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Species | Charles ReynoldsSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Early intervention to reduce the global health and economic burden of major depression in older adultsCharles F Reynolds
School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Annu Rev Public Health 33:123-35. 2012..We suggest in this review that the time is right for research into the translation of depression-prevention strategies for use in LMICs...- Organizational factors and depression management in community-based primary care settingsEdward P Post
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Implement Sci 4:84. 2009..In addition, survey information can inform efforts of individual primary care practices in customizing intervention strategies to improve depression management... 
Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivationCharles F Reynolds
Intervention Research Center for Late Life Mood Disorders IRC LLMD, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, E 113521, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 13:353-8. 2005..Authors tested the hypothesis that one night of total sleep deprivation (TSD) would accelerate antidepressant response to paroxetine, as compared with TSD+placebo (PBO) and paroxetine-alone, in late-life major depression...
Commentary: Out of the silence: confronting depression in medical students and residentsCharles F Reynolds
Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Acad Med 84:159-60. 2009..The authors outline the chronic nature of depression and discuss its possibility for long-term impacts on trainees. Given these conditions, the leadership of the nation's schools of medicine and AHCs...- Maintenance treatment of major depression in old ageCharles F Reynolds
Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
N Engl J Med 354:1130-8. 2006..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death... - Protecting sleep, promoting health in later life: a randomized clinical trialCharles F Reynolds
Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Psychosom Med 72:178-86. 2010..5 years; and 2) if maintenance or enhancement of sleep continuity and depth promotes the maintenance or enhancement of health-related quality of life... - Paroxetine treatment of primary insomnia in older adultsCharles F Reynolds
Advanced Center for Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:803-7. 2006..The goal of this study was to test the efficacy of paroxetine for primary insomnia in older adults... - Preventing depression in medical illness: a new lead?Charles F Reynolds
Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 64:884-5. 2007 - Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapyCharles F Reynolds
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 68:51-60. 2011..Cognitive impairment in late-life depression is a core feature of the illness... - The future of psychiatry as clinical neuroscienceCharles F Reynolds
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Acad Med 84:446-50. 2009.... - Persistence of neuropsychologic deficits in the remitted state of late-life depressionRishi K Bhalla
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 14:419-27. 2006..In addition, a substantial proportion of older depressed individuals who are cognitively intact when depressed are likely to be impaired one year later, although their depression has remitted... - Residual symptoms and recurrence during maintenance treatment of late-life depressionAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
J Affect Disord 103:77-82. 2007..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression... - Cognitive performance in suicidal depressed elderly: preliminary reportAlexandre Y Dombrovski
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:109-15. 2008..This study examined cognitive function in general and executive functioning specifically in depressed elderly with and without suicidal ideation and attempts... - Risk factors for falls during treatment of late-life depressionJin H Joo
Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Clin Psychiatry 63:936-41. 2002..Additionally, augmenting paroxetine with bupropion may also increase the risk of falls, and this medication combination should be used with caution in elderly patients... - Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trialMartha L Bruce
Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
JAMA 291:1081-91. 2004..The intervention's effectiveness in reducing suicidal ideation, regardless of depression severity, reinforces its role as a prevention strategy to reduce risk factors for suicide in late life... - Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT studyGeorge S Alexopoulos
Department of Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Rd, White Plains, NY 10605, USA
Am J Psychiatry 166:882-90. 2009..This is the first report of outcomes over a 2-year period... - Cardiovascular changes associated with venlafaxine in the treatment of late-life depressionEllyn M Johnson
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:796-802. 2006..Systematic monitoring of cardiovascular parameters during treatment with venlafaxine-XR should be strongly recommended, especially in the elderly... - Impact of prior treatment exposure on response to antidepressant treatment in late lifeJames D Tew
Advanced Center for Interventions and Services Research in Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:957-65. 2006..Most TR and TI patients eventually respond, but TR patients may require more intensive and longer courses of treatment than TI and TN patients... - Effect of depression treatment on chronic pain outcomesCARRIE FARMER TEH
RAND Corporation, Pittsburgh, PA 15213, USA
Psychosom Med 72:61-7. 2010..People with chronic pain and depression have worse health outcomes than those with chronic pain alone. Little is known about the effectiveness of depression treatment for this population... - Marital quality in the context of mild cognitive impairmentLinda Garand
University of Pittsburgh, Pittsburgh, PA, USA
West J Nurs Res 29:976-92. 2007..Results of this study suggest the need for mental health interventions designed to preserve the quality of these marital relationships... - Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatmentStephen Blank
Intervention Research Center for Late-Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 67:468-72. 2006..CONCLUSIONS: In this 32-week study of citalopram for elderly persons with anxiety disorders, 60% responded. Those who received a full course of treatment experience significant improvements in quality of life and sleep quality... - Patterns of mild cognitive impairment after treatment of depression in the elderlyRishi K Bhalla
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 17:308-16. 2009.... - Anxiety impairs depression remission in partial responders during extended treatment in late-lifeAdam Greenlee
Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Depress Anxiety 27:451-6. 2010..This study characterizes the effect of anxiety on remission during extended treatment for partial responders... - Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old ageAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:550-4. 2006..CONCLUSIONS: Anxiety symptoms tend to persist in patients with late-life depression... - Cognitive impairment in late-life generalized anxiety disorderRose C Mantella
Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 15:673-9. 2007..This study sought to characterize cognitive functioning in elderly patients with generalized anxiety disorder (GAD), as compared with normal comparison subjects and patients with major depression... - Impact of close family members on older adults' early response to depression treatmentLynn M Martire
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Psychol Aging 23:447-52. 2008..Future research may identify family attitudes and behaviors that stem from burden and compromise older adults' ability to recover from depression... - The Mood Disorder Burden Index: a scale for assessing the burden of caregivers to adults with unipolar or bipolar disorderLynn M Martire
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States University Center for Social and Urban Research, Pittsburgh, PA, United States
Psychiatry Res 168:67-77. 2009..It will be important for future research to administer the MDBI to caregivers of middle-aged and older patients as well as those receiving treatment through inpatient settings or community outpatient clinics... - The nature and determinants of neuropsychological functioning in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Arch Gen Psychiatry 61:587-95. 2004..Further studies of neuropsychological functioning in remitted LLD patients are needed to parse episode-related and persistent factors and to relate them to underlying neural dysfunction... - The prevalence of mental and physical health disorders among older methadone patientsDaniel Rosen
University of Pittsburgh School of Social Work, Pittsburgh, PA 15260, USA
Am J Geriatr Psychiatry 16:488-97. 2008..The goal of this study was to assess the physical and mental health status of older methadone patients... - Remission in depressed geriatric primary care patients: a report from the PROSPECT studyGeorge S Alexopoulos
Department of Psychiatry, Weill Medical College of Cornell University, New York, USA
Am J Psychiatry 162:718-24. 2005..In addition, it sought to identify risk factors for nonremission that could guide treatment planning and referral to care managers or specialists... - Late-onset major depression: clinical and treatment-response variabilityHenry C Driscoll
Intervention Research Center for Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 20:661-7. 2005..Further study of biological, neuropsychologic, and psychosocial correlates of late-onset, recurrent depression is needed... - Medical burden in late-life bipolar and major depressive disordersAriel G Gildengers
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:194-200. 2008..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder... - The relationship of medical comorbidity and depression in older, primary care patientsJeffrey M Lyness
Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
Psychosomatics 47:435-9. 2006..This generates the hypothesis that, in general primary care populations, the relationship of medical illness to depression may be multimodal and/or may involve shared pathobiological or psychosocial mechanisms... - Occurrence and course of suicidality during short-term treatment of late-life depressionKatalin Szanto
Department of Psychiatry, The Intervention Research Center for the Study of Late-Life Mood Disorders, Pittsburgh, PA, USA
Arch Gen Psychiatry 60:610-7. 2003..Suicidal elderly persons with depression require special attention during depression treatment because they have a lower response rate and need a longer time to respond... - An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patientsEllen M Whyte
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
Cerebrovasc Dis 26:317-21. 2008..We investigated the feasibility of using acetylcholinesterase inhibitors in older patients with acute post-stroke cognitive impairment and examined their effects on functional recovery... - Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and olderHenry C Driscoll
Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 16:74-82. 2008.... - Alone? Perceived social support and chronic interpersonal difficulties in suicidal eldersKatrin E Harrison
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, USA
Int Psychogeriatr 22:445-54. 2010..Thus, we investigated the role of chronic interpersonal difficulties and perceived social support in depressed elders with and without suicidal thoughts and attempts... - Paroxetine: population pharmacokinetic analysis in late-life depression using sparse concentration samplingYan Feng
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA, and Rotman Research Institute, Baycrest Hospital, University of Toronto, Canada
Br J Clin Pharmacol 61:558-69. 2006..The data indicate that female and male subjects with different CYP2D6 polymorphisms have different elimination rates and therefore may need to be dosed differently based on metabolizer genotype... - Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairmentLinda Garand
The University of Pittsburgh School of Nursing, Health and Community Systems Department, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 20:512-22. 2005..We characterized the nature and level of caregiver burden and psychiatric morbidity in spouses of persons diagnosed with MCI... - Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remissionMeera Sheffrin
Advanced Center in Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 70:208-13. 2009.... - Course and rate of antidepressant response in the very oldAriel G Gildengers
The Intervention Research Centers for Late-Life and Mid-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Affect Disord 69:177-84. 2002..RESULTS: Older-old patients responded as quickly and successfully as the young- and middle-old. CONCLUSIONS: Major depression in the very old can be treated as successfully as in early old age... - Clinically relevant behaviors in elderly hip fracture inpatientsHelen H Dorra
University of Pittsburgh School of Medicine, USA
Int J Psychiatry Med 32:249-59. 2002..It is recommended that staff observations be routinely added to mental health evaluations. Additionally, routine mental health screening and required staff documentation of behaviors would improve case detection rate... - Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorderRamin Saghafi
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
Int J Geriatr Psychiatry 22:1141-6. 2007..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life... - Disability in late-life major depression: patterns of self-reported task abilities, task habits, and observed task performanceJoan C Rogers
Department of Occupational Therapy, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, USA
Psychiatry Res 178:475-9. 2010..The findings led us to conclude that when performance testing is not feasible, self-reports of functional status that focus on habits may be more accurate than those that focus on abilities... - A controlled evaluation of monthly maintenance interpersonal psychotherapy in late-life depression with varying levels of cognitive functionKristen Carreira
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 23:1110-3. 2008..To evaluate the effect of maintenance Interpersonal Psychotherapy (IPT) on recurrence rates and time to recurrence of major depression in elderly patients with varying levels of cognitive function... - Statistical analysis of longitudinal psychiatric data with dropoutsSati Mazumdar
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
J Psychiatr Res 41:1032-41. 2007.... - Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapyAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 55:1325-32. 2007..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression... - Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustmentEric J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Psychiatry 159:466-8. 2002..CONCLUSIONS: Treatment of late-life depression with nortriptyline and psychotherapy is more likely to maintain social adjustment than treatment with either alone. Combination therapy improves not only duration but quality of wellness... - Effects of a brief behavioral treatment for late-life insomnia: preliminary findingsAnne Germain
Department Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Sleep Med 2:403-6. 2006..CONCLUSION: BBTI was associated with significant improvements in sleep measures and in daytime symptoms of anxiety and depression. BBTI appears to be a promising intervention for older adults with insomnia... - Outcomes of minor and subsyndromal depression among elderly patients in primary care settingsJeffrey M Lyness
Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
Ann Intern Med 144:496-504. 2006..Although depressive conditions in later life are a major public health problem, the outcomes of minor and subsyndromal depression are largely unknown... - Response speed and rate of remission in primary and specialty care of elderly patients with depressionLeslie Thomas
Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 10:583-91. 2002..CONCLUSION: Notwithstanding these differences in speed and rate of symptom resolution, good treatment can work well in geriatric depression in the primary care sector... - Venlafaxine ER as a treatment for generalized anxiety disorder in older adults: pooled analysis of five randomized placebo-controlled clinical trialsIra R Katz
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Am Geriatr Soc 50:18-25. 2002..CONCLUSION: Venlafaxine ER is equally safe and well tolerated by and shows similar efficacy in younger and older patients in the treatment of GAD... - CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderlyEllen M Whyte
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
Int J Geriatr Psychiatry 21:542-9. 2006.... - Does education moderate neuropsychological impairment in late-life depression?Rishi K Bhalla
Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Int J Geriatr Psychiatry 20:413-7. 2005..This study examined whether educational level influences the degree of neuropsychological impairment associated with late-life depression... - Preventing depression in later life: translation from concept to experimental design and implementationRoy Sriwattanakomen
Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:460-8. 2008..Special attention is given to the recruitment of African Americans because of well-documented inequalities in mental health services and depression treatment outcomes between races... - Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness durationSandra Bell-McGinty
Neuropsychology Research Program, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
Am J Psychiatry 159:1424-7. 2002..CONCLUSIONS: These data provide further evidence of structural brain abnormalities in geriatric depression, particularly in patients with a longer course of illness... - Public-academic partnerships: improving depression care for disadvantaged adults by partnering with non-mental health agenciesDeborah Dobransky-Fasiska
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Psychiatr Serv 61:110-2. 2010.... - Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomenaHoward J Aizenstein
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:30-42. 2009..To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults... - Comparisons of methods for multiple hypothesis testing in neuropsychological researchRichard E Blakesley
Department of Biostatistics, University of Pittsburgh, PA, USA
Neuropsychology 23:255-64. 2009..The authors note caveats regarding the implementation of these methods using available software... - Comorbid anxiety disorder in late life depression: association with memory decline over four yearsAlison K DeLuca
The Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 20:848-54. 2005..The data also suggest that anxiety disorders with an onset later in life may be associated with cognitive impairment, although further study is needed to confirm this finding... - Cognitive functioning and instrumental activities of daily living in late-life bipolar disorderAriel G Gildengers
Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 15:174-9. 2007..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder... - Apathy after hip fracture: a potential target for intervention to improve functional outcomesEric J Lenze
Department of Psychiatry, Washington University School of Medicine, USA
J Neuropsychiatry Clin Neurosci 21:271-8. 2009..Interventions to prevent or improve apathy in elderly persons deserve further attention... - Predictors of adequacy of depression management in the primary care settingJin H Joo
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Psychiatr Serv 56:1524-8. 2005..These findings have implications for ways that primary care physicians could be trained to more adequately manage the spectrum of severity of depression... - What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?Benoit H Mulsant
Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychopharmacol 26:113-20. 2006..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement... - Somatic symptoms of depression in elderly patients with medical comorbiditiesRebecca A Drayer
Center for Research on Health Care, Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 20:973-82. 2005..Rating scales emphasizing somatic symptoms associated with depression may provide a more accurate measure of depression severity than those excluding such symptoms... - Racial preferences for participation in a depression prevention trial involving problem-solving therapyJohn Kasckow
Department of Behavioral Health, U S Department of Veterans Affairs Pittsburgh Health Care System, 7180 Highland Dr, Pittsburgh, PA 15206, USA
Psychiatr Serv 61:722-4. 2010..It also examined participants' problem-solving skills. Hypotheses stated that there would be no racial differences in consent rates and that social problem-solving coping skills would be lower among African Americans than Caucasians... - Placebo-controlled study of relapse prevention with risperidone augmentation in older patients with resistant depressionGeorge S Alexopoulos
Department of Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY, USA
Am J Geriatr Psychiatry 16:21-30. 2008..The effect of risperidone augmentation of citalopram for relapse prevention in older patients with antidepressant-resistant depression was evaluated... - Psychotherapy in long-term care: A reviewAshok J Bharucha
Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Am Med Dir Assoc 7:568-80. 2006.... - Perspectives on depression, mild cognitive impairment, and cognitive declineDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Arch Gen Psychiatry 63:130-8. 2006.... - Social inequalities in response to antidepressant treatment in older adultsAlex Cohen
Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
Arch Gen Psychiatry 63:50-6. 2006..We examined the relationship between socioeconomic status and response to treatment for depression among older adults... - Identification of suicidal ideation and prevention of suicidal behaviour in the elderlyKatalin Szanto
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Drugs Aging 19:11-24. 2002..Prevention and treatment trials are underway to detect the effectiveness of improved treatment of depression by primary care physicians as a means of reducing the prevalence of depressive symptoms, hopelessness and suicidal ideation... - Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depressionGwenn S Smith
Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Am J Geriatr Psychiatry 10:561-7. 2002.... - The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT studyHillary R Bogner
Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Geriatr Psychiatry 22:922-9. 2007..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients... - Methylphenidate-enhanced antidepressant response to citalopram in the elderly: a double-blind, placebo-controlled pilot trialHelen Lavretsky
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
Am J Geriatr Psychiatry 14:181-5. 2006..The authors evaluated the potential of methylphenidate to accelerate and enhance antidepressant response to citalopram in elderly depressed patients... - Does depression, apathy or cognitive impairment reduce the benefit of inpatient rehabilitation facilities for elderly hip fracture patients?Eric J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, Advanced Center for Interventions and Services Research in Late Life Mood Disorders and John A Hartford Center of Excellence in Geriatric Psychiatry, PA 15213, USA
Gen Hosp Psychiatry 29:141-6. 2007.... - The prevalence and correlates of psychiatric comorbidity in individuals with complicated griefNaomi M Simon
Massachusetts General Hospital and Harvard Medical School, MA, USA
Compr Psychiatry 48:395-9. 2007..One issue that remains under debate is whether this condition can be clearly distinguished from other psychiatric disorders, such as major depression and posttraumatic stress disorder, with which CG frequently coexists... - The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot studyHelen Lavretsky
UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
Int J Geriatr Psychiatry 23:55-9. 2008.... - Investigating moderator hypotheses in aging research: statistical, methodological, and conceptual difficulties with comparing separate regressionsJason T Newsom
Institute on Aging, Portland State University, OR 97207 0751, USA
Int J Aging Hum Dev 57:119-50. 2003..These results clearly illustrate that the analysis strategy researchers choose may have important bearing on theory in aging research such as conclusions regarding the role of social support across the life span... - Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trialHelen Lavretsky
Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles 90095, USA
J Clin Psychiatry 64:1410-4. 2003..We evaluated the potential of methylphenidate to accelerate antidepressant response to citalopram and the safety and tolerability of the combined treatment in patients with geriatric major depressive disorder... - Impact of concurrent naturalistic pharmacotherapy on psychotherapy of complicated griefNaomi M Simon
Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
Psychiatry Res 159:31-6. 2008..77%). Our naturalistic data underscore the need for prospective, randomized controlled studies of CG pharmacotherapy and psychotherapy alone and in combination... - alpha1-acid glycoprotein in late-life depression: relationship to medical burden and geneticsOpeolu M Adeoye
Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA
J Geriatr Psychiatry Neurol 16:235-9. 2003..Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients... - The role of medical comorbidity in outcome of major depression in primary care: the PROSPECT studyHillary R Bogner
Dept of Family Practice and Community Medicine, Univ of Pennsylvania, 3400 Spruce Street, 2 Gates Building, Philadelphia, PA 19104, USA
Am J Geriatr Psychiatry 13:861-8. 2005..The authors described the influence of specific medical conditions on clinical remission and response of major depression (MDD) in a clinical trial evaluating a care-management intervention among older primary-care patients... - Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled studyCarmen Andreescu
Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
Br J Psychiatry 190:344-9. 2007..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment... - Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late lifeDennis S Charney
National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 60:664-72. 2003.... - Confronting depression and suicide in physicians: a consensus statementClaudia Center
Employment Law Center and the University of California, Hastings College of Law, San Francisco, USA
JAMA 289:3161-6. 2003..As barriers are removed and physicians confront depression and suicidality in their peers, they are more likely to recognize and treat these conditions in patients, including colleagues and medical students... - Career development and training in geriatric mental health: report of an NIMH workshopJason T Olin
National Institute of Mental Health, 6001 Executive Boulevard, Room 7160, MSC 9635, Bethesda, MD 20892 9635, USA
Am J Geriatr Psychiatry 11:275-9. 2003..Federal, public, and private mechanisms need to be better leveraged to grow late-life mental-illness research infrastructure and meet increasing demand and scientific opportunities...
Research Grants
- PREVENTION OF SUICIDE IN OLDER PRIMARY CARE PATIENTSCharles Reynolds; Fiscal Year: 2002..Data will also be collected to document the impact of intervention on patient care, and on physician knowledge, attitudes, and satisfaction and test hypothesis derived from preliminary studies of the three IRCs. ..
- 3/4-Optimizing Complicated Grief TherapyCharles F Reynolds; Fiscal Year: 2010..We will explore mediator and moderator hypotheses to answer questions about how these treatments work and who might benefit most from each approach. Answers to these questions have important public health significance. ..
- Maintenance Therapies in Late-Life Depression-IIICharles Reynolds; Fiscal Year: 2004..Testing ways of "staying well, staying sharp" is the objective of the MTLD-III protocol. The application has been amended (A1). ..
- MAINTENANCE THERAPIES IN LATE LIFE DEPRESSIONCharles Reynolds; Fiscal Year: 2003..We will also examine the cost- effectiveness of combined versus monotherapy in maintenance treatment and determine moderating variables of long-term treatment response. This proposal is the competing renewal of MH43832. ..
- GERIATRIC DEPRESSION--NEUROBIOLOGY OF TREATMENTCharles Reynolds; Fiscal Year: 2003....
- CLINICAL RESEARCH TRAINING IN PSYCHIATRYCharles Reynolds; Fiscal Year: 2006..Both components of the program, pre- and post-doctoral, are part of a broad research training strategy at the University of Pittsburgh Department of Psychiatry, to respond to a national shortage of clinical researchers in psychiatry. ..
- Geriatric Depression: Getting Better, Getting WellCharles Reynolds; Fiscal Year: 2007..This is an amended (A2) competing continuation of (MH37869-21). ..
- 1/3-Incomplete Response in Late-Life Depression: Getting to RemissionCharles F Reynolds; Fiscal Year: 2010..There are is no evidence-based pharmacotherapy for TRLLD;thus, this study seeks to address a major gap in the evidence base for treating depression. ..
- 1/3-Incomplete Response in Late-Life Depression: Getting to RemissionCharles Reynolds; Fiscal Year: 2009..There are is no evidence-based pharmacotherapy for TRLLD; thus, this study seeks to address a major gap in the evidence base for treating depression. ..
- CLINICAL RESEARCH TRAINING IN LATE-LIFE MOOD DISORDERSCharles Reynolds; Fiscal Year: 2007..The Department fosters many research career development activities for students and faculty at all levels. This training grant both contributes to and benefits from this developmental strategy. ..
- EEG, SLEEP, AGING, AND MENTAL ILLNESSCharles Reynolds; Fiscal Year: 1993....
- EEG SLEEP, AGING AND MENTAL ILLNESSCharles Reynolds; Fiscal Year: 1992..Exploratory data analyses will assess possible interrelations among biological REM sleep abnormalities, severity of psychopathology, and disruption in social rhythms...