Research Topics
Genomes and Genes
| Marian RewersSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Celiac disease associated with type 1 diabetes mellitusMarian Rewers
Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, 4200 East 9th Avenue, B-140, Denver, CO 80262, USA
Endocrinol Metab Clin North Am 33:197-214, xi. 2004- Insulin sensitivity, insulinemia, and coronary artery disease: the Insulin Resistance Atherosclerosis StudyMarian Rewers
Barbara Davis Center, University of Colorado HSC, Denver, Colorado 80262, USA
Diabetes Care 27:781-7. 2004.... - Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease?Marian Rewers
Barbara Davis for Childhood Diabetes, University of Colorado School of Medicine, Denver, Colorado 802626 3110, USA
Gastroenterology 128:S47-51. 2005 - Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)Lars C Stene
Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045-6511, USA
Pediatr Diabetes 7:247-53. 2006..4, 95% confidence interval 1.02-1.8, per SD of 1.1 mmol/L). CONCLUSIONS: Normal but increasing Hb1Ac may be useful in early detection of type 1 diabetes, whereas random plasma glucose levels were less predictive... - Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)Jennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 89:3896-902. 2004..Predictive value of autoantibodies increases with blinded duplicate and independent sample retesting and incorporation of the level of autoantibody in the predictive algorithm... - Homozygosity for premature stop codon of the MHC class I chain-related gene A (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relativesAkane Ide
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 N Ursula Street, Aurora, Colorado, 80010, USA
J Clin Immunol 25:303-8. 2005..1 homozygosity suggesting that there are additional factors contributing to the marked risk of relatives compared to the general population with the DR3-DQ2/DR4-DQ8 genotype... 
Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetesKendra Vehik
University of Colorado Denver, School of Medicine, Denver, Colorado, USA
Diabetes Care 31:1392-6. 2008....- Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of diseaseJill M Norris
Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
JAMA 293:2343-51. 2005..While gluten ingestion is responsible for the signs and symptoms of celiac disease, it is not known what factors are associated with initial appearance of the disease... - Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) StudyDana Dabelea
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Diabetes 52:2833-9. 2003..In conclusion, gender differences in insulin resistance-associated fat distribution may explain why type 1 diabetes increases coronary calcification in women relatively more than in men... - Relationship between cystatin C and coronary artery atherosclerosis progression differs by type 1 diabetesDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
Diabetes Technol Ther 12:25-33. 2010..To expand on our previous report, we investigated whether the relationship of cystatin C to progression of coronary artery atherosclerosis (CA) differed between individuals with type 1 diabetes (T1D) and persons without diabetes... - Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal studyLars C Stene
Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045-6511, USA
Am J Gastroenterol 101:2333-40. 2006..CONCLUSIONS: This prospective study provides the first indication that a high frequency of rotavirus infections may increase the risk of celiac disease autoimmunity in childhood in genetically predisposed individuals... - Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesityJian Wang
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, PO Box 6511, Mail Stop B140, Aurora, Colorado 80045 6511, USA
J Clin Endocrinol Metab 92:88-92. 2007..A significant percentage of nonautoimmune forms of diabetes presents among children in all age groups, with a remarkable increase with age... - Determinants of serum adiponectin in persons with and without type 1 diabetesDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Am J Epidemiol 166:731-40. 2007..Although some of the difference can be explained, further study is needed to better understand the relation between elevated adiponectin levels and patient outcomes, including coronary heart disease... 
SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetesJanet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
Ann N Y Acad Sci 1150:256-9. 2008..We conclude that SLC30A8 provides an important additional and independent predictive marker for T1D...- Clinical features of children with screening-identified evidence of celiac diseaseEdward J Hoffenberg
Department of Pediatrics, Children s Hospital, and the University of Colorado School of Medicine, Denver, Colorado, USA
Pediatrics 113:1254-9. 2004..However, the clinical significance of a positive test remains uncertain. The objective of this study was to evaluate growth and clinical features of children who test positive for an autoantibody associated with CD... - Perinatal factors and development of islet autoimmunity in early childhood: the diabetes autoimmunity study in the youngLars C Stene
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Epidemiol 160:3-10. 2004..008. Other factors evaluated were not related to risk of islet autoimmunity. In conclusion, influences in utero or during delivery may affect the fetal immune system... - ACE-I/ARB treatment in type 1 diabetes patients with albuminuria is associated with lower odds of progression of coronary artery calcificationDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO, USA
J Diabetes Complications 21:273-9. 2007.... - Dietary glycemic index, development of islet autoimmunity, and subsequent progression to type 1 diabetes in young childrenMolly M Lamb
University of Colorado, Denver, Colorado 80262, USA
J Clin Endocrinol Metab 93:3936-42. 2008..Dietary factors may trigger or exacerbate the autoimmune disease process... - Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric populationKendra A Young
Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box B119, Denver, CO 80262, USA
Ann Rheum Dis 66:179-83. 2007..To examine perinatal and childhood risk factors for the presence of rheumatoid factor in healthy children... - Low plasma adiponectin levels predict progression of coronary artery calcificationDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
Circulation 111:747-53. 2005..However, it is not known whether low adiponectin levels predict development of atherosclerosis independently of other cardiovascular risk factors... - Impact of celiac autoimmunity on children with type 1 diabetesJill H Simmons
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado, USA
J Pediatr 150:461-6. 2007..Children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD); however, the benefits of screening for IgA tissue transglutaminase autoantibodies (TG), a marker for CD, are unclear... - Soluble interleukin-2 receptor as a marker for progression of coronary artery calcification in type 1 diabetesR Paul Wadwa
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, 80045, USA
Int J Biochem Cell Biol 38:996-1003. 2006.... - Evaluation of urinary biomarkers for coronary artery disease, diabetes, and diabetic kidney diseaseJanet K Snell-Bergeon
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, 80045, USA
Diabetes Technol Ther 11:1-9. 2009..In this study we sought to validate urinary biomarkers for diabetes and two common complications, coronary artery disease (CAD) and diabetic nephropathy (DN)... - Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosisAdam Kretowski
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
Diabetes 56:863-71. 2007.... - Lifestyle risk factors for atherosclerosis in adults with type 1 diabetesFranziska K Bishop
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, MS F527, Aurora, CO 80045, USA
Diab Vasc Dis Res 6:269-75. 2009..5, 95% CI: 2.5-5.0, p<0.0001). Differences exist in lifestyle-related cardiovascular risk factors in men and women with type 1 diabetes compared with non-diabetic subjects in the CACTI study... - Maternal diet during pregnancy and islet autoimmunity in offspringMolly M Lamb
Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
Pediatr Diabetes 9:135-41. 2008..The role of prenatal nutritional exposures has not been thoroughly investigated... - The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetesJanet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 104:17040-5. 2007..The combination of bioinformatics and molecular engineering used here will potentially generate other diabetes autoimmunity markers and is also broadly applicable to other autoimmune disorders... - Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimatesLisa M Emery
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
Pediatr Diabetes 6:136-44. 2005..To characterize the role of the HLA-DR,DQ genotype and ethnicity on the onset age of T1DM, we analyzed these factors in patients with T1DM and the general population... - Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetesGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
Autoimmun Rev 1:139-45. 2002..An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway... - Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritisShailaja S Bhatia
Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, 4200 East Ninth Avenue, Box B119, Denver, CO 80262, USA
Ann Rheum Dis 66:267-9. 2007..To examine whether oral contraceptive use is associated with the presence of serum rheumatoid factor in women of reproductive age without rheumatoid arthritis... - Reproductive history and hormonal birth control use are associated with coronary calcium progression in women with type 1 diabetes mellitusJanet K Snell-Bergeon
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
J Clin Endocrinol Metab 93:2142-8. 2008..Coronary artery disease is increased in women with type 1 diabetes (T1D), compared with nondiabetic (Non-DM) women. Women with T1D have more menstrual dysfunction and are less likely to use hormonal birth control (BC) than Non-DM women... - Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assaysNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
Diabetes Metab Res Rev 25:665-70. 2009..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay... - Lipoprotein subfraction cholesterol distribution is proatherogenic in women with type 1 diabetes and insulin resistanceDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 59:1771-9. 2010..We investigated differences in lipoprotein subfraction cholesterol distribution and insulin resistance between subjects with and without type 1 diabetes to better understand the etiology of increased CVD risk... - Is presence of islet autoantibodies at birth associated with development of persistent islet autoimmunity? The Diabetes Autoimmunity Study in the Young (DAISY)Heather M Stanley
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Diabetes Care 27:497-502. 2004..To determine whether the presence of islet autoantibodies in the umbilical cord blood is predictive of subsequent development of islet autoimmunity... - Prevalence and correlates of depression in individuals with and without type 1 diabetesNicole Gendelman
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes Care 32:575-9. 2009..We assessed the prevalence of depression and antidepressant medication use among adults with and without type 1 diabetes and the association between depression and diabetes complications... - Plasminogen activator inhibitor-1 is associated with coronary artery calcium in Type 1 diabetesKatherine A Pratte
Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, CO 80262, USA
J Diabetes Complications 23:387-93. 2009..It is not known if PAI-1 is associated with sub-clinical CAD in Type 1 diabetes or if this association is independent of IR... - Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetesDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, Mail Stop A140, Aurora, CO 80045, USA
Diabetes 56:2774-9. 2007.... - Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetesKendra A Young
Colorado School of Public Health, University of Colorado, Denver, Colorado, USA
Diabetes Care 34:454-8. 2011.... - Use of insulin glargine in children under age 6 with type 1 diabetesBrenner Dixon
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
Pediatr Diabetes 6:150-4. 2005..CONCLUSIONS: SH was decreased, particularly at night (from 12 episodes to one), after the introduction of glargine in young children with T1D... - Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodiesDavid T Robles
Barbara Davis Center, Department of Immunology, University of Colorado, Denver, Colorado 80262, USA
Clin Immunol 102:217-24. 2002..These results suggest that a high incidence and early appearance of islet autoantibodies for siblings of patients with type 1A diabetes are associated with DR3/4, DQB1*0302 and potentially increased with HLA-A genotype A1, A2... - Systematic shifts in cystatin C between 2006 and 2010David M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, PO Box 6511, Mail Stop A140, Aurora, CO 80045, USA
Clin J Am Soc Nephrol 6:1952-5. 2011..Our objective was to compare cystatin C results within the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study over time and in repeated measures to evaluate for assay drift... - Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groupsJennifer M Barker
Barbara Davis Center, University of Colorado Health Sciences Center, 4200 E 9th Ave, B140, Denver, CO 80262, USA
Diabetes Care 28:850-5. 2005..The objective of this study was to define the prevalence of these autoantibodies and clinical disease in a population with type 1 diabetes... - "Extended" A1, B8, DR3 haplotype shows remarkable linkage disequilibrium but is similar to nonextended haplotypes in terms of diabetes riskAkane Ide
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B140, Denver, CO 80262, USA
Diabetes 54:1879-83. 2005.... - Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic controlJanet K Snell-Bergeon
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Diabetes Care 26:2923-8. 2003.... - Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes autoimmunity study in the young (DAISY)Patricia M Graves
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Diabetes Res Clin Pract 59:51-61. 2003..Further study is needed to assess whether persistent or repeated EV infections occur frequently in individuals with beta-cell autoimmunity... - Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetesJill M Norris
Department of Preventive Medicine and Biostatistics, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
JAMA 298:1420-8. 2007..Cod liver oil supplements in infancy have been associated with a decreased risk of type 1 diabetes mellitus in a retrospective study... - Type 1 diabetes: chronic progressive autoimmune diseaseLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible... - Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assayLiping Yu
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 61:179-86. 2012..We hypothesize that factors related to the mechanism of loss of tolerance leading to diabetes determine high affinity and MSD-IAA reactivity... - Elevated C-reactive protein levels in the development of type 1 diabetesH Peter Chase
Department of Pediatrics, The Barbara Davis Center for Childhood Diabetes, Denver, Colorado, USA
Diabetes 53:2569-73. 2004..The elevated CRP levels may provide an additional marker for risk of progression to type 1 diabetes... - Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variabilityJohn E Hokanson
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, 4200 E Ninth Ave, B 119, Denver, CO 80262, USA
AJR Am J Roentgenol 182:1327-32. 2004..The transformation that stabilized the variation in calcium volume scores was applied to progression of calcium volume scores in 109 subjects with diabetes... - Redefining the clinical remission period in children with type 1 diabetesH Peter Chase
University of Colorado Health Sciences Center, Denver, CO 80262, USA
Pediatr Diabetes 5:16-9. 2004..To redefine the clinical remission period for different aged children receiving the current standard of diabetes care... - Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-upJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Box B140, Denver, CO 80262
Diabetes Care 27:1399-404. 2004..The objective of this study was to determine whether earlier diagnosis of diabetes in prospectively followed autoantibody-positive children lowered onset morbidity and improved the clinical course after diagnosis... - Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youthKendra Vehik
University of Colorado School of Medicine, Denver, Colorado, USA
Diabetes Care 30:503-9. 2007.... - Awareness and treatment of dyslipidemia in young adults with type 1 diabetesR Paul Wadwa
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B140, Denver, CO 80262, USA
Diabetes Care 28:1051-6. 2005..In this report, we describe the prevalence of dyslipidemia and adequacy of pharmacological treatment in patients with type 1 diabetes and comparable nondiabetic subjects... - Susceptibility to type 1 diabetes is associated with ApoCIII gene haplotypesJohn E Hokanson
Department of Preventive Medicine and Biometrics, Box B119, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Diabetes 55:834-8. 2006..00, 0.97, and 0.73, respectively; P = 0.03). This haplotype block contains an insulin response element. Screening for this haplotype may identify at-risk individuals, and this pathway may offer a target for prevention of type 1 diabetes... - Reduced heart rate variability predicts progression of coronary artery calcification in adults with type 1 diabetes and controls without diabetesTiciana C Rodrigues
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
Diabetes Technol Ther 12:963-9. 2010..Reduced heart rate variability (HRV) is a manifestation of cardiac autonomic neuropathy, a known complication of type 1 diabetes (T1D). We evaluated whether HRV predicted coronary artery calcium (CAC) progression... - Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetesTaylor M Triolo
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
J Clin Endocrinol Metab 94:4517-23. 2009..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D... - Epidemiology of type 1 Diabetes MellitusMarian Rewers
Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, USA
Adv Exp Med Biol 552:219-46. 2004..Current research effort is focused on identification of the genetic and environmental determinants of this process and the ways they interact... - Symptoms of common maternal infections in pregnancy and risk of islet autoimmunity in early childhoodLars C Stene
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Diabetes Care 26:3136-41. 2003..CONCLUSIONS: Symptoms of maternal infections in pregnancy predicted a significantly lower risk of islet autoimmunity in young girls, suggesting a protective effect of such infections... - A prospective study of the incidence of childhood celiac diseaseEdward J Hoffenberg
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, USA
J Pediatr 143:308-14. 2003..00-10.9, P=.048). Evidence of CD was not observed before age 2.6 years. CONCLUSIONS: Celiac disease may affect 0.9% of Denver children by 5 years of age. Children positive for the HLA-DR3 allele and females appear to be at increased risk... - Antibodies to the wheat storage globulin Glo-3A in children before and at diagnosis of celiac diseaseCraig E Taplin
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, USA
J Pediatr Gastroenterol Nutr 52:21-5. 2011..Antibodies to wheat storage globulin Glo-3A have been studied in type 1 diabetes, and may be a marker of altered mucosal barrier and/or immune function. In the present study, we investigated antibody responses to Glo-3A in CD... - Reduced hypoglycemic episodes and improved glycemic control in children with type 1 diabetes using insulin glargine and neutral protamine Hagedorn insulinH Peter Chase
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado, USA
J Pediatr 143:737-40. 2003..The numbers of nonsevere and severe hypoglycemic events, hemoglobin A1c values, body weight, and daily insulin dose were recorded at each clinic visit... - Dyslipidemia in youth with diabetes: to treat or not to treat?David M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
J Pediatr 153:458-65. 2008 - Assessment and monitoring of glycemic control in children and adolescents with diabetesMarian Rewers
Barbara Davis Center, University of Colorado Denver, Aurora, CO, USA
Pediatr Diabetes 8:408-18. 2007 - Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease?Edwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Gastroenterology 128:S33-7. 2005.... - Predictors of acute complications in children with type 1 diabetesArleta Rewers
Pediatric Emergency Medicine, Department of Pediatrics, University of Colorado, School of Medicine, The Children s Hospital, Denver, CO 80218, USA
JAMA 287:2511-8. 2002..Diabetic ketoacidosis and severe hypoglycemia are acute complications of type 1 diabetes that are related, respectively, to insufficient or excessive insulin treatment. However, little is known about additional modifiable risk factors... - HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY populationErin E Baschal
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045 6511, USA
Diabetes 56:2405-9. 2007.... - Association of the PTPN22/LYP gene with type 1 diabetesAndrea K Steck
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO, USA
Pediatr Diabetes 7:274-8. 2006..The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene in non-Hispanic whites (NHWs) and Hispanics from Colorado... - A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetesJohn E Hokanson
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Diabetes 51:1208-13. 2002..In conclusion, the LIPC-480C>T polymorphism was associated with subclinical CHD in type 1 diabetes. This genetic variant may identify subjects in which early intervention to prevent CHD may be appropriate... - Timing of initial cereal exposure in infancy and risk of islet autoimmunityJill M Norris
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver 80262, USA
JAMA 290:1713-20. 2003..Dietary exposures in infancy have been implicated, albeit inconsistently, in the etiology of type 1 diabetes mellitus (DM)... - Timing of initial exposure to cereal grains and the risk of wheat allergyJill A Poole
Division of Allergy and Clinical Immunology, Department of Medicine and Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
Pediatrics 117:2175-82. 2006..The aim of this study was to examine the association between cereal-grain exposures (wheat, barley, rye, oats) in the infant diet and development of wheat allergy... - The rising tide of childhood type 1 diabetes--what is the elusive environmental trigger?Marian Rewers
Barbara Davis Center, Denver, Denver, Colorado, USA
Lancet 364:1645-7. 2004 - Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's diseasePeter R Baker
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
J Clin Endocrinol Metab 95:E263-70. 2010..Multiple autoimmune disorders (e.g. Addison's disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of additional genes in linkage disequilibrium with HLA-DRB1 contribute to disease... - Association of non-HLA genes with type 1 diabetes autoimmunityAndrea K Steck
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
Diabetes 54:2482-6. 2005..Genes involved in the IL-4 regulatory pathway (IL-4, IL-4R, IL-13) may confer susceptibility or protection to type 1 diabetes depending on individual SNPs or specific haplotypes... - Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?Andrea K Steck
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 58:1028-33. 2009..We examined whether some of these alleles influence development of islet autoimmunity or progression from persistent islet autoimmunity to type 1 diabetes in children with high-risk HLA-DR,DQ genotypes... - Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetesTheresa A Aly
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue B 140, Denver, CO 80262, USA
J Autoimmun 25:40-5. 2005..These results highlight the multiplicative risk of combined high-risk genotypes at different loci in terms of time to autoantibody and autoimmune disease development... - Hypertension prevalence, awareness, treatment, and control in an adult type 1 diabetes population and a comparable general populationDavid M Maahs
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Denver, CO 80262, USA
Diabetes Care 28:301-6. 2005..To compare the prevalence, awareness, treatment, and control of hypertension in a population-representative sample of adults with type 1 diabetes and comparable nondiabetic control subjects... - Secondary attack rate of type 1 diabetes in Colorado familiesAndrea K Steck
Barbara Davis Center for Childhood Diabetes University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B 140, Denver, CO 80262, USA
Diabetes Care 28:296-300. 2005..No U.S. population-specific life-table risk estimates are currently available for parents, and those for siblings (2-6% by age 20 years) are based on family studies completed before 1987... - Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac diseaseEdwin Liu
Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, and Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
J Pediatr Gastroenterol Nutr 45:293-300. 2007..A new generation of anti-gliadin antibody assays has been developed to detect synthetic, deamidated homologous gliadin peptides (DGP) with high sensitivity and specificity... - Fluctuating transglutaminase autoantibodies are related to histologic features of celiac diseaseEdwin Liu
Section of Pediatric Gastroenterology, Hepatology and Nutrition, Roche Molecular Systems, Alameda, CA, USA
Clin Gastroenterol Hepatol 1:356-62. 2003..We have followed a group of children with serial testing for TGAA... - Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screeningJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Coloradoat Denver, Colorado, USA
Diabetes 57:3152-5. 2008..We sought to find an inexpensive, rapid test to identify DR3/4-DQ8 subjects using two single nucleotide polymorphisms (SNPs)... - ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodiesDongmei Miao
Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver 80262, USA
J Autoimmun 18:191-6. 2002.... - Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complexTheresa A Aly
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 6511, USA
Diabetes 57:770-6. 2008..Our goal was to search for non-DR/DQ MHC genetic determinants that cause the additional risk in the DR3/4-DQ8 siblings who share both MHC haplotypes... - Multi-SNP analysis of MHC region: remarkable conservation of HLA-A1-B8-DR3 haplotypeTheresa A Aly
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Mail Stop B140, P.O. Box 6511, Aurora, CO 80045-6511, USA
Diabetes 55:1265-9. 2006..1 AH, since individuals who carry this haplotype provide no information about the differential effects of the alleles that are present on this haplotype... - Need for quantitative assessment of transglutaminase autoantibodies for celiac disease in screening-identified childrenEdwin Liu
Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Pediatr 146:494-9. 2005..Multicenter workshops are needed to identify critical differences and to standardize TGAA assays among laboratories... - Cardiovascular disease mortality in Hispanics and non-Hispanic whitesCarolyn J Swenson
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Epidemiol 156:919-28. 2002..43 (95% CI: 0.21, 0.91). A statistically significant decreased risk of CVD death was observed only in male Hispanics with diabetes. Competing mortality or factors that interact with diabetes may explain these differences... - Inflammatory markers and diabetic retinopathy in type 1 diabetesKenneth E Izuora
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B-140, Denver, CO, USA
Diabetes Care 28:714-5. 2005 - Urinary F2-isoprostanes in young healthy children at risk for type 1 diabetes mellitusLaura D Kauffman
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Free Radic Biol Med 35:551-7. 2003..Normal values in this healthy population can be used as the basis for future studies of disease mechanisms involving oxidative stress... - Differences in LDL oxidizability by glycemic status: the insulin resistance atherosclerosis studyDawn C Schwenke
Carl T Hayden Veterans Affairs Medical Center, Phoenix, Arizona 85012, USA
Diabetes Care 26:1449-55. 2003..To investigate differences in LDL oxidizability by glycemic status within the Insulin Resistance Atherosclerosis Study cohort... - TEDDY--The Environmental Determinants of Diabetes in the Young: an observational clinical trialWilliam A Hagopian
Pacific Northwest Research Institute, Seattle, WA 98122, USA
Ann N Y Acad Sci 1079:320-6. 2006..8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study... - Extreme genetic risk for type 1A diabetesTheresa A Aly
Barbara Davis Center for Childhood Diabetes and Human Medical Genetics Program, University Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 103:14074-9. 2006..A subset of siblings at extremely high risk for T1D can now be identified at birth for trials to prevent islet autoimmunity... - Health-related quality of life of children and adolescents with type 1 or type 2 diabetes mellitus: SEARCH for Diabetes in Youth StudyMichelle J Naughton
Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, 2000 W First St, Winston Salem, NC 27104, USA
Arch Pediatr Adolesc Med 162:649-57. 2008..To examine the associations between demographic and diabetes management variables and the health-related quality of life (HRQOL) of youths with type 1 or type 2 diabetes mellitus (DM)...
Research Grants
- GENETIC AND ENVIRONMENTAL CAUSES OF CELIAC DISEASEMarian Rewers; Fiscal Year: 2006..Assess the clinical impact of seropositivity for TG IgA in screening detected cases on intestinal mucosa morphology, intestinal permeability, growth and development, bone mineralization and micronutrient deficiencies. ..
- Environmental Causes of Type 1 DiabetesMarian Rewers; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbe_ Face Page ....................................................................................................................................... 1 Description, ..
- The 10th Symposium of the International Diabetes Epidemiology GroupMarian Rewers; Fiscal Year: 2006....
- Natural History of Pre-diabetic Autoimmunity (DAISY)Marian Rewers; Fiscal Year: 2007..abstract_text> ..
- GENETIC AND ENVIRONMENTAL CAUSES OF CELIAC DISEASEMarian Rewers; Fiscal Year: 2007..4. Assess the impact of seropositivity for TG IgA on intestinal mucosa morphology, intestinal permeability,growth and development, bone mineralization and micronutrient deficiencies in screening detected children with and without T1D. ..
- Determinants of Accelerated CVD in Type 1 DiabetesMarian Rewers; Fiscal Year: 2007....
- Coronary Artery Calcification in Type 1 DiabetesMarian Rewers; Fiscal Year: 2007..project, called Coronary Artery Calcification in Type 1 Diabetes (CACTI) study began in 2000 (R01 HL61753, Marian Rewers, P.I.)...
- GENETIC AND ENVIRONMENTAL CAUSES OF CELIAC DISEASEMarian Rewers; Fiscal Year: 1999..Identification of additional environmental and genetic causes of CD will significantly increase prevention opportunities for this as well as other autoimmune diseases. ..
- SUBCLINICAL HEART DISEASE IN INSULIN-DEPENDENT DIABETESMarian Rewers; Fiscal Year: 2003..This proposed study will better define the causes of increased heart disease risk in IDDM patients, develop appropriate screening methods, and set the stage for effective primary prevention. ..
- Viral Triggers of Type 1 DiabetesMarian Rewers; Fiscal Year: 2003..support to establish formal collaboration between the Diabetes Autoimmunity Study in the Young (R01 DK32493, Marian Rewers P.I., University of Colorado) and the Virus Identification and Discovery Program (Drs...
- GENETIC AND ENVIRONMENTAL CAUSES OF CELIAC DISEASEMarian J Rewers; Fiscal Year: 2010..Assess the impact of seropositivity for TG IgA on intestinal mucosa morphology, intestinal permeability,growth and development, bone mineralization and micronutrient deficiencies in screening detected children with and without T1D. ..