YANA K contact RESHETNYAK

Summary

Affiliation: University of Rhode Island
Country: USA

Publications

  1. ncbi request reprint Evidence of inter- and intra-molecular crosslinking of tyrosine residues of calmodulin induced by photo-activation of ruthenium(II)
    Oleg A Andreev
    Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 7610, USA
    Photochem Photobiol Sci 1:834-6. 2002
  2. pmc Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix
    Yana K Reshetnyak
    Department of Molecular Biophysics and Biochemistry, Yale University, P O Box 208114, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:6460-5. 2006
  3. pmc Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane
    Yana K Reshetnyak
    Physics Department, University of Rhode Island, 2 Lippitt Road, Kingston, RI 02881, USA
    Proc Natl Acad Sci U S A 105:15340-5. 2008
  4. pmc A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers
    Yana K Reshetnyak
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Biophys J 93:2363-72. 2007
  5. ncbi request reprint Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase
    Yana Reshetnyak
    Department of Physics, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Biomol Struct Dyn 24:75-82. 2006
  6. ncbi request reprint Membrane protein folding: beyond the two stage model
    Donald M Engelman
    Department of Molecular Biophysics and Biochemistry, Yale University, P O Box 208114, New Haven, CT 06520 8114, USA
    FEBS Lett 555:122-5. 2003
  7. ncbi request reprint Mechanism of formation of actomyosin interface
    Oleg A Andreev
    Physics Department, University of Rhode Island, East Hall, 2 Lippitt Road, Kingston, RI 02881, USA
    J Mol Biol 365:551-4. 2007
  8. pmc pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path
    Oleg A Andreev
    Physics Department, University of Rhode Island, 2 Lippitt Road, Kingston, RI 02881, USA
    Proc Natl Acad Sci U S A 107:4081-6. 2010
  9. pmc Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP)
    James Segala
    Physics Department, University of Rhode Island, Kingston, RI 02881, USA
    Int J Mol Sci 10:3478-87. 2009
  10. pmc Tuning the insertion properties of pHLIP
    Monika Musial-Siwek
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    Biochim Biophys Acta 1798:1041-6. 2010

Research Grants

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Evidence of inter- and intra-molecular crosslinking of tyrosine residues of calmodulin induced by photo-activation of ruthenium(II)
    Oleg A Andreev
    Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 7610, USA
    Photochem Photobiol Sci 1:834-6. 2002
    ..Tris(2,2'-bipyridyl)ruthenium(n) upon illumination with light at a wavelength of 450 nm in the presence of an electron acceptor induces dityrosine crosslinking in proteins...
  2. pmc Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix
    Yana K Reshetnyak
    Department of Molecular Biophysics and Biochemistry, Yale University, P O Box 208114, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:6460-5. 2006
    ....
  3. pmc Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane
    Yana K Reshetnyak
    Physics Department, University of Rhode Island, 2 Lippitt Road, Kingston, RI 02881, USA
    Proc Natl Acad Sci U S A 105:15340-5. 2008
    ..The results give the amount of energy that might be used to move cargo molecules across a membrane...
  4. pmc A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers
    Yana K Reshetnyak
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Biophys J 93:2363-72. 2007
    ....
  5. ncbi request reprint Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase
    Yana Reshetnyak
    Department of Physics, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Biomol Struct Dyn 24:75-82. 2006
    ..We propose that the redistribution of charged residues in mutant LCAT may be a major factor responsible for the dramatically reduced activity of the enzyme with HDL and reconstituted high density lipoprotein (rHDL)...
  6. ncbi request reprint Membrane protein folding: beyond the two stage model
    Donald M Engelman
    Department of Molecular Biophysics and Biochemistry, Yale University, P O Box 208114, New Haven, CT 06520 8114, USA
    FEBS Lett 555:122-5. 2003
    ..Here we present a three stage model which gives considerations to ligand binding, folding of extramembranous loops, insertion of peripheral domains and the formation of quaternary structure...
  7. ncbi request reprint Mechanism of formation of actomyosin interface
    Oleg A Andreev
    Physics Department, University of Rhode Island, East Hall, 2 Lippitt Road, Kingston, RI 02881, USA
    J Mol Biol 365:551-4. 2007
    ..The sequential mechanism of formation of actomyosin interface starting from one end and developing towards the barbed end might be involved in force generation and directional movement in actin-myosin system...
  8. pmc pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path
    Oleg A Andreev
    Physics Department, University of Rhode Island, 2 Lippitt Road, Kingston, RI 02881, USA
    Proc Natl Acad Sci U S A 107:4081-6. 2010
    ..These insights may guide understanding of membrane protein folding/unfolding and the design of medically useful peptides for imaging and drug delivery...
  9. pmc Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP)
    James Segala
    Physics Department, University of Rhode Island, Kingston, RI 02881, USA
    Int J Mol Sci 10:3478-87. 2009
    ..The approach is tested in vivo by co-localization of GFP-tumors and NIR emission from the fluorescently labeled pHLIP, and it is found that boundaries are accurately reported and that sub-millimeter masses can be detected...
  10. pmc Tuning the insertion properties of pHLIP
    Monika Musial-Siwek
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    Biochim Biophys Acta 1798:1041-6. 2010
    ..However, variants with either of the Asp residues changed to Glu remained soluble in an aqueous environment and inserted into the membrane at acidic pH with a higher pK(app) of membrane insertion...
  11. pmc Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors
    Manuela Zoonens
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Biophys J 95:225-35. 2008
    ..Using parallax analysis, the change of the penetration depth of pHLIP was estimated to be 0.4 A from the bilayer center and 2.8 A from the membrane surface after the liquid-to-gel phase transition...
  12. doi request reprint The protein fluorescence and structural toolkit: Database and programs for the analysis of protein fluorescence and structural data
    Chi Shen
    Department of Computer Sciences and Statistics, University of Rhode Island, Kingston, Rhode Island 02881, USA
    Proteins 71:1744-54. 2008
    ..3) The last module is a PFAST database that contains protein fluorescence and structural data obtained from results of the FCAT and SCAT analyses...
  13. pmc Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo
    Oleg A Andreev
    Physics Department, University of Rhode Island, 2 Lippitt Road, Kingston, RI 02881, USA
    Proc Natl Acad Sci U S A 104:7893-8. 2007
    ..pHLIP nanotechnology introduces a new method of detecting, targeting, and possibly treating acidic diseased tissue by using the selective insertion and folding of membrane peptides...
  14. pmc Fluorescence probing of aminofluorene-induced conformational heterogeneity in DNA duplexes
    Nidhi Jain
    Department of Biomedical and Pharmaceutical Sciences and Physics, University of Rhode Island, Kingston, RI 02881, USA
    Chem Res Toxicol 21:445-52. 2008
    ..This work represents a novel utility of AP in probing adduct-induced conformational heterogeneities in DNA duplexes...
  15. doi request reprint Fabrication of semiconductor nanowires by conjugation of quantum dots to actin filaments
    Lan Yao
    Physics Department, University of Rhode Island, 2 Lippitt Rd, Kingston, RI 02881, USA
    Anal Bioanal Chem 395:1563-6. 2009
    ..Three different approaches of assembling quantum dots into nanowires are described. The nanowires were characterized by fluorescence microscopy...
  16. pmc Folding kinetics and structure of OEP16
    Dirk Linke
    Max Volmer Laboratorium, Institut fur Chemie der Technischen Universitat Berlin, 10623 Berlin, Germany
    Biophys J 86:1479-87. 2004
    ....
  17. ncbi request reprint Conformational and enzymatic changes of 20S proteasome of rat natural killer cells induced by mono- and divalent cations
    Yana K Reshetnyak
    Department of Molecular Biology and Immunology, Institute for Cancer Research, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    J Struct Biol 145:263-71. 2004
    ....
  18. ncbi request reprint Topography studies on the membrane interaction mechanism of the eosinophil cationic protein
    Marc Torrent
    Departamento de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    Biochemistry 46:720-33. 2007
    ..No significant leakage of the vesicle aqueous content takes place below that protein concentration threshold. The data are consistent with a membrane destabilization "carpet-like" mechanism...

Research Grants4

  1. pHLIP Nanotechnology Platform for Cancer Imaging and Therapy
    YANA K contact RESHETNYAK; Fiscal Year: 2010
    ..Such improvements are especially important for cancer treatment, since the majority of anti-cancer drugs are poisons that damage normal cells. ..
  2. pHLIP Nanotechnology Platform for Cancer Imaging and Therapy
    Yana Reshetnyak; Fiscal Year: 2009
    ..Such improvements are especially important for cancer treatment, since the majority of anti-cancer drugs are poisons that damage normal cells. ..