Research Topics
Species | C F ReynoldsSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 yearsC F Reynolds
The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
JAMA 281:39-45. 1999..Elderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability...- Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levelsC F Reynolds
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Psychiatry 156:1177-81. 1999..This study compared the long-term efficacy of two fixed plasma levels of nortriptyline in preventing or delaying recurrence of major depression in elderly patients and in minimizing residual depressive symptoms and somatic complaints... - Paroxetine treatment of depression in late lifeCharles F Reynolds
MHIRC for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA
Psychopharmacol Bull 37:123-34. 2003..With the significant personal and societal burden that is associated with major depression in the elderly, appropriate treatment is important and must be incorporated into standard practices by healthcare professionals... - Which elderly patients with remitted depression remain well with continued interpersonal psychotherapy after discontinuation of antidepressant medication?C F Reynolds
Mental Health Clinical Research Center for the Study of Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
Am J Psychiatry 154:958-62. 1997..This study was conducted to identify which elderly patients with remitted recurrent major depression remain well with maintenance interpersonal psychotherapy after discontinuation of active antidepressant medication (nortriptyline)... - Career development in old-age psychiatry: opportunities through the American Association for Geriatric PsychiatryCharles F Reynolds
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, E-1135, Pittsburgh, PA 15213, USA
Acad Psychiatry 31:105-6. 2007 - Depression and aging: a look to the futureC F Reynolds
Department of Psychiatry at the University of Pittsburgh School of Medicine, Pennsylvania, USA
Psychiatr Serv 50:1167-72. 1999.... 
Training future generations of mental health researchers: devising strategies for tough timesCharles F Reynolds
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Acad Psychiatry 31:152-9. 2007....- Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapyC F Reynolds
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213, USA
Am J Psychiatry 156:202-8. 1999..The authors tested the hypothesis that nortriptyline and interpersonal psychotherapy, alone and in combination, are superior to placebo in achieving remission of bereavement-related major depressive episodes... - Chronic depression in the elderly: approaches for preventionC F Reynolds
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Drugs Aging 18:507-14. 2001..Depression in old age is a major contributor to the global burden of illness-related disability, but it is extremely treatable if appropriate pharmacotherapy is prescribed and accepted by patients and their caregivers... - Treatment as usual (TAU) control practices in the PROSPECT Study: managing the interaction and tension between research design and ethicsC F Reynolds
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 16:602-8. 2001.... - High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depressionC F Reynolds
Mental Health Clinical Research Center for the Study of Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Am J Psychiatry 153:1418-22. 1996..Twenty-eight patients (17.7%) received inpatient care at some point during acute-phase treatment... - Temporal profiles of the course of depression during treatment. Predictors of pathways toward recovery in the elderlyM A Dew
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
Arch Gen Psychiatry 54:1016-24. 1997..Whether patients vary in their pathways toward those outcomes--and the extent to which such variation can be anticipated by patient characteristics prior to treatment--has not been empirically examined... - Subjective health measures and acute treatment outcomes in geriatric depressionE J Lenze
The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Int J Geriatr Psychiatry 16:1149-55. 2001..However, successful treatment for depression has been associated with improvement in self-rated health and other health measures... - Initial recovery patterns may predict which maintenance therapies for depression will keep older adults wellM A Dew
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Affect Disord 65:155-66. 2001..Patients' temporal patterns of acute treatment response may predict who requires which maintenance therapy to remain well... - PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disordersC C Meltzer
Department of Radiology, University of Pittsburgh, PA, USA
Am J Psychiatry 156:1871-8. 1999.... - Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderlyG M Bump
Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Depress Anxiety 13:38-44. 2001..Paroxetine and nortriptyline demonstrated similar efficacy in relapse and recurrence prevention in elderly depressed patients over an 18-month period... - Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depressionG S Smith
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
Am J Psychiatry 156:683-9. 1999.... - A double-blind randomized comparison of nortriptyline plus perphenazine versus nortriptyline plus placebo in the treatment of psychotic depression in late lifeB H Mulsant
Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Clin Psychiatry 62:597-604. 2001..To conduct the first randomized study comparing the efficacy of an antidepressant alone versus an antidepressant plus a neuroleptic in the treatment of late-life psychotic depression... - A twelve-week, double-blind, randomized comparison of nortriptyline and paroxetine in older depressed inpatients and outpatientsB H Mulsant
Intervention Research Center for the Study of Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 9:406-14. 2001.... - Complicated grief as a disorder distinct from bereavement-related depression and anxiety: a replication studyH G Prigerson
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Am J Psychiatry 153:1484-6. 1996..This study sought to confirm in an independent, nonclinical study group previous work which demonstrated that the symptoms of complicated grief were distinct from the symptoms of bereavement related depression and anxiety... - Effects of diagnosis on treatment recommendations in chronic insomnia--a report from the APA/NIMH DSM-IV field trialD J Buysse
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
Sleep 20:542-52. 1997..Site-related differences suggest a lack of consensus in how these disorders are conceptualized and treated... - Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depressionR D Nebes
Western Psychiatric Institute and Clinic, Thomas Detre Hall, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 158:878-84. 2001.... - Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depressionE M Whyte
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Am J Psychiatry 158:2074-6. 2001..Variations in the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism may influence the degree of activation. The authors examined the association among depression, platelet activation, and 5-HTTLPR genotype... - A longitudinal study of laboratory- and diary-based sleep measures in healthy "old old" and "young old" volunteersC C Hoch
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
Sleep 17:489-96. 1994..To our knowledge, this is the first longitudinal data set on sleep in the healthy old old... - Symptoms of stress and depression as correlates of sleep in primary insomniaM Hall
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
Psychosom Med 62:227-30. 2000..In the preliminary study described here, we evaluated the extent to which symptoms of stress and depression are associated with subjective sleep complaints and quantitative measures of sleep in individuals with chronic insomnia... - Traumatic grief as a risk factor for mental and physical morbidityH G Prigerson
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
Am J Psychiatry 154:616-23. 1997..The aim of this study was to confirm and extend the authors' previous work indicating that symptoms of traumatic grief are predictors of future physical and mental health outcomes... - Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correctionC C Meltzer
Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Brain Res 813:167-71. 1998..This finding, which is consistent with prior postmortem and in vivo studies, has both etiological and potential therapeutic implications for behavioral changes commonly observed in the elderly, including geriatric depression... - Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depressionB G Pollock
Intervention Research Center for Late Life Mood Disorders and the Geriatric Psychopharmacology Program, Graduate School of Public Health, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 23:587-90. 2000..Onset of response to nortriptyline was not affected. Allelic variation of 5-HTTLPR may contribute to the variable initial response of patients treated with a selective serotonin reuptake inhibitor... - Serum anticholinergicity in elderly depressed patients treated with paroxetine or nortriptylineB G Pollock
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Am J Psychiatry 155:1110-2. 1998..The authors' goal was to compare serum anticholinergicity of 61 elderly depressed patients randomly assigned to double-blind treatment with paroxetine (N=31) or nortriptyline (N=30)... - Pharmacological treatment of depression in older primary care patients: the PROSPECT algorithmB H Mulsant
Intervention Research Center for the Study of Late Life Mood Disorders, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 16:585-92. 2001..However, treatments that are often poorly tolerated by elderly patients are given lower priority than treatments more likely to be tolerated. Similarly, trials that are simpler to implement in primary care are favored... - Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI)D J Buysse
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
Sleep 14:331-8. 1991..Extremely healthy elderly subjects appear to adapt in their perception of objectively disturbed sleep... - Do nocturnal penile tumescence recordings alter electroencephalographic sleep?M E Thase
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
Sleep 10:486-90. 1987.... - Dual-task performance in depressed geriatric patientsR D Nebes
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Psychiatry Res 102:139-51. 2001.... - Longitudinal changes in diary- and laboratory-based sleep measures in healthy "old old" and "young old" subjects: a three-year follow-upC C Hoch
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Sleep 20:192-202. 1997..The current results are representative of healthy elderly; sleep would probably deteriorate earlier and more quickly in elderly with more serious health problems and heavier medication use... - Treatment outcome in suicidal vs. non-suicidal elderly patientsK Szanto
Intervention Research Center for the Study of Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Am J Geriatr Psychiatry 9:261-8. 2001..Our data suggest that elderly suicidal patients have an overall favorable treatment outcome. However, treatment response may be more brittle and may require the continuing use of adjunctive medications to prevent early relapse... - Protecting sleep quality in later life: a pilot study of bed restriction and sleep hygieneC C Hoch
The Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
J Gerontol B Psychol Sci Soc Sci 56:P52-9. 2001..The use of sleep hygiene was associated with initial improvement in daytime well-being, whereas bed restriction led to sustained improvements in sleep continuity and sleep depth... - Nocturnal penile tumescence in healthy 20- to 59-year-olds: a revisitC F Reynolds
Sleep Evaluation Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
Sleep 12:368-73. 1989..Maximum buckling force and maximum erectile fullness showed stability across the four decades of the Pittsburgh sample... - Patterns of sleep episodes in young and elderly adults during a 36-hour constant routineD J Buysse
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
Sleep 16:632-7. 1993..They also confirm the presence of sex differences in sleep patterns among the elderly and support the distinction between objective and subjective measures of sleepiness... - Concordance between habitual sleep times and laboratory recording schedulesC F Reynolds
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania
Sleep 15:571-5. 1992..We strongly recommend a policy of routinely including data on laboratory versus habitual sleep times in peer-reviewed publications... - The effect of patient and visit characteristics on diagnosis of depression in primary careJ S Harman
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Suite 430, Pittsburgh, PA, 15213, USA
J Fam Pract 50:1068. 2001..The purpose of our study was to determine if factors other than the patient' clinical presentation were associated with the likelihood of depression being recognized during a physician office visit... - Narrowing the gap in treatment of depressionJ S Harman
University of Pittsburgh School of Medicine, Pennsylvania, USA
Int J Psychiatry Med 31:239-53. 2001..The purpose of this study is to assess treatment rates in 1993-1994 and 1996-1997... - Trial design and informed consent for a clinic-based study with a treatment as usual control armH B Degenholtz
Department of Health Services Administration and Center for Bioethics and Health Law, University of Pittsburgh, 3708 5th Ave, Pittsburgh, PA 15213, USA
Ethics Behav 12:43-62. 2002..Our analysis reveals the tension between ethics and scientific integrity involved with using TAU as a control condition and the difficulty in designing high-quality research in a community-based setting... - Interpersonal psychotherapy for late-life depression: past, present, and futureM D Miller
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
J Psychother Pract Res 10:231-8. 2001..In addition, preliminary results using IPT combined with paroxetine in depressed elders reveals no difference in remission rates between cognitively intact and cognitively impaired depressed elders... - Accounting for covariate measurement error in a Cox model analysis of recurrence of depressionK Liu
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Psychiatr Res 35:177-85. 2001..In the depression data, these methods render comparable results that have less bias than the results when measurement error is ignored... - Managing late-life depression in primary care practice: a case study of the Health Specialist's roleH C Schulberg
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
Int J Geriatr Psychiatry 16:577-84. 2001..Evolution of this role and its rewards/stressors during the study's first year are described... - The association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future researchE J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
Am J Geriatr Psychiatry 9:113-35. 2001..The authors discuss how these findings inform current concepts of physical disability and discuss the implications for future intervention studies of late-life depression and anxiety disorders... - Traumatic grief treatment: a pilot studyM K Shear
Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
Am J Psychiatry 158:1506-8. 2001..The effects of a treatment program targeting debilitating grief symptoms were tested in a pilot study... - Cognitive and motor slowing in Alzheimer's disease and geriatric depressionR D Nebes
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
J Int Neuropsychol Soc 4:426-34. 1998..Thus, this study suggests that AD produces a slowing in both cognitive and motor processes, whereas depression results solely in a motor retardation... - Are buckling force measurements reliable in nocturnal penile tumescence studies?E A Nofzinger
Sleep and Chronobiology Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
Sleep 16:156-62. 1993.... - Morbidity of homebound versus inpatient elderly psychiatric patientsR Pasternak
University of Pittsburgh School of Medicine, Western Psychiatry Institute and Clinic, Pennsylvania, USA
Int Psychogeriatr 10:117-25. 1998..3%, nursing home placement in 9.2% and mortality in 8.4%. These preliminary data show that the HB group had psychiatric problems that were comparable to those of the IP group but were not as severely impaired... - Comparison of sleep-disordered breathing among healthy elderly in the seventh, eighth, and ninth decades of lifeC C Hoch
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
Sleep 13:502-11. 1990..4% of men versus 5.4% of women (chi 2 = 4.25, p less than 0.05). These data suggest that SDB increases with advancing age even in the healthy elderly and may be more marked in healthy men than women... - EEG sleep in African-American patients with major depression: a historical case control studyD E Giles
Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
Depress Anxiety 8:58-64. 1998..The pathological implications of these differences remained to be explored in careful prospective studies of African-American depressed patients and in well-characterized, racially matched normal control comparisons... - Comorbidity of depression and anxiety disorders in later lifeE J Lenze
Intervention Research Centers in Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Depress Anxiety 14:86-93. 2001..We also recommend directions for future research in the area of psychiatric comorbidity in late life... - The temptation of suicide: striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depressionA Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA PA 15213, USA
Psychol Med 42:1203-15. 2012..Thus, we tested whether, in late-life depression, changes in the basal ganglia were associated with suicide attempts and with increased delay discounting... - Electroencephalographic sleep of healthy children. Part II: Findings using automated delta and REM sleep measurement methodsP A Coble
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213
Sleep 10:551-62. 1987..Findings are discussed relative to those obtained in the same children using standard measurement methods... - Daily social rhythms in the elderly and their relation to objectively recorded sleepT H Monk
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213
Sleep 15:322-9. 1992.... - Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression?A G Gildengers
University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA
Psychol Med 43:801-11. 2013..We assessed IADLs using a criterion-referenced, performance-based instrument. We employed repeated-measures mixed-effects linear models to examine trajectory of cognitive function. We employed non-parametric tests for analysis of IADLs... - Subsyndromal depression and anxiety in older adults: health related, functional, cognitive and diagnostic implicationsJ W Kasckow
VA Pittsburgh MIRECC and Behavioral Health, 7180 Highland Dr 116a, Pittsburgh, PA 15206, USA
J Psychiatr Res 47:599-603. 2013.... - Gender-specific aging effects on the serotonin 1A receptorC Cidis Meltzer
Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15231, USA
Brain Res 895:9-17. 2001..Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan... - Reliability of NPT scoring and visual estimates of erectile fullnessP I Campbell
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
Sleep 10:480-5. 1987..Thus, the gender of a technologist may affect visual estimates of erectile fullness during NPT assessment... - Post-traumatic stress disorder symptoms in emotionally distressed individuals referred for a depression prevention intervention: relationship to problem-solving skillsJ Kasckow
VA Pittsburgh MIRECC and Behavioral Health, Pittsburgh, PA, USA
Int J Geriatr Psychiatry 27:1106-11. 2012..In addition, some reports have suggested that there are higher rates of PTSD in minority populations relative to Caucasians; thus we hypothesized that race would also predict problem-solving skills in these individuals... - Clinical diagnoses in 216 insomnia patients using the International Classification of Sleep Disorders (ICSD), DSM-IV and ICD-10 categories: a report from the APA/NIMH DSM-IV Field TrialD J Buysse
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania
Sleep 17:630-7. 1994..ICSD and DSM-IV sleep disorder diagnoses have similar patterns of use by experienced clinicians... - Feasibility of a dyadic intervention for management of osteoarthritis: a pilot study with older patients and their spousal caregiversL M Martire
Department of Psychiatry, University of Pittsburgh School of Medicine, and University Center for Social and Urban Research, 121 University Place, Room 508, Pittsburgh, PA 15260, USA
Aging Ment Health 7:53-60. 2003..The findings of this pilot study point to the utility of a dyadic intervention approach to management of OA in late life... - The relation of White Matter Hyperintensities to implicit learning in healthy older adultsH J Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Int J Geriatr Psychiatry 17:664-9. 2002.... - Statistical analysis of longitudinal psychiatric data with dropoutsSati Mazumdar
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
J Psychiatr Res 41:1032-41. 2007.... - Effect of comorbid anxiety on treatment response and relapse risk in late-life depression: controlled studyCarmen Andreescu
Western Psychiatric Institute and Clinic, 3811 O Hara Street, Room E 823, Pittsburgh, PA15213, USA
Br J Psychiatry 190:344-9. 2007..Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment... - Cognitive performance in suicidal depressed elderly: preliminary reportAlexandre Y Dombrovski
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:109-15. 2008..This study examined cognitive function in general and executive functioning specifically in depressed elderly with and without suicidal ideation and attempts... - Cardiovascular changes associated with venlafaxine in the treatment of late-life depressionEllyn M Johnson
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:796-802. 2006..Systematic monitoring of cardiovascular parameters during treatment with venlafaxine-XR should be strongly recommended, especially in the elderly... - Does depression, apathy or cognitive impairment reduce the benefit of inpatient rehabilitation facilities for elderly hip fracture patients?Eric J Lenze
Department of Psychiatry, University of Pittsburgh School of Medicine, Advanced Center for Interventions and Services Research in Late Life Mood Disorders and John A Hartford Center of Excellence in Geriatric Psychiatry, PA 15213, USA
Gen Hosp Psychiatry 29:141-6. 2007.... - Residual symptoms and recurrence during maintenance treatment of late-life depressionAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, United States
J Affect Disord 103:77-82. 2007..Our study assesses the impact of these residual symptoms on the risk of recurrence during maintenance treatment of late-life depression... - The relationship of medical comorbidity and depression in older, primary care patientsJeffrey M Lyness
Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
Psychosomatics 47:435-9. 2006..This generates the hypothesis that, in general primary care populations, the relationship of medical illness to depression may be multimodal and/or may involve shared pathobiological or psychosocial mechanisms... - The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT studyHillary R Bogner
Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Int J Geriatr Psychiatry 22:922-9. 2007..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients... - Impact of prior treatment exposure on response to antidepressant treatment in late lifeJames D Tew
Advanced Center for Interventions and Services Research in Late-Life Mood Disorders, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:957-65. 2006..Most TR and TI patients eventually respond, but TR patients may require more intensive and longer courses of treatment than TI and TN patients... - Cognitive functioning and instrumental activities of daily living in late-life bipolar disorderAriel G Gildengers
Advanced Center for Intervention and Services Research for Late Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 15:174-9. 2007..The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder... - Cognitive impairment in late-life generalized anxiety disorderRose C Mantella
Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Center of Excellence in Geriatric Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 15:673-9. 2007..This study sought to characterize cognitive functioning in elderly patients with generalized anxiety disorder (GAD), as compared with normal comparison subjects and patients with major depression... - Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorderRamin Saghafi
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
Int J Geriatr Psychiatry 22:1141-6. 2007..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life... - Effects of a brief behavioral treatment for late-life insomnia: preliminary findingsAnne Germain
Department Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Sleep Med 2:403-6. 2006..CONCLUSION: BBTI was associated with significant improvements in sleep measures and in daytime symptoms of anxiety and depression. BBTI appears to be a promising intervention for older adults with insomnia... - Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-BMeryl A Butters
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Alzheimer Dis Assoc Disord 22:261-8. 2008..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals... - Speed of improvement in sleep disturbance and anxiety compared with core mood symptoms during acute treatment of depression in old ageAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 14:550-4. 2006..CONCLUSIONS: Anxiety symptoms tend to persist in patients with late-life depression... - Impact of close family members on older adults' early response to depression treatmentLynn M Martire
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Psychol Aging 23:447-52. 2008..Future research may identify family attitudes and behaviors that stem from burden and compromise older adults' ability to recover from depression... 
The prevalence of mental and physical health disorders among older methadone patientsDaniel Rosen
University of Pittsburgh School of Social Work, Pittsburgh, PA 15260, USA
Am J Geriatr Psychiatry 16:488-97. 2008..The goal of this study was to assess the physical and mental health status of older methadone patients...- Preventing depression in later life: translation from concept to experimental design and implementationRoy Sriwattanakomen
Advanced Center for Interventions and Services Research for Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:460-8. 2008..Special attention is given to the recruitment of African Americans because of well-documented inequalities in mental health services and depression treatment outcomes between races... - Impact of concurrent naturalistic pharmacotherapy on psychotherapy of complicated griefNaomi M Simon
Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
Psychiatry Res 159:31-6. 2008..77%). Our naturalistic data underscore the need for prospective, randomized controlled studies of CG pharmacotherapy and psychotherapy alone and in combination... - Medical burden in late-life bipolar and major depressive disordersAriel G Gildengers
Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Am J Geriatr Psychiatry 16:194-200. 2008..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder... - Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful agers" 75 and olderHenry C Driscoll
Sleep and Chronobiology Program, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 16:74-82. 2008.... - Marital quality in the context of mild cognitive impairmentLinda Garand
University of Pittsburgh, Pittsburgh, PA, USA
West J Nurs Res 29:976-92. 2007..Results of this study suggest the need for mental health interventions designed to preserve the quality of these marital relationships... - Maintenance treatment for old-age depression preserves health-related quality of life: a randomized, controlled trial of paroxetine and interpersonal psychotherapyAlexandre Y Dombrovski
Western Psychiatric Institute and Clinic, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
J Am Geriatr Soc 55:1325-32. 2007..To determine whether maintenance antidepressant pharmacotherapy and interpersonal psychotherapy sustain gains in health-related quality of life (HR-QOL) achieved during short-term treatment in older patients with depression... - The prevalence and correlates of psychiatric comorbidity in individuals with complicated griefNaomi M Simon
Massachusetts General Hospital and Harvard Medical School, MA, USA
Compr Psychiatry 48:395-9. 2007..One issue that remains under debate is whether this condition can be clearly distinguished from other psychiatric disorders, such as major depression and posttraumatic stress disorder, with which CG frequently coexists... - The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot studyHelen Lavretsky
UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
Int J Geriatr Psychiatry 23:55-9. 2008.... - Persistence of neuropsychologic deficits in the remitted state of late-life depressionRishi K Bhalla
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Geriatr Psychiatry 14:419-27. 2006..In addition, a substantial proportion of older depressed individuals who are cognitively intact when depressed are likely to be impaired one year later, although their depression has remitted... - Paroxetine: population pharmacokinetic analysis in late-life depression using sparse concentration samplingYan Feng
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA, and Rotman Research Institute, Baycrest Hospital, University of Toronto, Canada
Br J Clin Pharmacol 61:558-69. 2006..The data indicate that female and male subjects with different CYP2D6 polymorphisms have different elimination rates and therefore may need to be dosed differently based on metabolizer genotype... - Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatmentStephen Blank
Intervention Research Center for Late-Life Mood Disorders, The Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 67:468-72. 2006..CONCLUSIONS: In this 32-week study of citalopram for elderly persons with anxiety disorders, 60% responded. Those who received a full course of treatment experience significant improvements in quality of life and sleep quality... - Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trialHelen Lavretsky
Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles 90095, USA
J Clin Psychiatry 64:1410-4. 2003..We evaluated the potential of methylphenidate to accelerate antidepressant response to citalopram and the safety and tolerability of the combined treatment in patients with geriatric major depressive disorder... - alpha1-acid glycoprotein in late-life depression: relationship to medical burden and geneticsOpeolu M Adeoye
Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA
J Geriatr Psychiatry Neurol 16:235-9. 2003..Frequency differences in ORM1 allelic variants apparently did not influence increased AAG concentrations in depressed patients... - Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late lifeDennis S Charney
National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Arch Gen Psychiatry 60:664-72. 2003.... - Confronting depression and suicide in physicians: a consensus statementClaudia Center
Employment Law Center and the University of California, Hastings College of Law, San Francisco, USA
JAMA 289:3161-6. 2003..As barriers are removed and physicians confront depression and suicidality in their peers, they are more likely to recognize and treat these conditions in patients, including colleagues and medical students... - Occurrence and course of suicidality during short-term treatment of late-life depressionKatalin Szanto
Department of Psychiatry, The Intervention Research Center for the Study of Late-Life Mood Disorders, Pittsburgh, PA, USA
Arch Gen Psychiatry 60:610-7. 2003..Suicidal elderly persons with depression require special attention during depression treatment because they have a lower response rate and need a longer time to respond... - Career development and training in geriatric mental health: report of an NIMH workshopJason T Olin
National Institute of Mental Health, 6001 Executive Boulevard, Room 7160, MSC 9635, Bethesda, MD 20892 9635, USA
Am J Geriatr Psychiatry 11:275-9. 2003..Federal, public, and private mechanisms need to be better leveraged to grow late-life mental-illness research infrastructure and meet increasing demand and scientific opportunities... - Clinically relevant behaviors in elderly hip fracture inpatientsHelen H Dorra
University of Pittsburgh School of Medicine, USA
Int J Psychiatry Med 32:249-59. 2002..It is recommended that staff observations be routinely added to mental health evaluations. Additionally, routine mental health screening and required staff documentation of behaviors would improve case detection rate... - Risk factors for falls during treatment of late-life depressionJin H Joo
Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
J Clin Psychiatry 63:936-41. 2002..Additionally, augmenting paroxetine with bupropion may also increase the risk of falls, and this medication combination should be used with caution in elderly patients... - Response speed and rate of remission in primary and specialty care of elderly patients with depressionLeslie Thomas
Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 10:583-91. 2002..CONCLUSION: Notwithstanding these differences in speed and rate of symptom resolution, good treatment can work well in geriatric depression in the primary care sector...