Research Topics
Species | Krzysztof J ReszkaSummaryAffiliation: University of Cincinnati Country: USA Publications
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Publications
Peroxidative metabolism of beta2-agonists salbutamol and fenoterol and their analoguesKrzysztof J Reszka
Research Services and Department of Internal Medicine, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
Chem Res Toxicol 22:1137-50. 2009..These processes may affect therapeutic efficacy and also play a role in adverse reactions of the beta(2)-agonists...
Oxidation of anthracyclines by peroxidase metabolites of salicylic AcidKrzysztof J Reszka
Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, ML 0557, Cincinnati, OH 45267 0557
J Pharmacol Exp Ther 315:283-90. 2005....- Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activityKrzysztof J Reszka
Department of Internal Medicine, Veterans Affairs Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0557, USA
J Pharmacol Exp Ther 336:440-9. 2011..These results suggest that under inflammatory conditions associated with asthma, phenolic β(2)-agonists may be subject to peroxidase-catalyzed nitration that could potentially diminish their therapeutic efficacy... - Photochemistry of naphthalene diimides: EPR study of free radical formation via photoredox processKrzysztof J Reszka
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Research Triangle Park, NC, USA
Photochem Photobiol 81:573-80. 2005..These observations could be pertinent to the application of naphthalene diimides as selective photonucleases, PDT anticancer agents or both... - Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosaKrzysztof J Reszka
Research Service, VA Medical Center, Iowa City, Iowa, USA
Photochem Photobiol 82:466-73. 2006..These results also suggest that photosensitization could be a potentially useful method for inactivation of PyO- and, possibly, detoxification of superficial wounds (skin, eye) infected with P. aeruginosa... - Nitric oxide decreases the stability of DMPO spin adductsKrzysztof J Reszka
VA Medical Center Cincinnati, OH, USA
Nitric Oxide 15:133-41. 2006.... - Doxorubicin inhibits oxidation of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) by a lactoperoxidase/H(2)O(2) system by reacting with ABTS-derived radicalKrzysztof J Reszka
Research Service, VA Medical Center, Cincinnati, OH 45230, USA
Arch Biochem Biophys 466:164-71. 2007..These observations support the assertion that under certain conditions doxorubicin can function as an antioxidant. They also suggest that interaction of doxorubicin with oxidants may lead to its oxidative degradation... 
Quenching of singlet oxygen by pyocyanin and related phenazinesKrzysztof J Reszka
Research Service and Medical Service, VA Medical Center, Cincinnati, OH, USA
Photochem Photobiol 86:742-6. 2010..aeruginosa from infected tissues...- Inactivation of anthracyclines by serum heme proteinsBrett A Wagner
Department of Internal Medicine, University of Iowa, USA
Chem Res Toxicol 20:920-6. 2007..Finally, this study also points out that addition of H2O2 to media containing FBS will stimulate peroxidase-type of reactions, which may affect cytotoxic properties of studied compounds... - Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitriteKrzysztof J Reszka
Department of Internal Medicine, University of Cincinnati, Ohio, USA
Am J Physiol Lung Cell Mol Physiol 302:L1044-56. 2012.... - Oxidation of pyocyanin, a cytotoxic product from Pseudomonas aeruginosa, by microperoxidase 11 and hydrogen peroxideKrzysztof J Reszka
Research Service, VA Medical Center, Iowa City, IA 42246, USA
Free Radic Biol Med 36:1448-59. 2004..This latter property may cause pyocyanin degradation and inactivation, which may be of considerable biomedical interest... - Effects of peroxidase substrates on the Amplex red/peroxidase assay: antioxidant properties of anthracyclinesKrzysztof J Reszka
Research Service, VA Medical Center, Iowa City, IA 52246, USA
Anal Biochem 342:327-37. 2005..They also demonstrate that the anticancer anthracyclines may function as antioxidants... - The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cellsKrzysztof J Reszka
Research Service, Veterans Affairs Medical Center-Iowa City, Iowa, USA
Am J Physiol Lung Cell Mol Physiol 285:L1077-86. 2003..Decreased cellular catalase activity and failure to augment MnSOD could contribute to pyocyanin-dependent cytotoxicity... - Role of thiocyanate, bromide and hypobromous acid in hydrogen peroxide-induced apoptosisBrett A Wagner
Department of Medicine, Free Radical and Radiation Biology Graduate Program, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA
Free Radic Res 38:167-75. 2004..In contrast, bromide can support H2O2/MPO/halide apoptosis, but is less potent than chloride and it has no effect in the presence of physiological levels of chloride... - Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cellsBrett A Wagner
Department of Medicine, The University of Iowa Carver College of Medicine and Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA
Arch Biochem Biophys 440:181-90. 2005..This study demonstrates that a specific oxidative event associated with the exposure of PC3 human prostate cancer cells to anthracyclines results in an increase in intracellular hydrogen peroxide... - Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processesAliye Uc
The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
Am J Physiol Cell Physiol 292:C1906-14. 2007..These novel effects of SnPP-photosensitized oxidation may also lead to a new understanding of how intestinal Cl(-) secretion can be regulated by the redox environment of the cell... - Acetaminophen stimulates the peroxidative metabolism of anthracyclinesKrzysztof J Reszka
Research Service, VA Medical Center, Iowa City, IA 52246, USA
Arch Biochem Biophys 427:16-29. 2004.... - Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cellsKrzysztof J Reszka
Department of Internal Medicine, Veterans Affairs Medical Center-Iowa City, Iowa 52242, USA
Am J Physiol Lung Cell Mol Physiol 287:L94-103. 2004..Pyocyanin-mediated alterations in cellular GSH may alter epithelial cell functions by modulating redox sensitive signaling events... - Oxidation of anthracycline anticancer agents by the peroxidase mimic microperoxidase 11 and hydrogen peroxideKrzysztof J Reszka
Research Service, VA Medical Center, Research 151, 601 Highway 6 West, Iowa City, IA 52246, USA
Free Radic Biol Med 35:78-93. 2003..Given that, at sites of inflammation or cancer, the anthracyclines can colocalize with peroxidases, protein degradation products, and with H(2)O(2), peroxidation could be one possible fate of these anticancer agents in vivo... - Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cellsMaher Y Abdalla
Research Service, Iowa City Veterans Affairs Medical Center, Iowa City, IA 52246, USA
Am J Physiol Lung Cell Mol Physiol 284:L420-30. 2003..How pyocyanin leads to ATP depletion, the mechanism of cellular metabolism of pyocyanin, and the impact of mitochondrial pyocyanin redox cycling on other cellular events are important areas for future study... - Phenazine-1-carboxylic acid, a secondary metabolite of Pseudomonas aeruginosa, alters expression of immunomodulatory proteins by human airway epithelial cellsGerene M Denning
Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
Am J Physiol Lung Cell Mol Physiol 285:L584-92. 2003..Thus PCA is a biologically active factor secreted by P. aeruginosa that has several activities that could alter the host immune and inflammatory response and thereby contribute to bacterial disease pathogenesis... - Direct oxidation of 2',7'-dichlorodihydrofluorescein by pyocyanin and other redox-active compounds independent of reactive oxygen species productionKrzysztof J Reszka
Research Service, VA Medical Center, Iowa City, IA, USA
Free Radic Biol Med 36:90-100. 2004..Direct oxidation of the fluorescent probes needs to be controlled for when employing these compounds to assess ROS formation by biological systems exposed to redox active compounds... - Spin trapping of nitric oxide by aci anions of nitroalkanesKrzysztof J Reszka
Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
Nitric Oxide 10:53-9. 2004..These results indicate that nitroalkanes could potentially be used as prototypes for development of *NO-specific spin traps suitable for EPR analysis... - Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondriaBrian D Fink
Department of Internal Medicine, Division of Endocrinology and Metabolism, Iowa City Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa, USA
Am J Physiol Endocrinol Metab 288:E71-9. 2005.... - Hydrogen peroxide-induced apoptosis of HL-60 human leukemia cells is mediated by the oxidants hypochlorous acid and chloraminesBrett A Wagner
Department of Medicine and Radiation Oncology (Free Radical and Radiation Biology Graduate Program, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
Arch Biochem Biophys 401:223-34. 2002..We conclude that the signal for apoptosis induced by H(2)O(2) in the MPO-containing HL-60 cell involves the reaction of the diffusible oxidant HOCl with amines producing chloramines and a subsequent non-TNB-reactive product... - Extracellular superoxide dismutase (ecSOD) in vascular biology: an update on exogenous gene transfer and endogenous regulators of ecSODZhenyu Qin
Division of Cardiovascular Disease, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
Transl Res 151:68-78. 2008.... - Alterations in the host defense properties of human milk following prolonged storage or pasteurizationHenry Akinbi
Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
J Pediatr Gastroenterol Nutr 51:347-52. 2010..Our objectives were to assess the impact of pasteurization or prolonged storage at -20 degrees C on the immunologic components of human milk and the capability of the different forms of human milk to support bacterial proliferation... - Inactivation of anthracyclines by cellular peroxidaseKrzysztof J Reszka
Research Service and Department of Internal Medicine, The Veterans Affairs Medical Center, USA
Cancer Res 65:6346-53. 2005..These findings may have important implications for the cellular pharmacology of anthracyclines and for clinical oncology...