Jane E B Reusch

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Type 2 diabetes mellitus and exercise impairment
    Jane E B Reusch
    Denver VA Medical Center, Clermont Street, Denver, CO 80220, USA
    Rev Endocr Metab Disord 14:77-86. 2013
  2. pmc Cardiovascular disease in diabetes: where does glucose fit in?
    Jane E B Reusch
    Denver VA Medical Center, Clermont Street, Denver, Colorado 80220, USA
    J Clin Endocrinol Metab 96:2367-76. 2011
  3. pmc Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome
    Cecilia C Low Wang
    Endocrine Section, VA Medical Center, Denver, and University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, USA
    J Diabetes Complications 27:307-15. 2013
  4. pmc Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells
    Chrystelle V Garat
    Cardiovascular Pulmonary Research, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Campus Box B 133, Denver, CO 80262, USA
    Mol Cell Biol 26:4934-48. 2006
  5. ncbi request reprint Rosiglitazone improves exercise capacity in individuals with type 2 diabetes
    Judith G Regensteiner
    Division of Internal Medicine, Center for Women s Health Research, Box B 180, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Diabetes Care 28:2877-83. 2005
  6. ncbi request reprint Skeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes
    Timothy A Bauer
    Division of Cardiology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Diabetes Care 30:2880-5. 2007
  7. ncbi request reprint SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway
    Dhara Vaishnav
    Division of Endocrinology, Department of Medicine, 4200 East Ninth Avenue, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochem Biophys Res Commun 307:855-60. 2003
  8. ncbi request reprint Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells
    Purevsuren Jambal
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:23055-65. 2003
  9. ncbi request reprint Thiazolidinedione therapy: the benefits of aggressive and early use in type 2 diabetes
    Jane E B Reusch
    Denver Research Institute, Denver Veterans Administration Medical Center, Denver, CO, USA
    Diabetes Technol Ther 5:685-93. 2003
  10. ncbi request reprint Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles
    Peter A Watson
    Denver Research Institute, Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center, 1055 Clermont Street, Denver, CO 80220, USA
    Endocrinology 143:2922-9. 2002

Collaborators

Detail Information

Publications26

  1. pmc Type 2 diabetes mellitus and exercise impairment
    Jane E B Reusch
    Denver VA Medical Center, Clermont Street, Denver, CO 80220, USA
    Rev Endocr Metab Disord 14:77-86. 2013
    ..Understanding the molecular details of endothelial dysfunction in diabetes may provide specific therapeutic targets for the remediation of this defect. Rat models to test this hypothesis are under study...
  2. pmc Cardiovascular disease in diabetes: where does glucose fit in?
    Jane E B Reusch
    Denver VA Medical Center, Clermont Street, Denver, Colorado 80220, USA
    J Clin Endocrinol Metab 96:2367-76. 2011
    ..Recent prospective clinical trials have failed to confirm a unique benefit from normalization of glycemia on cardiovascular disease outcomes, despite evidence from basic vascular biology, epidemiological, and cohort studies...
  3. pmc Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome
    Cecilia C Low Wang
    Endocrine Section, VA Medical Center, Denver, and University of Colorado Anschutz Medical Campus School of Medicine, Aurora, CO, USA
    J Diabetes Complications 27:307-15. 2013
    ..Accordingly, we utilized a porcine dietary model of metabolic syndrome without atherosclerosis to investigate early abnormalities of vascular function and signaling...
  4. pmc Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells
    Chrystelle V Garat
    Cardiovascular Pulmonary Research, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Campus Box B 133, Denver, CO 80262, USA
    Mol Cell Biol 26:4934-48. 2006
    ..These results indicate that in addition to direct phosphorylation, proteolysis and intracellular localization are key mechanisms regulating CREB content and activity in SMCs...
  5. ncbi request reprint Rosiglitazone improves exercise capacity in individuals with type 2 diabetes
    Judith G Regensteiner
    Division of Internal Medicine, Center for Women s Health Research, Box B 180, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Diabetes Care 28:2877-83. 2005
    ..We hypothesized that administration of a thiazolidinedione (TZD) agent would improve exercise capacity in type 2 diabetes...
  6. ncbi request reprint Skeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes
    Timothy A Bauer
    Division of Cardiology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Diabetes Care 30:2880-5. 2007
    ....
  7. ncbi request reprint SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway
    Dhara Vaishnav
    Division of Endocrinology, Department of Medicine, 4200 East Ninth Avenue, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochem Biophys Res Commun 307:855-60. 2003
    ..SB203580, an inhibitor of p38 MAPK, partially blocked SP600125-mediated activation of CREB. These observations suggest that SP600125 could be used as a small molecular weight activator of CREB...
  8. ncbi request reprint Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells
    Purevsuren Jambal
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:23055-65. 2003
    ..Together, these results point to CREB as a novel target for strategies aimed at improving the survival of beta-cells...
  9. ncbi request reprint Thiazolidinedione therapy: the benefits of aggressive and early use in type 2 diabetes
    Jane E B Reusch
    Denver Research Institute, Denver Veterans Administration Medical Center, Denver, CO, USA
    Diabetes Technol Ther 5:685-93. 2003
    ..This paper reviews the rationale and evidence for early combination therapy including a thiazolidinedione in improving glycemic control, and considers the potential for such aggressive therapy in reducing diabetic complications...
  10. ncbi request reprint Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles
    Peter A Watson
    Denver Research Institute, Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center, 1055 Clermont Street, Denver, CO 80220, USA
    Endocrinology 143:2922-9. 2002
    ..Thus, both in vitro and in vivo loss of CREB content and activity and subsequent accumulation of PDGFRalpha may contribute to SMC activation during diabetes...
  11. pmc Impaired contractile recovery after low-flow myocardial ischemia in a porcine model of metabolic syndrome
    Janice V Huang
    Cardiology Section, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Am J Physiol Heart Circ Physiol 304:H861-73. 2013
    ..Contributory mechanisms may include remodeling of cardiolipin, abnormal activation of Akt, and excessive utilization of fatty acid substrates...
  12. pmc CREB downregulation in vascular disease: a common response to cardiovascular risk
    Irene E Schauer
    Department of Medicine, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO, USA
    Arterioscler Thromb Vasc Biol 30:733-41. 2010
    ....
  13. ncbi request reprint Atherosclerosis in diabetes and insulin resistance
    Jane E B Reusch
    Research Service of Department of Veterans Affairs, and Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Diabetes Obes Metab 9:455-63. 2007
    ....
  14. ncbi request reprint Oral L-arginine and vitamins E and C improve endothelial function in women with type 2 diabetes
    Judith G Regensteiner
    Department of Medicine, Division of Internal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Vasc Med 8:169-75. 2003
    ..No significant changes in the responses of controls from pre to post vitamin administration were observed. We concluded that administration of two types of oral agents improved measures of endothelial function in people with T2DM...
  15. pmc Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity
    Kristen J Nadeau
    Division of Pediatric Endocrinology, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 94:3687-95. 2009
    ..Cardiopulmonary fitness, a marker of morbidity and mortality, is abnormal in adults with T2D, yet the mechanisms are incompletely understood...
  16. doi request reprint Women with type 2 diabetes perceive harder effort during exercise than nondiabetic women
    Amy G Huebschmann
    Division of General Internal Medicine, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Appl Physiol Nutr Metab 34:851-7. 2009
    ..Harder perceived effort during exercise may be a barrier to physical activity for those with T2D...
  17. pmc Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function
    Kristen J Nadeau
    AssistantUniversity of Colorado Health Sciences Center, The Children s Hospital, Department of Pediatric Endocrinology B265, 13123 East 16th Avenue, Aurora, Colorado 80045, USA
    J Clin Endocrinol Metab 95:513-21. 2010
    ..The phenotype of IR in T1D youth was unique, suggesting a pathophysiology that is different from T2D, yet may adversely affect long-term cardiovascular outcomes...
  18. ncbi request reprint Cardiovascular risk in women with type 2 diabetes
    Suzanne L Brandenburg
    Division of General Internal Medicine, Department of Medicine, University of Colorado Health Sciences Center, Box B 180, 4200 East 9th Avenue, Denver, CO 80262, USA
    Med Clin North Am 87:955-69. 2003
    ....
  19. pmc Nonesterified fatty acid exposure activates protective and mitogenic pathways in vascular smooth muscle cells by alternate signaling pathways
    Irene E Schauer
    Denver Research Institute, Denver Veterans Administration Medical Center, Denver, CO 80220, USA
    Metabolism 58:319-27. 2009
    ....
  20. pmc Diabetes and cardiovascular disease: changing the focus from glycemic control to improving long-term survival
    Cecilia C Low Wang
    University of Colorado Anschutz Medical Campus, Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, Aurora, Colorado, and Denver Veterans Affairs Medical Center, Denver, Colorado 80045, USA
    Am J Cardiol 110:58B-68B. 2012
    ....
  21. ncbi request reprint Novel actions of thiazolidinediones on vascular function and exercise capacity
    Jane E B Reusch
    Denver Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    Am J Med 115:69S-74S. 2003
    ..Preliminary data suggest that TZDs improve measures of cardiac function and exercise capacity, and investigators are assessing the impact of treatment with rosiglitazone on exercise capacity in an ongoing clinical trial...
  22. ncbi request reprint Loss of CREB regulation of vascular smooth muscle cell quiescence in diabetes
    Jane E B Reusch
    Associate Professor of Medicine, University of Colorado, Staff Endocrinologist, Denver VA Medical Center, American Federation for Medical Research, Colorado, USA
    Rev Endocr Metab Disord 5:209-19. 2004
  23. ncbi request reprint Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons
    Subbiah Pugazhenthi
    The Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    J Neurochem 84:982-96. 2003
    ..These findings demonstrate that loss of CREB function contributes to oxidative stress-induced neuronal dysfunction...
  24. ncbi request reprint Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
    Joseph T Crossno
    Pulmonary and Critical Care Services, Veterans Affairs Medical Center, Denver, USA
    Am J Physiol Lung Cell Mol Physiol 292:L885-97. 2007
    ..However, this agent fails to block the development of PH, apparently because of its inability to repress sustained Rho kinase-mediated arterial vasoconstriction...
  25. pmc Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose?
    Jane E B Reusch
    Section of Endocrinology 111H, Veterans Affairs Medical Center, 1055 Clermont Street, Denver, Colorado 80220, USA
    J Clin Invest 112:986-8. 2003
    ..Inhibitors of PARP may have potential therapeutic roles in the prevention of diabetic complications...
  26. ncbi request reprint Current concepts in insulin resistance, type 2 diabetes mellitus, and the metabolic syndrome
    Jane E B Reusch
    Denver Veterans Affairs Medical Center, 1055 Clairmont Street, M C 111 H, Denver, CO 80220, USA
    Am J Cardiol 90:19G-26G. 2002
    ..Studies have shown that enhancing insulin sensitivity with insulin sensitizers, such as thiazolidinediones, may improve insulin resistance and limit the development of adverse cardiovascular consequences...