Research Topics
Species | Stephen RennardSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Publications
Smoking cessationS I Rennard
University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
Chest 117:360S-4S. 2000..These strategies assist a significant minority of smokers to stop smoking and, thus, they can have an important positive impact on COPD as well as on other health outcomes...- Efficacy of the nicotine inhaler in smoking reduction: A double-blind, randomized trialStephen I Rennard
Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
Nicotine Tob Res 8:555-64. 2006..In conclusion, the nicotine inhaler can help smokers who are unable or unwilling to quit to reduce daily cigarette consumption, which may be a health benefit on its own and may further promote quitting... - Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary diseaseS I Rennard
University of Nebraska Medical Center, Omaha, Nebraska, USA
Am J Respir Crit Care Med 163:1087-92. 2001..The long duration of action of salmeterol offers the advantage of twice daily dosing compared with the required four times a day dosing with ipratropium... 
NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extractXiangde Liu
Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Respir Res 9:66. 2008..Since NF-kappaB is also involved in regulating apoptosis and cell survival, the current study was designed to investigate the role of NF-kappaB in mediating cell survival in response to cigarette smoke exposure in HBECs...
A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparisonStephen Rennard
University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, Omaha, Nebraska 68198 5885, USA
Respir Med 102:1033-44. 2008..Indacaterol demonstrated a good overall safety and tolerability profile...- The efficacy and safety of cilomilast in COPDStephen Rennard
University of Nebraska Medical Center, Omaha, 68198 5885, USA
Drugs 68:3-57. 2008..However, subsequent phase III studies failed to definitively confirm the earlier programme results, which led to termination of the development of cilomilast... - A randomized placebo-controlled trial of varenicline for smoking cessation allowing flexible quit datesStephen Rennard
Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
Nicotine Tob Res 14:343-50. 2012..The objective of this study was to compare varenicline 1 mg twice daily (b.i.d.) with placebo in subjects using a flexible quit date paradigm after starting medication... - Chronic obstructive pulmonary disease: linking outcomes and pathobiology of disease modificationStephen I Rennard
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68198 5300, USA
Proc Am Thorac Soc 3:276-80. 2006..The development of biomarkers of lung damage, pulmonary inflammation, and systemic disease will be essential to our further understanding of the natural history of COPD and the discovery of new, effective treatments for its progression... - Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expressionAnn M Kapoun
Scios Inc, Fremont, CA 94555, USA
Mol Pharmacol 70:518-31. 2006..Our findings suggest that inhibitors such as SD-208 may be therapeutically useful in human interstitial lung diseases and pulmonary fibrosis... - Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closurePraveen R Arany
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:9250-5. 2006..These studies highlight a previously undescribed role for Smad3 in the mechanotransduction of matrix unsupported ear wound closure... - Exacerbations and progression of disease in asthma and chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Proc Am Thorac Soc 1:88-92. 2004.... - Biomarkers to assess the utility of potential reduced exposure tobacco productsDorothy K Hatsukami
Tobacco Use Research Center, University of Minnesota Cancer Center, Minneapolis, MN 55414, USA
Nicotine Tob Res 8:169-91. 2006..Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area... - COPD: the dangerous underestimate of 15%Stephen I Rennard
University of Nebraska Medical Center, Omaha, NE 68198, USA
Lancet 367:1216-9. 2006 - Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4Stephen I Rennard
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Chest 129:56-66. 2006..COPD is a relentless, progressive disease. This study evaluated the efficacy of cilomilast, a selective phosphodiesterase (PDE) 4 inhibitor, in the treatment of COPD... - Reactive nitrogen species augment fibroblast-mediated collagen gel contraction, mediator production, and chemotaxisHisatoshi Sugiura
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Am J Respir Cell Mol Biol 34:592-9. 2006..01), and neutralizing anti-TGF-beta antibody suppressed peroxynitrite-augmented alpha5beta1 expression (P < 0.01). These results suggest that RNS can affect the tissue repair process by modulating TGF-beta1... - Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung fibroblastsTetsu Kobayashi
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Biochem Biophys Res Commun 339:290-5. 2006..Thus, Smad3 mediates TGF-beta1-induced contraction and alpha-SMA induction in human lung fibroblasts. Smad3, therefore, could be a target for blocking contraction of human fibrotic tissue induced by TGF-beta1... - Proposal for a multidimensional staging system for chronic obstructive pulmonary diseaseBartolome R Celli
Department of Pulmonary and Critical Care Medicine, Tufts University, Boston, MA 02135, USA
Respir Med 99:1546-54. 2005..Although the staging boundaries were based on existing literature, they have proven useful in predicting survival. We conclude that a multidimensional grading system is useful to assess the impact of COPD... - Challenges and opportunities for combination therapy in chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, 985125 Nebraska Medical Center, Omaha, NE 68198 5125, USA
Proc Am Thorac Soc 2:391-3; discussion 394-5. 2005..The use of a truly multidimensional outcome parameter promises an entirely novel paradigm for the assessment of novel combinations of therapies... - Clinical approach to patients with chronic obstructive pulmonary disease and cardiovascular diseaseStephen I Rennard
Department of Internal Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Proc Am Thorac Soc 2:94-100. 2005..It is plausible that treatment of pulmonary inflammation characteristic of COPD will alter cardiac risk. Such an approach would offer a novel approach for the development of treatments for these common conditions... - TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gelsTetsu Kobayashi
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Respir Res 6:141. 2005..Contraction induced by different factors, therefore, may be differentially associated with apoptosis, which may be related to the persistence or resolution of the fibroblasts that accumulate following injury... - Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradationQiuhong Fang
Pulmonary and Critical Care Department, First Hospital of Tsinghua University, Beijing, China
Am J Respir Cell Mol Biol 35:714-21. 2006..Through such mechanisms, thrombin could contribute to many chronic lung disorders characterized by tissue remodeling... - Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysemaStephen I Rennard
University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, 985125 Nebraska Medical Center, Omaha, NE 98198 5125, USA
Proc Am Thorac Soc 3:703-8. 2006.... - Biomarkers to assess the utility of potential reduced exposure tobacco productsDorothy K Hatsukami
University of Minnesota Cancer Center, Minneapolis, MN, USA
Nicotine Tob Res 8:600-22. 2006..Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area... - The many "small COPDs": COPD should be an orphan diseaseStephen I Rennard
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Chest 134:623-7. 2008..This strategy may help to address the increasing burden that COPD presents and for which no novel clinical class of treatment has been introduced for 30 years... - Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary diseaseBipen D Patel
Department of Medicine, University of Cambridge, Cambridge, UK
Am J Respir Crit Care Med 178:500-5. 2008..It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families... - Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptorMitsu Hashimoto
Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan
Am J Respir Cell Mol Biol 39:356-63. 2008..The pathways by which S1P mediates this effect, therefore, represent a potential therapeutic target to affect tissue repair and remodeling... - PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contractionQiuhong Fang
Beijing Shijitan Hospital, Peking University, Beijing, China
Biochem Biophys Res Commun 369:1199-203. 2008..These results suggest that thrombin contributes to the tissue remodeling in inflammatory airways and lung diseases at least partially through both PKCdelta and PKCepsilon signaling... - Effects of exercise on hematological parameters, circulating side population cells, and cytokinesGina G Wardyn
Department of Internal Medicine, Pulmonary Section, University of Nebraska Medical Center, Omaha, NE 68198 2055, USA
Exp Hematol 36:216-23. 2008.... - Knowledge and beliefs about genetics and smoking among visitors and staff at a health care facilityJulia Fisco Houfek
University of Nebraska Medical Center, College of Nursing, Omaha, Nebraska 98198 5330, USA
Public Health Nurs 25:77-87. 2008..Because genetics influences smoking, genetic information will likely be used to individualize future cessation treatment... - Exacerbation-free COPD: a goal too far?Stephen I Rennard
Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, Nebraska Medical Center, Omaha, USA
Proc Am Thorac Soc 4:583-5. 2007..The challenge addressed by the participants was whether more effective treatments could be developed that could further eliminate COPD exacerbations... - IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiencyDawn L DeMeo
Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 38:114-20. 2008..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency... - Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normalHisatoshi Sugiura
Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
Am J Respir Cell Mol Biol 37:424-30. 2007..The augmented profibrotic activity and mediator release of asthmatic fibroblasts could contribute to airway remodeling in asthma... - Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathwayKoichiro Kamio
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Am J Respir Cell Mol Biol 37:113-20. 2007..The ability of prostacyclin to modulate fibroblast function suggests that prostacyclin can contribute to tissue remodeling... - The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary diseaseStephen I Rennard
University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198, USA
Am J Respir Crit Care Med 175:926-34. 2007..Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-alpha is overexpressed and has been suggested to play a pathogenic role... - Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblastsJun Kato
The Department of Respiratory Medicine, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
Clin Immunol 117:177-81. 2005..These findings suggest that LTD4 has a potential to augment fibroblast chemotaxis, and to contribute to regulation of the wound healing and following remodeling in fibrotic processes of the lung... - Pathogenesis of COPDJohn R Spurzem
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
Semin Respir Crit Care Med 26:142-53. 2005..Advances in understanding the pathogenesis of COPD have the potential for identifying new therapeutic targets that could alter the natural history of this devastating disorder... - Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contractionHuijung Kim
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Am J Respir Cell Mol Biol 28:111-21. 2003..Taken together, these results demonstrate the ability of ultrafine particles to contribute to altered tissue repair and extend the known mechanisms by which these biologically active particles exert their effects... - Nerve growth factor stimulates fibronectin-induced fibroblast migrationTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Japan
J Lab Clin Med 140:329-35. 2002.... - Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell densityHangjun Wang
Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
Am J Physiol Lung Cell Mol Physiol 284:L205-13. 2003..These effects may help explain the varied pathologies associated with exposure to cigarette smoke... - Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastaseTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Japan
Am J Respir Cell Mol Biol 27:487-94. 2002..These results suggest that cilomilast may be a potentially effective therapeutic agent in diseases characterized by excessive tissue destruction, such as emphysema... - PGD(2) modulates fibroblast-mediated native collagen gel contractionTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
Am J Respir Cell Mol Biol 27:375-81. 2002.... - Prostacyclin analogs inhibit fibroblast migrationTadashi Kohyama
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Am J Physiol Lung Cell Mol Physiol 283:L428-32. 2002..Such an effect may contribute to the regulation of fibroblasts in wound healing and could contribute to the pathogenesis of diseases characterized by abnormal tissue repair remodeling... - Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smokeHui Jung Kim
Pulmonary Division, Department of Internal Medicine, Seoul Adventist Hospital, Seoul 130-650, Korea
Am J Physiol Lung Cell Mol Physiol 283:L409-17. 2002..In conclusion, smoke inhibition of fibroblast repair, as reflected by collagen gel contraction and fibronectin production, may be modulated by intracellular GSH levels... - Overview of causes of COPD. New understanding of pathogenesis and mechanisms can guide future therapyStephen I Rennard
University of Nebraska Medical Center, 600 S 42nd St, Omaha, NE 68198, USA
Postgrad Med 111:28-30, 33-4, 37-8. 2002..Moreover, mediators that drive these processes have systemic effects that contribute to the syndromes characteristic of COPD. Understanding these mechanisms has created novel therapeutic approaches to the management of this disorder... - Lysophosphatidic acid in airway function and diseaseMyron L Toews
Department of Pharmacology, University of Nebraska Medical Center, 986260 Nebraska Medical Center, Omaha, NE 68198 6260, USA
Biochim Biophys Acta 1582:240-50. 2002.... - PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gelsTadashi Kohyama
University of Nebraska Medical Center, Omaha 68198-5125, USA
Am J Respir Cell Mol Biol 26:694-701. 2002..In summary, these in vitro results suggest that PDE4 inhibitors may be able to suppress fibroblast activity and, thus, have the potential to block the development of progressive fibrosis... - COPD in 2001: a major challenge for medicine, the pharmaceutical industry, and societyStephen I Rennard
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198-5125, USA
Chest 121:113S-115S. 2002 - Activation of protein kinase A accelerates bovine bronchial epithelial cell migrationJohn R Spurzem
Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
Am J Physiol Lung Cell Mol Physiol 282:L1108-16. 2002..Augmentation of PKA activity reduced the levels of active Rho and the formation of focal adhesions. These studies suggest that PKA activation modulates Rho activity, migration mechanisms, and thus bronchial epithelial repair mechanisms... - Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cellsXiangde Liu
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Am J Physiol Lung Cell Mol Physiol 282:L1049-56. 2002..These findings suggest that IL-4 and IL-13 may modulate airway tissue remodeling and, therefore, could play a role in the altered airway connective tissue which characterizes asthma... - Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gelsTadashi Mio
Chest Disease Research Institute, Kyoto University, Japan
J Lab Clin Med 139:20-7. 2002..By modulating fibroblast-mediated remodeling, LPA could play a role in the tissue remodeling that characterizes wound repair... - Evaluation of subclinical respiratory tract inflammation in heavy smokers who switch to a cigarette-like nicotine delivery device that primarily heats tobaccoStephen I Rennard
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198, USA
Nicotine Tob Res 4:467-76. 2002..One individual experienced a transient twofold increase in CO and concurrently experienced transient headaches. Eclipse use may be a strategy to reduce the health risks for heavy smokers unwilling or unable to quit... - Glucocorticoids modulate TGF-beta productionFu-Qiang Wen
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Inflammation 26:279-90. 2002..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun... - COPD: treatments benefit patientsStephen I Rennard
University of Nebraska Medical Center, Omaha, NE 68198, USA
Lancet 361:444-5. 2003 - Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysinesThomas L Freeman
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Chem Res Toxicol 18:817-24. 2005..These data suggest that cigarette smoke may promote the modification of proteins, like those associated with oxidized low-density lipoprotein, and may contribute to smoking-related disease... - Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cellsXiangde Liu
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198-5885, USA
Am J Respir Cell Mol Biol 33:121-9. 2005.... - Cigarette smoke in researchStephen I Rennard
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198-5885, USA
Am J Respir Cell Mol Biol 31:479-80. 2004 - Treatment of stable chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5885, USA
Lancet 364:791-802. 2004..Treatment for stable COPD can improve the function and quality of life of many patients, could reduce admissions to hospital, and has been suggested to improve survival... - Cells derived from the circulation contribute to the repair of lung injuryShinji Abe
University of Nebraska Medical Center, Department of Internal Medicine, Pulmonary and Critical Care Medicine Section 985125, Nebraska Medical Center, Omaha, NE 68198-5125, USA
Am J Respir Crit Care Med 170:1158-63. 2004..This study demonstrates that stem/progenitor cells in blood contribute to the repair of lung injury in irradiated mice... - Reversible cigarette smoke extract-induced DNA damage in human lung fibroblastsHuijung Kim
Department of Internal Medicine, Seoul Adventist Hospital and WonKwang University Sanbon Medical Center, Korea
Am J Respir Cell Mol Biol 31:483-90. 2004..Moreover, this DNA damage is reversible, with cells surviving and TUNEL positivity reversing when CSE is removed within 24 h... - Cytokines modulate cilomilast response in lung fibroblastsTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
Clin Immunol 111:297-302. 2004..In summary, the inhibitory effect of cilomilast on fibroblast migration and collagen gel contraction is modulated by IL-1beta and IL-4 through regulation of PGE(2) production... - IL-4 and IL-13 induce chemotaxis of human foreskin fibroblasts, but not human fetal lung fibroblastsTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
Inflammation 28:33-7. 2004..Therefore, the role of specific cytokines in mediating fibrotic responses might vary depending on local mesenchymal cell responses... - Platelets stimulate fibroblast-mediated contraction of collagen gelsUlrika Zagai
Department of Medicine, Karolinska Hospital, Stockholm, Sweden
Respir Res 4:13. 2003..We also sought to determine to what extent platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) contribute to this effect... - Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary diseaseElizabeth Gamble
Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
Am J Respir Crit Care Med 168:976-82. 2003..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease... - TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroidsFu-Qiang Wen
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198-5125, USA
J Allergy Clin Immunol 111:1307-18. 2003..CONCLUSIONS: T(H)2 cytokines and TGF-beta stimulate ASMC release of VEGF. This can be inhibited by IFN-gamma and glucocorticoids... - Glucocorticoids modulate TGF-beta production by human fetal lung fibroblastsFu Qiang Wen
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
Inflammation 27:9-19. 2003..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun... - Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cellsXiangde Liu
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5125, USA
Osteoporos Int 14:235-42. 2003..The current study demonstrates that cigarette smoke can interfere with the ability of bone cells to participate in repair and remodeling events. Such an effect may be one mechanism leading to the development of osteoporosis... - Synergetic effect of interleukin-4 and transforming growth factor-beta1 on type I collagen gel contraction and degradation by HFL-1 cells: implication in tissue remodelingXiangde Liu
University of Nebraska Medical Center, Omaha, NE 68198-5125, USA
Chest 123:427S-8S. 2003 - New therapeutic drugs in the management of chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary and Critical Care Section, Internal Medicine Department, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
Curr Opin Pulm Med 8:106-11. 2002..Therapeutic recommendations will require publication of appropriately designed and adequately powered clinical trials...
Research Grants
- Stem Cells for the Prevention and Treatment of EmphysemaStephen Rennard; Fiscal Year: 2006..These studies will establish a role for stem cells in modulating lung repair and provide evidence that use of such cells could play a role in the therapy of destructive lung disorders such as emphysema. ..
- CYTOKINE MODULATION OF MATRIX REMODELINGStephen Rennard; Fiscal Year: 2002..The proposed studies should, therefore, help to define the mechanisms by which inflammatory mediators can regulate remodeling processes in the airway in asthma. ..
- Fetal Smoke Exposure and Emphysema: Role of Stem CellsStephen Rennard; Fiscal Year: 2007..This will establish fetal environmental smoke exposure as a cause of adult COPD and provide a novel basis for therapy. ..