Stephen Rennard

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Efficacy of the nicotine inhaler in smoking reduction: A double-blind, randomized trial
    Stephen I Rennard
    Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Nicotine Tob Res 8:555-64. 2006
  2. ncbi request reprint Smoking cessation
    S I Rennard
    University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Chest 117:360S-4S. 2000
  3. ncbi request reprint Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease
    S I Rennard
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Respir Crit Care Med 163:1087-92. 2001
  4. pmc NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract
    Xiangde Liu
    Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Respir Res 9:66. 2008
  5. ncbi request reprint A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison
    Stephen Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, Omaha, Nebraska 68198 5885, USA
    Respir Med 102:1033-44. 2008
  6. doi request reprint The efficacy and safety of cilomilast in COPD
    Stephen Rennard
    University of Nebraska Medical Center, Omaha, 68198 5885, USA
    Drugs 68:3-57. 2008
  7. ncbi request reprint Vitamin D, vitamin D binding protein, lung function and structure in COPD
    Isaac Berg
    Division of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5300, United States
    Respir Med 107:1578-88. 2013
  8. pmc A randomized placebo-controlled trial of varenicline for smoking cessation allowing flexible quit dates
    Stephen Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Nicotine Tob Res 14:343-50. 2012
  9. ncbi request reprint Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression
    Ann M Kapoun
    Scios Inc, Fremont, CA 94555, USA
    Mol Pharmacol 70:518-31. 2006
  10. pmc Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure
    Praveen R Arany
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9250-5. 2006

Research Grants

  1. CYTOKINE MODULATION OF MATRIX REMODELING
    Stephen Rennard; Fiscal Year: 1999
  2. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2006
  3. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2005
  4. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2004
  5. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2004
  6. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2003
  7. CYTOKINE MODULATION OF MATRIX REMODELING
    Stephen Rennard; Fiscal Year: 2002
  8. CYTOKINE MODULATION OF MATRIX REMODELING
    Stephen Rennard; Fiscal Year: 2001
  9. CYTOKINE MODULATION OF MATRIX REMODELING
    Stephen Rennard; Fiscal Year: 2000
  10. Fetal Smoke Exposure and Emphysema: Role of Stem Cells
    Stephen Rennard; Fiscal Year: 2007

Detail Information

Publications69

  1. ncbi request reprint Efficacy of the nicotine inhaler in smoking reduction: A double-blind, randomized trial
    Stephen I Rennard
    Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Nicotine Tob Res 8:555-64. 2006
    ..In conclusion, the nicotine inhaler can help smokers who are unable or unwilling to quit to reduce daily cigarette consumption, which may be a health benefit on its own and may further promote quitting...
  2. ncbi request reprint Smoking cessation
    S I Rennard
    University of Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Chest 117:360S-4S. 2000
    ..These strategies assist a significant minority of smokers to stop smoking and, thus, they can have an important positive impact on COPD as well as on other health outcomes...
  3. ncbi request reprint Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease
    S I Rennard
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Respir Crit Care Med 163:1087-92. 2001
    ..The long duration of action of salmeterol offers the advantage of twice daily dosing compared with the required four times a day dosing with ipratropium...
  4. pmc NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract
    Xiangde Liu
    Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Respir Res 9:66. 2008
    ..Since NF-kappaB is also involved in regulating apoptosis and cell survival, the current study was designed to investigate the role of NF-kappaB in mediating cell survival in response to cigarette smoke exposure in HBECs...
  5. ncbi request reprint A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison
    Stephen Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, Omaha, Nebraska 68198 5885, USA
    Respir Med 102:1033-44. 2008
    ..Indacaterol demonstrated a good overall safety and tolerability profile...
  6. doi request reprint The efficacy and safety of cilomilast in COPD
    Stephen Rennard
    University of Nebraska Medical Center, Omaha, 68198 5885, USA
    Drugs 68:3-57. 2008
    ..However, subsequent phase III studies failed to definitively confirm the earlier programme results, which led to termination of the development of cilomilast...
  7. ncbi request reprint Vitamin D, vitamin D binding protein, lung function and structure in COPD
    Isaac Berg
    Division of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5300, United States
    Respir Med 107:1578-88. 2013
    ..Vitamin D and vitamin D binding protein (DBP) have been associated with COPD and FEV1. There are limited data regarding emphysema and vitamin D and DBP...
  8. pmc A randomized placebo-controlled trial of varenicline for smoking cessation allowing flexible quit dates
    Stephen Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Nicotine Tob Res 14:343-50. 2012
    ..The objective of this study was to compare varenicline 1 mg twice daily (b.i.d.) with placebo in subjects using a flexible quit date paradigm after starting medication...
  9. ncbi request reprint Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression
    Ann M Kapoun
    Scios Inc, Fremont, CA 94555, USA
    Mol Pharmacol 70:518-31. 2006
    ..Our findings suggest that inhibitors such as SD-208 may be therapeutically useful in human interstitial lung diseases and pulmonary fibrosis...
  10. pmc Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure
    Praveen R Arany
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9250-5. 2006
    ..These studies highlight a previously undescribed role for Smad3 in the mechanotransduction of matrix unsupported ear wound closure...
  11. ncbi request reprint Biomarkers to assess the utility of potential reduced exposure tobacco products
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota Cancer Center, Minneapolis, MN 55414, USA
    Nicotine Tob Res 8:169-91. 2006
    ..Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area...
  12. ncbi request reprint Clinical approach to patients with chronic obstructive pulmonary disease and cardiovascular disease
    Stephen I Rennard
    Department of Internal Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Proc Am Thorac Soc 2:94-100. 2005
    ..It is plausible that treatment of pulmonary inflammation characteristic of COPD will alter cardiac risk. Such an approach would offer a novel approach for the development of treatments for these common conditions...
  13. pmc Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradation
    Qiuhong Fang
    Pulmonary and Critical Care Department, First Hospital of Tsinghua University, Beijing, China
    Am J Respir Cell Mol Biol 35:714-21. 2006
    ..Through such mechanisms, thrombin could contribute to many chronic lung disorders characterized by tissue remodeling...
  14. ncbi request reprint Chronic obstructive pulmonary disease: linking outcomes and pathobiology of disease modification
    Stephen I Rennard
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68198 5300, USA
    Proc Am Thorac Soc 3:276-80. 2006
    ..The development of biomarkers of lung damage, pulmonary inflammation, and systemic disease will be essential to our further understanding of the natural history of COPD and the discovery of new, effective treatments for its progression...
  15. ncbi request reprint COPD: the dangerous underestimate of 15%
    Stephen I Rennard
    University of Nebraska Medical Center, Omaha, NE 68198, USA
    Lancet 367:1216-9. 2006
  16. ncbi request reprint Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4
    Stephen I Rennard
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Chest 129:56-66. 2006
    ..COPD is a relentless, progressive disease. This study evaluated the efficacy of cilomilast, a selective phosphodiesterase (PDE) 4 inhibitor, in the treatment of COPD...
  17. ncbi request reprint Reactive nitrogen species augment fibroblast-mediated collagen gel contraction, mediator production, and chemotaxis
    Hisatoshi Sugiura
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 34:592-9. 2006
    ..01), and neutralizing anti-TGF-beta antibody suppressed peroxynitrite-augmented alpha5beta1 expression (P < 0.01). These results suggest that RNS can affect the tissue repair process by modulating TGF-beta1...
  18. ncbi request reprint Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung fibroblasts
    Tetsu Kobayashi
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Biochem Biophys Res Commun 339:290-5. 2006
    ..Thus, Smad3 mediates TGF-beta1-induced contraction and alpha-SMA induction in human lung fibroblasts. Smad3, therefore, could be a target for blocking contraction of human fibrotic tissue induced by TGF-beta1...
  19. ncbi request reprint Proposal for a multidimensional staging system for chronic obstructive pulmonary disease
    Bartolome R Celli
    Department of Pulmonary and Critical Care Medicine, Tufts University, Boston, MA 02135, USA
    Respir Med 99:1546-54. 2005
    ..Although the staging boundaries were based on existing literature, they have proven useful in predicting survival. We conclude that a multidimensional grading system is useful to assess the impact of COPD...
  20. ncbi request reprint Challenges and opportunities for combination therapy in chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, 985125 Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Proc Am Thorac Soc 2:391-3; discussion 394-5. 2005
    ..The use of a truly multidimensional outcome parameter promises an entirely novel paradigm for the assessment of novel combinations of therapies...
  21. pmc TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels
    Tetsu Kobayashi
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Respir Res 6:141. 2005
    ..Contraction induced by different factors, therefore, may be differentially associated with apoptosis, which may be related to the persistence or resolution of the fibroblasts that accumulate following injury...
  22. ncbi request reprint Biomarkers to assess the utility of potential reduced exposure tobacco products
    Dorothy K Hatsukami
    University of Minnesota Cancer Center, Minneapolis, MN, USA
    Nicotine Tob Res 8:600-22. 2006
    ..Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area...
  23. pmc Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema
    Stephen I Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, 985125 Nebraska Medical Center, Omaha, NE 98198 5125, USA
    Proc Am Thorac Soc 3:703-8. 2006
    ....
  24. doi request reprint The many "small COPDs": COPD should be an orphan disease
    Stephen I Rennard
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Chest 134:623-7. 2008
    ..This strategy may help to address the increasing burden that COPD presents and for which no novel clinical class of treatment has been introduced for 30 years...
  25. ncbi request reprint Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease
    Bipen D Patel
    Department of Medicine, University of Cambridge, Cambridge, UK
    Am J Respir Crit Care Med 178:500-5. 2008
    ..It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families...
  26. pmc Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor
    Mitsu Hashimoto
    Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan
    Am J Respir Cell Mol Biol 39:356-63. 2008
    ..The pathways by which S1P mediates this effect, therefore, represent a potential therapeutic target to affect tissue repair and remodeling...
  27. pmc PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction
    Qiuhong Fang
    Beijing Shijitan Hospital, Peking University, Beijing, China
    Biochem Biophys Res Commun 369:1199-203. 2008
    ..These results suggest that thrombin contributes to the tissue remodeling in inflammatory airways and lung diseases at least partially through both PKCdelta and PKCepsilon signaling...
  28. doi request reprint Effects of exercise on hematological parameters, circulating side population cells, and cytokines
    Gina G Wardyn
    Department of Internal Medicine, Pulmonary Section, University of Nebraska Medical Center, Omaha, NE 68198 2055, USA
    Exp Hematol 36:216-23. 2008
    ....
  29. doi request reprint Knowledge and beliefs about genetics and smoking among visitors and staff at a health care facility
    Julia Fisco Houfek
    University of Nebraska Medical Center, College of Nursing, Omaha, Nebraska 98198 5330, USA
    Public Health Nurs 25:77-87. 2008
    ..Because genetics influences smoking, genetic information will likely be used to individualize future cessation treatment...
  30. ncbi request reprint Exacerbation-free COPD: a goal too far?
    Stephen I Rennard
    Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, Nebraska Medical Center, Omaha, USA
    Proc Am Thorac Soc 4:583-5. 2007
    ..The challenge addressed by the participants was whether more effective treatments could be developed that could further eliminate COPD exacerbations...
  31. pmc IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency
    Dawn L DeMeo
    Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 38:114-20. 2008
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency...
  32. pmc Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normal
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Respir Cell Mol Biol 37:424-30. 2007
    ..The augmented profibrotic activity and mediator release of asthmatic fibroblasts could contribute to airway remodeling in asthma...
  33. pmc Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway
    Koichiro Kamio
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 37:113-20. 2007
    ..The ability of prostacyclin to modulate fibroblast function suggests that prostacyclin can contribute to tissue remodeling...
  34. ncbi request reprint The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease
    Stephen I Rennard
    University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198, USA
    Am J Respir Crit Care Med 175:926-34. 2007
    ..Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-alpha is overexpressed and has been suggested to play a pathogenic role...
  35. ncbi request reprint Exacerbations and progression of disease in asthma and chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Proc Am Thorac Soc 1:88-92. 2004
    ..Future studies of how exacerbation affects the "natural history" of asthma and COPD will require a better understanding of the heterogeneity of exacerbations but promises to identify new therapeutic strategies to treat these disorders...
  36. ncbi request reprint Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts
    Jun Kato
    The Department of Respiratory Medicine, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Clin Immunol 117:177-81. 2005
    ..These findings suggest that LTD4 has a potential to augment fibroblast chemotaxis, and to contribute to regulation of the wound healing and following remodeling in fibrotic processes of the lung...
  37. ncbi request reprint Pathogenesis of COPD
    John R Spurzem
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Semin Respir Crit Care Med 26:142-53. 2005
    ..Advances in understanding the pathogenesis of COPD have the potential for identifying new therapeutic targets that could alter the natural history of this devastating disorder...
  38. ncbi request reprint Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction
    Huijung Kim
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Am J Respir Cell Mol Biol 28:111-21. 2003
    ..Taken together, these results demonstrate the ability of ultrafine particles to contribute to altered tissue repair and extend the known mechanisms by which these biologically active particles exert their effects...
  39. ncbi request reprint Nerve growth factor stimulates fibronectin-induced fibroblast migration
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Japan
    J Lab Clin Med 140:329-35. 2002
    ....
  40. ncbi request reprint Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell density
    Hangjun Wang
    Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Am J Physiol Lung Cell Mol Physiol 284:L205-13. 2003
    ..These effects may help explain the varied pathologies associated with exposure to cigarette smoke...
  41. ncbi request reprint Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Japan
    Am J Respir Cell Mol Biol 27:487-94. 2002
    ..These results suggest that cilomilast may be a potentially effective therapeutic agent in diseases characterized by excessive tissue destruction, such as emphysema...
  42. ncbi request reprint PGD(2) modulates fibroblast-mediated native collagen gel contraction
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
    Am J Respir Cell Mol Biol 27:375-81. 2002
    ....
  43. ncbi request reprint Prostacyclin analogs inhibit fibroblast migration
    Tadashi Kohyama
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Am J Physiol Lung Cell Mol Physiol 283:L428-32. 2002
    ..Such an effect may contribute to the regulation of fibroblasts in wound healing and could contribute to the pathogenesis of diseases characterized by abnormal tissue repair remodeling...
  44. ncbi request reprint Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke
    Hui Jung Kim
    Pulmonary Division, Department of Internal Medicine, Seoul Adventist Hospital, Seoul 130 650, Korea
    Am J Physiol Lung Cell Mol Physiol 283:L409-17. 2002
    ..In conclusion, smoke inhibition of fibroblast repair, as reflected by collagen gel contraction and fibronectin production, may be modulated by intracellular GSH levels...
  45. ncbi request reprint Overview of causes of COPD. New understanding of pathogenesis and mechanisms can guide future therapy
    Stephen I Rennard
    University of Nebraska Medical Center, 600 S 42nd St, Omaha, NE 68198, USA
    Postgrad Med 111:28-30, 33-4, 37-8. 2002
    ..Moreover, mediators that drive these processes have systemic effects that contribute to the syndromes characteristic of COPD. Understanding these mechanisms has created novel therapeutic approaches to the management of this disorder...
  46. ncbi request reprint Lysophosphatidic acid in airway function and disease
    Myron L Toews
    Department of Pharmacology, University of Nebraska Medical Center, 986260 Nebraska Medical Center, Omaha, NE 68198 6260, USA
    Biochim Biophys Acta 1582:240-50. 2002
    ....
  47. ncbi request reprint PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels
    Tadashi Kohyama
    University of Nebraska Medical Center, Omaha 68198 5125, USA
    Am J Respir Cell Mol Biol 26:694-701. 2002
    ..In summary, these in vitro results suggest that PDE4 inhibitors may be able to suppress fibroblast activity and, thus, have the potential to block the development of progressive fibrosis...
  48. ncbi request reprint COPD in 2001: a major challenge for medicine, the pharmaceutical industry, and society
    Stephen I Rennard
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Chest 121:113S-115S. 2002
  49. ncbi request reprint Activation of protein kinase A accelerates bovine bronchial epithelial cell migration
    John R Spurzem
    Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1108-16. 2002
    ..Augmentation of PKA activity reduced the levels of active Rho and the formation of focal adhesions. These studies suggest that PKA activation modulates Rho activity, migration mechanisms, and thus bronchial epithelial repair mechanisms...
  50. ncbi request reprint Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells
    Xiangde Liu
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1049-56. 2002
    ..These findings suggest that IL-4 and IL-13 may modulate airway tissue remodeling and, therefore, could play a role in the altered airway connective tissue which characterizes asthma...
  51. ncbi request reprint Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels
    Tadashi Mio
    Chest Disease Research Institute, Kyoto University, Japan
    J Lab Clin Med 139:20-7. 2002
    ..By modulating fibroblast-mediated remodeling, LPA could play a role in the tissue remodeling that characterizes wound repair...
  52. ncbi request reprint Evaluation of subclinical respiratory tract inflammation in heavy smokers who switch to a cigarette-like nicotine delivery device that primarily heats tobacco
    Stephen I Rennard
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198, USA
    Nicotine Tob Res 4:467-76. 2002
    ..One individual experienced a transient twofold increase in CO and concurrently experienced transient headaches. Eclipse use may be a strategy to reduce the health risks for heavy smokers unwilling or unable to quit...
  53. ncbi request reprint Glucocorticoids modulate TGF-beta production
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Inflammation 26:279-90. 2002
    ..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun...
  54. ncbi request reprint COPD: treatments benefit patients
    Stephen I Rennard
    University of Nebraska Medical Center, Omaha, NE 68198, USA
    Lancet 361:444-5. 2003
  55. ncbi request reprint Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines
    Thomas L Freeman
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Chem Res Toxicol 18:817-24. 2005
    ..These data suggest that cigarette smoke may promote the modification of proteins, like those associated with oxidized low-density lipoprotein, and may contribute to smoking-related disease...
  56. ncbi request reprint Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells
    Xiangde Liu
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 33:121-9. 2005
    ....
  57. ncbi request reprint Cigarette smoke in research
    Stephen I Rennard
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 31:479-80. 2004
  58. ncbi request reprint Treatment of stable chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Lancet 364:791-802. 2004
    ..Treatment for stable COPD can improve the function and quality of life of many patients, could reduce admissions to hospital, and has been suggested to improve survival...
  59. ncbi request reprint Cells derived from the circulation contribute to the repair of lung injury
    Shinji Abe
    University of Nebraska Medical Center, Department of Internal Medicine, Pulmonary and Critical Care Medicine Section 985125, Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Am J Respir Crit Care Med 170:1158-63. 2004
    ..This study demonstrates that stem/progenitor cells in blood contribute to the repair of lung injury in irradiated mice...
  60. ncbi request reprint Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts
    Huijung Kim
    Department of Internal Medicine, Seoul Adventist Hospital and WonKwang University Sanbon Medical Center, Korea
    Am J Respir Cell Mol Biol 31:483-90. 2004
    ..Moreover, this DNA damage is reversible, with cells surviving and TUNEL positivity reversing when CSE is removed within 24 h...
  61. ncbi request reprint Cytokines modulate cilomilast response in lung fibroblasts
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
    Clin Immunol 111:297-302. 2004
    ..In summary, the inhibitory effect of cilomilast on fibroblast migration and collagen gel contraction is modulated by IL-1beta and IL-4 through regulation of PGE(2) production...
  62. ncbi request reprint IL-4 and IL-13 induce chemotaxis of human foreskin fibroblasts, but not human fetal lung fibroblasts
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
    Inflammation 28:33-7. 2004
    ..Therefore, the role of specific cytokines in mediating fibrotic responses might vary depending on local mesenchymal cell responses...
  63. pmc Platelets stimulate fibroblast-mediated contraction of collagen gels
    Ulrika Zagai
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Respir Res 4:13. 2003
    ..We also sought to determine to what extent platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) contribute to this effect...
  64. ncbi request reprint Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  65. ncbi request reprint TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198 5125, USA
    J Allergy Clin Immunol 111:1307-18. 2003
    ..T(H)2 and T(H)1 cytokines have opposite effects on many aspects of the inflammatory response...
  66. ncbi request reprint Glucocorticoids modulate TGF-beta production by human fetal lung fibroblasts
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Inflammation 27:9-19. 2003
    ..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun...
  67. ncbi request reprint Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cells
    Xiangde Liu
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Osteoporos Int 14:235-42. 2003
    ..The current study demonstrates that cigarette smoke can interfere with the ability of bone cells to participate in repair and remodeling events. Such an effect may be one mechanism leading to the development of osteoporosis...
  68. ncbi request reprint Synergetic effect of interleukin-4 and transforming growth factor-beta1 on type I collagen gel contraction and degradation by HFL-1 cells: implication in tissue remodeling
    Xiangde Liu
    University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Chest 123:427S-8S. 2003
  69. ncbi request reprint New therapeutic drugs in the management of chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary and Critical Care Section, Internal Medicine Department, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Curr Opin Pulm Med 8:106-11. 2002
    ..Therapeutic recommendations will require publication of appropriately designed and adequately powered clinical trials...

Research Grants10

  1. CYTOKINE MODULATION OF MATRIX REMODELING
    Stephen Rennard; Fiscal Year: 1999
    ..The proposed studies should, therefore, help to define the mechanisms by which inflammatory mediators can regulate remodeling processes in the airway in asthma. ..
  2. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2006
    ..These studies will establish a role for stem cells in modulating lung repair and provide evidence that use of such cells could play a role in the therapy of destructive lung disorders such as emphysema. ..
  3. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2005
    ..These studies will establish a role for stem cells in modulating lung repair and provide evidence that use of such cells could play a role in the therapy of destructive lung disorders such as emphysema. ..
  4. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2004
    ..These studies will establish a role for stem cells in modulating lung repair and provide evidence that use of such cells could play a role in the therapy of destructive lung disorders such as emphysema. ..
  5. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2004
    ..These studies will establish a role for stem cells in modulating lung repair and provide evidence that use of such cells could play a role in the therapy of destructive lung disorders such as emphysema. ..
  6. Stem Cells for the Prevention and Treatment of Emphysema
    Stephen Rennard; Fiscal Year: 2003
    ..These studies will establish a role for stem cells in modulating lung repair and provide evidence that use of such cells could play a role in the therapy of destructive lung disorders such as emphysema. ..
  7. CYTOKINE MODULATION OF MATRIX REMODELING
    Stephen Rennard; Fiscal Year: 2002
    ..The proposed studies should, therefore, help to define the mechanisms by which inflammatory mediators can regulate remodeling processes in the airway in asthma. ..
  8. CYTOKINE MODULATION OF MATRIX REMODELING
    Stephen Rennard; Fiscal Year: 2001
    ..The proposed studies should, therefore, help to define the mechanisms by which inflammatory mediators can regulate remodeling processes in the airway in asthma. ..
  9. CYTOKINE MODULATION OF MATRIX REMODELING
    Stephen Rennard; Fiscal Year: 2000
    ..The proposed studies should, therefore, help to define the mechanisms by which inflammatory mediators can regulate remodeling processes in the airway in asthma. ..
  10. Fetal Smoke Exposure and Emphysema: Role of Stem Cells
    Stephen Rennard; Fiscal Year: 2007
    ..This will establish fetal environmental smoke exposure as a cause of adult COPD and provide a novel basis for therapy. ..