L L Reznikov

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta
    L L Reznikov
    Division of Infectious Diseases, University of Colorado Health SciencesCenter, Denver 80262, USA
    Biol Reprod 60:1231-8. 1999
  2. ncbi request reprint Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells
    L L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Nephrol 61:324-36. 2004
  3. ncbi request reprint The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma
    Leonid L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Interferon Cytokine Res 22:593-601. 2002
  4. ncbi request reprint Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice
    L L Reznikov
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 278:R263-70. 2000
  5. pmc Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein
    S H Kim
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:3304-9. 2001
  6. pmc IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma
    L L Reznikov
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:2174-9. 2000
  7. ncbi request reprint Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain
    S H Kim
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 166:148-54. 2001
  8. ncbi request reprint Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation
    C H Selzman
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circ Res 84:867-75. 1999
  9. ncbi request reprint Suppression of tumor necrosis factor alpha production by cAMP in human monocytes: dissociation with mRNA level and independent of interleukin-10
    B D Shames
    Department of Surgery, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Surg Res 99:187-93. 2001
  10. pmc Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta
    B J Pomerantz
    Department of Surgery, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:2871-6. 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta
    L L Reznikov
    Division of Infectious Diseases, University of Colorado Health SciencesCenter, Denver 80262, USA
    Biol Reprod 60:1231-8. 1999
    ..This model using direct intracervical bacterial or LPS inoculation is useful for studying preterm pregnancy loss in genetically altered mice in order to develop novel interventions for infection-associated preterm labor...
  2. ncbi request reprint Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells
    L L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Nephrol 61:324-36. 2004
    ..In patients receiving hemodialysis, AGE are thought to contribute to the inflammatory components of the therapy, particularly in diabetic patients...
  3. ncbi request reprint The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma
    Leonid L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Interferon Cytokine Res 22:593-601. 2002
    ..These studies reveal that the combination of the ligand-binding and the nonligand-binding extracellular domains of IL-18R is needed to inhibit IL-18, whereas IL-18BP neutralizes at equimolar concentration...
  4. ncbi request reprint Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice
    L L Reznikov
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 278:R263-70. 2000
    ..This suppression was 25% greater in IL-1beta(-/-) than in IL-1beta(+/+) mice. These data suggest that constitutive NF-kappaB p65 protein synthesis is regulated by IL-1beta, particularly during pregnancy...
  5. pmc Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein
    S H Kim
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:3304-9. 2001
    ..The identification of E42 and K89 in the mature IL-18 peptide is consistent with previous modeling studies of IL-18 binding to IL-18BP and explains the unusually high affinity of IL-18BP for IL-18...
  6. pmc IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma
    L L Reznikov
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:2174-9. 2000
    ..These studies demonstrate that IL-18BP decreases endogenous IL-18 activity by reducing IFN-gamma-mediated responses...
  7. ncbi request reprint Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain
    S H Kim
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 166:148-54. 2001
    ..The synergism of IL-18 plus IL-12 for IFN-gamma production is, in part, due to IL-12 up-regulation of both IL-18R alpha and IL-18R beta chains, although postreceptor events likely contribute to IFN-gamma production...
  8. ncbi request reprint Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation
    C H Selzman
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circ Res 84:867-75. 1999
    ..Furthermore, liposomal delivery of endogenous inhibitory proteins may represent a novel, therapeutically accessible method for selective transcriptional suppression in the response to vascular injury...
  9. ncbi request reprint Suppression of tumor necrosis factor alpha production by cAMP in human monocytes: dissociation with mRNA level and independent of interleukin-10
    B D Shames
    Department of Surgery, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Surg Res 99:187-93. 2001
    ..CONCLUSION: The results indicate that cAMP inhibits LPS-stimulated TNF-alpha production through a posttranscriptional mechanism that is independent of endogenous IL-10...
  10. pmc Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta
    B J Pomerantz
    Department of Surgery, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:2871-6. 2001
    ....
  11. ncbi request reprint TNF receptor I is required for induction of macrophage heat shock protein 70
    J K Heimbach
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
    Am J Physiol Cell Physiol 281:C241-7. 2001
    ..These studies demonstrate that TNFR-I is required for the synthesis of HSP70 in stressed Mphi by a TNF-independent mechanism and support an intracellular role for TNFR-I...
  12. pmc Differences in signaling pathways by IL-1beta and IL-18
    Jae Kwon Lee
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:8815-20. 2004
    ..We conclude that in epithelial cells, IL-18 signal transduction is primarily via the MAPK p38 pathway rather than NF-kappaB, which may explain the absence of COX-2 and the failure of IL-18 to cause fever...
  13. ncbi request reprint Identification of amino acid residues critical for biological activity in human interleukin-18
    Soo Hyun Kim
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:10998-1003. 2002
    ..The present study reveals that Glu-42 and Lys-89 are critical amino acid residues for the integrity of IL-18 structure and are important for binding to cell surface receptors, for signal transduction, and for neutralization by IL-18BP...
  14. pmc A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
    Philip Bufler
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:13723-8. 2002
    ..We propose that after binding to IL-18BP, IL-1F7b forms a complex with IL-18Rbeta, depriving the beta-chain of forming a functional receptor complex with IL-18Ralpha and thus inhibiting IL-18 activity...
  15. ncbi request reprint Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
    Rogier J L Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Cytokine 21:65-73. 2003
    ..In conclusion, S. epidermidis stimulates IFN-gamma which is IL-18, IL-12 and TNF-dependent, but IL-1 independent...
  16. ncbi request reprint Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice
    Wei Wang
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 288:F997-1004. 2005
    ..Neutralization of IL-1beta and IL-18 is not functionally protective. The role of the intracellular proinflammatory cytokine IL-1alpha in endotoxemic ARF merits further study...
  17. pmc Eukaryotic translation initiation factor 5A small interference RNA-liposome complexes reduce inflammation and increase survival in murine models of severe sepsis and acute lung injury
    CHRISTOPHER C MOORE
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Infect Dis 198:1407-14. 2008
    ..Eukaryotic translation initiation factor 5A (eIF5A) is a regulator of apoptosis as well as inflammatory cell activation, making it a potential target for sepsis therapy...
  18. pmc The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
    Flavio Leoni
    Italfarmaco, SPA, 20092 Cinisello Balsamo, Italy
    Proc Natl Acad Sci U S A 99:2995-3000. 2002
    ..Because SAHA exhibits antiinflammatory properties in vivo and in vitro, inhibitors of histone deacetylase may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets...
  19. ncbi request reprint Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling
    Jason H Clarke
    Department of Surgery, University of Colorado Health Sciences Center, Denver, CO, USA
    J Am Coll Surg 201:418-25. 2005
    ..Stimulation of Toll-like receptor 4 (TLR-4) activates macrophages and results in the release of TNF-alpha. We hypothesized that melanoma inhibits macrophage activation by suppressing TLR-4 signaling...
  20. ncbi request reprint Lack of TNF-alpha attenuates intimal hyperplasia after mouse carotid artery injury
    Michael A Zimmerman
    Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Physiol Regul Integr Comp Physiol 283:R505-12. 2002
    ..Finally, TNF(-/-) animals demonstrated a sevenfold reduction in IH compared with WT animals. Cumulatively, these data mechanistically link TNF-alpha and NF-kappaB in vivo and suggest an important influence of TNF-alpha on postinjury IH...
  21. ncbi request reprint Relative contribution of the TNF-alpha receptors to murine intimal hyperplasia
    Michael A Zimmerman
    Divisions of Cardiothoracic Surgery and Infectious Disease, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1213-8. 2003
    ..Suppression of the transcriptional activator nuclear factor-kappaB may provide a mechanism by which p55-mediated IH is attenuated...
  22. pmc Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect
    Pavan Reddy
    Department of Internal Medicine, University of Michigan Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0942, USA
    Proc Natl Acad Sci U S A 101:3921-6. 2004
    ....
  23. ncbi request reprint Interleukin-11 attenuates human vascular smooth muscle cell proliferation
    Michael A Zimmerman
    Division of Cardiothoracic Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Heart Circ Physiol 283:H175-80. 2002
    ..Stimulated VSMC did not secrete IL-11, suggesting that endogenous IL-11 did not account for our observations. In conclusion, IL-11 inhibits human VSMC proliferation in vitro and is associated with suppression of NF-kappa B...
  24. ncbi request reprint Interleukin-10 attenuates the response to vascular injury
    Michael A Zimmerman
    Department of Surgery, University of Colorado Health, Sciences Center, Denver, Colorado, USA
    J Surg Res 121:206-13. 2004
    ..Few studies have evaluated the effects of IL-10 in experimental atherosclerosis. The purpose of the present study was to determine the influence of IL-10 on vascular inflammation and IH following mechanical injury...
  25. ncbi request reprint Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardium
    Brian D Shames
    Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA
    Shock 17:114-9. 2002
    ..The results suggest that therapeutic strategies attempting to decrease myocardial TNF-alpha production need to be applied before or in the early phase of ischemia...