Affiliation: University of California
- Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cellsSilvia Resta-Lenert
Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California, USA
Gastroenterology 130:731-46. 2006..We hypothesized that probiotics and/or commensals may also reverse epithelial damage produced by cytokines...
- Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activityS Resta-Lenert
Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California 92103, USA
Am J Physiol Cell Physiol 281:C1837-49. 2001..However, these effects may not all be equally important in determining Cl(-) secretion in response to physiologically relevant secretagogues...
- Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2Silvia Resta-Lenert
Department of Medicine, and Biomedical Sciences Ph D Program, University of California, San Diego, School of Medicine, San Diego, California, USA
Gastroenterology 122:1070-87. 2002....
- Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC)S Resta-Lenert
Department of Medicine, School of Medicine, University of California San Diego, UCSD Medical Center 8414, 200 West Arbor Drive, San Diego, CA 92103, USA
Gut 52:988-97. 2003..The colonic epithelium maintains a life long reciprocally beneficial interaction with the colonic microbiota. Disruption is associated with mucosal injury...
- Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- miceSilvia Resta-Lenert
Division of Gastroenterology, Department of Medicine, University of California, School of Medicine, San Diego, CA 92103, USA
Am J Physiol Gastrointest Liver Physiol 289:G153-62. 2005..Our data support the hypothesis that alterations in the intestinal barrier alone, in the absence of immune dysfunction, may rapidly lead to colitis in the setting of a normal colonic flora...
- Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integritySilvia Resta-Lenert
Department of Medicine, University of California San Diego, USA
Am J Physiol Gastrointest Liver Physiol 300:G1144-55. 2011..In conclusion, these data suggest that both native and exogenous MUC17 play a role in attachment and invasion of EIEC in colonic cell lines and in maintaining epithelial barrier function...