Research Topics
| V I ReusSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Varenicline: new treatment with efficacy in smoking cessationVictor I Reus
Department of Psychiatry, University of California School of Medicine, San Francisco, California 94143 0984, USA
Drugs Today (Barc) 43:65-75. 2007..Its targeted mechanism of action, superior efficacy and excellent tolerability make varenicline a welcome and useful addition to the therapeutic options for smoking cessation...
Multimodal techniques for smoking cessation: a review of their efficacy and utilisation and clinical practice guidelinesV I Reus
Department of Psychiatry, University of California School of Medicine, Langley Porter Neuropsychiatric Institute, San Francisco, CA 94143 0984, USA
Int J Clin Pract 62:1753-68. 2008..This paper reviews current recommendations for smoking cessation and the efficacy of pharmacotherapy and behavioural modification techniques, used either alone or in combination, for smoking cessation...- Mood management and nicotine gum in smoking treatment: a therapeutic contact and placebo-controlled studyS M Hall
Department of Psychology, University of California, San Francisco, USA
J Consult Clin Psychol 64:1003-9. 1996..History-positive smokers may be best treated by interventions providing additional support and contact, independent of therapeutic content... - Repeated psychological stress testing in stimulant-dependent patientsDebra S Harris
Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:669-77. 2005..Although less convincing because of the heterogeneity of the subjects, they also suggest that HPA axis responsivity is not clearly linked to acute stress-induced stimulant craving or affective response... - Development of major depression after treatment for smoking cessationJ Y Tsoh
Department of Psychiatry, University of California, San Francisco 94143, USA
Am J Psychiatry 157:368-74. 2000..Case studies suggest cigarette abstinence may precipitate a major depressive episode. This study examined the incidence and predictors of major depression in the 12 months after treatment for smoking cessation... - Double-blind treatment of major depression with dehydroepiandrosteroneO M Wolkowitz
Department of Psychiatry, University of California Medical Center, San Francisco, USA
Am J Psychiatry 156:646-9. 1999..This study was designed to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans... - Immunogenicity and smoking-cessation outcomes for a novel nicotine immunotherapeuticD K Hatsukami
Department of Psychiatry, University of Minnesota Tobacco Use Programs, Minneapolis, Minnesota, USA
Clin Pharmacol Ther 89:392-9. 2011..Its further development as a treatment for nicotine dependence is therefore justified... - DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled studyO M Wolkowitz
Department of Psychiatry, Center for Neurobiology and Psychiatry, University of California San Francisco UCSF School of Medicine, USA
Neurology 60:1071-6. 2003..To compare the efficacy and tolerability of dehydroepiandrosterone (DHEA) vs placebo in AD... - Stress hormone-related psychopathology: pathophysiological and treatment implicationsO M Wolkowitz
Department of Psychiatry, University of California, School of Medicine, San Francisco, USA
World J Biol Psychiatry 2:115-43. 2001..We then review certain clinical manifestations of such hormonal imbalances and discuss pharmacological and behavioural treatment strategies aimed at normalizing hormonal output and lessening psychiatric and physical pathology... - Movement disorder, memory, psychiatric symptoms and serum DHEA levels in schizophrenic and schizoaffective patientsD S Harris
Department of Psychiatry, Box CPR 0984, University of California, San Francisco Medical Center, 401 Parnassus Ave, San Francisco, CA 94143 0984, USA
World J Biol Psychiatry 2:99-102. 2001.... - Antiglucocorticoid drugs in the treatment of depressionV I Reus
Department of Psychiatry, Center on Neurobiology and Behavior, University of California, San Francisco, School of Medicine, 401 Parnassus Avenue, Box F 0984, CA 94143 0984, USA
Expert Opin Investig Drugs 10:1789-96. 2001.... - Cultural influences on diagnosis and perception of Tourette syndrome in Costa RicaC A Mathews
Department of Psychiatry, University of California at San Francisco, 401 Parnassus Avenue, Box NGL 0984, San Francisco, CA 94143, USA
J Am Acad Child Adolesc Psychiatry 40:456-63. 2001..This study examines the phenomenology and presentation of TS in Costa Rica... - Influences of mood, depression history, and treatment modality on outcomes in smoking cessationAmie L Haas
Department of Psychiatry, University of California, San Francisco, CA 94304, USA
J Consult Clin Psychol 72:563-70. 2004..The study replicated results reported by R. A. Brown et al. (2001) and expanded upon them by evaluating the differential contribution of poor mood on cessation outcomes relative to MDD history... - Depression gets old fast: do stress and depression accelerate cell aging?Owen M Wolkowitz
Department of Psychiatry, University of California School of Medicine, San Francisco, California, USA
Depress Anxiety 27:327-38. 2010.... - Glucocorticoids. Mood, memory, and mechanismsOwen M Wolkowitz
Department of Psychiatry, University of California San Francisco UCSF School of Medicine, San Francisco, California, USA
Ann N Y Acad Sci 1179:19-40. 2009..The article concludes with a conceptual model of glucocorticoid actions in the brain that may lead to novel therapeutic opportunities... 
Extended treatment of older cigarette smokersSharon M Hall
University of California, San Francisco, CA 94143 0984, USA
Addiction 104:1043-52. 2009..The aims of the present study were to determine the efficacy of extended cognitive behavioral and pharmacological interventions in smokers > or = 50 years of age, and to determine if gender differences in efficacy existed...- Of sound mind and body: depression, disease, and accelerated agingOwen M Wolkowitz
Department of Psychiatry, School of Medicine, University of California, San Francisco, California, USA
Dialogues Clin Neurosci 13:25-39. 2011..These factors interact in increasing the likelihood of physical disease and of accelerated aging at the cellular level. We conclude with suggestions for novel mechanism-based therapeutics based on these mediators... - Cost-effectiveness of bupropion, nortriptyline, and psychological intervention in smoking cessationSharon M Hall
Department of Psychiatry, University of California, San Francisco, 94143, USA
J Behav Health Serv Res 32:381-92. 2005..Prospective investigations of the cost and cost-effectiveness of psychological and pharmacological intervention, using adequate sample sizes, are warranted... - Association between maternal smoking and increased symptom severity in Tourette's syndromeCarol A Mathews
Department of Psychiatry, University of California San Diego, La Jolla, CA, and the Department of Psychiatry, North Shore University Hospital New York University School of Medicine, Manhasset, NY, USA
Am J Psychiatry 163:1066-73. 2006.... - Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoardingCarol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
Am J Med Genet B Neuropsychiatr Genet 144:174-82. 2007..39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding... - Older versus younger treatment-seeking smokers: differences in smoking behavior, drug and alcohol use, and psychosocial and physical functioningSharon M Hall
University of California, San Francisco, San Francisco, CA 94143 0984, USA
Nicotine Tob Res 10:463-70. 2008..Implications for the assessment and treatment of older adults are discussed... - Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptylineSharon M Hall
University of California, San Francisco, San Francisco, CA 94143 0984, USA
Nicotine Tob Res 9:467-71. 2007.... - Extended nortriptyline and psychological treatment for cigarette smokingSharon M Hall
University of California San Francisco, 401 Parnassus Ave, Box 0984, San Francisco, CA 94143 0984, USA
Am J Psychiatry 161:2100-7. 2004..Using a chronic disease model of smoking, the authors undertook a study to determine the effects of long-term antidepressant and psychological treatment... - Psychological intervention and antidepressant treatment in smoking cessationSharon M Hall
Department of Psychiatry, University of California, San Francisco, 94143 0984, USA
Arch Gen Psychiatry 59:930-6. 2002..This study compared both drugs with placebo. It also examined the efficacy of these 2 drugs and placebo with and without psychological intervention... - Altering cortisol level does not change the pleasurable effects of methamphetamine in humansDebra S Harris
Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
Neuropsychopharmacology 28:1677-84. 2003..Metyrapone was associated with significant premature ventricular complexes in two subjects during methamphetamine administration and may not be safe for those who use methamphetamine... - Resting leukocyte telomerase activity is elevated in major depression and predicts treatment responseO M Wolkowitz
Department of Psychiatry, School of Medicine, University of California, San Francisco UCSF, San Francisco, CA 94143 0984, USA
Mol Psychiatry 17:164-72. 2012..PBMC telomerase activity might reflect a novel aspect of depressive pathophysiology and might represent a novel biomarker of antidepressant responsiveness... - Antiglucocorticoid treatments in psychiatryV I Reus
University of California, San Francisco, School of Medicine, Department of Psychiatry 94143 0984, USA
Psychoneuroendocrinology 22:S121-4. 1997..The data thus far suggest that antiglucocorticoid drug treatment may be useful in certain subgroups of depressed patients and may offer a theoretical rationale for alternative drug design... - Cortisol levels predict cognitive impairment induced by electroconvulsive therapyT C Neylan
Department of Psychiatry, University of California, San Francisco, CA 94121, USA
Biol Psychiatry 50:331-6. 2001.... - Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studiesMichael A Escamilla
Department of Psychiatry, 7792, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
J Affect Disord 71:71-83. 2002..Although SA/SD may be a risk factor for precipitating BPI in those at risk, in this population comorbid BPI subjects do not have a different onset or course of BPI in comparison to BPI patients without comorbidity... - Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot studyElysa J Marco
University of California, Langley Porter Psychiatric Institute, San Francisco, USA
World J Biol Psychiatry 3:156-61. 2002..Further studies with larger sample sizes, more extensive endocrine assessments and longer duration of drug administration seem warranted... - Glucocorticoid medication, memory and steroid psychosis in medical illnessO M Wolkowitz
Department of Psychiatry, University of California Medical Center San Francisco 94143, USA
Ann N Y Acad Sci 823:81-96. 1997.... - Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedationSharon E Meieran
University of California, San Francisco School of Medicine, San Francisco, CA, USA
Psychoneuroendocrinology 29:486-500. 2004..Further larger-scale studies, utilizing a broader range of doses and experimental conditions, are warranted... - Longitudinal analysis of abstinence-specific social support and smoking cessationDawn Lawhon
Department of Psychiatry, University of California, San Francisco, CA, USA
Health Psychol 28:465-72. 2009..2) To describe time-related changes in abstinence-specific support, including how support provided during middle and later phases of the quitting process is associated with treatment outcome... - Treatment of depression with antiglucocorticoid drugsO M Wolkowitz
Department of Psychiatry, University of California, San Francisco, School of Medicine 94143 0984, USA
Psychosom Med 61:698-711. 1999..The theoretical and empirical rationales for the potential therapeutic use of antiglucocorticoid agents in the treatment of depression are reviewed... - Self injurious behaviour in Tourette syndrome: correlates with impulsivity and impulse controlC A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
J Neurol Neurosurg Psychiatry 75:1149-55. 2004..Although SIB occurs in up to 60% of individuals with TS, and can cause significant clinical impairment and distress, little is known about its aetiology... - Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populationsCarol A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0810, USA
Biol Psychiatry 61:292-300. 2007..Tourette Syndrome (TS) has a complex etiology and wide variability in phenotypic expression. Identifying underlying symptom patterns may be useful for etiological and outcome studies of TS... - Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)Nicole Maninger
Department of Psychiatry, University of California San Francisco, School of Medicine, San Francisco 94143, USA
Front Neuroendocrinol 30:65-91. 2009..Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed... - Assortative mating in the affective disorders: a systematic review and meta-analysisC A Mathews
Department of Psychiatry, University of California at San Francisco, 94143, USA
Compr Psychiatry 42:257-62. 2001..These results support the previously reported findings, and may have important implications for genetic studies... - Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican populationL A McInnes
Neurogenetics Laboratory, Center for Neurobiology and Psychiatry, and Department of Psychiatry, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 98:11485-90. 2001..Our results suggest a candidate region containing six genes but also highlight the complexities of LD mapping of common disorders... - Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: a follow-up study on chromosome 18M A Escamilla
Neurogenetics Laboratory, University of California at San Francisco, San Francisco, California, USA
Am J Med Genet 105:207-13. 2001..Furthermore, the analysis continues to support a possible BP-I locus on 18pter, suggested by previous analyses in this population. Evidence for a possible BP-I locus on 18q12.2 is also described... - A comparative study of obsessive-compulsive disorder in Costa Rica and the United StatesDenise A Chavira
Department of Psychiatry, University of California San Diego, San Diego, California 92037, USA
Depress Anxiety 25:609-19. 2008..However some features of OCD, such as impairment, may be culturally influenced, leading to differences in prevalence rates and treatment utilization... - Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolateRoel A Ophoff
Neurogenetics Laboratory, University of California, San Francisco, CA, USA
Am J Hum Genet 71:565-74. 2002..This region could be important for severe psychiatric disorders, rather than for a specific phenotype... - Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populationsCarol A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
Psychiatr Genet 14:13-23. 2004..In this paper we highlight the studies currently being conducted by our groups in the Central Valley of Costa Rica to illustrate the potential advantages of this population for genetic studies... - Neurotransmitters, neurosteroids and neurotrophins: new models of the pathophysiology and treatment of depressionOwen M Wolkowitz
World J Biol Psychiatry 4:98-102. 2003 - Behavioral implications of lowering cholesterol levels: a double-blind pilot studyTom Ormiston
Santa Clara Valley Medical Center, San Jose, CA 95128, USA
Psychosomatics 44:412-4. 2003..This pilot study, although limited in size, raises the possibility that cholesterol-lowering drugs are associated with mild, time-limited increases in impulsivity and with mild, time-delayed improvements in depression ratings... - Benzodiazepines in schizophrenia: prefrontal cortex atrophy predicts clinical response to alprazolam augmentationWilliam W Seeley
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
World J Biol Psychiatry 3:221-4. 2002..Mechanistic considerations and suggestions for future research are discussed... - Genetic mapping using haplotype and model-free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31-33Kyung Sue Hong
Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California 90095-1761, USA
Am J Med Genet B Neuropsychiatr Genet 125:83-6. 2004..These results support the suggestion that a locus at 5q31-33, together with a previously reported locus at 18q22-23, may provide the major genetic risk for BP-I in this family...
Research Grants
- TRAINING NEXT GENERATION MENTAL HEALTH RESEARCHERSVictor Reus; Fiscal Year: 2007..The career development of minority and women trainees in clinical research is specifically emphasized. ..