KAREN L REUE

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Metabolic impact of sex chromosomes
    Jenny C Link
    Molecular Biology Institute, University of California, Los Angeles CA USA
    Adipocyte 2:74-9. 2013
  2. pmc The number of x chromosomes causes sex differences in adiposity in mice
    Xuqi Chen
    Department of Integrative Biology and Physiology and Laboratory of Neuroendocrinology or the Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 8:e1002709. 2012
  3. ncbi request reprint Approaches to lipid metabolism gene identification and characterization in the postgenomic era
    Karen Reue
    Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 47:1891-907. 2006
  4. ncbi request reprint Evidence for hormone-sensitive lipase mRNA expression in human monocyte/macrophages
    K Reue
    Lipid Research Laboratory, West Los Angeles VA Medical Center, CA 90073, USA
    Arterioscler Thromb Vasc Biol 17:3428-32. 1997
  5. pmc The lipin protein family: dual roles in lipid biosynthesis and gene expression
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
    FEBS Lett 582:90-6. 2008
  6. ncbi request reprint Genetic factors in type 2 diabetes: all in the (lipin) family
    Karen Reue
    Department of Human Genetics, 6506A, David Geffen School of Medicine at UCLA, 695 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Diabetes 56:2842-3. 2007
  7. pmc Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 49:2493-503. 2008
  8. pmc Lipin proteins and metabolic homeostasis
    Karen Reue
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:S109-14. 2009
  9. pmc The lipin family: mutations and metabolism
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Curr Opin Lipidol 20:165-70. 2009
  10. ncbi request reprint Metabolic consequences of lipodystrophy in mouse models
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine at UCLA, USA
    Curr Opin Clin Nutr Metab Care 9:436-41. 2006

Collaborators

Detail Information

Publications39

  1. pmc Metabolic impact of sex chromosomes
    Jenny C Link
    Molecular Biology Institute, University of California, Los Angeles CA USA
    Adipocyte 2:74-9. 2013
    ..Here we review recent data in mice and humans concerning the potential impact of sex chromosome complement on obesity and metabolic disease. ..
  2. pmc The number of x chromosomes causes sex differences in adiposity in mice
    Xuqi Chen
    Department of Integrative Biology and Physiology and Laboratory of Neuroendocrinology or the Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 8:e1002709. 2012
    ..Overall, our study is the first to identify sex chromosome complement, a factor distinguishing all male and female cells, as a cause of sex differences in obesity and metabolism...
  3. ncbi request reprint Approaches to lipid metabolism gene identification and characterization in the postgenomic era
    Karen Reue
    Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 47:1891-907. 2006
    ..We review key approaches and lipid genes identified in the first years of this century and discuss how genomic resources are likely to streamline gene identification and functional characterization in the future...
  4. ncbi request reprint Evidence for hormone-sensitive lipase mRNA expression in human monocyte/macrophages
    K Reue
    Lipid Research Laboratory, West Los Angeles VA Medical Center, CA 90073, USA
    Arterioscler Thromb Vasc Biol 17:3428-32. 1997
    ..These results indicate that further studies addressing the role of HSL in macrophage metabolism and its potential role in development of foam cells in human atherosclerotic lesions are warranted...
  5. pmc The lipin protein family: dual roles in lipid biosynthesis and gene expression
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
    FEBS Lett 582:90-6. 2008
    ..The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution...
  6. ncbi request reprint Genetic factors in type 2 diabetes: all in the (lipin) family
    Karen Reue
    Department of Human Genetics, 6506A, David Geffen School of Medicine at UCLA, 695 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Diabetes 56:2842-3. 2007
  7. pmc Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 49:2493-503. 2008
    ....
  8. pmc Lipin proteins and metabolic homeostasis
    Karen Reue
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:S109-14. 2009
    ..Here, we review some of the progress toward elucidating the molecular and physiological functions of the lipin proteins...
  9. pmc The lipin family: mutations and metabolism
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Curr Opin Lipidol 20:165-70. 2009
    ..Here we examine the most recent studies that provide information about the roles of lipin proteins in metabolism and human disease...
  10. ncbi request reprint Metabolic consequences of lipodystrophy in mouse models
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine at UCLA, USA
    Curr Opin Clin Nutr Metab Care 9:436-41. 2006
    ....
  11. ncbi request reprint Mouse models of lipodystrophy
    K Reue
    Department of Medicine, University of California, Los Angeles, 11301 Wilshire Blvd, Building 113, Room 312, Los Angeles, CA 90073, USA
    Curr Atheroscler Rep 2:390-6. 2000
    ..Studies on these mice suggest that adipose is the primary tissue affected in lipodystrophy, and that secondary leptin deficiency may be responsible for the associated insulin resistance...
  12. ncbi request reprint Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression
    Laurent Vergnes
    Departments of Medicine and Human Genetics, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:42774-84. 2003
    ....
  13. ncbi request reprint Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
    J Biol Chem 280:32883-9. 2005
    ....
  14. ncbi request reprint Lipin, a lipodystrophy and obesity gene
    Jack Phan
    Department of Human Genetics, David Geffen School of Medicine and Molecular Biology Institute, University of California, Los Angeles 90073, USA
    Cell Metab 1:73-83. 2005
    ..Thus, variations in lipin levels alone are sufficient to induce extreme states of adiposity and may represent a mechanism by which adipose tissue and skeletal muscle modulate fat mass and energy balance...
  15. pmc Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity
    Laurent Vergnes
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 47:745-54. 2006
    ..Thus, Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family...
  16. pmc Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes
    Miklos Peterfy
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 285:3857-64. 2010
    ..In summary, our studies suggest that insulin may modulate the cellular function of lipin-1 by regulating its subcellular localization through interactions with 14-3-3 proteins...
  17. pmc Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis
    Peixiang Zhang
    Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 49:1519-28. 2008
    ....
  18. pmc Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men
    Jimmy Donkor
    University of California, Department of Human Genetics, 6506A Gonda, 695 Charles E Young Drive South, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 93:233-9. 2008
    ..Lipin-1 functions in adipocyte triglyceride biosynthesis and in the regulation of gene expression, both of which may influence metabolic homeostasis...
  19. ncbi request reprint Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro
    Jack Phan
    Departments of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Biol Chem 279:29558-64. 2004
    ..Thus, we conclude that lipin expression is required prior to PPARgamma during adipocyte differentiation...
  20. pmc Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium
    Anne P Beigneux
    Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 47:734-44. 2006
    ..Thus, we identified a novel glycerolipid acyltransferase of the ER, AGPAT6, which is crucial for the production of milk fat by the mammary gland...
  21. pmc Lipins: multifunctional lipid metabolism proteins
    Lauren S Csaki
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Nutr 30:257-72. 2010
    ....
  22. ncbi request reprint Lamins A and C but not lamin B1 regulate nuclear mechanics
    Jan Lammerding
    Cardiovascular Division, Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 281:25768-80. 2006
    ..Our study indicates that lamins A and C are important contributors to the mechanical stiffness of nuclei, whereas lamin B1 contributes to nuclear integrity but not stiffness...
  23. pmc Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models
    Jack Phan
    Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:1006-16. 2009
    ....
  24. pmc Metabolic syndrome: from epidemiology to systems biology
    Aldons J Lusis
    Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Genet 9:819-30. 2008
    ..Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn...
  25. pmc Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice
    Loren G Fong
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:18111-6. 2004
    ..These data suggest that prelamin A is toxic and that reducing its levels by as little as 50% provides striking protection from disease...
  26. ncbi request reprint Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 39:1483-7. 2007
    ..Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia...
  27. ncbi request reprint Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns
    Jimmy Donkor
    Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 282:3450-7. 2007
    ..The different lipins showed distinct tissue expression patterns. Our results establish the three mammalian lipin proteins as PAP1 enzymes and explain the biochemical basis for lipodystrophy in the lipin-1-deficient fld mouse...
  28. ncbi request reprint Biphasic expression of lipin suggests dual roles in adipocyte development
    Jack Phan
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Drug News Perspect 18:5-11. 2005
    ..Thus, lipin appears to have critical roles in both adipocyte differentiation and in the function of mature adipocytes...
  29. ncbi request reprint The role of lipin 1 in adipogenesis and lipid metabolism
    Karen Reue
    Department of Human Genetics, David Geffen School of Medicine, Universioy of Calfornia, Los Angeles, CA 90095, USA
    Novartis Found Symp 286:58-68; discussion 68-71, 162-3, 196-203. 2007
    ..The mechanism of lipin 1 action appears to be complex, with evidence for roles in triglyceride biosynthesis and in the regulation of gene expression...
  30. pmc Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:2106-13. 2010
    ..To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake...
  31. pmc Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77
    Lily C Chao
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, USA
    Diabetes 58:2788-96. 2009
    ..However, the net functional impact of these pathways is unknown. To examine the consequence of Nur77 signaling for glucose metabolism in vivo, we challenged Nur77 null mice with high-fat feeding...
  32. ncbi request reprint The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression
    Hironori Waki
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 5:357-70. 2007
    ....
  33. pmc A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2
    Jimmy Donkor
    Department of Human Genetics and Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:29968-78. 2009
    ..These results raise the possibility that the loss of lipin-2 PAP activity in erythrocytes and lymphocytes may contribute to the anemia and inflammation phenotypes observed in Majeed syndrome patients...
  34. doi request reprint Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt
    Jason T Dean
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA
    Cell Metab 9:525-36. 2009
    ..This work suggests that using non-native pathways in higher organisms to explore and modulate metabolism may be a useful approach...
  35. pmc Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
    Kazuharu Takeuchi
    Dept of Human Genetics, Gonda 6506A, David Geffen School of Medicine at UCLA, 695 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Am J Physiol Endocrinol Metab 296:E1195-209. 2009
    ....
  36. ncbi request reprint Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation
    Aiwei Yao-Borengasser
    Department of Medicine, Division of Endocrinology, Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Diabetes 55:2811-8. 2006
    ..These results suggest that increased adipogenesis and/or lipogenesis in subcutaneous fat, mediated by the LPIN1 gene, may prevent lipotoxicity in muscle, leading to improved insulin sensitivity...
  37. ncbi request reprint The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism
    Jack Phan
    Department of Medicine, UCLA and the Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Biol Chem 277:469-77. 2002
    ..Genetic analysis of serum bile acid levels revealed co-segregation with Diet1, indicating that this locus is likely responsible for both increased bile acid excretion and resistance to hypercholesterolemia in B6By mice...
  38. pmc Lamin B1 is required for mouse development and nuclear integrity
    Laurent Vergnes
    Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Proc Natl Acad Sci U S A 101:10428-33. 2004
    ..These mutant mice and cell lines derived from them will be useful models for studying the role of the nuclear lamina in various cellular processes...
  39. ncbi request reprint A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13
    Laurent Vergnes
    Department of Human Genetics and Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Lipid Res 44:503-11. 2003
    ..Our findings dramatically expand the repertoire of AKR genes and identify unrecognized family members with potential roles in the regulation of steroid metabolism...

Research Grants7

  1. Characterization of Diet1, a hypercholesterolemia resistance gene
    Karen Reue; Fiscal Year: 2010
    ..Results will further elucidate the mechanisms that control cholesterol homeostasis, and may suggest new strategies for protection or treatment of hypercholesterolemia and related disorders. ..
  2. ISOLATION OF A HYPERCHOLESTEROLEMIA RESISTANCE GENE
    Karen Reue; Fiscal Year: 1999
    ..In addition, we compare Bailey and J substrains for susceptibility to aortic lesion development, as a model in which similar HDL levels occur in conjunction with vastly different LDL/VLDL levels. ..
  3. ISOLATION OF A HYPERCHOLESTEROLEMIA RESISTANCE GENE
    Karen Reue; Fiscal Year: 2000
    ..In addition, we compare Bailey and J substrains for susceptibility to aortic lesion development, as a model in which similar HDL levels occur in conjunction with vastly different LDL/VLDL levels. ..
  4. ISOLATION OF A HYPERCHOLESTEROLEMIA RESISTANCE GENE
    Karen Reue; Fiscal Year: 2001
    ..In addition, we compare Bailey and J substrains for susceptibility to aortic lesion development, as a model in which similar HDL levels occur in conjunction with vastly different LDL/VLDL levels. ..
  5. ISOLATION OF A HYPERCHOLESTEROLEMIA RESISTANCE GENE
    Karen Reue; Fiscal Year: 2002
    ..In addition, we compare Bailey and J substrains for susceptibility to aortic lesion development, as a model in which similar HDL levels occur in conjunction with vastly different LDL/VLDL levels. ..
  6. Validation of C. elegans "fat genes" in the mouse
    Karen Reue; Fiscal Year: 2005
    ..This pilot study will reveal whether "fat genes" identified in the invertebrate C. elegans have a similar role in mammals, and may identify novel genes involved in fat storage and metabolism. ..