Research Topics
Species | S RennardSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Detail Information
Publications
The many "small COPDs": COPD should be an orphan diseaseStephen I Rennard
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Chest 134:623-7. 2008..This strategy may help to address the increasing burden that COPD presents and for which no novel clinical class of treatment has been introduced for 30 years...- Long-term safety study of infliximab in moderate-to-severe chronic obstructive pulmonary diseaseStephen I Rennard
Division of Pulmonary, Critical Care, Sleep and Allergy, Internal Medicine, University of Nebraska Medical Center, 4111 Dewey Avenue, Omaha, NE 68198, USA
Respir Med 107:424-32. 2013..There was an increased number of malignancies in infliximab-treated (5.7%) over placebo-treated (1.3%) patients in a 44-week, phase 2 clinical study of 234 patients with moderate-to-severe chronic obstructive pulmonary disease (COPD)... - Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4Joel Michalski
Department of Internal Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198 5910, USA
Am J Respir Cell Mol Biol 47:729-37. 2012..These alterations may contribute to COPD pathogenesis and could provide novel therapeutic targets... 
Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiencyWoo Jin Kim
Channing Laboratory and the Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Respir Res 13:16. 2012..We investigated whether SNPs in the chromosome 15q region would be modifiers for lung function and COPD in AAT deficiency...- Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary diseaseMatthew J Loza
Immunology Biomarkers, Janssen Research and Development, LLC, Malvern, PA, USA
Respir Res 13:12. 2012..This study sought to evaluate the systemic inflammatory profile associated with COPD and to assess the impact of tumor necrosis factor neutralization on systemic inflammation... - A randomized placebo-controlled trial of varenicline for smoking cessation allowing flexible quit datesStephen Rennard
Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
Nicotine Tob Res 14:343-50. 2012..The objective of this study was to compare varenicline 1 mg twice daily (b.i.d.) with placebo in subjects using a flexible quit date paradigm after starting medication... - Prostaglandin E2 stimulates the production of vascular endothelial growth factor through the E-prostanoid-2 receptor in cultured human lung fibroblastsMasanori Nakanishi
Division of Pulmonary, Critical Care, Sleep and Allergy Medicine, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5910, USA
Am J Respir Cell Mol Biol 46:217-23. 2012..This activity may contribute to the maintenance of pulmonary microvasculature in the alveolar wall... - Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary diseasePaul W Jones
St George s, University of London, London, UK
Respir Res 12:55. 2011..The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD)... - Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gelsY Zhu
University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198-5125, USA
Respir Res 2:300-5. 2001..01). PGE2 appeared to decrease both MMP production and activation. CONCLUSION: The current study demonstrates that interactions between monocytes and fibroblasts can mediate tissue remodeling... - Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE studyDave Singh
University of Manchester, Medicines Evaluation Unit, South Manchester University Hospitals Trust, Southmoor Road, Manchester M23 9QZ, UK
Respir Res 11:77. 2010..We studied the relationships between sputum neutrophils and FEV1, health status, exacerbation rates, systemic inflammation and emphysema, and long term variability at 1 year... - One-year treatment with mometasone furoate in chronic obstructive pulmonary diseasePeter M A Calverley
Department of Medicine, University Hospital Aintree, Liverpool, UK
Respir Res 9:73. 2008..031). MF-DPI treatment was well tolerated.Once-daily MF-DPI improved lung function and health status in subjects with moderate-to-severe COPD and was comparable to BID MF-DPI... - Characterisation of COPD heterogeneity in the ECLIPSE cohortAlvar Agusti
Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
Respir Res 11:122. 2010..Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE)... - Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-cultureY Zhu
University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198-5125, USA
Respir Res 2:295-9. 2001..CONCLUSION: The current study, therefore, demonstrates that interaction between monocytes and fibroblasts can contract and degrade extracellular matrix in extended culture... - TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gelsTetsu Kobayashi
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Respir Res 6:141. 2005..Contraction induced by different factors, therefore, may be differentially associated with apoptosis, which may be related to the persistence or resolution of the fibroblasts that accumulate following injury... - Differentiation of embryonic stem cells into fibroblast-like cells in three-dimensional type I collagen gel culturesShinsaku Togo
Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198 5910, USA
In Vitro Cell Dev Biol Anim 47:114-24. 2011..This methodology provides a means to investigate and define the mechanisms that regulate fibroblast differentiation... 
Challenges and opportunities for combination therapy in chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, 985125 Nebraska Medical Center, Omaha, NE 68198 5125, USA
Proc Am Thorac Soc 2:391-3; discussion 394-5. 2005..The use of a truly multidimensional outcome parameter promises an entirely novel paradigm for the assessment of novel combinations of therapies...- NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extractXiangde Liu
Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Respir Res 9:66. 2008..Since NF-kappaB is also involved in regulating apoptosis and cell survival, the current study was designed to investigate the role of NF-kappaB in mediating cell survival in response to cigarette smoke exposure in HBECs... - Treatment of stable chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5885, USA
Lancet 364:791-802. 2004..Treatment for stable COPD can improve the function and quality of life of many patients, could reduce admissions to hospital, and has been suggested to improve survival... - Cigarette smoke in researchStephen I Rennard
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198-5885, USA
Am J Respir Cell Mol Biol 31:479-80. 2004 - A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparisonStephen Rennard
University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, Omaha, Nebraska 68198 5885, USA
Respir Med 102:1033-44. 2008..Indacaterol demonstrated a good overall safety and tolerability profile... - Chronic obstructive pulmonary disease: linking outcomes and pathobiology of disease modificationStephen I Rennard
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68198 5300, USA
Proc Am Thorac Soc 3:276-80. 2006..The development of biomarkers of lung damage, pulmonary inflammation, and systemic disease will be essential to our further understanding of the natural history of COPD and the discovery of new, effective treatments for its progression... - Reactive nitrogen species augment fibroblast-mediated collagen gel contraction, mediator production, and chemotaxisHisatoshi Sugiura
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Am J Respir Cell Mol Biol 34:592-9. 2006..01), and neutralizing anti-TGF-beta antibody suppressed peroxynitrite-augmented alpha5beta1 expression (P < 0.01). These results suggest that RNS can affect the tissue repair process by modulating TGF-beta1... - Minimal clinically important difference, clinical perspective: an opinionStephen I Rennard
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
COPD 2:51-5. 2005..The limits of the concept, particularly as it relates to issues of importance to patients, however, needs to be recognized... - Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysemaStephen I Rennard
University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, 985125 Nebraska Medical Center, Omaha, NE 98198 5125, USA
Proc Am Thorac Soc 3:703-8. 2006.... - The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary diseaseStephen I Rennard
University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198, USA
Am J Respir Crit Care Med 175:926-34. 2007..Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-alpha is overexpressed and has been suggested to play a pathogenic role... - Exacerbation-free COPD: a goal too far?Stephen I Rennard
Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, Nebraska Medical Center, Omaha, USA
Proc Am Thorac Soc 4:583-5. 2007..The challenge addressed by the participants was whether more effective treatments could be developed that could further eliminate COPD exacerbations... - Exacerbations and progression of disease in asthma and chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Proc Am Thorac Soc 1:88-92. 2004.... - COPD: the dangerous underestimate of 15%Stephen I Rennard
University of Nebraska Medical Center, Omaha, NE 68198, USA
Lancet 367:1216-9. 2006 - Antiinflammatory therapies other than corticosteroidsStephen I Rennard
University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198, USA
Proc Am Thorac Soc 1:282-7. 2004..The complex network of regulatory molecules that controls the inflammatory response, therefore, presents a number of potential therapeutic targets with the promise of altering the disease process in COPD... - Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4Stephen I Rennard
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Chest 129:56-66. 2006..COPD is a relentless, progressive disease. This study evaluated the efficacy of cilomilast, a selective phosphodiesterase (PDE) 4 inhibitor, in the treatment of COPD... - Clinical approach to patients with chronic obstructive pulmonary disease and cardiovascular diseaseStephen I Rennard
Department of Internal Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Proc Am Thorac Soc 2:94-100. 2005..It is plausible that treatment of pulmonary inflammation characteristic of COPD will alter cardiac risk. Such an approach would offer a novel approach for the development of treatments for these common conditions... - Lessons from multidisciplinary cross-fertilization: chronic obstructive pulmonary disease, lung cancer, and heart diseaseStephen I Rennard
Pulmonary and Critical Care Medicine, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Proc Am Thorac Soc 5:865-8. 2008..Exploration of those relationships promises to advance the understanding of all three diseases and holds the potential to advance the diagnosis and treatment of these common and devastating conditions... - Natural histories of chronic obstructive pulmonary diseaseStephen I Rennard
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Proc Am Thorac Soc 5:878-83. 2008..With advances in understanding the clinical features of COPD and with the development of evaluating new tools to assess patients with COPD, longitudinal studies evaluating COPD in novel ways and for longer durations are needed... - Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPDStephen I Rennard
Nebraska Medical Center, Omaha, Nebraska, USA
Respir Res 12:18. 2011..This led to the question of whether a responsive subset existed that could be investigated further... - Impact of COPD in North America and Europe in 2000: subjects' perspective of Confronting COPD International SurveyS Rennard
University of Nebraska, Pulmonary and Critical Care Medicine Section, Omaha 68198 5125, USA
Eur Respir J 20:799-805. 2002..This international survey confirmed the great burden to society and high individual morbidity associated with chronic obstructive pulmonary disease in subjects in North America and Europe... - COPD heterogeneity: what this will mean in practiceStephen I Rennard
Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Internal Medicine, University of Nebraska Medical Center Omaha, Omaha Nebraska 68198 5910, USA
Respir Care 56:1181-7. 2011..The clinical implications of improved understanding of COPD heterogeneity will be better care and outcomes for COPD patients, which will depend on increased diagnostic accuracy and selective administration of treatments... - Rationale and emerging approaches for targeting lung repair and regeneration in the treatment of chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, Omaha, Nebraska, USA
Proc Am Thorac Soc 8:368-75. 2011..In contrast to therapy designed to slow the progression of COPD, it may be much easier and less expensive to demonstrate efficacy for a therapy that restores lung function... - Inflammation and repair processes in chronic obstructive pulmonary diseaseS I Rennard
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
Am J Respir Crit Care Med 160:S12-6. 1999..Rennard SI. Inflammation and repair processes in chronic obstructive pulmonary disease... - Overview of causes of COPD. New understanding of pathogenesis and mechanisms can guide future therapyStephen I Rennard
University of Nebraska Medical Center, 600 S 42nd St, Omaha, NE 68198, USA
Postgrad Med 111:28-30, 33-4, 37-8. 2002..Moreover, mediators that drive these processes have systemic effects that contribute to the syndromes characteristic of COPD. Understanding these mechanisms has created novel therapeutic approaches to the management of this disorder... - COPD in 2001: a major challenge for medicine, the pharmaceutical industry, and societyStephen I Rennard
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198-5125, USA
Chest 121:113S-115S. 2002 - New therapeutic drugs in the management of chronic obstructive pulmonary diseaseStephen I Rennard
Pulmonary and Critical Care Section, Internal Medicine Department, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
Curr Opin Pulm Med 8:106-11. 2002..Therapeutic recommendations will require publication of appropriately designed and adequately powered clinical trials... - Evaluation of subclinical respiratory tract inflammation in heavy smokers who switch to a cigarette-like nicotine delivery device that primarily heats tobaccoStephen I Rennard
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198, USA
Nicotine Tob Res 4:467-76. 2002..One individual experienced a transient twofold increase in CO and concurrently experienced transient headaches. Eclipse use may be a strategy to reduce the health risks for heavy smokers unwilling or unable to quit... - Efficacy and tolerability of budesonide/formoterol in one hydrofluoroalkane pressurized metered-dose inhaler in patients with chronic obstructive pulmonary disease: results from a 1-year randomized controlled clinical trialStephen I Rennard
Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
Drugs 69:549-65. 2009.... - The efficacy and safety of cilomilast in COPDStephen Rennard
University of Nebraska Medical Center, Omaha, 68198 5885, USA
Drugs 68:3-57. 2008..However, subsequent phase III studies failed to definitively confirm the earlier programme results, which led to termination of the development of cilomilast... - COPD: treatments benefit patientsStephen I Rennard
University of Nebraska Medical Center, Omaha, NE 68198, USA
Lancet 361:444-5. 2003 - Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trialDonald P Tashkin
Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
Drugs 68:1975-2000. 2008..Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patients with COPD... - PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblastsShinsaku Togo
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5885, USA
Am J Physiol Lung Cell Mol Physiol 296:L959-69. 2009..The present study supports the concept that PDE4 inhibitors may attenuate fibroblast activities that can lead to fibrosis and that PDE4 inhibitors may be particularly effective in the presence of TGF-beta1-induced fibroblast stimulation... - Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cellsXiangde Liu
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Am J Physiol Lung Cell Mol Physiol 282:L1049-56. 2002..These findings suggest that IL-4 and IL-13 may modulate airway tissue remodeling and, therefore, could play a role in the altered airway connective tissue which characterizes asthma... - Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathwayKoichiro Kamio
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Am J Respir Cell Mol Biol 37:113-20. 2007..The ability of prostacyclin to modulate fibroblast function suggests that prostacyclin can contribute to tissue remodeling... - Cells derived from the circulation contribute to the repair of lung injuryShinji Abe
University of Nebraska Medical Center, Department of Internal Medicine, Pulmonary and Critical Care Medicine Section 985125, Nebraska Medical Center, Omaha, NE 68198-5125, USA
Am J Respir Crit Care Med 170:1158-63. 2004..This study demonstrates that stem/progenitor cells in blood contribute to the repair of lung injury in irradiated mice... - Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cellsXiangde Liu
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5125, USA
Osteoporos Int 14:235-42. 2003..The current study demonstrates that cigarette smoke can interfere with the ability of bone cells to participate in repair and remodeling events. Such an effect may be one mechanism leading to the development of osteoporosis... - TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroidsFu-Qiang Wen
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198-5125, USA
J Allergy Clin Immunol 111:1307-18. 2003..CONCLUSIONS: T(H)2 cytokines and TGF-beta stimulate ASMC release of VEGF. This can be inhibited by IFN-gamma and glucocorticoids... - Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cellsXiangde Liu
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198-5885, USA
Am J Respir Cell Mol Biol 33:121-9. 2005.... - Reduced miR-146a increases prostaglandin E₂in chronic obstructive pulmonary disease fibroblastsTadashi Sato
Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5910, USA
Am J Respir Crit Care Med 182:1020-9. 2010..Overproduction of the inflammatory mediator prostaglandin (PG) E₂ by COPD fibroblasts contributes to reduced repair function... - PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gelsTadashi Kohyama
University of Nebraska Medical Center, Omaha 68198-5125, USA
Am J Respir Cell Mol Biol 26:694-701. 2002..In summary, these in vitro results suggest that PDE4 inhibitors may be able to suppress fibroblast activity and, thus, have the potential to block the development of progressive fibrosis... - Glucocorticoids modulate TGF-beta production by human fetal lung fibroblastsFu Qiang Wen
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
Inflammation 27:9-19. 2003..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun... - Activation of protein kinase A accelerates bovine bronchial epithelial cell migrationJohn R Spurzem
Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
Am J Physiol Lung Cell Mol Physiol 282:L1108-16. 2002..Augmentation of PKA activity reduced the levels of active Rho and the formation of focal adhesions. These studies suggest that PKA activation modulates Rho activity, migration mechanisms, and thus bronchial epithelial repair mechanisms... - Synergetic effect of interleukin-4 and transforming growth factor-beta1 on type I collagen gel contraction and degradation by HFL-1 cells: implication in tissue remodelingXiangde Liu
University of Nebraska Medical Center, Omaha, NE 68198-5125, USA
Chest 123:427S-8S. 2003 - MicroRNA-146a modulates human bronchial epithelial cell survival in response to the cytokine-induced apoptosisXiangde Liu
Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Biochem Biophys Res Commun 380:177-82. 2009..The MicroRNA-146a mimic appears to modulate HBEC survival through a mechanism of up-regulating Bcl-XL and STAT3 phosphorylation, and by this mechanism it could contribute to tissue repair and remodeling... - Lung cells transplanted to irradiated recipients generate lymphohematopoietic progenyShinji Abe
Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198-6395, USA
Am J Respir Cell Mol Biol 30:491-9. 2004..CD45(+) cells in the lung cells have lymphohematopoietic stem/progenitor cell characteristics, and this has implications for cell or gene therapy applications... - Pathogenesis of COPDJohn R Spurzem
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
Semin Respir Crit Care Med 26:142-53. 2005..Advances in understanding the pathogenesis of COPD have the potential for identifying new therapeutic targets that could alter the natural history of this devastating disorder... - Knowledge and beliefs about genetics and smoking among visitors and staff at a health care facilityJulia Fisco Houfek
University of Nebraska Medical Center, College of Nursing, Omaha, Nebraska 98198 5330, USA
Public Health Nurs 25:77-87. 2008..Because genetics influences smoking, genetic information will likely be used to individualize future cessation treatment... - Effects of exercise on hematological parameters, circulating side population cells, and cytokinesGina G Wardyn
Department of Internal Medicine, Pulmonary Section, University of Nebraska Medical Center, Omaha, NE 68198 2055, USA
Exp Hematol 36:216-23. 2008.... - Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysinesThomas L Freeman
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Chem Res Toxicol 18:817-24. 2005..These data suggest that cigarette smoke may promote the modification of proteins, like those associated with oxidized low-density lipoprotein, and may contribute to smoking-related disease... - Interferon-gamma reduces interleukin-4- and interleukin-13-augmented transforming growth factor-beta2 production in human bronchial epithelial cells by targeting SmadsFu-Qiang Wen
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198-5125, USA
Chest 123:372S-3S. 2003 - Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung fibroblastsTetsu Kobayashi
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Biochem Biophys Res Commun 339:290-5. 2006..Thus, Smad3 mediates TGF-beta1-induced contraction and alpha-SMA induction in human lung fibroblasts. Smad3, therefore, could be a target for blocking contraction of human fibrotic tissue induced by TGF-beta1... - Lysophosphatidic acid in airway function and diseaseMyron L Toews
Department of Pharmacology, University of Nebraska Medical Center, 986260 Nebraska Medical Center, Omaha, NE 68198 6260, USA
Biochim Biophys Acta 1582:240-50. 2002.... - Prostacyclin analogs inhibit fibroblast migrationTadashi Kohyama
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Am J Physiol Lung Cell Mol Physiol 283:L428-32. 2002..Such an effect may contribute to the regulation of fibroblasts in wound healing and could contribute to the pathogenesis of diseases characterized by abnormal tissue repair remodeling... - Efficacy of the nicotine inhaler in smoking reduction: A double-blind, randomized trialStephen I Rennard
Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
Nicotine Tob Res 8:555-64. 2006..In conclusion, the nicotine inhaler can help smokers who are unable or unwilling to quit to reduce daily cigarette consumption, which may be a health benefit on its own and may further promote quitting... - Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contractionHuijung Kim
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Am J Respir Cell Mol Biol 28:111-21. 2003..Taken together, these results demonstrate the ability of ultrafine particles to contribute to altered tissue repair and extend the known mechanisms by which these biologically active particles exert their effects... - Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gammaFu-Qiang Wen
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Am J Respir Cell Mol Biol 26:484-90. 2002..The ability of these cytokines to modulate TGF-beta release may contribute to both normal airway repair and to the development of subepithelial fibrosis in asthma... - Glucocorticoids modulate TGF-beta productionFu-Qiang Wen
Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-5125, USA
Inflammation 26:279-90. 2002..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun... - Smoking cessationMichael A Chandler
Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Chest 137:428-35. 2010..As smoking is an etiologic and exacerbating factor for lung diseases, the pulmonary physician should be particularly expert in smoking cessation interventions... - Conference report - 9th Annual Meeting of the Society for Research on Nicotine and TobaccoStephen I Rennard
University of Nebraska Medical Center, Omaha, Nebraska, USA
MedGenMed 5:36. 2003 - Cigarette smoke stimulates MMP-1 production by human lung fibroblasts through the ERK1/2 pathwayHuijung Kim
Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, Nebraska 68198, USA
COPD 1:13-23. 2004..By inducing MMP-1, cigarette smoke may result in excess tissue destruction and contribute to the development of emphysema... - Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblastsTetsu Kobayashi
University of Nebraska Medical Center, Omaha, NE, USA
Biochem Biophys Res Commun 327:393-8. 2005..These result suggest that TGF-beta1 stimulation of VEGF production by fibroblasts is regulated by Smad3 but not by Smad2 signaling... - Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanismsShinsaku Togo
University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Am J Respir Crit Care Med 178:248-60. 2008..Alterations in fibroblast functional capacity, therefore, could play a role in the pathogenesis of pulmonary emphysema, which is characterized by inadequate maintenance of tissue structure... - The CC chemokine ligand 2 (CCL2) mediates fibroblast survival through IL-6Xiangde Liu
University of Nebraska Medical Center, Department of Pulmonary and Critical Care Medicine, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
Am J Respir Cell Mol Biol 37:121-8. 2007..These data suggest that CCL2 mediates fibroblast survival by inhibiting apoptosis through IL-6/STAT3 signaling and provides a novel mechanism through which CCL2 may contribute to the development and maintenance of lung fibrosis... - Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activationHisatoshi Sugiura
University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198, USA
J Cell Physiol 210:99-110. 2007..Through such a mechanism, PGE(2) may alter survival of cells in the smoke-exposed lungs, thus affecting the pathogenesis of cigarette smoke-induced disease... - Smad3 mediates the TGF-beta-induced contraction of type I collagen gels by mouse embryo fibroblastsXiangde Liu
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5125, USA
Cell Motil Cytoskeleton 54:248-53. 2003..Thus, the Smad3 gene could be a target for blocking contraction of fibrotic tissue induced by TGF-beta... - Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease?Rose A Maciewicz
Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198 5910, USA
Proc Am Thorac Soc 6:614-7. 2009.... - Inhalation of tobacco smoke induces increased proliferation of urinary bladder epithelium and endothelium in female C57BL/6 miceTakamasa Ohnishi
Department of Pathology and Microbiology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 3135, United States
Toxicology 241:58-65. 2007..The increased urothelial proliferation appeared to be due to superficial cell cytotoxicity with consequent regeneration... - Prostaglandin E₂ inhibits human lung fibroblast chemotaxis through disparate actions on different E-prostanoid receptorsYing Ji Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
Am J Respir Cell Mol Biol 44:99-107. 2011..Alterations in EP receptor expression may have the potential to alter PGE(2) action. Targeting specific EP receptors may offer therapeutic opportunities in conditions characterized by abnormal tissue repair and remodeling... - Statins inhibit matrix metalloproteinase release from human lung fibroblastsK Kamio
University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
Eur Respir J 35:637-46. 2010..The current data suggest that statins may modulate remodelling processes mediated by fibroblasts by inhibiting MMP release... - Platelets stimulate fibroblast-mediated contraction of collagen gelsUlrika Zagai
Department of Medicine, Karolinska Hospital, Stockholm, Sweden
Respir Res 4:13. 2003..We also sought to determine to what extent platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) contribute to this effect... - Biomarkers to assess the utility of potential reduced exposure tobacco productsDorothy K Hatsukami
University of Minnesota Cancer Center, Minneapolis, MN, USA
Nicotine Tob Res 8:600-22. 2006..Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area... - Nerve growth factor stimulates fibronectin-induced fibroblast migrationTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Japan
J Lab Clin Med 140:329-35. 2002.... - Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell densityHangjun Wang
Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
Am J Physiol Lung Cell Mol Physiol 284:L205-13. 2003..These effects may help explain the varied pathologies associated with exposure to cigarette smoke... - IL-4 and IL-13 induce chemotaxis of human foreskin fibroblasts, but not human fetal lung fibroblastsTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
Inflammation 28:33-7. 2004..Therefore, the role of specific cytokines in mediating fibrotic responses might vary depending on local mesenchymal cell responses... - Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradationQiuhong Fang
Pulmonary and Critical Care Department, First Hospital of Tsinghua University, Beijing, China
Am J Respir Cell Mol Biol 35:714-21. 2006..Through such mechanisms, thrombin could contribute to many chronic lung disorders characterized by tissue remodeling... - Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smokeHui Jung Kim
Pulmonary Division, Department of Internal Medicine, Seoul Adventist Hospital, Seoul 130-650, Korea
Am J Physiol Lung Cell Mol Physiol 283:L409-17. 2002..In conclusion, smoke inhibition of fibroblast repair, as reflected by collagen gel contraction and fibronectin production, may be modulated by intracellular GSH levels... - Biomarkers to assess the utility of potential reduced exposure tobacco productsDorothy K Hatsukami
Tobacco Use Research Center, University of Minnesota Cancer Center, Minneapolis, MN 55414, USA
Nicotine Tob Res 8:169-91. 2006..Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area... - Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closurePraveen R Arany
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:9250-5. 2006..These studies highlight a previously undescribed role for Smad3 in the mechanotransduction of matrix unsupported ear wound closure... - Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary diseaseBipen D Patel
Department of Medicine, University of Cambridge, Cambridge, UK
Am J Respir Crit Care Med 178:500-5. 2008..It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families... - Reversible cigarette smoke extract-induced DNA damage in human lung fibroblastsHuijung Kim
Department of Internal Medicine, Seoul Adventist Hospital and WonKwang University Sanbon Medical Center, Korea
Am J Respir Cell Mol Biol 31:483-90. 2004..Moreover, this DNA damage is reversible, with cells surviving and TUNEL positivity reversing when CSE is removed within 24 h... - Cytokines modulate cilomilast response in lung fibroblastsTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
Clin Immunol 111:297-302. 2004..In summary, the inhibitory effect of cilomilast on fibroblast migration and collagen gel contraction is modulated by IL-1beta and IL-4 through regulation of PGE(2) production... - Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary diseaseElizabeth Gamble
Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
Am J Respir Crit Care Med 168:976-82. 2003..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease... - IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiencyDawn L DeMeo
Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 38:114-20. 2008..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency... - PGD(2) modulates fibroblast-mediated native collagen gel contractionTadashi Kohyama
Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
Am J Respir Cell Mol Biol 27:375-81. 2002.... - Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normalHisatoshi Sugiura
Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
Am J Respir Cell Mol Biol 37:424-30. 2007..The augmented profibrotic activity and mediator release of asthmatic fibroblasts could contribute to airway remodeling in asthma... - PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contractionQiuhong Fang
Beijing Shijitan Hospital, Peking University, Beijing, China
Biochem Biophys Res Commun 369:1199-203. 2008..These results suggest that thrombin contributes to the tissue remodeling in inflammatory airways and lung diseases at least partially through both PKCdelta and PKCepsilon signaling...