Research Topics
Genomes and Genes | OSVALDO A REYSummaryAffiliation: University of California Country: USA Publications
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Publications
Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epitheliumOsvaldo Rey
Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, CURE Digestive Diseases Research Center, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 287:1158-67. 2012..These studies demonstrate that signaling pathways emanating from the CaSR control colonic epithelial cell proliferation in vivo and suggest that the mechanism involves regulation of β-catenin phosphorylation...- Extracellular calcium sensing receptor stimulation in human colonic epithelial cells induces intracellular calcium oscillations and proliferation inhibitionOsvaldo Rey
Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, CURE, Digestive Diseases Research Center, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, California 90095 1786, USA
J Cell Physiol 225:73-83. 2010..Thus, these results indicate that the CaR can function in two signaling modes in human colonic epithelial cells offering a potential link between gastrointestinal responses and food/nutrients uptake and metabolism... 
Requirement of the TRPC1 cation channel in the generation of transient Ca2+ oscillations by the calcium-sensing receptorOsvaldo Rey
Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 900 Veteran Avenue, Los Angeles, CA 90095, USA
J Biol Chem 281:38730-7. 2006..We propose a model for the generation of CaR-mediated transient [Ca(2+)](i) oscillations that integrates its stimulation by aromatic amino acids with TRPC1 regulation by PKC and calmodulin...- The nuclear import of protein kinase D3 requires its catalytic activityOsvaldo Rey
Division of Digestive Diseases, Department of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1786, USA
J Biol Chem 281:5149-57. 2006.... - Amino acid-stimulated Ca2+ oscillations produced by the Ca2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeletonOsvaldo Rey
Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, UCLA CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California at Los Angeles, 90095, USA
J Biol Chem 280:22875-82. 2005..Our model envisages that Ca(2+) or amino acids stabilize unique CaR conformations that favor coupling to different G proteins and subsequent activation of distinct downstream signaling pathways... - G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase CepsilonOsvaldo Rey
Department of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
J Biol Chem 279:34361-72. 2004..Based on these and previous results, we propose a model of GPCR-mediated PKD regulation that integrates its changes in distribution, catalytic activity, and multisite phosphorylation... - Protein kinase D3 activation and phosphorylation by signaling through G alpha qJingzhen Yuan
Department of Medicine, David Geffen School of Medicine and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
Biochem Biophys Res Commun 335:270-6. 2005..Our results indicate that G alpha q activation is sufficient to stimulate sustained PKD3 activation and show that the endogenous G alpha q is a major component in the signaling pathway that mediates bombesin-induced PKD3 activation... - Activation of protein kinase D3 by signaling through Rac and the alpha subunits of the heterotrimeric G proteins G12 and G13Jingzhen Yuan
Department of Medicine, David Geffen School of Medicine and Molecular Biology Institute, University of California, 900 Veteran Ave, Warren Hall, Rm. 11-124, Los Angeles, CA 90095-1786, USA
Cell Signal 18:1051-62. 2006..Our results indicate that Galpha12/13 and Rac are important components in the signal transduction pathways that mediate bombesin receptor-induced PKD3 activation... - Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonistsOsvaldo Rey
Department of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095 1786, USA
J Biol Chem 278:23773-85. 2003..Thus, this study demonstrates that the intracellular distribution of PKD isoenzymes are distinct, and suggests that their signaling properties are regulated by differential localization... - Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylationRodrigo Jacamo
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 283:12877-87. 2008..The present studies identify a novel mechanism induced by GPCR activation that leads to late, PKC-independent PKD activation... - Insulin potentiates Ca2+ signaling and phosphatidylinositol 4,5-bisphosphate hydrolysis induced by Gq protein-coupled receptor agonists through an mTOR-dependent pathwayKrisztina Kisfalvi
Unit of Signal Transduction and Gastrointestinal Cancer, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles Center for Ulcer Research and Education, Los Angeles, California 90095 1786, USA
Endocrinology 148:3246-57. 2007.... 
Protein kinase D isozymes activation and localization during mitosisRomeo Papazyan
Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 90095 1786, USA
Exp Cell Res 314:3057-68. 2008..Thus, this study reveals a connection between the PKD isozymes and cell division, suggesting a novel role for this family of serine/threonine kinases...- Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2Steven H Young
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1786, USA
Am J Physiol Cell Physiol 298:C1401-13. 2010.... - Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutantsPaul Krogstad
Department of Pediatrics, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
Virology 294:282-8. 2002..Conservative amino acid differences between HXB2 and NL4-3 NCs were sufficient to explain the difference in infectivity of viruses carrying the R10A and K11A mutations... - Neurotensin induces protein kinase C-dependent protein kinase D activation and DNA synthesis in human pancreatic carcinoma cell line PANC-1Sushovan Guha
Department of Medicine, Division of Digestive Diseases, School of Medicine and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
Cancer Res 62:1632-40. 2002..Collectively our results demonstrate, for the first time, the existence of a functional PKC/PKD signaling pathway in human ductal pancreatic carcinoma cells and suggest that PKCs mediate the mitogenic signaling process initiated by NT... - Protein kinase D signalingEnrique Rozengurt
Department of Medicine, UCLA-CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Biol Chem 280:13205-8. 2005 - Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase DRichard T Waldron
Division of Digestive Diseases, Department of Medicine, UCLA David Geffen School of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, UCLA, Los Angeles, California 90095 1786, USA
J Biol Chem 279:27482-93. 2004..Taken together, these results indicate that PKC-mediated PKD Ser(744) and Ser(748) phosphorylation induced by oxidative stress integrates PKD activation with redistribution to the nucleus... - Effects of altered expression and localization of cyclophilin A on differentiation of p19 embryonic carcinoma cellsRobert Chiu
Dental Research Institute, UCLA School of Dentistry, Los Angeles, California 90095 1668, USA
Cell Mol Neurobiol 23:929-43. 2003..5. The evidence of enriched CypA and colocalization of RB with CypA in the nucleus of primary adult sensory neurons substantiated the important event of RB-mediated neuronal differentiation of p19 EC cells... - The C-terminal tail of protein kinase D2 and protein kinase D3 regulates their intracellular distributionRomeo Papazyan
Division of Digestive Diseases, Department of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California at Los Angeles, USA
Biochem Biophys Res Commun 342:685-9. 2006..Collectively, these data demonstrate that the short C-terminal tail of these kinases plays a critical role in determining their cytoplasmic/nuclear localization... - Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylationJames Sinnett-Smith
Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
J Biol Chem 284:13434-45. 2009..Thus, our results identify a novel mechanism of G(q)-coupled receptor-induced mitogenesis mediated by sustained PKD activation through a PKC-independent pathway... - Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonistsOsvaldo Rey
Division of Digestive Diseases, Department of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, 90095 1786, USA
Biochem Biophys Res Commun 302:817-24. 2003.... - CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathwayEugenia Torres-Marquez
Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE, Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095 1786, USA
Biochem Biophys Res Commun 391:63-8. 2010.... - Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos accumulation and DNA synthesis induced by bombesin in Swiss 3T3 cellsJames Sinnett-Smith
Division of Digestive Diseases, Department of Medicine, School of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
J Cell Physiol 211:781-90. 2007.... - Vasopressin-induced intracellular redistribution of protein kinase D in intestinal epithelial cellsOsvaldo Rey
Division of Digestive Diseases, Department of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California at Los Angeles, California, USA
J Cell Physiol 196:483-92. 2003..These findings provide evidence for a mechanism by which PKC coordinates in intestinal epithelial cells the translocation and activation of PKD in response to vasopressin-induced GPCR activation...
Research Grants
- SPATIAL AND TEMPORAL REGULATION OF PROTEIN KINASE DOsvaldo Rey; Fiscal Year: 2007..Our hypothesis is that the kinase activity of PKC regulates PKD by coordinating its catalytic activation and intracellular localization. ..
- Calcium Sensing Receptor Signaling in the Gastrointestinal TractOsvaldo Rey; Fiscal Year: 2007..We also anticipate that these mechanistic studies will be extended to normal colon epithelial cells and thus provide a robust base for the formulation of an R01 award application. ..