Research Topics
Genomes and GenesSpecies | KAREN L REUESummaryAffiliation: University of California Country: USA Publications
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Publications
Evidence for hormone-sensitive lipase mRNA expression in human monocyte/macrophagesK Reue
Lipid Research Laboratory, West Los Angeles VA Medical Center, CA 90073, USA
Arterioscler Thromb Vasc Biol 17:3428-32. 1997..These results indicate that further studies addressing the role of HSL in macrophage metabolism and its potential role in development of foam cells in human atherosclerotic lesions are warranted...
The lipin family: mutations and metabolismKaren Reue
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Curr Opin Lipidol 20:165-70. 2009..Here we examine the most recent studies that provide information about the roles of lipin proteins in metabolism and human disease...- Approaches to lipid metabolism gene identification and characterization in the postgenomic eraKaren Reue
Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Lipid Res 47:1891-907. 2006..We review key approaches and lipid genes identified in the first years of this century and discuss how genomic resources are likely to streamline gene identification and functional characterization in the future... - Lipin proteins and metabolic homeostasisKaren Reue
Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
J Lipid Res 50:S109-14. 2009..Here, we review some of the progress toward elucidating the molecular and physiological functions of the lipin proteins... - The lipin protein family: dual roles in lipid biosynthesis and gene expressionKaren Reue
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
FEBS Lett 582:90-6. 2008..The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution... - Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expressionLaurent Vergnes
Departments of Medicine and Human Genetics, UCLA, Los Angeles, California 90095, USA
J Biol Chem 278:42774-84. 2003.... - Genetic factors in type 2 diabetes: all in the (lipin) familyKaren Reue
Department of Human Genetics, 6506A, David Geffen School of Medicine at UCLA, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA
Diabetes 56:2842-3. 2007 - Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolismKaren Reue
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 49:2493-503. 2008.... - Mouse models of lipodystrophyK Reue
Department of Medicine, University of California, Los Angeles, 11301 Wilshire Blvd, Building 113, Room 312, Los Angeles, CA 90073, USA
Curr Atheroscler Rep 2:390-6. 2000..Studies on these mice suggest that adipose is the primary tissue affected in lipodystrophy, and that secondary leptin deficiency may be responsible for the associated insulin resistance... - Metabolic consequences of lipodystrophy in mouse modelsKaren Reue
Department of Human Genetics, David Geffen School of Medicine at UCLA, USA
Curr Opin Clin Nutr Metab Care 9:436-41. 2006.... - Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesisMiklos Peterfy
Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
J Biol Chem 280:32883-9. 2005.... - Lipin, a lipodystrophy and obesity geneJack Phan
Department of Human Genetics, David Geffen School of Medicine and Molecular Biology Institute, University of California, Los Angeles 90073, USA
Cell Metab 1:73-83. 2005..Thus, variations in lipin levels alone are sufficient to induce extreme states of adiposity and may represent a mechanism by which adipose tissue and skeletal muscle modulate fat mass and energy balance... - Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesityLaurent Vergnes
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 47:745-54. 2006..Thus, Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family... - Regulation of lipin-1 gene expression by glucocorticoids during adipogenesisPeixiang Zhang
Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
J Lipid Res 49:1519-28. 2008.... - Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytesMiklos Peterfy
Department of Medicine, University of California, Los Angeles, California 90095, USA
J Biol Chem 285:3857-64. 2010..In summary, our studies suggest that insulin may modulate the cellular function of lipin-1 by regulating its subcellular localization through interactions with 14-3-3 proteins... - Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitroJack Phan
Departments of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
J Biol Chem 279:29558-64. 2004..Thus, we conclude that lipin expression is required prior to PPARgamma during adipocyte differentiation... - Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young menJimmy Donkor
University of California, Department of Human Genetics, 6506A Gonda, 695 Charles E Young Drive South, Los Angeles, California 90095, USA
J Clin Endocrinol Metab 93:233-9. 2008..Lipin-1 functions in adipocyte triglyceride biosynthesis and in the regulation of gene expression, both of which may influence metabolic homeostasis... - Metabolic syndrome: from epidemiology to systems biologyAldons J Lusis
Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Nat Rev Genet 9:819-30. 2008..Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn... - Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse modelsJack Phan
Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
Hum Mol Genet 18:1006-16. 2009.... - Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemiaMiklos Peterfy
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Nat Genet 39:1483-7. 2007..Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia... - Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient miceLoren G Fong
Department of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 101:18111-6. 2004..These data suggest that prelamin A is toxic and that reducing its levels by as little as 50% provides striking protection from disease... - Lamins A and C but not lamin B1 regulate nuclear mechanicsJan Lammerding
Cardiovascular Division, Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
J Biol Chem 281:25768-80. 2006..Our study indicates that lamins A and C are important contributors to the mechanical stiffness of nuclei, whereas lamin B1 contributes to nuclear integrity but not stiffness... 
Lipins: multifunctional lipid metabolism proteinsLauren S Csaki
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Annu Rev Nutr 30:257-72. 2010....- Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epitheliumAnne P Beigneux
Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 47:734-44. 2006..Thus, we identified a novel glycerolipid acyltransferase of the ER, AGPAT6, which is crucial for the production of milk fat by the mammary gland... - Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77Lily C Chao
Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, USA
Diabetes 58:2788-96. 2009..However, the net functional impact of these pathways is unknown. To examine the consequence of Nur77 signaling for glucose metabolism in vivo, we challenged Nur77 null mice with high-fat feeding... - The role of lipin 1 in adipogenesis and lipid metabolismKaren Reue
Department of Human Genetics, David Geffen School of Medicine, Universioy of Calfornia, Los Angeles, CA 90095, USA
Novartis Found Symp 286:58-68; discussion 68-71, 162-3, 196-203. 2007..The mechanism of lipin 1 action appears to be complex, with evidence for roles in triglyceride biosynthesis and in the regulation of gene expression... - Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient miceMichael M Weinstein
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
Arterioscler Thromb Vasc Biol 30:2106-13. 2010..To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake... - Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patternsJimmy Donkor
Department of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Biol Chem 282:3450-7. 2007..The different lipins showed distinct tissue expression patterns. Our results establish the three mammalian lipin proteins as PAP1 enzymes and explain the biochemical basis for lipodystrophy in the lipin-1-deficient fld mouse... - Biphasic expression of lipin suggests dual roles in adipocyte developmentJack Phan
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
Drug News Perspect 18:5-11. 2005..Thus, lipin appears to have critical roles in both adipocyte differentiation and in the function of mature adipocytes... - A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2Jimmy Donkor
Department of Human Genetics and Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 284:29968-78. 2009..These results raise the possibility that the loss of lipin-2 PAP activity in erythrocytes and lymphocytes may contribute to the anemia and inflammation phenotypes observed in Majeed syndrome patients... - Resistance to diet-induced obesity in mice with synthetic glyoxylate shuntJason T Dean
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA
Cell Metab 9:525-36. 2009..This work suggests that using non-native pathways in higher organisms to explore and modulate metabolism may be a useful approach... - Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesisKazuharu Takeuchi
Dept of Human Genetics, Gonda 6506A, David Geffen School of Medicine at UCLA, 695 Charles E Young Drive South, Los Angeles, CA 90095, USA
Am J Physiol Endocrinol Metab 296:E1195-209. 2009.... - Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activationAiwei Yao-Borengasser
Department of Medicine, Division of Endocrinology, Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th St, Little Rock, AR 72205, USA
Diabetes 55:2811-8. 2006..These results suggest that increased adipogenesis and/or lipogenesis in subcutaneous fat, mediated by the LPIN1 gene, may prevent lipotoxicity in muscle, leading to improved insulin sensitivity... - The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expressionHironori Waki
Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Metab 5:357-70. 2007.... - Lamin B1 is required for mouse development and nuclear integrityLaurent Vergnes
Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
Proc Natl Acad Sci U S A 101:10428-33. 2004..These mutant mice and cell lines derived from them will be useful models for studying the role of the nuclear lamina in various cellular processes... - The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolismJack Phan
Department of Medicine, UCLA and the Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
J Biol Chem 277:469-77. 2002..Genetic analysis of serum bile acid levels revealed co-segregation with Diet1, indicating that this locus is likely responsible for both increased bile acid excretion and resistance to hypercholesterolemia in B6By mice... - A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13Laurent Vergnes
Department of Human Genetics and Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Lipid Res 44:503-11. 2003..Our findings dramatically expand the repertoire of AKR genes and identify unrecognized family members with potential roles in the regulation of steroid metabolism...
Research Grants
- ISOLATION OF A HYPERCHOLESTEROLEMIA RESISTANCE GENEKaren Reue; Fiscal Year: 2002..In addition, we compare Bailey and J substrains for susceptibility to aortic lesion development, as a model in which similar HDL levels occur in conjunction with vastly different LDL/VLDL levels. ..
- Validation of C. elegans "fat genes" in the mouseKaren Reue; Fiscal Year: 2005..This pilot study will reveal whether "fat genes" identified in the invertebrate C. elegans have a similar role in mammals, and may identify novel genes involved in fat storage and metabolism. ..
- Characterization of Diet1, a hypercholesterolemia resistance geneKaren Reue; Fiscal Year: 2010..Results will further elucidate the mechanisms that control cholesterol homeostasis, and may suggest new strategies for protection or treatment of hypercholesterolemia and related disorders. ..