Matthew R Reynolds

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Macaques vaccinated with live-attenuated SIV control replication of heterologous virus
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53715, USA
    J Exp Med 205:2537-50. 2008
  2. pmc A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, 555 Science Drive, Madison, WI 53711, USA
    Vaccine 30:4465-75. 2012
  3. pmc The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, 555 Science Dr, Madison, WI 53711, USA
    J Virol 85:9637-40. 2011
  4. pmc Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, 555 Science Dr, Madison, WI 53711, USA
    J Virol 84:9190-9. 2010
  5. pmc GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo
    Lara Vojnov
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e23515. 2011
  6. pmc Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge
    Nancy A Wilson
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    J Virol 83:6508-21. 2009
  7. pmc High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239
    Thomas C Friedrich
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 537061, USA
    J Virol 84:5443-7. 2010
  8. pmc Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein
    Jonah B Sacha
    Wisconsin National Primate Research Center WNPRC, Madison, WI 53711, USA
    J Virol 82:9293-8. 2008
  9. doi request reprint Ex vivo analysis of SIV-infected cells by flow cytometry
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    Cytometry A 77:1059-66. 2010
  10. pmc Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239
    Nancy A Wilson
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
    J Virol 80:5875-85. 2006

Collaborators

Detail Information

Publications15

  1. pmc Macaques vaccinated with live-attenuated SIV control replication of heterologous virus
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53715, USA
    J Exp Med 205:2537-50. 2008
    ....
  2. pmc A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, 555 Science Drive, Madison, WI 53711, USA
    Vaccine 30:4465-75. 2012
    ..Our results are consistent with those observed in the Step trial and indicate that SIV immunization and challenge studies in macaque models of HIV infection can be informative in assessing pre-clinical HIV vaccines...
  3. pmc The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, 555 Science Dr, Madison, WI 53711, USA
    J Virol 85:9637-40. 2011
    ..Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses...
  4. pmc Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, 555 Science Dr, Madison, WI 53711, USA
    J Virol 84:9190-9. 2010
    ..Overall, our results suggest that a well-designed HIV vaccine might both reduce the rate of acquisition and control viral replication...
  5. pmc GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo
    Lara Vojnov
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e23515. 2011
    ..It is possible that these seven animals failed to control viral replication because of the narrow TCR repertoire expressed by the GagCM9-specific CD8(+) T cell population elicited by vaccination and infection...
  6. pmc Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge
    Nancy A Wilson
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    J Virol 83:6508-21. 2009
    ....
  7. pmc High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239
    Thomas C Friedrich
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 537061, USA
    J Virol 84:5443-7. 2010
    ..Our results suggest that a high level of MHC-I downregulation is a hallmark of fast disease progression in SIV infection...
  8. pmc Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein
    Jonah B Sacha
    Wisconsin National Primate Research Center WNPRC, Madison, WI 53711, USA
    J Virol 82:9293-8. 2008
    ..These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein...
  9. doi request reprint Ex vivo analysis of SIV-infected cells by flow cytometry
    Matthew R Reynolds
    AIDS Vaccine Research Laboratory, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    Cytometry A 77:1059-66. 2010
    ..This novel protocol provides a direct analytical tool to assess interactions between SIV and host cells, which is of key importance to investigators in AIDS research...
  10. pmc Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239
    Nancy A Wilson
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
    J Virol 80:5875-85. 2006
    ....
  11. pmc Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hosts
    Thomas C Friedrich
    Wisconsin National Primate Research Center, 1220 Capitol Court, Madison, WI 53715, USA
    J Virol 78:10064-73. 2004
    ..Moreover, since the mutant epitope sequences did not revert to wild type during the study period, it is possible that low-frequency CTL exerted enough selective pressure to preserve epitope mutations in viruses replicating in vivo...
  12. pmc Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239
    Thorsten U Vogel
    Wisconsin Primate Research Center Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 77:13348-60. 2003
    ....
  13. pmc Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239
    Andrea M Weiler
    AIDS Vaccine Laboratory, WNPRC, 555 Science Dr, Madison, WI 53711, USA
    J Virol 82:4154-8. 2008
    ....
  14. pmc Simian immunodeficiency virus SIVmac239Deltanef vaccination elicits different Tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/adenovirus type 5 boost regimen in rhesus macaques
    Benjamin J Burwitz
    Department of Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Virol 85:3683-9. 2011
    ....
  15. pmc Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?
    Thorsten U Vogel
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:11623-36. 2002
    ..Differential selection by CTL may therefore be a paradigm of immunodeficiency virus infection...