Krzysztof J Reszka

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Peroxidative metabolism of beta2-agonists salbutamol and fenoterol and their analogues
    Krzysztof J Reszka
    Research Services and Department of Internal Medicine, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    Chem Res Toxicol 22:1137-50. 2009
  2. ncbi request reprint Oxidation of anthracyclines by peroxidase metabolites of salicylic Acid
    Krzysztof J Reszka
    Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, ML 0557, Cincinnati, OH 45267 0557
    J Pharmacol Exp Ther 315:283-90. 2005
  3. pmc Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activity
    Krzysztof J Reszka
    Department of Internal Medicine, Veterans Affairs Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0557, USA
    J Pharmacol Exp Ther 336:440-9. 2011
  4. ncbi request reprint Photochemistry of naphthalene diimides: EPR study of free radical formation via photoredox process
    Krzysztof J Reszka
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Research Triangle Park, NC, USA
    Photochem Photobiol 81:573-80. 2005
  5. ncbi request reprint Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosa
    Krzysztof J Reszka
    Research Service, VA Medical Center, Iowa City, Iowa, USA
    Photochem Photobiol 82:466-73. 2006
  6. ncbi request reprint Nitric oxide decreases the stability of DMPO spin adducts
    Krzysztof J Reszka
    VA Medical Center Cincinnati, OH, USA
    Nitric Oxide 15:133-41. 2006
  7. pmc Doxorubicin inhibits oxidation of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) by a lactoperoxidase/H(2)O(2) system by reacting with ABTS-derived radical
    Krzysztof J Reszka
    Research Service, VA Medical Center, Cincinnati, OH 45230, USA
    Arch Biochem Biophys 466:164-71. 2007
  8. doi request reprint Quenching of singlet oxygen by pyocyanin and related phenazines
    Krzysztof J Reszka
    Research Service and Medical Service, VA Medical Center, Cincinnati, OH, USA
    Photochem Photobiol 86:742-6. 2010
  9. pmc Inactivation of anthracyclines by serum heme proteins
    Brett A Wagner
    Department of Internal Medicine, University of Iowa, USA
    Chem Res Toxicol 20:920-6. 2007
  10. doi request reprint Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite
    Krzysztof J Reszka
    Department of Internal Medicine, University of Cincinnati, Ohio, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1044-56. 2012

Collaborators

Detail Information

Publications28

  1. pmc Peroxidative metabolism of beta2-agonists salbutamol and fenoterol and their analogues
    Krzysztof J Reszka
    Research Services and Department of Internal Medicine, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    Chem Res Toxicol 22:1137-50. 2009
    ..These processes may affect therapeutic efficacy and also play a role in adverse reactions of the beta(2)-agonists...
  2. ncbi request reprint Oxidation of anthracyclines by peroxidase metabolites of salicylic Acid
    Krzysztof J Reszka
    Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, ML 0557, Cincinnati, OH 45267 0557
    J Pharmacol Exp Ther 315:283-90. 2005
    ....
  3. pmc Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activity
    Krzysztof J Reszka
    Department of Internal Medicine, Veterans Affairs Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0557, USA
    J Pharmacol Exp Ther 336:440-9. 2011
    ..These results suggest that under inflammatory conditions associated with asthma, phenolic β(2)-agonists may be subject to peroxidase-catalyzed nitration that could potentially diminish their therapeutic efficacy...
  4. ncbi request reprint Photochemistry of naphthalene diimides: EPR study of free radical formation via photoredox process
    Krzysztof J Reszka
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Research Triangle Park, NC, USA
    Photochem Photobiol 81:573-80. 2005
    ..These observations could be pertinent to the application of naphthalene diimides as selective photonucleases, PDT anticancer agents or both...
  5. ncbi request reprint Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosa
    Krzysztof J Reszka
    Research Service, VA Medical Center, Iowa City, Iowa, USA
    Photochem Photobiol 82:466-73. 2006
    ..These results also suggest that photosensitization could be a potentially useful method for inactivation of PyO- and, possibly, detoxification of superficial wounds (skin, eye) infected with P. aeruginosa...
  6. ncbi request reprint Nitric oxide decreases the stability of DMPO spin adducts
    Krzysztof J Reszka
    VA Medical Center Cincinnati, OH, USA
    Nitric Oxide 15:133-41. 2006
    ....
  7. pmc Doxorubicin inhibits oxidation of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) by a lactoperoxidase/H(2)O(2) system by reacting with ABTS-derived radical
    Krzysztof J Reszka
    Research Service, VA Medical Center, Cincinnati, OH 45230, USA
    Arch Biochem Biophys 466:164-71. 2007
    ..These observations support the assertion that under certain conditions doxorubicin can function as an antioxidant. They also suggest that interaction of doxorubicin with oxidants may lead to its oxidative degradation...
  8. doi request reprint Quenching of singlet oxygen by pyocyanin and related phenazines
    Krzysztof J Reszka
    Research Service and Medical Service, VA Medical Center, Cincinnati, OH, USA
    Photochem Photobiol 86:742-6. 2010
    ..aeruginosa from infected tissues...
  9. pmc Inactivation of anthracyclines by serum heme proteins
    Brett A Wagner
    Department of Internal Medicine, University of Iowa, USA
    Chem Res Toxicol 20:920-6. 2007
    ..Finally, this study also points out that addition of H2O2 to media containing FBS will stimulate peroxidase-type of reactions, which may affect cytotoxic properties of studied compounds...
  10. doi request reprint Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite
    Krzysztof J Reszka
    Department of Internal Medicine, University of Cincinnati, Ohio, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1044-56. 2012
    ....
  11. ncbi request reprint Oxidation of pyocyanin, a cytotoxic product from Pseudomonas aeruginosa, by microperoxidase 11 and hydrogen peroxide
    Krzysztof J Reszka
    Research Service, VA Medical Center, Iowa City, IA 42246, USA
    Free Radic Biol Med 36:1448-59. 2004
    ..This latter property may cause pyocyanin degradation and inactivation, which may be of considerable biomedical interest...
  12. ncbi request reprint Effects of peroxidase substrates on the Amplex red/peroxidase assay: antioxidant properties of anthracyclines
    Krzysztof J Reszka
    Research Service, VA Medical Center, Iowa City, IA 52246, USA
    Anal Biochem 342:327-37. 2005
    ..They also demonstrate that the anticancer anthracyclines may function as antioxidants...
  13. ncbi request reprint The Pseudomonas secretory product pyocyanin inhibits catalase activity in human lung epithelial cells
    Yunxia Q O'Malley
    Research Service, Veterans Affairs Medical Center Iowa City, Iowa, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1077-86. 2003
    ..Decreased cellular catalase activity and failure to augment MnSOD could contribute to pyocyanin-dependent cytotoxicity...
  14. ncbi request reprint Role of thiocyanate, bromide and hypobromous acid in hydrogen peroxide-induced apoptosis
    Brett A Wagner
    Department of Medicine, Free Radical and Radiation Biology Graduate Program, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Free Radic Res 38:167-75. 2004
    ..In contrast, bromide can support H2O2/MPO/halide apoptosis, but is less potent than chloride and it has no effect in the presence of physiological levels of chloride...
  15. ncbi request reprint Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells
    Brett A Wagner
    Department of Medicine, The University of Iowa Carver College of Medicine and Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA
    Arch Biochem Biophys 440:181-90. 2005
    ..This study demonstrates that a specific oxidative event associated with the exposure of PC3 human prostate cancer cells to anthracyclines results in an increase in intracellular hydrogen peroxide...
  16. ncbi request reprint Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes
    Aliye Uc
    The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Cell Physiol 292:C1906-14. 2007
    ..These novel effects of SnPP-photosensitized oxidation may also lead to a new understanding of how intestinal Cl(-) secretion can be regulated by the redox environment of the cell...
  17. ncbi request reprint Acetaminophen stimulates the peroxidative metabolism of anthracyclines
    Krzysztof J Reszka
    Research Service, VA Medical Center, Iowa City, IA 52246, USA
    Arch Biochem Biophys 427:16-29. 2004
    ....
  18. ncbi request reprint Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells
    Yunxia Q O'Malley
    Department of Internal Medicine, Veterans Affairs Medical Center Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 287:L94-103. 2004
    ..Pyocyanin-mediated alterations in cellular GSH may alter epithelial cell functions by modulating redox sensitive signaling events...
  19. ncbi request reprint Oxidation of anthracycline anticancer agents by the peroxidase mimic microperoxidase 11 and hydrogen peroxide
    Krzysztof J Reszka
    Research Service, VA Medical Center, Research 151, 601 Highway 6 West, Iowa City, IA 52246, USA
    Free Radic Biol Med 35:78-93. 2003
    ..Given that, at sites of inflammation or cancer, the anthracyclines can colocalize with peroxidases, protein degradation products, and with H(2)O(2), peroxidation could be one possible fate of these anticancer agents in vivo...
  20. ncbi request reprint Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cells
    Yunxia Q O'Malley
    Research Service, Iowa City Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Am J Physiol Lung Cell Mol Physiol 284:L420-30. 2003
    ..How pyocyanin leads to ATP depletion, the mechanism of cellular metabolism of pyocyanin, and the impact of mitochondrial pyocyanin redox cycling on other cellular events are important areas for future study...
  21. ncbi request reprint Phenazine-1-carboxylic acid, a secondary metabolite of Pseudomonas aeruginosa, alters expression of immunomodulatory proteins by human airway epithelial cells
    Gerene M Denning
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Am J Physiol Lung Cell Mol Physiol 285:L584-92. 2003
    ..Thus PCA is a biologically active factor secreted by P. aeruginosa that has several activities that could alter the host immune and inflammatory response and thereby contribute to bacterial disease pathogenesis...
  22. ncbi request reprint Direct oxidation of 2',7'-dichlorodihydrofluorescein by pyocyanin and other redox-active compounds independent of reactive oxygen species production
    Yunxia Q O'Malley
    Research Service, VA Medical Center, Iowa City, IA, USA
    Free Radic Biol Med 36:90-100. 2004
    ..Direct oxidation of the fluorescent probes needs to be controlled for when employing these compounds to assess ROS formation by biological systems exposed to redox active compounds...
  23. ncbi request reprint Spin trapping of nitric oxide by aci anions of nitroalkanes
    Krzysztof J Reszka
    Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Nitric Oxide 10:53-9. 2004
    ..These results indicate that nitroalkanes could potentially be used as prototypes for development of *NO-specific spin traps suitable for EPR analysis...
  24. ncbi request reprint Respiratory uncoupling by UCP1 and UCP2 and superoxide generation in endothelial cell mitochondria
    Brian D Fink
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Iowa City Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Endocrinol Metab 288:E71-9. 2005
    ....
  25. ncbi request reprint Hydrogen peroxide-induced apoptosis of HL-60 human leukemia cells is mediated by the oxidants hypochlorous acid and chloramines
    Brett A Wagner
    Department of Medicine and Radiation Oncology Free Radical and Radiation Biology Graduate Program, The University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Arch Biochem Biophys 401:223-34. 2002
    ..We conclude that the signal for apoptosis induced by H(2)O(2) in the MPO-containing HL-60 cell involves the reaction of the diffusible oxidant HOCl with amines producing chloramines and a subsequent non-TNB-reactive product...
  26. doi request reprint Extracellular superoxide dismutase (ecSOD) in vascular biology: an update on exogenous gene transfer and endogenous regulators of ecSOD
    Zhenyu Qin
    Division of Cardiovascular Disease, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Transl Res 151:68-78. 2008
    ....
  27. doi request reprint Alterations in the host defense properties of human milk following prolonged storage or pasteurization
    Henry Akinbi
    Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Pediatr Gastroenterol Nutr 51:347-52. 2010
    ..Our objectives were to assess the impact of pasteurization or prolonged storage at -20 degrees C on the immunologic components of human milk and the capability of the different forms of human milk to support bacterial proliferation...
  28. ncbi request reprint Inactivation of anthracyclines by cellular peroxidase
    Krzysztof J Reszka
    Research Service and Department of Internal Medicine, The Veterans Affairs Medical Center, USA
    Cancer Res 65:6346-53. 2005
    ..These findings may have important implications for the cellular pharmacology of anthracyclines and for clinical oncology...