Marian Rewers

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Challenges in diagnosing type 1 diabetes in different populations
    Marian Rewers
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
    Diabetes Metab J 36:90-7. 2012
  2. pmc The next big idea
    Marian Rewers
    Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Diabetes Technol Ther 15:S2-29-S2-36. 2013
  3. doi request reprint The fallacy of reduction
    Marian Rewers
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Pediatr Diabetes 13:340-3. 2012
  4. pmc Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes
    Melissa Simpson
    Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA
    Cardiovasc Diabetol 10:99. 2011
  5. pmc Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY)
    Lars C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Diabetes 59:3174-80. 2010
  6. ncbi request reprint Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045 6511, USA
    Pediatr Diabetes 7:247-53. 2006
  7. pmc Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes
    Kendra Vehik
    University of Colorado Denver, School of Medicine, Denver, Colorado, USA
    Diabetes Care 31:1392-6. 2008
  8. ncbi request reprint Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:3896-902. 2004
  9. ncbi request reprint Homozygosity for premature stop codon of the MHC class I chain-related gene A (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relatives
    Akane Ide
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 N Ursula Street, Aurora, Colorado, 80010, USA
    J Clin Immunol 25:303-8. 2005
  10. ncbi request reprint Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045 6511, USA
    Am J Gastroenterol 101:2333-40. 2006

Collaborators

Detail Information

Publications78

  1. pmc Challenges in diagnosing type 1 diabetes in different populations
    Marian Rewers
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
    Diabetes Metab J 36:90-7. 2012
    ..This review summarizes evidence that may be helpful in diagnosing T1D in various ethnic groups. Challenges in interpretation of results commonly used to determine the type of diabetes are highlighted...
  2. pmc The next big idea
    Marian Rewers
    Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Diabetes Technol Ther 15:S2-29-S2-36. 2013
    ..Despite his tremendous contributions to our understanding of the natural history of pre-type 1 diabetes and potential mechanisms, George left us with several big questions to answer before his quest is completed...
  3. doi request reprint The fallacy of reduction
    Marian Rewers
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Pediatr Diabetes 13:340-3. 2012
    ..However, there is hardly any evidence that insulin resistance can cause development of islet autoimmunity, thus be responsible for the ongoing pandemic of type 1 diabetes in children...
  4. pmc Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes
    Melissa Simpson
    Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA
    Cardiovasc Diabetol 10:99. 2011
    ..We hypothesized that the Hp genotype would predict progression of coronary artery calcification (CAC), a marker of subclinical atherosclerosis...
  5. pmc Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY)
    Lars C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Diabetes 59:3174-80. 2010
    ..To investigate whether enterovirus infections predict progression to type 1 diabetes in genetically predisposed children repeatedly positive for islet autoantibodies...
  6. ncbi request reprint Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO 80045 6511, USA
    Pediatr Diabetes 7:247-53. 2006
    ..The aim of this study was to assess the utility of hemoglobin A1c (HbA1c) measurements in the early detection of clinical type 1 diabetes during prospective follow-up of children with islet autoimmunity...
  7. pmc Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes
    Kendra Vehik
    University of Colorado Denver, School of Medicine, Denver, Colorado, USA
    Diabetes Care 31:1392-6. 2008
    ....
  8. ncbi request reprint Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 89:3896-902. 2004
    ..Predictive value of autoantibodies increases with blinded duplicate and independent sample retesting and incorporation of the level of autoantibody in the predictive algorithm...
  9. ncbi request reprint Homozygosity for premature stop codon of the MHC class I chain-related gene A (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relatives
    Akane Ide
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 N Ursula Street, Aurora, Colorado, 80010, USA
    J Clin Immunol 25:303-8. 2005
    ..1 homozygosity suggesting that there are additional factors contributing to the marked risk of relatives compared to the general population with the DR3-DQ2/DR4-DQ8 genotype...
  10. ncbi request reprint Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045 6511, USA
    Am J Gastroenterol 101:2333-40. 2006
    ..We investigated whether increased frequency of rotavirus infection, a common cause of gastrointestinal infection and inflammation, predicts increased risk of celiac disease autoimmunity...
  11. doi request reprint SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Ann N Y Acad Sci 1150:256-9. 2008
    ..We conclude that SLC30A8 provides an important additional and independent predictive marker for T1D...
  12. ncbi request reprint Determinants of serum adiponectin in persons with and without type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Epidemiol 166:731-40. 2007
    ..Although some of the difference can be explained, further study is needed to better understand the relation between elevated adiponectin levels and patient outcomes, including coronary heart disease...
  13. pmc Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI study
    Irene E Schauer
    Department of Medicine, University of Colorado Denver, Aurora, USA
    Diabetes 60:306-14. 2011
    ..To assess insulin action on peripheral glucose utilization and nonesterified fatty acid (NEFA) suppression as a predictor of coronary artery calcification (CAC) in patients with type 1 diabetes and nondiabetic controls...
  14. pmc Early-life predictors of higher body mass index in healthy children
    Molly M Lamb
    Department of Epidemiology, University of Colorado Denver, Aurora, 80045, USA
    Ann Nutr Metab 56:16-22. 2010
    ..Prospective analyses may better define the pathways between early life factors and greater childhood body mass index (BMI), a measure of obesity...
  15. pmc Lipoprotein-associated phospholipase A₂ activity predicts progression of subclinical coronary atherosclerosis
    Gregory L Kinney
    The Barbara Davis Center for Childhood Diabetes, Aurora, Colorado, USA
    Diabetes Technol Ther 13:381-7. 2011
    ..Levels of Lp-PLA₂ in type 1 diabetes are not known, nor is the relationship between Lp-PLA₂ and progression of coronary calcification...
  16. pmc Relationship between cystatin C and coronary artery atherosclerosis progression differs by type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Diabetes Technol Ther 12:25-33. 2010
    ..To expand on our previous report, we investigated whether the relationship of cystatin C to progression of coronary artery atherosclerosis (CA) differed between individuals with type 1 diabetes (T1D) and persons without diabetes...
  17. pmc The importance of palmitoleic acid to adipocyte insulin resistance and whole-body insulin sensitivity in type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045
    J Clin Endocrinol Metab 98:E40-50. 2013
    ..Our previous report implicated skeletal muscle and liver insulin resistance in people with type 1 diabetes, but this occurred independently of generalized, visceral, or ectopic fat...
  18. pmc Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes
    Bryan C Bergman
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, P O Box 6511, MS 8106, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 97:1663-72. 2012
    ..It is unclear whether insulin resistance is due to glucose toxicity in the post-Diabetes Control and Complications Trial era of tighter glucose control...
  19. pmc Evaluation of urinary biomarkers for coronary artery disease, diabetes, and diabetic kidney disease
    Janet K Snell-Bergeon
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, 80045, USA
    Diabetes Technol Ther 11:1-9. 2009
    ..In this study we sought to validate urinary biomarkers for diabetes and two common complications, coronary artery disease (CAD) and diabetic nephropathy (DN)...
  20. ncbi request reprint Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity
    Jian Wang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, PO Box 6511, Mail Stop B140, Aurora, Colorado 80045 6511, USA
    J Clin Endocrinol Metab 92:88-92. 2007
    ..A significant percentage of nonautoimmune forms of diabetes presents among children in all age groups, with a remarkable increase with age...
  21. ncbi request reprint ACE-I/ARB treatment in type 1 diabetes patients with albuminuria is associated with lower odds of progression of coronary artery calcification
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO, USA
    J Diabetes Complications 21:273-9. 2007
    ....
  22. doi request reprint Lifestyle risk factors for atherosclerosis in adults with type 1 diabetes
    Franziska K Bishop
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, MS F527, Aurora, CO 80045, USA
    Diab Vasc Dis Res 6:269-75. 2009
    ..5, 95% CI: 2.5-5.0, p<0.0001). Differences exist in lifestyle-related cardiovascular risk factors in men and women with type 1 diabetes compared with non-diabetic subjects in the CACTI study...
  23. ncbi request reprint Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes
    George S Eisenbarth
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
    Autoimmun Rev 1:139-45. 2002
    ..An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway...
  24. ncbi request reprint Impact of celiac autoimmunity on children with type 1 diabetes
    Jill H Simmons
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado, USA
    J Pediatr 150:461-6. 2007
    ..Children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD); however, the benefits of screening for IgA tissue transglutaminase autoantibodies (TG), a marker for CD, are unclear...
  25. pmc Reproductive history and hormonal birth control use are associated with coronary calcium progression in women with type 1 diabetes mellitus
    Janet K Snell-Bergeon
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Clin Endocrinol Metab 93:2142-8. 2008
    ..Coronary artery disease is increased in women with type 1 diabetes (T1D), compared with nondiabetic (Non-DM) women. Women with T1D have more menstrual dysfunction and are less likely to use hormonal birth control (BC) than Non-DM women...
  26. pmc Prevalence and correlates of depression in individuals with and without type 1 diabetes
    Nicole Gendelman
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 32:575-9. 2009
    ..We assessed the prevalence of depression and antidepressant medication use among adults with and without type 1 diabetes and the association between depression and diabetes complications...
  27. pmc Lipoprotein subfraction cholesterol distribution is proatherogenic in women with type 1 diabetes and insulin resistance
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 59:1771-9. 2010
    ..We investigated differences in lipoprotein subfraction cholesterol distribution and insulin resistance between subjects with and without type 1 diabetes to better understand the etiology of increased CVD risk...
  28. ncbi request reprint Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, Mail Stop A140, Aurora, CO 80045, USA
    Diabetes 56:2774-9. 2007
    ....
  29. doi request reprint Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
    Diabetes Metab Res Rev 25:665-70. 2009
    ..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay...
  30. pmc Erythrocyte membrane omega-3 fatty acid levels and omega-3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY)
    Melissa R Miller
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Campus Box B119, Aurora, CO 80045, USA
    Pediatr Diabetes 12:669-75. 2011
    ..We investigated whether omega-3 fatty acid intake and erythrocyte membrane omega-3 fatty acid levels are associated with conversion to type 1 diabetes in children with islet autoimmunity (IA)...
  31. pmc Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates
    Lisa M Emery
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO, USA
    Pediatr Diabetes 6:136-44. 2005
    ..To characterize the role of the HLA-DR,DQ genotype and ethnicity on the onset age of T1DM, we analyzed these factors in patients with T1DM and the general population...
  32. ncbi request reprint Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes
    Petter Bjornstad
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO Electronic address
    J Diabetes Complications 28:298-304. 2014
    ..SUA is also inversely associated with IS in non-diabetics, but has not been examined in type 1 diabetes. We hypothesized SUA would be associated with reduced IS in adolescents and adults with type 1 diabetes...
  33. pmc Obesity and coronary artery calcium in diabetes: the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study
    Ticiana C Rodrigues
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    Diabetes Technol Ther 13:991-6. 2011
    ..The aim was to examine whether excess weight is associated with coronary artery calcium (CAC), independent of metabolic parameters in adults with type 1 diabetes (T1D)...
  34. doi request reprint Plasminogen activator inhibitor-1 is associated with coronary artery calcium in Type 1 diabetes
    Katherine A Pratte
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, CO 80262, USA
    J Diabetes Complications 23:387-93. 2009
    ..It is not known if PAI-1 is associated with sub-clinical CAD in Type 1 diabetes or if this association is independent of IR...
  35. ncbi request reprint Soluble interleukin-2 receptor as a marker for progression of coronary artery calcification in type 1 diabetes
    R Paul Wadwa
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, 80045, USA
    Int J Biochem Cell Biol 38:996-1003. 2006
    ....
  36. ncbi request reprint Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis
    Adam Kretowski
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 56:863-71. 2007
    ....
  37. pmc The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    Janet M Wenzlau
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 104:17040-5. 2007
    ..The combination of bioinformatics and molecular engineering used here will potentially generate other diabetes autoimmunity markers and is also broadly applicable to other autoimmune disorders...
  38. pmc Systematic shifts in cystatin C between 2006 and 2010
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, PO Box 6511, Mail Stop A140, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 6:1952-5. 2011
    ..Our objective was to compare cystatin C results within the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study over time and in repeated measures to evaluate for assay drift...
  39. ncbi request reprint Perinatal factors and development of islet autoimmunity in early childhood: the diabetes autoimmunity study in the young
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Epidemiol 160:3-10. 2004
    ..008. Other factors evaluated were not related to risk of islet autoimmunity. In conclusion, influences in utero or during delivery may affect the fetal immune system...
  40. doi request reprint Maternal diet during pregnancy and islet autoimmunity in offspring
    Molly M Lamb
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    Pediatr Diabetes 9:135-41. 2008
    ..The role of prenatal nutritional exposures has not been thoroughly investigated...
  41. pmc GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes
    Dongmei Miao
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado
    Diabetes 62:4174-8. 2013
    ..In conclusion, the new ECL assay identifies disease-relevant GADA by radioassay. It may help to improve the prediction and correct diagnosis of T1D among subjects positive only for GADA and no other islet autoantibodies. ..
  42. ncbi request reprint Awareness and treatment of dyslipidemia in young adults with type 1 diabetes
    R Paul Wadwa
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B140, Denver, CO 80262, USA
    Diabetes Care 28:1051-6. 2005
    ..In this report, we describe the prevalence of dyslipidemia and adequacy of pharmacological treatment in patients with type 1 diabetes and comparable nondiabetic subjects...
  43. pmc Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
    ..We hypothesize that factors related to the mechanism of loss of tolerance leading to diabetes determine high affinity and MSD-IAA reactivity...
  44. pmc Adiponectin dysregulation and insulin resistance in type 1 diabetes
    Rocio I Pereira
    University of Colorado, Anschutz Medical Campus, Division of Endocrinology, MS 8106, Aurora, Colorado 80045 0511, USA
    J Clin Endocrinol Metab 97:E642-7. 2012
    ..Whether the expected positive correlation between adiponectin and insulin sensitivity is preserved in a T1D population is unknown...
  45. pmc Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease
    Ticiana C Rodrigues
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 33:2471-3. 2010
    ..To examine uric acid (UA) as a possible predictor of the progression of coronary artery calcification (CAC) using data from the prospective Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study...
  46. pmc Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study
    Diana I Jalal
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA
    Nephrol Dial Transplant 25:1865-9. 2010
    ..Recent studies suggest that uric acid is a mediator of diabetic nephropathy. We hypothesized that elevated serum uric acid levels are a strong predictor of albuminuria in patients with type 1 diabetes...
  47. ncbi request reprint Use of insulin glargine in children under age 6 with type 1 diabetes
    Brenner Dixon
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Pediatr Diabetes 6:150-4. 2005
    ..The purpose of this study is to evaluate the use of insulin glargine (Lantus in children under age 6 with type 1 diabetes (T1D)...
  48. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
    ..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible...
  49. pmc Reduced heart rate variability predicts progression of coronary artery calcification in adults with type 1 diabetes and controls without diabetes
    Ticiana C Rodrigues
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Technol Ther 12:963-9. 2010
    ..Reduced heart rate variability (HRV) is a manifestation of cardiac autonomic neuropathy, a known complication of type 1 diabetes (T1D). We evaluated whether HRV predicted coronary artery calcium (CAC) progression...
  50. doi request reprint Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young
    Jill M Norris
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, 13001 E 17th Place, Campus Box B119, Aurora, CO, 80045, USA
    Diabetologia 57:295-304. 2014
    ..We hypothesise that specific n-3 fatty acids and genetic markers contribute synergistically to this increased risk of IA in the Diabetes Autoimmunity Study in the Young (DAISY)...
  51. ncbi request reprint Symptoms of common maternal infections in pregnancy and risk of islet autoimmunity in early childhood
    Lars C Stene
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes Care 26:3136-41. 2003
    ..The aim of this study was to test whether symptoms of maternal infections during pregnancy and indicators of postnatal infections predict development of islet autoimmunity in children at genetically increased risk of type 1 diabetes...
  52. ncbi request reprint Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes
    Petter Bjornstad
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO
    J Clin Hypertens (Greenwich) 16:283-8. 2014
    ..A positive association was observed between serum uric acid and systolic blood pressure in nondiabetic adults. In contrast, an inverse relationship was demonstrated after multivariable adjustments in type 1 diabetes. ..
  53. pmc Evidence of stage- and age-related heterogeneity of non-HLA SNPs and risk of islet autoimmunity and type 1 diabetes: the diabetes autoimmunity study in the young
    Brittni N Frederiksen
    Colorado School of Public Health, University of Colorado, 13001 E 17th Place, Box B119, Aurora, CO 80045, USA
    Clin Dev Immunol 2013:417657. 2013
    ..This prospective investigation of non-HLA T1D candidate loci shows that some SNPs may exhibit stage- and age-related heterogeneity in the etiology of T1D. ..
  54. ncbi request reprint Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth
    Kendra Vehik
    University of Colorado School of Medicine, Denver, Colorado, USA
    Diabetes Care 30:503-9. 2007
    ....
  55. pmc Antibodies to the wheat storage globulin Glo-3A in children before and at diagnosis of celiac disease
    Craig E Taplin
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, USA
    J Pediatr Gastroenterol Nutr 52:21-5. 2011
    ..Antibodies to wheat storage globulin Glo-3A have been studied in type 1 diabetes, and may be a marker of altered mucosal barrier and/or immune function. In the present study, we investigated antibody responses to Glo-3A in CD...
  56. ncbi request reprint "Extended" A1, B8, DR3 haplotype shows remarkable linkage disequilibrium but is similar to nonextended haplotypes in terms of diabetes risk
    Akane Ide
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box B140, Denver, CO 80262, USA
    Diabetes 54:1879-83. 2005
    ....
  57. pmc Impaired renal function further increases odds of 6-year coronary artery calcification progression in adults with type 1 diabetes: the CACTI study
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 36:2607-14. 2013
    ....
  58. pmc Association between vitamin D metabolism gene polymorphisms and risk of islet autoimmunity and progression to type 1 diabetes: the diabetes autoimmunity study in the young (DAISY)
    Brittni N Frederiksen
    MPH, PhD, Colorado School of Public Health, 13001 East 17th Place, Box B119, Aurora, Colorado 80045
    J Clin Endocrinol Metab 98:E1845-51. 2013
    ..Studies of vitamin D metabolism genes may elucidate the role of vitamin D in complex diseases...
  59. pmc Early childhood infections and the risk of islet autoimmunity: the Diabetes Autoimmunity Study in the Young (DAISY)
    Janet K Snell-Bergeon
    Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
    Diabetes Care 35:2553-8. 2012
    ..The association of reported illnesses during infancy and later development of islet autoimmunity (IA) were examined in the Diabetes Autoimmunity Study in the Young...
  60. ncbi request reprint Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease?
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Gastroenterology 128:S33-7. 2005
    ....
  61. ncbi request reprint Low plasma adiponectin levels predict progression of coronary artery calcification
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Circulation 111:747-53. 2005
    ..However, it is not known whether low adiponectin levels predict development of atherosclerosis independently of other cardiovascular risk factors...
  62. pmc Dyslipidemia in youth with diabetes: to treat or not to treat?
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    J Pediatr 153:458-65. 2008
  63. ncbi request reprint Celiac disease associated with type 1 diabetes mellitus
    Marian Rewers
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
    Endocrinol Metab Clin North Am 33:197-214, xi. 2004
  64. ncbi request reprint Assessment and monitoring of glycemic control in children and adolescents with diabetes
    Marian Rewers
    Barbara Davis Center, University of Colorado Denver, Aurora, CO, USA
    Pediatr Diabetes 8:408-18. 2007
  65. pmc Lessons learned from a lipid lowering trial in adolescents with type 1 diabetes
    Franziska K Bishop
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Mail Stop F527, Aurora, CO, 80045, USA
    Int J Pediatr Endocrinol 2012:24. 2012
    ..Based on our experience, future studies will require multiple centers to enroll a sufficient number of participants for adequate data to direct dyslipidemia medication treatment guidelines for adolescents with type 1 diabetes...
  66. ncbi request reprint Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease?
    Marian Rewers
    Barbara Davis for Childhood Diabetes, University of Colorado School of Medicine, Denver, Colorado 802626 3110, USA
    Gastroenterology 128:S47-51. 2005
  67. pmc Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals
    Natalie Nokoff
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Ann N Y Acad Sci 1281:1-15. 2013
    ..Current risk-stratification models for T1D take into account genetic risk factors and autoantibodies. In the future, metabolic profiles, epigenetics, as well as environmental risk factors may be included in such models...
  68. pmc Genetic determinants of 21-hydroxylase autoantibodies amongst patients of the Type 1 Diabetes Genetics Consortium
    Peter Baker
    Barbara Davis Center for Childhood Diabetes, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 97:E1573-8. 2012
    ..Screening for 21OH-AA in newly diagnosed T1DM patients is a valuable prognostic tool, made stronger when MHC genotype is considered...
  69. ncbi request reprint ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies
    Dongmei Miao
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver 80262, USA
    J Autoimmun 18:191-6. 2002
    ....
  70. pmc Erythrocyte membrane fatty acid content in infants consuming formulas supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): an observational study
    Melissa R Miller
    Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado 80045, USA
    Matern Child Nutr 6:338-46. 2010
    ..81 versus 4.45, P = 0.008) than infants drinking breast milk. In infants whose mothers did not receive any dietary advice, use of supplemented formula is associated with higher omega-3 and lower omega-6 fatty acid status...
  71. doi request reprint The epidemic of type 1 diabetes: what is it telling us?
    Gregory P Forlenza
    Department of Pediatrics, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 18:248-51. 2011
    ..The incidence of T1D in children is increasing worldwide at a rate that cannot be explained by genetics alone. This review explores the recent research regarding possible causes of this epidemic...
  72. ncbi request reprint A prospective study of the incidence of childhood celiac disease
    Edward J Hoffenberg
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, USA
    J Pediatr 143:308-14. 2003
    ..To estimate the frequency of celiac disease (CD) in children in the general population of Denver, Colorado...
  73. ncbi request reprint Asymptomatic circulation of HEV71 in Norway
    Elisabet Witsø
    Norwegian Institute of Public Health, Oslo, Norway
    Virus Res 123:19-29. 2007
    ..Complete sequencing of this strain, HEV71 804/NO/03, revealed differences in the 5'UTR and polymerase with respect to more pathogenic genotypes that may explain its reduced neurovirulence...
  74. ncbi request reprint Reduced hypoglycemic episodes and improved glycemic control in children with type 1 diabetes using insulin glargine and neutral protamine Hagedorn insulin
    H Peter Chase
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado, USA
    J Pediatr 143:737-40. 2003
    ..The numbers of nonsevere and severe hypoglycemic events, hemoglobin A1c values, body weight, and daily insulin dose were recorded at each clinic visit...
  75. ncbi request reprint The interplay of autoimmunity and insulin resistance in type 1 diabetes
    Natalie J Nokoff
    Department of Pediatrics and Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Discov Med 13:115-22. 2012
    ..Further studies are needed to define environmental factors causing T1D as well as the role of insulin resistance in the pathogenesis of T1D and its complications...
  76. ncbi request reprint Epidemiology of type 1 Diabetes Mellitus
    Marian Rewers
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Health Sciences Center, Denver, USA
    Adv Exp Med Biol 552:219-46. 2004
    ..Current research effort is focused on identification of the genetic and environmental determinants of this process and the ways they interact...
  77. pmc Effectiveness of an informational video method to improve enrollment and retention of a pediatric cohort
    Patricia Gesualdo
    University of Colorado Denver, The Barbara Davis Center for Childhood Diabetes 1775 Aurora Court, Campus Box F 527, Aurora, CO 80045, United States
    Contemp Clin Trials 33:273-8. 2012
    ..The objective of this analysis was to evaluate the use of an informational video in the enrollment and retention of eligible participants at the Colorado TEDDY clinical center...