Research Topics
| M I RestrepoSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Detail Information
Publications
Impact of statins and ACE inhibitors on mortality after COPD exacerbationsEric M Mortensen
VERDICT research unit, South Texas Veterans Health Care System, San Antonio, Texas, USA
Respir Res 10:45. 2009..The purpose of our study was to examine the association of prior outpatient use of statins and angiotensin converting enzyme (ACE) inhibitors on mortality for subjects >or= 65 years of age hospitalized with acute COPD exacerbations...
Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: a retrospective cohort studyEric M Mortensen
VERDICT research program, Audie L Murphy VA Hospital, 7400 Merton Minter Blvd 11C6, San Antonio, Texas, 78229, USA
BMC Res Notes 1:120. 2008..The purpose of this study was to examine whether prior outpatient antibiotic use is associated with increased 30-day mortality, after adjusting for potential confounders, for those subsequently hospitalized with pneumonia...
A clinical pathway for community-acquired pneumonia: an observational cohort studyChristopher R Frei
College of Pharmacy, The University of Texas at Austin, 1 University Station A1900, Austin, TX 78712, USA
BMC Infect Dis 11:188. 2011..We proposed this study to determine the impact of pathway antibiotics on patient survival, hospital length of stay (LOS), and total hospital cost...
Disparities of care for African-Americans and Caucasians with community-acquired pneumonia: a retrospective cohort studyChristopher R Frei
The University of Texas at Austin College of Pharmacy, Austin, TX 78712, USA
BMC Health Serv Res 10:143. 2010..S. hospitals with community-acquired pneumonia (CAP) are more likely than Caucasians to experience prolonged hospital length of stay (LOS), possibly due to either differential treatment decisions or patient characteristics...
Late admission to the ICU in patients with community-acquired pneumonia is associated with higher mortalityMarcos I Restrepo
Veterans Evidence Based Research Dissemination and Implementation Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
Chest 137:552-7. 2010..Our objective was to examine the association of time to ICU admission and 30-day mortality in patients with severe CAP...
Severe community-acquired pneumoniaMarcos I Restrepo
Division of Pulmonary Critical Care Medicine, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, TX 78229, USA
Infect Dis Clin North Am 23:503-20. 2009..This article reviews epidemiologic, microbiologic, therapeutic, preventive, and outcomes data in patients who have CAP in the ICU...
Efficacy of intravenous infusion of doripenemMarcos I Restrepo
University of Texas Health Science Center San Antonio and Audie L Murphy Division, VERDICT South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX 78229, USA
Clin Infect Dis 49:S17-27. 2009..Overall, the clinical data indicate that doripenem has the potential to be an important option in the treatment of NP, including VAP...
Severe community-acquired pneumonia: current outcomes, epidemiology, etiology, and therapyM I Restrepo
University of Texas Health Science Center at San Antonio 78229 3900, USA
Curr Opin Infect Dis 14:703-9. 2001..A number of recent studies and guidelines addressing these issues have been published, and they will be reviewed in this article...
The role of gram-negative bacteria in healthcare-associated pneumoniaMarcos I Restrepo
Division of Pulmonary and Critical Care Medicine at the South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, Texas 78284, USA
Semin Respir Crit Care Med 30:61-6. 2009..We will focus our attention on the potential multidrug-resistant pathogens to suggest a new treatment approach for these patients...
A comparative study of community-acquired pneumonia patients admitted to the ward and the ICUMarcos I Restrepo
VERDICT 11C6, South Texas Veterans Health Care System ALMD, 7400 Merton Minter Blvd, San Antonio, TX 78229, USA
Chest 133:610-7. 2008..Our aim was to compare the clinical characteristics, etiologies, and outcomes of patients with CAP who were admitted to the ICU with those admitted who were to the ward service...
Common medications that increase the risk for developing community-acquired pneumoniaMarcos I Restrepo
VERDICT, South Texas Veterans Healthcare System ALMD, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, USA
Curr Opin Infect Dis 23:145-51. 2010..In addition, we review the data regarding the use of gastric-acid suppressants including histamine-2 receptor antagonists and proton pump inhibitors and the increased incidence of CAP...
COPD is associated with increased mortality in patients with community-acquired pneumoniaM I Restrepo
The Veterans Evidence based Research, Dissemination, and Implementation CenTer, Audie L Murphy Veterans Hospital, San Antonio, TX 78284, USA
Eur Respir J 28:346-51. 2006..Chronic obstructive pulmonary disease should be evaluated for inclusion in community-acquired pneumonia prediction instruments...
Impact of macrolide therapy on mortality for patients with severe sepsis due to pneumoniaM I Restrepo
Veterans Evidence Based Research Dissemination Implementation Center, Audie L Murphy Veterans Affairs Hospital, San Antonio, TX, USA
Eur Respir J 33:153-9. 2009..Confirmatory studies are needed to determine whether macrolide therapy may be protective for patients with sepsis...
Health economics of use fluoroquinolones to treat patients with community-acquired pneumoniaMarcos I Restrepo
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Am J Med 123:S39-46. 2010..In this review, we focus on the empiric antibiotic choices and associated costs of treatment for hospitalized patients with CAP, focusing on the use of fluoroquinolone therapy as recommended by the CAP guidelines...
[Influenza A (H1N1). Experience in the United States]Marcos I Restrepo
South Texas Veterans Health Care System, Audie L Murphy Division, Departmento de Medicina, University of Texas Health Science Center, San Antonio, Texas, USA
Arch Bronconeumol 46:13-8. 2010..Therefore, the present review aims to examine the North American experience of the influenza A (H1N1) epidemic, focussing chronologically on the epidemiology of the virus, high risk groups, diagnosis, vaccination and management...
Economic burden of ventilator-associated pneumonia based on total resource utilizationMarcos I Restrepo
Veterans Evidence Based Research Dissemination Implementation Center, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 4404, USA
Infect Control Hosp Epidemiol 31:509-15. 2010..To characterize the current economic burden of ventilator-associated pneumonia (VAP) and to determine which services increase the cost of VAP in North American hospitals...
Antimicrobial resistance in Hispanic patients hospitalized in San Antonio, TX with community-acquired pneumoniaMarcos I Restrepo
Veterans Evidence based Research, Dissemination, and Implementation Center VERDICT, San Antonio, TX 78229, USA
Hosp Pract (1995) 38:108-13. 2010....
Guideline-concordant antibiotic use and survival among patients with community-acquired pneumonia admitted to the intensive care unitChristopher R Frei
University of Texas at Austin, College of Pharmacy, Austin, Texas, USA
Clin Ther 32:293-9. 2010..This study evaluated the survival benefit of US community-acquired pneumonia (CAP) practice guidelines in the intensive care unit (ICU) setting...
Guideline-concordant therapy and outcomes in healthcare-associated pneumoniaR T Attridge
Feik School of Pharmacy, University of the Incarnate Word, School of Medicine, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
Eur Respir J 38:878-87. 2011..12, 95% CI 1.82-2.48) in the propensity score analysis. In nonsevere HCAP patients, GC-HCAP therapy is not associated with improved survival compared with GC-CAP therapy...
Monotherapy versus combination antibiotic therapy for patients with bacteremic Streptococcus pneumoniae community-acquired pneumoniaR Chokshi
Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
Eur J Clin Microbiol Infect Dis 26:447-51. 2007..Randomized controlled trials are needed to determine what is the optimal empiric antimicrobial regime for patients with community-acquired pneumonia...
Impact of statins and angiotensin-converting enzyme inhibitors on mortality of subjects hospitalised with pneumoniaE M Mortensen
VERDICT, ALMD UTHSCSA, Ambulatory Care 11C6, 7400 Merton Minter Boulevard, San Antonio, TX 78229, USA
Eur Respir J 31:611-7. 2008..Randomised controlled trials are needed to examine whether the use of these medications in patients hospitalised with community-acquired pneumonia may be beneficial...
Inhaled corticosteroid use is associated with lower mortality for subjects with COPD and hospitalised with pneumoniaR Malo de Molina
Veterans Evidence based Research, Disseminations and Implementation Center VERDICT South Texas Veterans Health Care System, San Antonio, TX 78229, USA
Eur Respir J 36:751-7. 2010..76, 95% CI 0.70-0.83), and 90 days (OR 0.80, 95% CI 0.75-0.86). Outpatient therapy with ICS was associated with a significantly lower 30- and 90-day mortality in hospitalised COPD patients with pneumonia...
Medical resource utilization among community-acquired pneumonia patients initially treated with levofloxacin 750 mg daily versus ceftriaxone 1000 mg plus azithromycin 500 mg daily: a US-based studyC R Frei
University of Texas at Austin, Austin, TX, USA
Curr Med Res Opin 25:859-68. 2009....
Antimicrobial treatment of community-acquired pneumoniaMarcos I Restrepo
Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
Clin Chest Med 26:65-73. 2005..Early clinical suspicion and prompt empiric antimicrobial therapies are mandatory in patients with CAP. This article provides a review of recent studies and guidelines addressing antimicrobial therapy for hospitalized patients with CAP...
Incidence of Clostridium difficile-associated diarrhea before and after autologous peripheral blood stem cell transplantation for lymphoma and multiple myelomaJ I Arango
Department of Medicine, Division of Hematology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Bone Marrow Transplant 37:517-21. 2006..Patients treated with paclitaxel as part of the mobilization regimen had a lower incidence of CDAD than patients who received hematopoietic growth factor only (P = 0.01)...
Association of hydrophilic versus lipophilic angiotensin-converting enzyme inhibitor use on pneumonia-related mortalityEric M Mortensen
VERDICT Research Center, South Texas Veterans Health Care System, San Antonio, Texas 78284, USA
Am J Med Sci 336:462-6. 2008..Our aim was to examine the associations of prior outpatient use of lipophilic and hydrophilic ACE inhibitors on mortality for patients hospitalized with community-acquired pneumonia...
Diagnosis of pulmonary malignancy after hospitalization for pneumoniaEric M Mortensen
VERDICT Research Program and South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, TX, USA
Am J Med 123:66-71. 2010..Our aims were to assess the frequency of the diagnosis of pulmonary malignancy, and to identify risk factors for pulmonary malignancy following hospitalization for pneumonia...
Impact of a lung transplantation donor-management protocol on lung donation and recipient outcomesLuis F Angel
Division of Pulmonary and Critical Care Medicine, Division of Cardiothoracic Surgery, Center for Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, TX 78229
Am J Respir Crit Care Med 174:710-6. 2006..One of the limitations associated with lung transplantation is the lack of available organs...
Community-Acquired Pneumonia Recovery in the Elderly (CAPRIE): efficacy and safety of moxifloxacin therapy versus that of levofloxacin therapyAntonio Anzueto
Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
Clin Infect Dis 42:73-81. 2006..This study aimed to determine the efficacy and safety of moxifloxacin versus that of levofloxacin for the treatment of CAP in hospitalized elderly patients (age, > or = 65 years)...
The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumoniaEric M Mortensen
VERDICT Research Center, Audie L Murphy VA Hospital, San Antonio, Texas, USA
Respir Res 6:82. 2005..We examined the effect of prior outpatient use of statins on mortality for patients hospitalized with community-acquired pneumonia...
Pulmonary disease among inpatient decedents: Impact of schizophreniaLaurel A Copeland
South Texas Veterans Health Care System VERDICT HSR and D, 7400 Merton Minter 11c6, San Antonio, Texas 78229 4404, United States
Prog Neuropsychopharmacol Biol Psychiatry 31:720-6. 2007..Determine the risk associated with schizophrenia for common pulmonary illness (pneumonia and chronic obstructive pulmonary disorder (COPD)) during the last year of life...
Impact of previous statin and angiotensin II receptor blocker use on mortality in patients hospitalized with sepsisEric M Mortensen
VERDICT Research Center, South Texas Veterans Health Care System, San Antonio, Texas 78284, USA
Pharmacotherapy 27:1619-26. 2007..To examine the effect of previous outpatient use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and/or angiotensin II receptor blockers (ARBs) on 30-day mortality in patients hospitalized with sepsis...
The impact of prior outpatient ACE inhibitor use on 30-day mortality for patients hospitalized with community-acquired pneumoniaEric M Mortensen
VERDICT Research Center, Audie L Murphy VA Hospital, San Antonio, Texas, USA
BMC Pulm Med 5:12. 2005..We examined the effect of prior outpatient use of ACE inhibitors on mortality for patients hospitalized with community-acquired pneumonia...
Postoperative complications in the seriously mentally ill: a systematic review of the literatureLaurel A Copeland
Veterans Affairs HSRD South Texas Veterans Health Care System VERDICT, San Antonio, TX 78229 4404, USA
Ann Surg 248:31-8. 2008..To determine the knowledge base on clinical outcomes of surgery among persons diagnosed with serious mental illness...
Antibiotic therapy and 48-hour mortality for patients with pneumoniaEric M Mortensen
Veterans Evidence Based Research Dissemination and Implementation Center, South Texas Veterans Health Care System, San Antonio, Tex 78284, USA
Am J Med 119:859-64. 2006..Our aim was to determine whether the use of guideline-concordant antibiotic therapy is associated with decreased mortality within the first 48 hours after admission for patients with pneumonia...
Association of hypoglycemia with mortality for subjects hospitalized with pneumoniaEric M Mortensen
VERDICT research program, Medicine Service, Audie L Murphy Division South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Am J Med Sci 339:239-43. 2010..The purpose of this study was to examine whether hypoglycemia (<70 mg/dL) is associated with increased 30-day mortality, after adjusting for potential confounders, for adults hospitalized with pneumonia...
Activity of daptomycin against recent North American isolates of Streptococcus pneumoniaeM I Restrepo
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
Antimicrob Agents Chemother 47:2974-7. 2003..Daptomycin zone diameters varied little on the same media...
Antifungal prophylaxis with voriconazole or itraconazole in lung transplant recipients: hepatotoxicity and effectivenessJ Cadena
Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio UTHSCSA, TX, USA
Am J Transplant 9:2085-91. 2009..Voriconazole prophylaxis after lung transplantation was associated with a higher incidence of hepatotoxicity and similar clinical effectiveness when compared to itraconazole...
Performance of a hybrid central venous catheter utilized for both peripheral blood stem cell harvest and transplant support of patients undergoing autologous peripheral blood stem cell transplantationA Restrepo
Department of Medicine, University of Texas Health Science Center, San Antonio, USA
Bone Marrow Transplant 30:389-95. 2002....
Fibrin ring granulomas in Rickettsia typhi infectionMarcos I Restrepo
Veterans Evidence Research Dissemination and Implementation Center VERDICT, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
Diagn Microbiol Infect Dis 66:322-5. 2010..The patient was given doxycycline, and the fever resolved within 48 h. We propose that fibrin ring granulomas also occur in murine typhus...
Incidence, risk factors, and outcome of ventilator-associated pneumoniaEva Tejerina
Intensive Care Unit, Hospital Universitario de Getafe, 28905-Getafe, Madrid, Spain
J Crit Care 21:56-65. 2006..Ventilator-associated pneumonia was associated with a significant increase in ICU length of stay but no increase in mortality...
Evaluation of ICU admission criteria and diagnostic methods for patients with severe community-acquired pneumonia: current practice surveyMarcos I Restrepo
Chest 133:828-9. 2008
Etiology of community-acquired pneumonia in hospitalized patients in chile: the increasing prevalence of respiratory viruses among classic pathogensAlejandro Diaz
Departamento de Enfermedades Respiratorias, Pontificia Universidad Catolica de Chile, Santiago, Chile
Chest 131:779-87. 2007..The aim of this study was to determine the microbial etiology of CAP in adults and to identify the risk factors for various specific pathogens...
Statins and outcomes in patients with pneumonia: not only healthy user biasEric M Mortensen
BMJ 333:1123-4. 2006
Steroid infusion for severe pneumonia: not so fastMarcos I Restrepo
Am J Respir Crit Care Med 172:781; author reply 782-3. 2005
Prognosis factors and outcome of community-acquired pneumonia needing mechanical ventilationEva Tejerina
Intensive Care Unit, Hospital Universitario de Getafe, 28905-Getafe, Madrid, Spain
J Crit Care 20:230-8. 2005..The main determinants of patient outcome were initial severity of illness and the development of shock and/or acute renal failure...
When to switch therapy in patients with severe community-acquired pneumoniaEric M Mortensen
Ann Intern Med 148:625; author reply 625-6. 2008
The role of new therapies for severe community-acquired pneumoniaMarcos I Restrepo
Division of Pulmonary and Crit Care Med, South Texas Veterans Healthcare System, Audie L. Murphy Division, University of Texas Health Science Center at San Antonio 78229, USA
Curr Opin Infect Dis 19:557-64. 2006..In particular, it is essential to administer an appropriate antimicrobial agent from the initiation of therapy, so that the risks of treatment failure and the morbidity of CAP may be minimized...
Impact of guideline-concordant empiric antibiotic therapy in community-acquired pneumoniaChristopher R Frei
University of Texas at Austin College of Pharmacy, Austin, Tex, USA
Am J Med 119:865-71. 2006....
Reply to Bodi et alEric M Mortensen
Clin Infect Dis 42:1345. 2006
Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trialMarin H Kollef
Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
JAMA 300:805-13. 2008..Ventilator-associated pneumonia (VAP) causes substantial morbidity. A silver-coated endotracheal tube has been designed to reduce VAP incidence by preventing bacterial colonization and biofilm formation...
