Research Topics
Genomes and GenesSpecies | Chandra ReynoldsSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Alcohol, tobacco and caffeine use: spouse similarity processesChandra A Reynolds
University of California, Riverside, USA
Behav Genet 36:201-15. 2006..Social homogamy may be more important for some substance use traits such as alcohol consumption and tobacco use status but not others...- Heritability of an age-dependent categorical phenotype: cognitive dysfunctionChandra A Reynolds
Department of Psychology, University of California at Riverside, 92521, USA
Twin Res Hum Genet 9:17-23. 2006..The findings emphasize the extent to which research is needed to uncover nonfamilial environmental influences on cognitive dysfunction in later life... - Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genesChandra A Reynolds
Department of Psychology, University of California Riverside, 92521, USA
Behav Genet 36:185-94. 2006..There were no significant findings for LRP. Dominance, often untested in previous studies, was important in the current study's findings... - Longitudinal change in memory performance associated with HTR2A polymorphismChandra A Reynolds
Department of Psychology, University of California at Riverside, 1344 Olmsted Hall, Riverside, CA 92521 0426, USA
Neurobiol Aging 27:150-4. 2006..These findings imply a role for the 5-HT2A serotonin receptor on the formation of episodic memories in older adults... - Quantitative genetic analysis of latent growth curve models of cognitive abilities in adulthoodChandra A Reynolds
Department of Psychology, University of California, 1344 Olmstead Hall, Riverside, CA 92521, USA
Dev Psychol 41:3-16. 2005..The present findings provide support for theories of the increasing influence of the environment with age on cognitive abilities... - Genotype-environment interactions: cognitive aging and social factorsChandra A Reynolds
University of California Riverside, Department of Psychology, Riverside, CA 92521, USA
Twin Res Hum Genet 10:241-54. 2007..Further work ought to consider larger sample sizes as well as consider additional social and contextual factors... 
Serum lipid levels and cognitive change in late lifeChandra A Reynolds
Department of Psychology, University of California at Riverside, Riverside, California 92521, USA
J Am Geriatr Soc 58:501-9. 2010..To assess the effect of lipids and lipoproteins on longitudinal cognitive performance and cognitive health in late life and to consider moderating factors such as age and sex that may clarify conflicting prior evidence...- Sources of influence on rate of cognitive change over time in Swedish twins: an application of latent growth modelsChandra A Reynolds
Department of Psychology, University of California Riverside, Riverside, California 92521, USA
Exp Aging Res 28:407-33. 2002..These same forces may overlap with those that influence higher or lower educational attainment or those leading to better or worse pulmonary functioning... - Individual variation for cognitive decline: quantitative methods for describing patterns of changeChandra A Reynolds
Department of Psychology, University of Southern California, Riverside 92532, USA
Psychol Aging 17:271-87. 2002..Predicted slopes from the RER model also showed the strongest interrelationships within and across cognitive domains as indicated by factor analysis results and stronger associations with demographic, health, and psychosocial predictors... - Role of genes and environments for explaining Alzheimer diseaseMargaret Gatz
Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
Arch Gen Psychiatry 63:168-74. 2006..Twin studies using selected samples have shown high heritability for Alzheimer disease (AD)... - Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY studyMargaret Gatz
Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
Neurobiol Aging 26:439-47. 2005..Among monozygotic twins where both twins had Alzheimer's disease, the within pair difference in age of onset ranged from both becoming demented in the same year to 7 years difference in onset... - Age changes in processing speed as a leading indicator of cognitive agingDeborah Finkel
Department of Psychology, Indiana University Southeast, 5201 Grant Line Road, New Albany, IN 47150, USA
Psychol Aging 22:558-68. 2007..The results suggest that, as predicted by the processing speed theory of cognitive aging, processing speed is a leading indicator of age changes in memory and spatial ability, but not verbal ability... - Stimulation seeking and intelligence: a prospective longitudinal studyAdrian Raine
Department of Psychology, University of Southern California, Los Angeles, 90089 1061, USA
J Pers Soc Psychol 82:663-74. 2002..It is hypothesized that young stimulation seekers create for themselves an enriched environment that stimulates cognitive development... 
Genetic variance in processing speed drives variation in aging of spatial and memory abilitiesDeborah Finkel
Department of Psychology, Indiana University Southeast, New Albany, IN 47150, USA
Dev Psychol 45:820-34. 2009..Model-fitting indicated that genetic variance for processing speed was a leading indicator of variation in age changes for spatial and memory ability, providing additional support for processing speed theories of cognitive aging...- Resting heart rate and the development of antisocial behavior from age 9 to 14: genetic and environmental influencesLaura A Baker
Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
Dev Psychopathol 21:939-60. 2009..Although the effect size is small, children with low resting heart rate appear to be genetically predisposed toward externalizing behavior problems as early as age 9 years old... - Cognitive engagement and cognitive aging: is openness protective?Emily Schoenhofen Sharp
Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
Psychol Aging 25:60-73. 2010..Openness, however, was not predictive of differences in the trajectories of cognitive performance over age... - Conscientiousness, career success, and longevity: a lifespan analysisMargaret L Kern
Department of Psychology, University of California, Riverside, CA 92521 0426, USA
Ann Behav Med 37:154-63. 2009..Markers of executive functioning, such as prudent planning for the future and impulse control, are related to conscientiousness and may be central to both occupational success and health outcomes... - Personality and health, subjective well-being, and longevityHoward S Friedman
Department of Psychology, University of California, Riverside, California 92521, USA
J Pers 78:179-216. 2010..Differential patterns of association between personality traits and healthy aging components are informative about individual personality characteristics and long-term health outcomes... - Stability of physical activity across the lifespanHoward S Friedman
Department of Psychology, University of California, Riverside, USA
J Health Psychol 13:1092-104. 2008..Further, a simplex model provided a better fit than a one factor model. Successful models and interventions to improve health will likely require a more nuanced, pattern-sensitive understanding of physical activity across time... - Anxiety, cognitive performance, and cognitive decline in normal agingJulie Loebach Wetherell
Department of Psychology, University of Southern California, Los Angeles 92161, USA
J Gerontol B Psychol Sci Soc Sci 57:P246-55. 2002..These results provide some support for Eysenck's processing efficiency theory but none for neuroticism as a risk factor for cognitive decline in normal aging... - Predictors of physical activity patterns across adulthood: a growth curve analysisMargaret L Kern
Department of Psychology, University of California, Riverside, CA 92521 0426, USA
Pers Soc Psychol Bull 36:1058-72. 2010..Results suggest that physical activity needs to be understood within the context of the individual's personality and long-term trajectory, not merely current motivations... - Comparative rating measures of health and environmental exposures: how well do twins agree?Chandra A Reynolds
Department of Psychology, University of California at Riverside, Riverside, California 92521, United States of America
Twin Res Hum Genet 8:113-9. 2005..Comparative ratings appear most accurate for smoking and alcohol use, and less consistent for mental health symptoms and self-rated health... - Performance on neurocognitive tests by co-twins to dementia cases compared to normal control twinsMargaret Gatz
Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
J Geriatr Psychiatry Neurol 18:202-7. 2005..These findings show that being at greater genetic risk for dementia is reflected in cognitive performance even in the absence of a diagnosis of dementia... - Sequence variation in SORL1 and dementia risk in SwedesChandra A Reynolds
Department of Psychology, University of California at Riverside, Riverside, CA 92521, USA
Neurogenetics 11:139-42. 2010.... - Telephone screening to identify potential dementia cases in a population-based sample of older adultsMargaret Gatz
Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
Int Psychogeriatr 14:273-89. 2002..One recommendation based on our experience is that longitudinal studies should include a telephone interview component for anyone who drops out of the study, to enable characterizing the cognitive status of dropouts... - Spatial but not verbal cognitive deficits at age 3 years in persistently antisocial individualsAdrian Raine
Department of Psychology, University of Southern California, 90089 1061, USA
Dev Psychopathol 14:25-44. 2002.... - Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia riskChandra A Reynolds
Department of Psychology, University of California at Riverside, Riverside, CA 92521, USA
Hum Mol Genet 19:2068-78. 2010..Several markers in strong LD (r(2) > 0.7) with rs3183702 were found to be significantly associated with AD risk in recent genome-wide association studies with similar effect sizes, providing independent support of the current findings... - A survey of ABCA1 sequence variation confirms association with dementiaChandra A Reynolds
Department of Psychology, University of California at Riverside, Riverside, California, USA
Hum Mutat 30:1348-54. 2009..Results further implicate ABCA1 in dementia, reinforcing the putative involvement of lipid transport in neurodegenerative disease... - Latent growth curve analyses of accelerating decline in cognitive abilities in late adulthoodDeborah Finkel
School of Social Sciences, Indiana University Southeast, New Albany 47150 6405, USA
Dev Psychol 39:535-50. 2003..Gender differences were found only in mean level, not in rate of decline... - Sex differences in genetic risk for dementiaMargaret Gatz
University of Southern California, Los Angeles, California, USA Karolinska Institutet, Stockholm, Sweden
Behav Genet 33:95-105. 2003..We conclude that women are not at higher risk of developing dementia, but there is a hint that different genetic processes may be involved for women than for men... - Surprising lack of sex differences in normal cognitive aging in twinsDeborah Finkel
Indiana University Southeast, New Albany 47150, USA
Int J Aging Hum Dev 62:335-57. 2006..Despite differential longevity and susceptibility to disease, there are no consistent indications that men and women show different patterns of cognitive aging... - The longitudinal relationship between processing speed and cognitive ability: genetic and environmental influencesDeborah Finkel
School of Social Sciences, Indiana University Southeast, 4201 Grant Line Road, New Albany, IN 47150, USA
Behav Genet 35:535-49. 2005..For measures of fluid abilities, it is not the linear age changes but the accelerating age changes in cognition that share genetic variance with processing speed... - Cohort differences in trajectories of cognitive agingDeborah Finkel
School of Social Sciences, Indiana University Southeast, New Albany, IN 47150
J Gerontol B Psychol Sci Soc Sci 62:P286-94. 2007..Trajectories of change with age in these four domains were fundamentally the same in middle-old age for individuals born during the first half of the 20th century... - Accounting for the relationship between low education and dementia: a twin studyMargaret Gatz
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
Physiol Behav 92:232-7. 2007..Low education is confirmed as a risk factor for dementia. Findings from three different analytic approaches showed that genetic influences did not explain this association... - Advances in statistical models and methodsChandra A Reynolds
Twin Res Hum Genet 9:311-2. 2006 - Genetic and environmental influences on decline in biobehavioral markers of agingDeborah Finkel
School of Social Sciences, Indiana University Southeast, New Albany, IN, USA
Behav Genet 33:107-23. 2003..Investigations of the aging process will differ depending on whether the focus is on static performance or change...
Research Grants
- ASSORTMENT AND TRANSMISSION OF ALCOHOL AND TOBACCO USEChandra Reynolds; Fiscal Year: 2001..abstract_text> ..
- Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease riskChandra A Reynolds; Fiscal Year: 2010....
- Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease riskChandra Reynolds; Fiscal Year: 2009....
- Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease riskChandra Reynolds; Fiscal Year: 2007....
- Latent Growth Curve Paths to Longevity: The Terman StudyChandra Reynolds; Fiscal Year: 2007..abstract_text> ..