Research Topics
Species | Matthew R ReynoldsSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Macaques vaccinated with live-attenuated SIV control replication of heterologous virusMatthew R Reynolds
AIDS Vaccine Research Laboratory, Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53715, USA
J Exp Med 205:2537-50. 2008....- A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challengeMatthew R Reynolds
AIDS Vaccine Research Laboratory, 555 Science Drive, Madison, WI 53711, USA
Vaccine 30:4465-75. 2012..Our results are consistent with those observed in the Step trial and indicate that SIV immunization and challenge studies in macaque models of HIV infection can be informative in assessing pre-clinical HIV vaccines... - The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challengeMatthew R Reynolds
AIDS Vaccine Research Laboratory, 555 Science Dr, Madison, WI 53711, USA
J Virol 85:9637-40. 2011..Our results indicate that the TRIM5 alleles can be a barrier to productive infection and that this should be taken into account when designing acquisition studies using SIVsmE660 or related viruses... - Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challengeMatthew R Reynolds
AIDS Vaccine Research Laboratory, 555 Science Dr, Madison, WI 53711, USA
J Virol 84:9190-9. 2010..Overall, our results suggest that a well-designed HIV vaccine might both reduce the rate of acquisition and control viral replication... - GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivoLara Vojnov
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
PLoS ONE 6:e23515. 2011..It is possible that these seven animals failed to control viral replication because of the narrow TCR repertoire expressed by the GagCM9-specific CD8(+) T cell population elicited by vaccination and infection... - Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challengeNancy A Wilson
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
J Virol 83:6508-21. 2009.... - High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239Thomas C Friedrich
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 537061, USA
J Virol 84:5443-7. 2010..Our results suggest that a high level of MHC-I downregulation is a hallmark of fast disease progression in SIV infection... - Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral proteinJonah B Sacha
Wisconsin National Primate Research Center WNPRC, Madison, WI 53711, USA
J Virol 82:9293-8. 2008..These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein... 
Ex vivo analysis of SIV-infected cells by flow cytometryMatthew R Reynolds
AIDS Vaccine Research Laboratory, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
Cytometry A 77:1059-66. 2010..This novel protocol provides a direct analytical tool to assess interactions between SIV and host cells, which is of key importance to investigators in AIDS research...- Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hostsThomas C Friedrich
Wisconsin National Primate Research Center, 1220 Capitol Court, Madison, WI 53715, USA
J Virol 78:10064-73. 2004..Moreover, since the mutant epitope sequences did not revert to wild type during the study period, it is possible that low-frequency CTL exerted enough selective pressure to preserve epitope mutations in viruses replicating in vivo... - Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239Nancy A Wilson
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
J Virol 80:5875-85. 2006.... - Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239Thorsten U Vogel
Wisconsin Primate Research Center. Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53715, USA
J Virol 77:13348-60. 2003.... - Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239Andrea M Weiler
AIDS Vaccine Laboratory, WNPRC, 555 Science Dr, Madison, WI 53711, USA
J Virol 82:4154-8. 2008.... - Simian immunodeficiency virus SIVmac239Deltanef vaccination elicits different Tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/adenovirus type 5 boost regimen in rhesus macaquesBenjamin J Burwitz
Department of Pathology, University of Wisconsin Madison, Madison, WI 53706, USA
J Virol 85:3683-9. 2011.... - Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?Thorsten U Vogel
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
J Virol 76:11623-36. 2002..Differential selection by CTL may therefore be a paradigm of immunodeficiency virus infection...