STEVEN REPPERT

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus)
    Haisun Zhu
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 3:e1345. 2008
  2. pmc MonarchBase: the monarch butterfly genome database
    Shuai Zhan
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Nucleic Acids Res 41:D758-63. 2013
  3. pmc Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies
    Patrick A Guerra
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Commun 3:958. 2012
  4. pmc Human cryptochrome exhibits light-dependent magnetosensitivity
    Lauren E Foley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Commun 2:356. 2011
  5. pmc Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases
    Christine Merlin
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genome Res 23:159-68. 2013
  6. pmc Defining behavioral and molecular differences between summer and migratory monarch butterflies
    Haisun Zhu
    Department of Neurobiology, University of Massachusetts Medical School, Plantation Street, Worcester, MA 01605, USA
    BMC Biol 7:14. 2009
  7. ncbi request reprint A colorful model of the circadian clock
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, 01605, USA
    Cell 124:233-6. 2006
  8. ncbi request reprint Polarized light helps monarch butterflies navigate
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 14:155-8. 2004
  9. pmc Navigational mechanisms of migrating monarch butterflies
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Trends Neurosci 33:399-406. 2010
  10. ncbi request reprint Coordination of circadian timing in mammals
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 418:935-41. 2002

Research Grants

  1. Circadian Clock: Differential Cryptochrome Functions
    STEVEN REPPERT; Fiscal Year: 2009
  2. Circadian Clock: Differential Cryptochrome Functions
    STEVEN REPPERT; Fiscal Year: 2009
  3. Circadian Clock: Differential Cryptochrome Functions
    Steven M Reppert; Fiscal Year: 2010
  4. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2007
  5. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2005
  6. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2006
  7. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2004
  8. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2004
  9. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2003
  10. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 1999

Collaborators

Detail Information

Publications32

  1. pmc Chasing migration genes: a brain expressed sequence tag resource for summer and migratory monarch butterflies (Danaus plexippus)
    Haisun Zhu
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 3:e1345. 2008
    ..The identified SNPs and microsatellite polymorphisms can be used as genetic markers to address questions of population and subspecies structure...
  2. pmc MonarchBase: the monarch butterfly genome database
    Shuai Zhan
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Nucleic Acids Res 41:D758-63. 2013
    ..MonarchBase utilizes a variety of retrieving methods to access data conveniently and for integrating biological interpretations...
  3. pmc Discordant timing between antennae disrupts sun compass orientation in migratory monarch butterflies
    Patrick A Guerra
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Commun 3:958. 2012
    ..This dual timing system is a novel example of the regulation of a brain-driven behaviour by paired organs...
  4. pmc Human cryptochrome exhibits light-dependent magnetosensitivity
    Lauren E Foley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Commun 2:356. 2011
    ..The results show that human CRY2 has the molecular capability to function as a light-sensitive magnetosensor and reopen an area of sensory biology that is ready for further exploration in humans...
  5. pmc Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases
    Christine Merlin
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genome Res 23:159-68. 2013
    ..Importantly, this approach could be used in other lepidopterans and "nonmodel" insects, thus opening new avenues to decipher the molecular underpinnings of a variety of biological processes...
  6. pmc Defining behavioral and molecular differences between summer and migratory monarch butterflies
    Haisun Zhu
    Department of Neurobiology, University of Massachusetts Medical School, Plantation Street, Worcester, MA 01605, USA
    BMC Biol 7:14. 2009
    ....
  7. ncbi request reprint A colorful model of the circadian clock
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, 01605, USA
    Cell 124:233-6. 2006
    ..The monarch circadian clock is involved in the induction of the migratory state and navigation over long distances, using the sun as a compass...
  8. ncbi request reprint Polarized light helps monarch butterflies navigate
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 14:155-8. 2004
    ..The existence of polarized-light detection could allow migrants to accurately navigate under a variety of atmospheric conditions and reveals a critical input pathway into the sun compass mechanism...
  9. pmc Navigational mechanisms of migrating monarch butterflies
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Trends Neurosci 33:399-406. 2010
    ..Monarch butterflies are thus emerging as an excellent model organism in which to study the molecular and neural basis of long-distance migration...
  10. ncbi request reprint Coordination of circadian timing in mammals
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 418:935-41. 2002
    ..However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world...
  11. ncbi request reprint Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
    Jean Pierre Etchegaray
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 421:177-82. 2003
    ..The delayed timing of the Cry1 mRNA rhythm, relative to the Per rhythms, is due to the coordinated activities of Rev-Erbalpha and Clock/Bmal1, and defines a new mechanism for circadian phase control...
  12. pmc Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation
    Haisun Zhu
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 6:e4. 2008
    ..Our data further suggest that CRY2 may have a dual role in the monarch butterfly's brain-as a core clock element and as an output that regulates circadian activity in the central complex, the likely site of the sun compass...
  13. pmc Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies
    Christine Merlin
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 325:1700-4. 2009
    ..These unexpected findings pose a novel function for the antennae and open a new line of investigation into clock-compass connections that may extend widely to other insects that use this orientation mechanism...
  14. ncbi request reprint Illuminating the circadian clock in monarch butterfly migration
    Oren Froy
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, MA 01605, USA
    Science 300:1303-5. 2003
    ..Tracing these distinct light-input pathways into the brain should aid our understanding of the clock-compass mechanisms necessary for successful migration...
  15. ncbi request reprint A clock shock: mouse CLOCK is not required for circadian oscillator function
    Jason P Debruyne
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Neuron 50:465-77. 2006
    ..Our data challenge a central feature of the current mammalian circadian clock model regarding the necessity of CLOCK:BMAL1 heterodimers for clock function...
  16. pmc Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism
    Robert J Gegear
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 463:804-7. 2010
    ..This work emphasizes the utility of Drosophila transgenesis for elucidating the precise mechanisms of Cry-mediated magnetosensitivity in insects and also in vertebrates such as migrating birds...
  17. pmc Cryptochrome mediates light-dependent magnetosensitivity in Drosophila
    Robert J Gegear
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 454:1014-8. 2008
    ..Moreover, Cry-dependent magnetosensitivity does not require a functioning circadian clock. Our work provides, to our knowledge, the first genetic evidence for a Cry-based magnetosensitive system in any animal...
  18. pmc CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock
    Jason P Debruyne
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Neurosci 10:543-5. 2007
    ..Here we report that the transcription factor NPAS2 (MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity...
  19. ncbi request reprint A novel C-terminal domain of drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription
    Dennis C Chang
    Department of Neurobiology, University of Massachusetts Medical Center, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 13:758-62. 2003
    ..The data indicate that nuclear PER inhibits dCLK:CYC-mediated transcription through a novel domain that additionally contains a potent NLS...
  20. pmc Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock
    Choogon Lee
    Department of Neurobiology, LRB 728, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 24:584-94. 2004
    ..We thus propose that the CKIepsilon-binding domain is critical not only for mPER phosphorylation but also for a functioning circadian clock...
  21. ncbi request reprint Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks
    Quan Yuan
    Department of Neurobiology, University of Massachusetts Medical School, USA
    Mol Biol Evol 24:948-55. 2007
    ..These data provide an evolutionary context for proposing novel circadian clock mechanisms in insects...
  22. pmc Casein kinase 1 delta regulates the pace of the mammalian circadian clock
    Jean Pierre Etchegaray
    Department of Neurobiology, LRB 723, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 29:3853-66. 2009
    ..These results reveal important functional differences between CK1delta and CK1epsilon: CK1delta plays an unexpectedly important role in maintaining the 24-h circadian cycle length...
  23. ncbi request reprint A rhythmic Ror
    Patrick Emery
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Neuron 43:443-6. 2004
    ..This finding defines the second feedback loop in mammals...
  24. ncbi request reprint The polycomb group protein EZH2 is required for mammalian circadian clock function
    Jean Pierre Etchegaray
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, 01605, USA
    J Biol Chem 281:21209-15. 2006
    ..These results indicate that EZH2 is important for the maintenance of circadian rhythms and extend the activity of the polycomb group proteins to the core clockwork mechanism of mammals...
  25. ncbi request reprint The two CRYs of the butterfly
    Haisun Zhu
    Curr Biol 15:R953-4. 2005
  26. ncbi request reprint Connecting the navigational clock to sun compass input in monarch butterfly brain
    Ivo Sauman
    Institute of Entomology, Czech Academy of Sciences, Ceske Budejovice, Czech Republic
    Neuron 46:457-67. 2005
    ..To provide a link between the clock and the sun compass, we identified a CRYPTOCHROME-staining neural pathway that likely connects the circadian clock to polarized light input entering brain...
  27. pmc Targeted disruption of the mouse Mel(1b) melatonin receptor
    Xiaowei Jin
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Mol Cell Biol 23:1054-60. 2003
    ..Mice with targeted disruption of melatonin receptor subtypes will allow molecular dissection of other melatonin receptor-mediated responses...
  28. pmc Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity
    Zdenka Travnickova-Bendova
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, B P 10142, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 99:7728-33. 2002
    ..Our results reveal that signaling-dependent activation of mPer genes is distinct from the CLOCK/BMAL1-driven transcription required within the clock feedback loop...
  29. ncbi request reprint Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi
    Dennis C Chang
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 278:38149-58. 2003
    ..Our analysis sheds light on the molecular function and evolution of clock genes in the animal kingdom...
  30. ncbi request reprint Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly
    Sang Hun Song
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 282:17608-12. 2007
    ....
  31. ncbi request reprint Peripheral circadian oscillators require CLOCK
    Jason P Debruyne
    Curr Biol 17:R538-9. 2007
  32. ncbi request reprint Redox potential: differential roles in dCRY and mCRY1 functions
    Oren Froy
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Curr Biol 12:147-52. 2002
    ..The data provide a multistep redox model for the light-dependent activities of dCRY and suggest that such a model does not apply to mCRY1 transcriptional responses...

Research Grants21

  1. Circadian Clock: Differential Cryptochrome Functions
    STEVEN REPPERT; Fiscal Year: 2009
    ..Likewise, such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders. ..
  2. Circadian Clock: Differential Cryptochrome Functions
    STEVEN REPPERT; Fiscal Year: 2009
    ..Likewise, such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders. ..
  3. Circadian Clock: Differential Cryptochrome Functions
    Steven M Reppert; Fiscal Year: 2010
    ..Likewise, such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders. ..
  4. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2007
    ..such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders ..
  5. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2005
    ..such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders ..
  6. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2006
    ..such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders ..
  7. Circadian Clock: Transcriptional Control
    STEVEN REPPERT; Fiscal Year: 2004
    ..such understanding should lead to new strategies for pharmacological manipulation of the human clock to improve the treatment of jet lag and shift-work ailments, and of clock-related sleep and psychiatric disorders ..
  8. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2004
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  9. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2003
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  10. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 1999
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  11. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2000
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  12. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 2000
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  13. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2001
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  14. COMPARATIVE ANALYSIS OF CLOCK GENES
    STEVEN REPPERT; Fiscal Year: 2001
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  15. MATERNAL INFLUENCE ON DEVELOPING 24-HOUR PERIODICITY
    STEVEN REPPERT; Fiscal Year: 2002
    ..Thus, increased understanding of the basic mechanisms of biological clock function may facilitate the development of better treatment strategies for a wide range of disorders. ..
  16. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2002
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..
  17. CIRCADIAN CLOCK MECHANISM IN THE SCN
    STEVEN REPPERT; Fiscal Year: 2001
    ..Increased understanding of the fundamental mechanisms of biological clock function will facilitate the development of better treatment strategies for a wide range of disorders. ..