Charles Reynolds

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Long term effect of depression care management on mortality in older adults: follow-up of cluster randomized clinical trial in primary care
    Joseph J Gallo
    Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, USA
    BMJ 346:f2570. 2013
  2. pmc Early intervention to reduce the global health and economic burden of major depression in older adults
    Charles F Reynolds
    School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Public Health 33:123-35. 2012
  3. pmc Organizational factors and depression management in community-based primary care settings
    Edward P Post
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Implement Sci 4:84. 2009
  4. ncbi request reprint Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivation
    Charles F Reynolds
    Intervention Research Center for Late Life Mood Disorders IRC LLMD, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, E 113521, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:353-8. 2005
  5. ncbi request reprint Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006
  6. ncbi request reprint Paroxetine treatment of primary insomnia in older adults
    Charles F Reynolds
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:803-7. 2006
  7. doi request reprint Commentary: Out of the silence: confronting depression in medical students and residents
    Charles F Reynolds
    Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Acad Med 84:159-60. 2009
  8. pmc The future of psychiatry as clinical neuroscience
    Charles F Reynolds
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Acad Med 84:446-50. 2009
  9. ncbi request reprint Preventing depression in medical illness: a new lead?
    Charles F Reynolds
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 64:884-5. 2007
  10. pmc Protecting sleep, promoting health in later life: a randomized clinical trial
    Charles F Reynolds
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Psychosom Med 72:178-86. 2010

Research Grants

  1. PREVENTION OF SUICIDE IN OLDER PRIMARY CARE PATIENTS
    Charles Reynolds; Fiscal Year: 2002
  2. 3/4-Optimizing Complicated Grief Therapy
    Charles F Reynolds; Fiscal Year: 2010
  3. Maintenance Therapies in Late-Life Depression-III
    Charles Reynolds; Fiscal Year: 2004
  4. MAINTENANCE THERAPIES IN LATE LIFE DEPRESSION
    Charles Reynolds; Fiscal Year: 2003
  5. GERIATRIC DEPRESSION--NEUROBIOLOGY OF TREATMENT
    Charles Reynolds; Fiscal Year: 2003
  6. CLINICAL RESEARCH TRAINING IN PSYCHIATRY
    Charles Reynolds; Fiscal Year: 2006
  7. Geriatric Depression: Getting Better, Getting Well
    Charles Reynolds; Fiscal Year: 2007
  8. 1/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Charles F Reynolds; Fiscal Year: 2010
  9. 1/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Charles Reynolds; Fiscal Year: 2009
  10. CLINICAL RESEARCH TRAINING IN LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2007

Collaborators

Detail Information

Publications87

  1. pmc Long term effect of depression care management on mortality in older adults: follow-up of cluster randomized clinical trial in primary care
    Joseph J Gallo
    Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, USA
    BMJ 346:f2570. 2013
    ..To investigate whether an intervention to improve treatment of depression in older adults in primary care modified the increased risk of death associated with depression...
  2. pmc Early intervention to reduce the global health and economic burden of major depression in older adults
    Charles F Reynolds
    School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Public Health 33:123-35. 2012
    ..We suggest in this review that the time is right for research into the translation of depression-prevention strategies for use in LMICs...
  3. pmc Organizational factors and depression management in community-based primary care settings
    Edward P Post
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Implement Sci 4:84. 2009
    ..In addition, survey information can inform efforts of individual primary care practices in customizing intervention strategies to improve depression management...
  4. ncbi request reprint Accelerating symptom-reduction in late-life depression: a double-blind, randomized, placebo-controlled trial of sleep deprivation
    Charles F Reynolds
    Intervention Research Center for Late Life Mood Disorders IRC LLMD, Univ of Pittsburgh School of Medicine, 3811 O Hara Street, E 113521, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 13:353-8. 2005
    ..Authors tested the hypothesis that one night of total sleep deprivation (TSD) would accelerate antidepressant response to paroxetine, as compared with TSD+placebo (PBO) and paroxetine-alone, in late-life major depression...
  5. ncbi request reprint Maintenance treatment of major depression in old age
    Charles F Reynolds
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    N Engl J Med 354:1130-8. 2006
    ..Elderly patients with major depression, including those having a first episode, are at high risk for recurrence of depression, disability, and death...
  6. ncbi request reprint Paroxetine treatment of primary insomnia in older adults
    Charles F Reynolds
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:803-7. 2006
    ..The goal of this study was to test the efficacy of paroxetine for primary insomnia in older adults...
  7. doi request reprint Commentary: Out of the silence: confronting depression in medical students and residents
    Charles F Reynolds
    Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Acad Med 84:159-60. 2009
    ..The authors outline the chronic nature of depression and discuss its possibility for long-term impacts on trainees. Given these conditions, the leadership of the nation's schools of medicine and AHCs...
  8. pmc The future of psychiatry as clinical neuroscience
    Charles F Reynolds
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Acad Med 84:446-50. 2009
    ....
  9. ncbi request reprint Preventing depression in medical illness: a new lead?
    Charles F Reynolds
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 64:884-5. 2007
  10. pmc Protecting sleep, promoting health in later life: a randomized clinical trial
    Charles F Reynolds
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Psychosom Med 72:178-86. 2010
    ..5 years; and 2) if maintenance or enhancement of sleep continuity and depth promotes the maintenance or enhancement of health-related quality of life...
  11. pmc Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy
    Charles F Reynolds
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 68:51-60. 2011
    ..Cognitive impairment in late-life depression is a core feature of the illness...
  12. ncbi request reprint Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
    ..Cognitive impairment in late-life depression (LLD) is prevalent, disabling, and persists despite the remission of depressive symptoms. This article characterizes neuropsychologic functioning during remission in LLD...
  13. pmc Cognitive performance in suicidal depressed elderly: preliminary report
    Alexandre Y Dombrovski
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:109-15. 2008
    ..This study examined cognitive function in general and executive functioning specifically in depressed elderly with and without suicidal ideation and attempts...
  14. pmc Residual symptoms and recurrence during maintenance treatment of late-life depression
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:77-82. 2007
    ..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression...
  15. ncbi request reprint Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
    ..Potential cardiovascular side effects from venlafaxine-XR must be considered when prescribing this medication, especially in geriatric patients, who often present with comorbid medical conditions...
  16. ncbi request reprint Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    JAMA 291:1081-91. 2004
    ..Depression is the strongest risk factor for late-life suicide and for suicide's precursor, suicidal ideation...
  17. ncbi request reprint Risk factors for falls during treatment of late-life depression
    Jin H Joo
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:936-41. 2002
    ..This study evaluated the time course and potential risk factors for falls in a treatment protocol for late-life depression to identify specific at-risk periods and risk factors for falls in this population...
  18. pmc Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Rd, White Plains, NY 10605, USA
    Am J Psychiatry 166:882-90. 2009
    ..This is the first report of outcomes over a 2-year period...
  19. ncbi request reprint Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment
    Stephen Blank
    Intervention Research Center for Late Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 67:468-72. 2006
    ..Anxiety disorders are common in later life, but little is known about the long-term benefits and risks of pharmacotherapy...
  20. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  21. ncbi request reprint Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
    ..The objective of this study was to describe the correlates of prior antidepressant exposure and its association with response to protocolized treatment in older patients with major depression...
  22. pmc Effect of depression treatment on chronic pain outcomes
    CARRIE FARMER TEH
    RAND Corporation, Pittsburgh, PA 15213, USA
    Psychosom Med 72:61-7. 2010
    ..People with chronic pain and depression have worse health outcomes than those with chronic pain alone. Little is known about the effectiveness of depression treatment for this population...
  23. pmc Marital quality in the context of mild cognitive impairment
    Linda Garand
    University of Pittsburgh, Pittsburgh, PA, USA
    West J Nurs Res 29:976-92. 2007
    ..Results of this study suggest the need for mental health interventions designed to preserve the quality of these marital relationships...
  24. ncbi request reprint Cognitive impairment in late-life generalized anxiety disorder
    Rose C Mantella
    Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 15:673-9. 2007
    ..This study sought to characterize cognitive functioning in elderly patients with generalized anxiety disorder (GAD), as compared with normal comparison subjects and patients with major depression...
  25. ncbi request reprint Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old age
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:550-4. 2006
    ..The objective of this study was to examine the relative speed of improvement in sleep disturbance and anxiety symptoms compared with core mood symptoms in acute treatment of late-life major depression...
  26. ncbi request reprint The nature and determinants of neuropsychological functioning in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Gen Psychiatry 61:587-95. 2004
    ..Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling, poorly understood, and likely related to long-term outcome...
  27. pmc Remission in depressed geriatric primary care patients: a report from the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, New York, USA
    Am J Psychiatry 162:718-24. 2005
    ..In addition, it sought to identify risk factors for nonremission that could guide treatment planning and referral to care managers or specialists...
  28. pmc Impact of close family members on older adults' early response to depression treatment
    Lynn M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Psychol Aging 23:447-52. 2008
    ..Future research may identify family attitudes and behaviors that stem from burden and compromise older adults' ability to recover from depression...
  29. pmc Anxiety impairs depression remission in partial responders during extended treatment in late-life
    Adam Greenlee
    Advanced Center for Intervention and Services Research for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Depress Anxiety 27:451-6. 2010
    ..This study characterizes the effect of anxiety on remission during extended treatment for partial responders...
  30. doi request reprint The prevalence of mental and physical health disorders among older methadone patients
    Daniel Rosen
    University of Pittsburgh School of Social Work, Pittsburgh, PA 15260, USA
    Am J Geriatr Psychiatry 16:488-97. 2008
    ..The goal of this study was to assess the physical and mental health status of older methadone patients...
  31. ncbi request reprint Late-onset major depression: clinical and treatment-response variability
    Henry C Driscoll
    Intervention Research Center for Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 20:661-7. 2005
    ..To explore clinical and treatment-response variability in late-onset vs early-onset non-bipolar, non-psychotic major depression...
  32. pmc The Mood Disorder Burden Index: a scale for assessing the burden of caregivers to adults with unipolar or bipolar disorder
    Lynn M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States University Center for Social and Urban Research, Pittsburgh, PA, United States
    Psychiatry Res 168:67-77. 2009
    ..It will be important for future research to administer the MDBI to caregivers of middle-aged and older patients as well as those receiving treatment through inpatient settings or community outpatient clinics...
  33. pmc An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patients
    Ellen M Whyte
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Cerebrovasc Dis 26:317-21. 2008
    ..We investigated the feasibility of using acetylcholinesterase inhibitors in older patients with acute post-stroke cognitive impairment and examined their effects on functional recovery...
  34. pmc Alone? Perceived social support and chronic interpersonal difficulties in suicidal elders
    Katrin E Harrison
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, USA
    Int Psychogeriatr 22:445-54. 2010
    ..Thus, we investigated the role of chronic interpersonal difficulties and perceived social support in depressed elders with and without suicidal thoughts and attempts...
  35. ncbi request reprint The relationship of medical comorbidity and depression in older, primary care patients
    Jeffrey M Lyness
    Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
    Psychosomatics 47:435-9. 2006
    ..This generates the hypothesis that, in general primary care populations, the relationship of medical illness to depression may be multimodal and/or may involve shared pathobiological or psychosocial mechanisms...
  36. ncbi request reprint Occurrence and course of suicidality during short-term treatment of late-life depression
    Katalin Szanto
    Department of Psychiatry, The Intervention Research Center for the Study of Late Life Mood Disorders, Pittsburgh, PA, USA
    Arch Gen Psychiatry 60:610-7. 2003
    ....
  37. pmc Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  38. pmc Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and older
    Henry C Driscoll
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 16:74-82. 2008
    ....
  39. pmc Paroxetine: population pharmacokinetic analysis in late-life depression using sparse concentration sampling
    Yan Feng
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA, and Rotman Research Institute, Baycrest Hospital, University of Toronto, Canada
    Br J Clin Pharmacol 61:558-69. 2006
    ..To develop a population pharmacokinetic (PK) model using sparse sampling of long-term treatment with paroxetine in elderly depressed subjects, incorporating CYP2D6 genotype as well as other covariates...
  40. pmc Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment
    Linda Garand
    The University of Pittsburgh School of Nursing, Health and Community Systems Department, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:512-22. 2005
    ..We characterized the nature and level of caregiver burden and psychiatric morbidity in spouses of persons diagnosed with MCI...
  41. ncbi request reprint Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment
    Eric J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Psychiatry 159:466-8. 2002
    ..The authors hypothesized that elderly patients recovering from depression would have better social adjustment with medication and interpersonal psychotherapy than with medication or psychotherapy alone...
  42. pmc Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remission
    Meera Sheffrin
    Advanced Center in Interventions and Services Research for Late Life Mood Disorders ACISR LLMD and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 70:208-13. 2009
    ....
  43. pmc A controlled evaluation of monthly maintenance interpersonal psychotherapy in late-life depression with varying levels of cognitive function
    Kristen Carreira
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 23:1110-3. 2008
    ..To evaluate the effect of maintenance Interpersonal Psychotherapy (IPT) on recurrence rates and time to recurrence of major depression in elderly patients with varying levels of cognitive function...
  44. ncbi request reprint Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapy
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1325-32. 2007
    ..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression...
  45. ncbi request reprint Clinically relevant behaviors in elderly hip fracture inpatients
    Helen H Dorra
    University of Pittsburgh School of Medicine, USA
    Int J Psychiatry Med 32:249-59. 2002
    ..To examine the range of behaviors documented by inpatient rehabilitation staff and the association of these behaviors with functional outcome, in elderly persons undergoing rehabilitation after hip fracture...
  46. pmc Disability in late-life major depression: patterns of self-reported task abilities, task habits, and observed task performance
    Joan C Rogers
    Department of Occupational Therapy, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15260, USA
    Psychiatry Res 178:475-9. 2010
    ..The findings led us to conclude that when performance testing is not feasible, self-reports of functional status that focus on habits may be more accurate than those that focus on abilities...
  47. pmc Statistical analysis of longitudinal psychiatric data with dropouts
    Sati Mazumdar
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Psychiatr Res 41:1032-41. 2007
    ....
  48. ncbi request reprint Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late Life and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate...
  49. pmc Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  50. ncbi request reprint Effects of a brief behavioral treatment for late-life insomnia: preliminary findings
    Anne Germain
    Department Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Sleep Med 2:403-6. 2006
    ..This preliminary report addresses the effects of a brief behavioral treatment for insomnia in older adults who present with the typical psychiatric and medical comorbidities of aging...
  51. ncbi request reprint Response speed and rate of remission in primary and specialty care of elderly patients with depression
    Leslie Thomas
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:583-91. 2002
    ....
  52. ncbi request reprint Outcomes of minor and subsyndromal depression among elderly patients in primary care settings
    Jeffrey M Lyness
    Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Intern Med 144:496-504. 2006
    ..Although depressive conditions in later life are a major public health problem, the outcomes of minor and subsyndromal depression are largely unknown...
  53. ncbi request reprint Venlafaxine ER as a treatment for generalized anxiety disorder in older adults: pooled analysis of five randomized placebo-controlled clinical trials
    Ira R Katz
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 50:18-25. 2002
    ....
  54. ncbi request reprint What is the optimal duration of a short-term antidepressant trial when treating geriatric depression?
    Benoit H Mulsant
    Advanced Center in Intervention and Services Research for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychopharmacol 26:113-20. 2006
    ..To determine the optimal duration of an antidepressant trial in elderly patients, the authors examined the probability of eventually responding to treatment based on early improvement...
  55. pmc Preventing depression in later life: translation from concept to experimental design and implementation
    Roy Sriwattanakomen
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:460-8. 2008
    ..Special attention is given to the recruitment of African Americans because of well-documented inequalities in mental health services and depression treatment outcomes between races...
  56. pmc Comparisons of methods for multiple hypothesis testing in neuropsychological research
    Richard E Blakesley
    Department of Biostatistics, University of Pittsburgh, PA, USA
    Neuropsychology 23:255-64. 2009
    ..The authors note caveats regarding the implementation of these methods using available software...
  57. ncbi request reprint Does education moderate neuropsychological impairment in late-life depression?
    Rishi K Bhalla
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Int J Geriatr Psychiatry 20:413-7. 2005
    ..This study examined whether educational level influences the degree of neuropsychological impairment associated with late-life depression...
  58. ncbi request reprint Comorbid anxiety disorder in late life depression: association with memory decline over four years
    Alison K DeLuca
    The Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:848-54. 2005
    ..The purpose of this study was to determine whether comorbid GAD or PD was associated with poorer long-term outcomes of late-life MDD, in terms of symptoms, functional disability, and cognitive status...
  59. ncbi request reprint Somatic symptoms of depression in elderly patients with medical comorbidities
    Rebecca A Drayer
    Center for Research on Health Care, Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 20:973-82. 2005
    ..These analyses were designed to determine if somatic symptoms in older patients are more strongly associated with chronic physical problems or with depression...
  60. pmc Public-academic partnerships: improving depression care for disadvantaged adults by partnering with non-mental health agencies
    Deborah Dobransky-Fasiska
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Psychiatr Serv 61:110-2. 2010
    ....
  61. pmc Altered functioning of the executive control circuit in late-life depression: episodic and persistent phenomena
    Howard J Aizenstein
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:30-42. 2009
    ..To characterize the functional neuroanatomy of late-life depression (LLD) by probing for both episodic and persistent alterations in the executive-control circuit of elderly adults...
  62. pmc Apathy after hip fracture: a potential target for intervention to improve functional outcomes
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, USA
    J Neuropsychiatry Clin Neurosci 21:271-8. 2009
    ..Interventions to prevent or improve apathy in elderly persons deserve further attention...
  63. ncbi request reprint CYP2D6 genotype and venlafaxine-XR concentrations in depressed elderly
    Ellen M Whyte
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Int J Geriatr Psychiatry 21:542-9. 2006
    ....
  64. ncbi request reprint Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder
    Ariel G Gildengers
    Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 15:174-9. 2007
    ..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder...
  65. ncbi request reprint Predictors of adequacy of depression management in the primary care setting
    Jin H Joo
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychiatr Serv 56:1524-8. 2005
    ..This study examined the adequacy of antidepressant treatment and overall depression management by primary care physicians and identified patient characteristics related to inadequate care...
  66. ncbi request reprint Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration
    Sandra Bell-McGinty
    Neuropsychology Research Program, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 159:1424-7. 2002
    ..The authors' goal was to compare regional brain volumes in depressed elderly subjects with those of nondepressed elderly subjects by using voxel-based morphometry...
  67. pmc Racial preferences for participation in a depression prevention trial involving problem-solving therapy
    John Kasckow
    Department of Behavioral Health, U S Department of Veterans Affairs Pittsburgh Health Care System, 7180 Highland Dr, Pittsburgh, PA 15206, USA
    Psychiatr Serv 61:722-4. 2010
    ..It also examined participants' problem-solving skills. Hypotheses stated that there would be no racial differences in consent rates and that social problem-solving coping skills would be lower among African Americans than Caucasians...
  68. pmc Placebo-controlled study of relapse prevention with risperidone augmentation in older patients with resistant depression
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:21-30. 2008
    ..The effect of risperidone augmentation of citalopram for relapse prevention in older patients with antidepressant-resistant depression was evaluated...
  69. ncbi request reprint Psychotherapy in long-term care: A review
    Ashok J Bharucha
    Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Am Med Dir Assoc 7:568-80. 2006
    ....
  70. ncbi request reprint Investigating moderator hypotheses in aging research: statistical, methodological, and conceptual difficulties with comparing separate regressions
    Jason T Newsom
    Institute on Aging, Portland State University, OR 97207 0751, USA
    Int J Aging Hum Dev 57:119-50. 2003
    ..These results clearly illustrate that the analysis strategy researchers choose may have important bearing on theory in aging research such as conclusions regarding the role of social support across the life span...
  71. ncbi request reprint Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:561-7. 2002
    ....
  72. ncbi request reprint Career development and training in geriatric mental health: report of an NIMH workshop
    Jason T Olin
    National Institute of Mental Health, 6001 Executive Boulevard, Room 7160, MSC 9635, Bethesda, MD 20892 9635, USA
    Am J Geriatr Psychiatry 11:275-9. 2003
    ..Federal, public, and private mechanisms need to be better leveraged to grow late-life mental-illness research infrastructure and meet increasing demand and scientific opportunities...
  73. pmc Does depression, apathy or cognitive impairment reduce the benefit of inpatient rehabilitation facilities for elderly hip fracture patients?
    Eric J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, Advanced Center for Interventions and Services Research in Late Life Mood Disorders and John A Hartford Center of Excellence in Geriatric Psychiatry, PA 15213, USA
    Gen Hosp Psychiatry 29:141-6. 2007
    ....
  74. ncbi request reprint Social inequalities in response to antidepressant treatment in older adults
    Alex Cohen
    Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    Arch Gen Psychiatry 63:50-6. 2006
    ..We examined the relationship between socioeconomic status and response to treatment for depression among older adults...
  75. pmc The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
    Hillary R Bogner
    Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Geriatr Psychiatry 22:922-9. 2007
    ..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients...
  76. ncbi request reprint Perspectives on depression, mild cognitive impairment, and cognitive decline
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:130-8. 2006
    ....
  77. ncbi request reprint Methylphenidate-enhanced antidepressant response to citalopram in the elderly: a double-blind, placebo-controlled pilot trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
    Am J Geriatr Psychiatry 14:181-5. 2006
    ..The authors evaluated the potential of methylphenidate to accelerate and enhance antidepressant response to citalopram in elderly depressed patients...
  78. ncbi request reprint Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
    ..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment...
  79. ncbi request reprint The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
    Helen Lavretsky
    UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:55-9. 2008
    ....
  80. ncbi request reprint The prevalence and correlates of psychiatric comorbidity in individuals with complicated grief
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, MA, USA
    Compr Psychiatry 48:395-9. 2007
    ..One issue that remains under debate is whether this condition can be clearly distinguished from other psychiatric disorders, such as major depression and posttraumatic stress disorder, with which CG frequently coexists...
  81. pmc The role of medical comorbidity in outcome of major depression in primary care: the PROSPECT study
    Hillary R Bogner
    Dept of Family Practice and Community Medicine, Univ of Pennsylvania, 3400 Spruce Street, 2 Gates Building, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 13:861-8. 2005
    ..The authors described the influence of specific medical conditions on clinical remission and response of major depression (MDD) in a clinical trial evaluating a care-management intervention among older primary-care patients...
  82. ncbi request reprint Confronting depression and suicide in physicians: a consensus statement
    Claudia Center
    Employment Law Center and the University of California, Hastings College of Law, San Francisco, USA
    JAMA 289:3161-6. 2003
    ..To encourage treatment of depression and prevention of suicide in physicians by calling for a shift in professional attitudes and institutional policies to support physicians seeking help...
  83. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  84. ncbi request reprint alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics
    Opeolu M Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Geriatr Psychiatry Neurol 16:235-9. 2003
    ..Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients...
  85. pmc Impact of concurrent naturalistic pharmacotherapy on psychotherapy of complicated grief
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Psychiatry Res 159:31-6. 2008
    ..77%). Our naturalistic data underscore the need for prospective, randomized controlled studies of CG pharmacotherapy and psychotherapy alone and in combination...
  86. ncbi request reprint Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles 90095, USA
    J Clin Psychiatry 64:1410-4. 2003
    ..We evaluated the potential of methylphenidate to accelerate antidepressant response to citalopram and the safety and tolerability of the combined treatment in patients with geriatric major depressive disorder...
  87. ncbi request reprint Identification of suicidal ideation and prevention of suicidal behaviour in the elderly
    Katalin Szanto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Drugs Aging 19:11-24. 2002
    ..Prevention and treatment trials are underway to detect the effectiveness of improved treatment of depression by primary care physicians as a means of reducing the prevalence of depressive symptoms, hopelessness and suicidal ideation...

Research Grants45

  1. PREVENTION OF SUICIDE IN OLDER PRIMARY CARE PATIENTS
    Charles Reynolds; Fiscal Year: 2002
    ..Data will also be collected to document the impact of intervention on patient care, and on physician knowledge, attitudes, and satisfaction and test hypothesis derived from preliminary studies of the three IRCs. ..
  2. 3/4-Optimizing Complicated Grief Therapy
    Charles F Reynolds; Fiscal Year: 2010
    ..We will explore mediator and moderator hypotheses to answer questions about how these treatments work and who might benefit most from each approach. Answers to these questions have important public health significance. ..
  3. Maintenance Therapies in Late-Life Depression-III
    Charles Reynolds; Fiscal Year: 2004
    ..Testing ways of "staying well, staying sharp" is the objective of the MTLD-III protocol. The application has been amended (A1). ..
  4. MAINTENANCE THERAPIES IN LATE LIFE DEPRESSION
    Charles Reynolds; Fiscal Year: 2003
    ..We will also examine the cost- effectiveness of combined versus monotherapy in maintenance treatment and determine moderating variables of long-term treatment response. This proposal is the competing renewal of MH43832. ..
  5. GERIATRIC DEPRESSION--NEUROBIOLOGY OF TREATMENT
    Charles Reynolds; Fiscal Year: 2003
    ....
  6. CLINICAL RESEARCH TRAINING IN PSYCHIATRY
    Charles Reynolds; Fiscal Year: 2006
    ..Both components of the program, pre- and post-doctoral, are part of a broad research training strategy at the University of Pittsburgh Department of Psychiatry, to respond to a national shortage of clinical researchers in psychiatry. ..
  7. Geriatric Depression: Getting Better, Getting Well
    Charles Reynolds; Fiscal Year: 2007
    ..This is an amended (A2) competing continuation of (MH37869-21). ..
  8. 1/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Charles F Reynolds; Fiscal Year: 2010
    ..There are is no evidence-based pharmacotherapy for TRLLD;thus, this study seeks to address a major gap in the evidence base for treating depression. ..
  9. 1/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Charles Reynolds; Fiscal Year: 2009
    ..There are is no evidence-based pharmacotherapy for TRLLD; thus, this study seeks to address a major gap in the evidence base for treating depression. ..
  10. CLINICAL RESEARCH TRAINING IN LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2007
    ..The Department fosters many research career development activities for students and faculty at all levels. This training grant both contributes to and benefits from this developmental strategy. ..
  11. EEG, SLEEP, AGING, AND MENTAL ILLNESS
    Charles Reynolds; Fiscal Year: 1993
    ....
  12. EEG SLEEP, AGING AND MENTAL ILLNESS
    Charles Reynolds; Fiscal Year: 1992
    ..Exploratory data analyses will assess possible interrelations among biological REM sleep abnormalities, severity of psychopathology, and disruption in social rhythms...