    ..This coupling fails in a checkpoint mutant background because stalled forks disassemble and release replisome factors prematurely, allowing for unregulated origin firing...
  11. pmc DNA replication timing: random thoughts about origin firing
    Nicholas Rhind
    Biochemistry and Molecular Pharmacology Department, University of Massachusetts Medical School, 364 Plantation Street, LRB904, Worcester, MA 01605, USA
    Nat Cell Biol 8:1313-6. 2006
    ..This model assumes varying origin efficiency instead of a strict origin-timing programme. Here, we discuss the evidence for both models...
  12. pmc The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling
    Mary E Porter-Goff
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 20:2096-107. 2009
    ..This observation leads us to conclude that other functions of MRN, possibly its role in replication fork metabolism, are required for S-phase DNA damage checkpoint function...
  13. pmc Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint
    Nicholas Willis
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 20:819-33. 2009
    ..We propose that restraining recombination is required for the slowing of replication in response to DNA damage...
  14. pmc DNA replication origins fire stochastically in fission yeast
    Prasanta K Patel
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 17:308-16. 2006
    ..Thus, the fission yeast strategy for the initiation of replication is different from models of eukaryotic replication that propose coordinated origin firing...
  15. pmc The Hsk1(Cdc7) replication kinase regulates origin efficiency
    Prasanta K Patel
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 19:5550-8. 2008
    ..By manipulating Hsk1-Dfp1 levels, we show that increasing or decreasing origin firing rates leads to an increase in genomic instability, demonstrating the biological importance of appropriate origin efficiency...
  16. pmc The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription
    Chaitali Dutta
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell Biol 28:5977-85. 2008
    ..Furthermore, the structural and regulatory similarity between MBF and E2F, the metazoan G(1)/S transcription factor, suggests that this checkpoint mechanism may be broadly conserved among eukaryotes...
  17. pmc Cdc2 tyrosine phosphorylation is not required for the S-phase DNA damage checkpoint in fission yeast
    Naveen Kommajosyula
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01609, USA
    Cell Cycle 5:2495-500. 2006
    ..Our results are consistent with a strictly Cdc2-Y15 phosphorylation-independent mechanism of the fission yeast S-phase DNA damage checkpoint...
  18. pmc Incorporation of thymidine analogs for studying replication kinetics in fission yeast
    Nicholas Rhind
    Biochemistry and Molecular Pharmacology Department, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 521:509-15. 2009
    ..This chapter describes the labeling of fission yeast, Schizosaccharomyces pombe, with the thymidine analog BrdU in order to identify sites and determine kinetics of DNA replication...
  19. pmc A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe
    Alla Sigova
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 18:2359-67. 2004
    ..Our findings suggest that these three proteins fulfill a common biochemical function in distinct siRNA-directed silencing pathways...
  20. ncbi In vivo labeling of fission yeast DNA with thymidine and thymidine analogs
    Sasirekha Sivakumar
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Methods 33:213-9. 2004
    ....

Research Grants7

  1. The Role of MRN in the S-Phase DNA Damage Checkpoint
    Nicholas Rhind; Fiscal Year: 2004
    ..This understanding will lead to new therapeutic targets and diagnostic tools for the treatment and prevention of human cancer. ..
  2. The Role of MRN in the S-Phase DNA Damage Checkpoint
    Nicholas Rhind; Fiscal Year: 2005
    ..This understanding will lead to new therapeutic targets and diagnostic tools for the treatment and prevention of human cancer. ..
  3. The Role of MRN in the S-Phase DNA Damage Checkpoint
    Nicholas Rhind; Fiscal Year: 2006
    ..This understanding will lead to new therapeutic targets and diagnostic tools for the treatment and prevention of human cancer. ..
  4. The Role of MRN in the S-Phase DNA Damage Checkpoint
    Nicholas Rhind; Fiscal Year: 2007
    ..This understanding will lead to new therapeutic targets and diagnostic tools for the treatment and prevention of human cancer. ..
  5. The Role of MRN in the S-Phase DNA Damage Checkpoint
    Nicholas Rhind; Fiscal Year: 2009
    ..This understanding will lead to new therapeutic targets and diagnostic tools for the treatment and prevention of human cancer. ..
  6. Mechanism of the S-Phase DNA Damage Checkpoint
    NICHOLAS R RHIND; Fiscal Year: 2010
    ..The proposed research will elucidate the function of this checkpoint, allowing for the identification of new therapeutic targets and diagnostic tools for the treatment and prevention of human cancer. ..