C F Reynolds

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:1177-81. 1999
  2. ncbi request reprint Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213, USA
    Am J Psychiatry 156:202-8. 1999
  3. ncbi request reprint Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years
    C F Reynolds
    The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    JAMA 281:39-45. 1999
  4. ncbi request reprint Depression and aging: a look to the future
    C F Reynolds
    Department of Psychiatry at the University of Pittsburgh School of Medicine, Pennsylvania, USA
    Psychiatr Serv 50:1167-72. 1999
  5. ncbi request reprint Which elderly patients with remitted depression remain well with continued interpersonal psychotherapy after discontinuation of antidepressant medication?
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 154:958-62. 1997
  6. ncbi request reprint Treatment as usual (TAU) control practices in the PROSPECT Study: managing the interaction and tension between research design and ethics
    C F Reynolds
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 16:602-8. 2001
  7. ncbi request reprint Chronic depression in the elderly: approaches for prevention
    C F Reynolds
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Drugs Aging 18:507-14. 2001
  8. ncbi request reprint Paroxetine treatment of depression in late life
    Charles F Reynolds
    MHIRC for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
    Psychopharmacol Bull 37:123-34. 2003
  9. ncbi request reprint Career development in old-age psychiatry: opportunities through the American Association for Geriatric Psychiatry
    Charles F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, E 1135, Pittsburgh, PA 15213, USA
    Acad Psychiatry 31:105-6. 2007
  10. pmc Training future generations of mental health researchers: devising strategies for tough times
    Charles F Reynolds
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Acad Psychiatry 31:152-9. 2007

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. ncbi request reprint Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:1177-81. 1999
    ..This study compared the long-term efficacy of two fixed plasma levels of nortriptyline in preventing or delaying recurrence of major depression in elderly patients and in minimizing residual depressive symptoms and somatic complaints...
  2. ncbi request reprint Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213, USA
    Am J Psychiatry 156:202-8. 1999
    ..The authors tested the hypothesis that nortriptyline and interpersonal psychotherapy, alone and in combination, are superior to placebo in achieving remission of bereavement-related major depressive episodes...
  3. ncbi request reprint Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years
    C F Reynolds
    The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    JAMA 281:39-45. 1999
    ..Elderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability...
  4. ncbi request reprint Depression and aging: a look to the future
    C F Reynolds
    Department of Psychiatry at the University of Pittsburgh School of Medicine, Pennsylvania, USA
    Psychiatr Serv 50:1167-72. 1999
    ....
  5. ncbi request reprint Which elderly patients with remitted depression remain well with continued interpersonal psychotherapy after discontinuation of antidepressant medication?
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 154:958-62. 1997
    ..This study was conducted to identify which elderly patients with remitted recurrent major depression remain well with maintenance interpersonal psychotherapy after discontinuation of active antidepressant medication (nortriptyline)...
  6. ncbi request reprint Treatment as usual (TAU) control practices in the PROSPECT Study: managing the interaction and tension between research design and ethics
    C F Reynolds
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 16:602-8. 2001
    ....
  7. ncbi request reprint Chronic depression in the elderly: approaches for prevention
    C F Reynolds
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Drugs Aging 18:507-14. 2001
    ..Depression in old age is a major contributor to the global burden of illness-related disability, but it is extremely treatable if appropriate pharmacotherapy is prescribed and accepted by patients and their caregivers...
  8. ncbi request reprint Paroxetine treatment of depression in late life
    Charles F Reynolds
    MHIRC for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
    Psychopharmacol Bull 37:123-34. 2003
    ..With the significant personal and societal burden that is associated with major depression in the elderly, appropriate treatment is important and must be incorporated into standard practices by healthcare professionals...
  9. ncbi request reprint Career development in old-age psychiatry: opportunities through the American Association for Geriatric Psychiatry
    Charles F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, E 1135, Pittsburgh, PA 15213, USA
    Acad Psychiatry 31:105-6. 2007
  10. pmc Training future generations of mental health researchers: devising strategies for tough times
    Charles F Reynolds
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Acad Psychiatry 31:152-9. 2007
    ....
  11. ncbi request reprint High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depression
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 153:1418-22. 1996
    ..Twenty-eight patients (17.7%) received inpatient care at some point during acute-phase treatment...
  12. ncbi request reprint Temporal profiles of the course of depression during treatment. Predictors of pathways toward recovery in the elderly
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
    Arch Gen Psychiatry 54:1016-24. 1997
    ..Whether patients vary in their pathways toward those outcomes--and the extent to which such variation can be anticipated by patient characteristics prior to treatment--has not been empirically examined...
  13. ncbi request reprint Subjective health measures and acute treatment outcomes in geriatric depression
    E J Lenze
    The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 16:1149-55. 2001
    ..However, successful treatment for depression has been associated with improvement in self-rated health and other health measures...
  14. ncbi request reprint PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders
    C C Meltzer
    Department of Radiology, University of Pittsburgh, PA, USA
    Am J Psychiatry 156:1871-8. 1999
    ....
  15. ncbi request reprint Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression
    G S Smith
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:683-9. 1999
    ....
  16. ncbi request reprint Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly
    G M Bump
    Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Depress Anxiety 13:38-44. 2001
    ..Paroxetine and nortriptyline demonstrated similar efficacy in relapse and recurrence prevention in elderly depressed patients over an 18-month period...
  17. ncbi request reprint Initial recovery patterns may predict which maintenance therapies for depression will keep older adults well
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 65:155-66. 2001
    ..Patients' temporal patterns of acute treatment response may predict who requires which maintenance therapy to remain well...
  18. ncbi request reprint A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late life
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 62:597-604. 2001
    ..To conduct the first randomized study comparing the efficacy of an antidepressant alone versus an antidepressant plus a neuroleptic in the treatment of late-life psychotic depression...
  19. ncbi request reprint A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatients
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 9:406-14. 2001
    ....
  20. ncbi request reprint Effects of diagnosis on treatment recommendations in chronic insomnia--a report from the APA/NIMH DSM-IV field trial
    D J Buysse
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Sleep 20:542-52. 1997
    ..Site-related differences suggest a lack of consensus in how these disorders are conceptualized and treated...
  21. ncbi request reprint Complicated grief as a disorder distinct from bereavement-related depression and anxiety: a replication study
    H G Prigerson
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 153:1484-6. 1996
    ..This study sought to confirm in an independent, nonclinical study group previous work which demonstrated that the symptoms of complicated grief were distinct from the symptoms of bereavement related depression and anxiety...
  22. pmc Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression?
    A G Gildengers
    University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA
    Psychol Med 43:801-11. 2013
    ..We assessed IADLs using a criterion-referenced, performance-based instrument. We employed repeated-measures mixed-effects linear models to examine trajectory of cognitive function. We employed non-parametric tests for analysis of IADLs...
  23. ncbi request reprint A longitudinal study of laboratory- and diary-based sleep measures in healthy "old old" and "young old" volunteers
    C C Hoch
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Sleep 17:489-96. 1994
    ..To our knowledge, this is the first longitudinal data set on sleep in the healthy old old...
  24. ncbi request reprint Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression
    R D Nebes
    Western Psychiatric Institute and Clinic, Thomas Detre Hall, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:878-84. 2001
    ....
  25. ncbi request reprint Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression
    E M Whyte
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 158:2074-6. 2001
    ..Variations in the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism may influence the degree of activation. The authors examined the association among depression, platelet activation, and 5-HTTLPR genotype...
  26. ncbi request reprint Symptoms of stress and depression as correlates of sleep in primary insomnia
    M Hall
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    Psychosom Med 62:227-30. 2000
    ..In the preliminary study described here, we evaluated the extent to which symptoms of stress and depression are associated with subjective sleep complaints and quantitative measures of sleep in individuals with chronic insomnia...
  27. ncbi request reprint Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    B G Pollock
    Intervention Research Center for Late Life Mood Disorders and the Geriatric Psychopharmacology Program, Graduate School of Public Health, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 23:587-90. 2000
    ..Onset of response to nortriptyline was not affected. Allelic variation of 5-HTTLPR may contribute to the variable initial response of patients treated with a selective serotonin reuptake inhibitor...
  28. ncbi request reprint Traumatic grief as a risk factor for mental and physical morbidity
    H G Prigerson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Am J Psychiatry 154:616-23. 1997
    ..The aim of this study was to confirm and extend the authors' previous work indicating that symptoms of traumatic grief are predictors of future physical and mental health outcomes...
  29. ncbi request reprint Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction
    C C Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 813:167-71. 1998
    ..This finding, which is consistent with prior postmortem and in vivo studies, has both etiological and potential therapeutic implications for behavioral changes commonly observed in the elderly, including geriatric depression...
  30. ncbi request reprint Serum anticholinergicity in elderly depressed patients treated with paroxetine or nortriptyline
    B G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 155:1110-2. 1998
    ..The authors' goal was to compare serum anticholinergicity of 61 elderly depressed patients randomly assigned to double-blind treatment with paroxetine (N=31) or nortriptyline (N=30)...
  31. pmc Subsyndromal depression and anxiety in older adults: health related, functional, cognitive and diagnostic implications
    J W Kasckow
    VA Pittsburgh MIRECC and Behavioral Health, 7180 Highland Dr 116a, Pittsburgh, PA 15206, USA
    J Psychiatr Res 47:599-603. 2013
    ....
  32. ncbi request reprint Do nocturnal penile tumescence recordings alter electroencephalographic sleep?
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 10:486-90. 1987
    ....
  33. ncbi request reprint Dual-task performance in depressed geriatric patients
    R D Nebes
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Psychiatry Res 102:139-51. 2001
    ....
  34. ncbi request reprint Longitudinal changes in diary- and laboratory-based sleep measures in healthy "old old" and "young old" subjects: a three-year follow-up
    C C Hoch
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Sleep 20:192-202. 1997
    ..The current results are representative of healthy elderly; sleep would probably deteriorate earlier and more quickly in elderly with more serious health problems and heavier medication use...
  35. ncbi request reprint Pharmacological treatment of depression in older primary care patients: the PROSPECT algorithm
    B H Mulsant
    Intervention Research Center for the Study of Late Life Mood Disorders, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 16:585-92. 2001
    ..However, treatments that are often poorly tolerated by elderly patients are given lower priority than treatments more likely to be tolerated. Similarly, trials that are simpler to implement in primary care are favored...
  36. ncbi request reprint Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI)
    D J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
    Sleep 14:331-8. 1991
    ..Extremely healthy elderly subjects appear to adapt in their perception of objectively disturbed sleep...
  37. ncbi request reprint Treatment outcome in suicidal vs. non-suicidal elderly patients
    K Szanto
    Intervention Research Center for the Study of Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 9:261-8. 2001
    ..Our data suggest that elderly suicidal patients have an overall favorable treatment outcome. However, treatment response may be more brittle and may require the continuing use of adjunctive medications to prevent early relapse...
  38. ncbi request reprint Nocturnal penile tumescence in healthy 20- to 59-year-olds: a revisit
    C F Reynolds
    Sleep Evaluation Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Sleep 12:368-73. 1989
    ..Maximum buckling force and maximum erectile fullness showed stability across the four decades of the Pittsburgh sample...
  39. ncbi request reprint The effect of patient and visit characteristics on diagnosis of depression in primary care
    J S Harman
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Suite 430, Pittsburgh, PA, 15213, USA
    J Fam Pract 50:1068. 2001
    ..The purpose of our study was to determine if factors other than the patient' clinical presentation were associated with the likelihood of depression being recognized during a physician office visit...
  40. ncbi request reprint Patterns of sleep episodes in young and elderly adults during a 36-hour constant routine
    D J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
    Sleep 16:632-7. 1993
    ..They also confirm the presence of sex differences in sleep patterns among the elderly and support the distinction between objective and subjective measures of sleepiness...
  41. ncbi request reprint Concordance between habitual sleep times and laboratory recording schedules
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
    Sleep 15:571-5. 1992
    ..We strongly recommend a policy of routinely including data on laboratory versus habitual sleep times in peer-reviewed publications...
  42. ncbi request reprint Protecting sleep quality in later life: a pilot study of bed restriction and sleep hygiene
    C C Hoch
    The Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Gerontol B Psychol Sci Soc Sci 56:P52-9. 2001
    ..The use of sleep hygiene was associated with initial improvement in daytime well-being, whereas bed restriction led to sustained improvements in sleep continuity and sleep depth...
  43. ncbi request reprint Managing late-life depression in primary care practice: a case study of the Health Specialist's role
    H C Schulberg
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 16:577-84. 2001
    ..Evolution of this role and its rewards/stressors during the study's first year are described...
  44. ncbi request reprint Narrowing the gap in treatment of depression
    J S Harman
    University of Pittsburgh School of Medicine, Pennsylvania, USA
    Int J Psychiatry Med 31:239-53. 2001
    ..The purpose of this study is to assess treatment rates in 1993-1994 and 1996-1997...
  45. ncbi request reprint Cognitive and motor slowing in Alzheimer's disease and geriatric depression
    R D Nebes
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Int Neuropsychol Soc 4:426-34. 1998
    ..Thus, this study suggests that AD produces a slowing in both cognitive and motor processes, whereas depression results solely in a motor retardation...
  46. pmc Interpersonal psychotherapy for late-life depression: past, present, and future
    M D Miller
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    J Psychother Pract Res 10:231-8. 2001
    ..In addition, preliminary results using IPT combined with paroxetine in depressed elders reveals no difference in remission rates between cognitively intact and cognitively impaired depressed elders...
  47. ncbi request reprint Accounting for covariate measurement error in a Cox model analysis of recurrence of depression
    K Liu
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Psychiatr Res 35:177-85. 2001
    ..In the depression data, these methods render comparable results that have less bias than the results when measurement error is ignored...
  48. ncbi request reprint Traumatic grief treatment: a pilot study
    M K Shear
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Am J Psychiatry 158:1506-8. 2001
    ..The effects of a treatment program targeting debilitating grief symptoms were tested in a pilot study...
  49. ncbi request reprint Trial design and informed consent for a clinic-based study with a treatment as usual control arm
    H B Degenholtz
    Department of Health Services Administration and Center for Bioethics and Health Law, University of Pittsburgh, 3708 5th Ave, Pittsburgh, PA 15213, USA
    Ethics Behav 12:43-62. 2002
    ..Our analysis reveals the tension between ethics and scientific integrity involved with using TAU as a control condition and the difficulty in designing high-quality research in a community-based setting...
  50. ncbi request reprint Are buckling force measurements reliable in nocturnal penile tumescence studies?
    E A Nofzinger
    Sleep and Chronobiology Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 16:156-62. 1993
    ....
  51. ncbi request reprint The association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future research
    E J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 9:113-35. 2001
    ..The authors discuss how these findings inform current concepts of physical disability and discuss the implications for future intervention studies of late-life depression and anxiety disorders...
  52. ncbi request reprint Morbidity of homebound versus inpatient elderly psychiatric patients
    R Pasternak
    University of Pittsburgh School of Medicine, Western Psychiatry Institute and Clinic, Pennsylvania, USA
    Int Psychogeriatr 10:117-25. 1998
    ..3%, nursing home placement in 9.2% and mortality in 8.4%. These preliminary data show that the HB group had psychiatric problems that were comparable to those of the IP group but were not as severely impaired...
  53. ncbi request reprint EEG sleep in African-American patients with major depression: a historical case control study
    D E Giles
    Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
    Depress Anxiety 8:58-64. 1998
    ..The pathological implications of these differences remained to be explored in careful prospective studies of African-American depressed patients and in well-characterized, racially matched normal control comparisons...
  54. ncbi request reprint Comparison of sleep-disordered breathing among healthy elderly in the seventh, eighth, and ninth decades of life
    C C Hoch
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 13:502-11. 1990
    ..4% of men versus 5.4% of women (chi 2 = 4.25, p less than 0.05). These data suggest that SDB increases with advancing age even in the healthy elderly and may be more marked in healthy men than women...
  55. ncbi request reprint Comorbidity of depression and anxiety disorders in later life
    E J Lenze
    Intervention Research Centers in Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:86-93. 2001
    ..We also recommend directions for future research in the area of psychiatric comorbidity in late life...
  56. doi request reprint Serotonin-norepinephrine reuptake inhibitor therapy in late-life depression is associated with increased marker of bone resorption
    M L O Shea
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Osteoporos Int 24:1741-9. 2013
    ..Bone resorption increased after antidepressant treatment, which may increase fracture risk...
  57. pmc Post-traumatic stress disorder symptoms in emotionally distressed individuals referred for a depression prevention intervention: relationship to problem-solving skills
    J Kasckow
    VA Pittsburgh MIRECC and Behavioral Health, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 27:1106-11. 2012
    ..In addition, some reports have suggested that there are higher rates of PTSD in minority populations relative to Caucasians; thus we hypothesized that race would also predict problem-solving skills in these individuals...
  58. pmc The temptation of suicide: striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression
    A Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA PA 15213, USA
    Psychol Med 42:1203-15. 2012
    ..Thus, we tested whether, in late-life depression, changes in the basal ganglia were associated with suicide attempts and with increased delay discounting...
  59. ncbi request reprint Daily social rhythms in the elderly and their relation to objectively recorded sleep
    T H Monk
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213
    Sleep 15:322-9. 1992
    ....
  60. ncbi request reprint Electroencephalographic sleep of healthy children. Part II: Findings using automated delta and REM sleep measurement methods
    P A Coble
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213
    Sleep 10:551-62. 1987
    ..Findings are discussed relative to those obtained in the same children using standard measurement methods...
  61. ncbi request reprint Gender-specific aging effects on the serotonin 1A receptor
    C Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15231, USA
    Brain Res 895:9-17. 2001
    ..Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan...
  62. ncbi request reprint Reliability of NPT scoring and visual estimates of erectile fullness
    P I Campbell
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Sleep 10:480-5. 1987
    ..Thus, the gender of a technologist may affect visual estimates of erectile fullness during NPT assessment...
  63. ncbi request reprint Clinical diagnoses in 216 insomnia patients using the International Classification of Sleep Disorders (ICSD), DSM-IV and ICD-10 categories: a report from the APA/NIMH DSM-IV Field Trial
    D J Buysse
    Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania
    Sleep 17:630-7. 1994
    ..ICSD and DSM-IV sleep disorder diagnoses have similar patterns of use by experienced clinicians...
  64. ncbi request reprint Feasibility of a dyadic intervention for management of osteoarthritis: a pilot study with older patients and their spousal caregivers
    L M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, and University Center for Social and Urban Research, 121 University Place, Room 508, Pittsburgh, PA 15260, USA
    Aging Ment Health 7:53-60. 2003
    ..The findings of this pilot study point to the utility of a dyadic intervention approach to management of OA in late life...
  65. ncbi request reprint The relation of White Matter Hyperintensities to implicit learning in healthy older adults
    H J Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 17:664-9. 2002
    ....
  66. ncbi request reprint Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled study
    Carmen Andreescu
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
    Br J Psychiatry 190:344-9. 2007
    ..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment...
  67. ncbi request reprint Cognitive impairment in late-life generalized anxiety disorder
    Rose C Mantella
    Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 15:673-9. 2007
    ..This study sought to characterize cognitive functioning in elderly patients with generalized anxiety disorder (GAD), as compared with normal comparison subjects and patients with major depression...
  68. pmc Does depression, apathy or cognitive impairment reduce the benefit of inpatient rehabilitation facilities for elderly hip fracture patients?
    Eric J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, Advanced Center for Interventions and Services Research in Late Life Mood Disorders and John A Hartford Center of Excellence in Geriatric Psychiatry, PA 15213, USA
    Gen Hosp Psychiatry 29:141-6. 2007
    ....
  69. pmc Residual symptoms and recurrence during maintenance treatment of late-life depression
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Affect Disord 103:77-82. 2007
    ..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression...
  70. pmc The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
    Hillary R Bogner
    Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Geriatr Psychiatry 22:922-9. 2007
    ..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients...
  71. ncbi request reprint Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder
    Ariel G Gildengers
    Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 15:174-9. 2007
    ..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder...
  72. pmc Statistical analysis of longitudinal psychiatric data with dropouts
    Sati Mazumdar
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Psychiatr Res 41:1032-41. 2007
    ....
  73. ncbi request reprint Impact of prior treatment exposure on response to antidepressant treatment in late life
    James D Tew
    Advanced Center for Interventions and Services Research in Late Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:957-65. 2006
    ..The objective of this study was to describe the correlates of prior antidepressant exposure and its association with response to protocolized treatment in older patients with major depression...
  74. ncbi request reprint Cardiovascular changes associated with venlafaxine in the treatment of late-life depression
    Ellyn M Johnson
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:796-802. 2006
    ..Potential cardiovascular side effects from venlafaxine-XR must be considered when prescribing this medication, especially in geriatric patients, who often present with comorbid medical conditions...
  75. pmc Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  76. ncbi request reprint Effects of a brief behavioral treatment for late-life insomnia: preliminary findings
    Anne Germain
    Department Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Sleep Med 2:403-6. 2006
    ..This preliminary report addresses the effects of a brief behavioral treatment for insomnia in older adults who present with the typical psychiatric and medical comorbidities of aging...
  77. ncbi request reprint The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
    Helen Lavretsky
    UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:55-9. 2008
    ....
  78. ncbi request reprint The relationship of medical comorbidity and depression in older, primary care patients
    Jeffrey M Lyness
    Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
    Psychosomatics 47:435-9. 2006
    ..This generates the hypothesis that, in general primary care populations, the relationship of medical illness to depression may be multimodal and/or may involve shared pathobiological or psychosocial mechanisms...
  79. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
    ..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals...
  80. pmc Impact of close family members on older adults' early response to depression treatment
    Lynn M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Psychol Aging 23:447-52. 2008
    ..Future research may identify family attitudes and behaviors that stem from burden and compromise older adults' ability to recover from depression...
  81. doi request reprint The prevalence of mental and physical health disorders among older methadone patients
    Daniel Rosen
    University of Pittsburgh School of Social Work, Pittsburgh, PA 15260, USA
    Am J Geriatr Psychiatry 16:488-97. 2008
    ..The goal of this study was to assess the physical and mental health status of older methadone patients...
  82. pmc Preventing depression in later life: translation from concept to experimental design and implementation
    Roy Sriwattanakomen
    Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:460-8. 2008
    ..Special attention is given to the recruitment of African Americans because of well-documented inequalities in mental health services and depression treatment outcomes between races...
  83. pmc Impact of concurrent naturalistic pharmacotherapy on psychotherapy of complicated grief
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Psychiatry Res 159:31-6. 2008
    ..77%). Our naturalistic data underscore the need for prospective, randomized controlled studies of CG pharmacotherapy and psychotherapy alone and in combination...
  84. pmc Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  85. pmc Cognitive performance in suicidal depressed elderly: preliminary report
    Alexandre Y Dombrovski
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:109-15. 2008
    ..This study examined cognitive function in general and executive functioning specifically in depressed elderly with and without suicidal ideation and attempts...
  86. pmc Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and older
    Henry C Driscoll
    Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 16:74-82. 2008
    ....
  87. pmc Marital quality in the context of mild cognitive impairment
    Linda Garand
    University of Pittsburgh, Pittsburgh, PA, USA
    West J Nurs Res 29:976-92. 2007
    ..Results of this study suggest the need for mental health interventions designed to preserve the quality of these marital relationships...
  88. ncbi request reprint Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapy
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1325-32. 2007
    ..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression...
  89. ncbi request reprint The prevalence and correlates of psychiatric comorbidity in individuals with complicated grief
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, MA, USA
    Compr Psychiatry 48:395-9. 2007
    ..One issue that remains under debate is whether this condition can be clearly distinguished from other psychiatric disorders, such as major depression and posttraumatic stress disorder, with which CG frequently coexists...
  90. ncbi request reprint Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old age
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 14:550-4. 2006
    ..The objective of this study was to examine the relative speed of improvement in sleep disturbance and anxiety symptoms compared with core mood symptoms in acute treatment of late-life major depression...
  91. ncbi request reprint Persistence of neuropsychologic deficits in the remitted state of late-life depression
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:419-27. 2006
    ..Cognitive impairment in late-life depression (LLD) is prevalent, disabling, and persists despite the remission of depressive symptoms. This article characterizes neuropsychologic functioning during remission in LLD...
  92. pmc Paroxetine: population pharmacokinetic analysis in late-life depression using sparse concentration sampling
    Yan Feng
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA, and Rotman Research Institute, Baycrest Hospital, University of Toronto, Canada
    Br J Clin Pharmacol 61:558-69. 2006
    ..To develop a population pharmacokinetic (PK) model using sparse sampling of long-term treatment with paroxetine in elderly depressed subjects, incorporating CYP2D6 genotype as well as other covariates...
  93. ncbi request reprint Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles 90095, USA
    J Clin Psychiatry 64:1410-4. 2003
    ..We evaluated the potential of methylphenidate to accelerate antidepressant response to citalopram and the safety and tolerability of the combined treatment in patients with geriatric major depressive disorder...
  94. ncbi request reprint alpha1-acid glycoprotein in late-life depression: relationship to medical burden and genetics
    Opeolu M Adeoye
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Geriatr Psychiatry Neurol 16:235-9. 2003
    ..Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients...
  95. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  96. ncbi request reprint Confronting depression and suicide in physicians: a consensus statement
    Claudia Center
    Employment Law Center and the University of California, Hastings College of Law, San Francisco, USA
    JAMA 289:3161-6. 2003
    ..To encourage treatment of depression and prevention of suicide in physicians by calling for a shift in professional attitudes and institutional policies to support physicians seeking help...
  97. ncbi request reprint Occurrence and course of suicidality during short-term treatment of late-life depression
    Katalin Szanto
    Department of Psychiatry, The Intervention Research Center for the Study of Late Life Mood Disorders, Pittsburgh, PA, USA
    Arch Gen Psychiatry 60:610-7. 2003
    ....
  98. ncbi request reprint Career development and training in geriatric mental health: report of an NIMH workshop
    Jason T Olin
    National Institute of Mental Health, 6001 Executive Boulevard, Room 7160, MSC 9635, Bethesda, MD 20892 9635, USA
    Am J Geriatr Psychiatry 11:275-9. 2003
    ..Federal, public, and private mechanisms need to be better leveraged to grow late-life mental-illness research infrastructure and meet increasing demand and scientific opportunities...
  99. ncbi request reprint Clinically relevant behaviors in elderly hip fracture inpatients
    Helen H Dorra
    University of Pittsburgh School of Medicine, USA
    Int J Psychiatry Med 32:249-59. 2002
    ..To examine the range of behaviors documented by inpatient rehabilitation staff and the association of these behaviors with functional outcome, in elderly persons undergoing rehabilitation after hip fracture...
  100. ncbi request reprint Risk factors for falls during treatment of late-life depression
    Jin H Joo
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    J Clin Psychiatry 63:936-41. 2002
    ..This study evaluated the time course and potential risk factors for falls in a treatment protocol for late-life depression to identify specific at-risk periods and risk factors for falls in this population...