Research Topics
| STEVEN REPPERTSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleasesChristine Merlin
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genome Res 23:159-68. 2013..Importantly, this approach could be used in other lepidopterans and "nonmodel" insects, thus opening new avenues to decipher the molecular underpinnings of a variety of biological processes...- Defining behavioral and molecular differences between summer and migratory monarch butterfliesHaisun Zhu
Department of Neurobiology, University of Massachusetts Medical School, Plantation Street, Worcester, MA 01605, USA
BMC Biol 7:14. 2009.... 
Polarized light helps monarch butterflies navigateSteven M Reppert
Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, MA 01605, USA
Curr Biol 14:155-8. 2004..The existence of polarized-light detection could allow migrants to accurately navigate under a variety of atmospheric conditions and reveals a critical input pathway into the sun compass mechanism...- A colorful model of the circadian clockSteven M Reppert
Department of Neurobiology, University of Massachusetts Medical School, Worcester, 01605, USA
Cell 124:233-6. 2006..The monarch circadian clock is involved in the induction of the migratory state and navigation over long distances, using the sun as a compass... - Coordination of circadian timing in mammalsSteven M Reppert
Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nature 418:935-41. 2002..However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world... - Navigational mechanisms of migrating monarch butterfliesSteven M Reppert
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Trends Neurosci 33:399-406. 2010..Monarch butterflies are thus emerging as an excellent model organism in which to study the molecular and neural basis of long-distance migration... - Rhythmic histone acetylation underlies transcription in the mammalian circadian clockJean Pierre Etchegaray
Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nature 421:177-82. 2003..The delayed timing of the Cry1 mRNA rhythm, relative to the Per rhythms, is due to the coordinated activities of Rev-Erbalpha and Clock/Bmal1, and defines a new mechanism for circadian phase control... - Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigationHaisun Zhu
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS Biol 6:e4. 2008..Our data further suggest that CRY2 may have a dual role in the monarch butterfly's brain-as a core clock element and as an output that regulates circadian activity in the central complex, the likely site of the sun compass... - Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterfliesChristine Merlin
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 325:1700-4. 2009..These unexpected findings pose a novel function for the antennae and open a new line of investigation into clock-compass connections that may extend widely to other insects that use this orientation mechanism... - Illuminating the circadian clock in monarch butterfly migrationOren Froy
Department of Neurobiology, University of Massachusetts Medical School, LRB-728, 364 Plantation Street, Worcester, MA 01605, USA
Science 300:1303-5. 2003..Tracing these distinct light-input pathways into the brain should aid our understanding of the clock-compass mechanisms necessary for successful migration... - Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanismRobert J Gegear
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nature 463:804-7. 2010..This work emphasizes the utility of Drosophila transgenesis for elucidating the precise mechanisms of Cry-mediated magnetosensitivity in insects and also in vertebrates such as migrating birds... - A clock shock: mouse CLOCK is not required for circadian oscillator functionJason P Debruyne
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Neuron 50:465-77. 2006..Our data challenge a central feature of the current mammalian circadian clock model regarding the necessity of CLOCK:BMAL1 heterodimers for clock function... - Cryptochrome mediates light-dependent magnetosensitivity in DrosophilaRobert J Gegear
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 454:1014-8. 2008..Moreover, Cry-dependent magnetosensitivity does not require a functioning circadian clock. Our work provides, to our knowledge, the first genetic evidence for a Cry-based magnetosensitive system in any animal... - CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clockJason P Debruyne
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nat Neurosci 10:543-5. 2007..Here we report that the transcription factor NPAS2 (MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity... - Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus)Haisun Zhu
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
PLoS ONE 3:e1345. 2008..The identified SNPs and microsatellite polymorphisms can be used as genetic markers to address questions of population and subspecies structure... - A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcriptionDennis C Chang
Department of Neurobiology, University of Massachusetts Medical Center, 364 Plantation Street, Worcester, MA 01605, USA
Curr Biol 13:758-62. 2003..The data indicate that nuclear PER inhibits dCLK:CYC-mediated transcription through a novel domain that additionally contains a potent NLS... - Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocksQuan Yuan
Department of Neurobiology, University of Massachusetts Medical School, USA
Mol Biol Evol 24:948-55. 2007..These data provide an evolutionary context for proposing novel circadian clock mechanisms in insects... - Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clockChoogon Lee
Department of Neurobiology, LRB 728, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Mol Cell Biol 24:584-94. 2004..We thus propose that the CKIepsilon-binding domain is critical not only for mPER phosphorylation but also for a functioning circadian clock... - A rhythmic RorPatrick Emery
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Neuron 43:443-6. 2004..This finding defines the second feedback loop in mammals... - The polycomb group protein EZH2 is required for mammalian circadian clock functionJean Pierre Etchegaray
Department of Neurobiology, University of Massachusetts Medical School, Worcester, 01605, USA
J Biol Chem 281:21209-15. 2006..These results indicate that EZH2 is important for the maintenance of circadian rhythms and extend the activity of the polycomb group proteins to the core clockwork mechanism of mammals... - Casein kinase 1 delta regulates the pace of the mammalian circadian clockJean Pierre Etchegaray
Department of Neurobiology, LRB 723, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Mol Cell Biol 29:3853-66. 2009..These results reveal important functional differences between CK1delta and CK1epsilon: CK1delta plays an unexpectedly important role in maintaining the 24-h circadian cycle length... - The two CRYs of the butterflyHaisun Zhu
Curr Biol 15:R953-4. 2005 - Connecting the navigational clock to sun compass input in monarch butterfly brainIvo Sauman
Institute of Entomology, Czech Academy of Sciences, Ceske Budejovice, Czech Republic
Neuron 46:457-67. 2005..To provide a link between the clock and the sun compass, we identified a CRYPTOCHROME-staining neural pathway that likely connects the circadian clock to polarized light input entering brain... - Peripheral circadian oscillators require CLOCKJason P Debruyne
Curr Biol 17:R538-9. 2007 - Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyiDennis C Chang
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 278:38149-58. 2003..Our analysis sheds light on the molecular function and evolution of clock genes in the animal kingdom... - Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterflySang Hun Song
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
J Biol Chem 282:17608-12. 2007.... - Targeted disruption of the mouse Mel(1b) melatonin receptorXiaowei Jin
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Mol Cell Biol 23:1054-60. 2003..Mice with targeted disruption of melatonin receptor subtypes will allow molecular dissection of other melatonin receptor-mediated responses... - Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activityZdenka Travnickova-Bendova
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, B P 10142, 67404 Illkirch Strasbourg, France
Proc Natl Acad Sci U S A 99:7728-33. 2002..Our results reveal that signaling-dependent activation of mPer genes is distinct from the CLOCK/BMAL1-driven transcription required within the clock feedback loop... - Redox potential: differential roles in dCRY and mCRY1 functionsOren Froy
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Curr Biol 12:147-52. 2002..The data provide a multistep redox model for the light-dependent activities of dCRY and suggest that such a model does not apply to mCRY1 transcriptional responses...
Research Grants
- Circadian Clock: Transcriptional ControlSTEVEN REPPERT; Fiscal Year: 2007..such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders ..
- Circadian Clock: Differential Cryptochrome FunctionsSTEVEN REPPERT; Fiscal Year: 2009..Likewise, such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders. ..
- Circadian Clock: Differential Cryptochrome FunctionsSTEVEN REPPERT; Fiscal Year: 2009..Likewise, such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders. ..
- Circadian Clock: Differential Cryptochrome FunctionsSteven M Reppert; Fiscal Year: 2010..Likewise, such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders. ..
- CIRCADIAN CLOCK MECHANISM IN THE SCNSTEVEN REPPERT; Fiscal Year: 2004..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
- COMPARATIVE ANALYSIS OF CLOCK GENESSTEVEN REPPERT; Fiscal Year: 2001..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
- MATERNAL INFLUENCE ON DEVELOPING 24-HOUR PERIODICITYSTEVEN REPPERT; Fiscal Year: 2002..Thus, increased understanding of the basic mechanisms of biological clock function may facilitate the development of better treatment strategies for a wide range of disorders. ..