S Rennard

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. doi request reprint The many "small COPDs": COPD should be an orphan disease
    Stephen I Rennard
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Chest 134:623-7. 2008
  2. pmc Effect of budesonide on fibroblast-mediated collagen gel contraction and degradation
    Qiuhong Fang
    Pulmonary and Critical Care Department, Beijing Shijitan Hospital, Capital Medical University, Beijing, People s Republic of China Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    J Inflamm Res 6:25-33. 2013
  3. ncbi request reprint Smoking cessation
    Stephen I Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, Nebraska 68198 5910, USA Electronic address
    Clin Chest Med 35:165-76. 2014
  4. ncbi request reprint ACCORD COPD II: a randomized clinical trial to evaluate the 12-week efficacy and safety of twice-daily aclidinium bromide in chronic obstructive pulmonary disease patients
    Stephen I Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198 5910, USA
    Clin Drug Investig 33:893-904. 2013
  5. pmc Examining fatigue in COPD: development, validity and reliability of a modified version of FACIT-F scale
    Khaled Al-shair
    University of Manchester, Medicines Evaluation Unit, NIHR Translational Research Facility, Manchester Academic Health Sciences Centre, University Hospital of South Manchester Foundation Trust, Wythenshawe, Manchester, UK
    Health Qual Life Outcomes 10:100. 2012
  6. doi request reprint Introducing the COPD Foundation Guide for Diagnosis and Management of COPD, recommendations of the COPD Foundation
    Stephen Rennard
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5910, USA
    COPD 10:378-89. 2013
  7. ncbi request reprint Long-term safety study of infliximab in moderate-to-severe chronic obstructive pulmonary disease
    Stephen I Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, Internal Medicine, University of Nebraska Medical Center, 4111 Dewey Avenue, Omaha, NE 68198, USA
    Respir Med 107:424-32. 2013
  8. doi request reprint Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4
    Joel Michalski
    Department of Internal Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Am J Respir Cell Mol Biol 47:729-37. 2012
  9. pmc Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency
    Woo Jin Kim
    Channing Laboratory and the Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Respir Res 13:16. 2012
  10. pmc Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease
    Matthew J Loza
    Immunology Biomarkers, Janssen Research and Development, LLC, Malvern, PA, USA
    Respir Res 13:12. 2012

Detail Information

Publications112 found, 100 shown here

  1. doi request reprint The many "small COPDs": COPD should be an orphan disease
    Stephen I Rennard
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Chest 134:623-7. 2008
    ..This strategy may help to address the increasing burden that COPD presents and for which no novel clinical class of treatment has been introduced for 30 years...
  2. pmc Effect of budesonide on fibroblast-mediated collagen gel contraction and degradation
    Qiuhong Fang
    Pulmonary and Critical Care Department, Beijing Shijitan Hospital, Capital Medical University, Beijing, People s Republic of China Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    J Inflamm Res 6:25-33. 2013
    ..The balance between production and degradation of extracellular matrix is crucial in maintaining normal tissue structure. This study was designed to investigate the effect of budesonide on fibroblast-mediated tissue repair and remodeling...
  3. ncbi request reprint Smoking cessation
    Stephen I Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, Nebraska 68198 5910, USA Electronic address
    Clin Chest Med 35:165-76. 2014
    ..Effective use of these medications requires their integration into an effective management plan, which is likely to be a long-term undertaking, involving several cycles of remission and relapse. ..
  4. ncbi request reprint ACCORD COPD II: a randomized clinical trial to evaluate the 12-week efficacy and safety of twice-daily aclidinium bromide in chronic obstructive pulmonary disease patients
    Stephen I Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, 985910 Nebraska Medical Center, Omaha, NE, 68198 5910, USA
    Clin Drug Investig 33:893-904. 2013
    ..This 12-week phase III study evaluated efficacy and tolerability of aclidinium 200 or 400 μg in patients with moderate-to-severe COPD...
  5. pmc Examining fatigue in COPD: development, validity and reliability of a modified version of FACIT-F scale
    Khaled Al-shair
    University of Manchester, Medicines Evaluation Unit, NIHR Translational Research Facility, Manchester Academic Health Sciences Centre, University Hospital of South Manchester Foundation Trust, Wythenshawe, Manchester, UK
    Health Qual Life Outcomes 10:100. 2012
    ..The availability of a short, simple, reliable and valid scale would improve assessment of the characteristics and influence of fatigue in COPD...
  6. doi request reprint Introducing the COPD Foundation Guide for Diagnosis and Management of COPD, recommendations of the COPD Foundation
    Stephen Rennard
    Pulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5910, USA
    COPD 10:378-89. 2013
    ..The current recommendations of the COPD Foundation have been summarized in the form of Pocket Cards, which may be obtained from the Foundation at no charge (1-866-316-COPD (2673), www.copdfoundation.org)...
  7. ncbi request reprint Long-term safety study of infliximab in moderate-to-severe chronic obstructive pulmonary disease
    Stephen I Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, Internal Medicine, University of Nebraska Medical Center, 4111 Dewey Avenue, Omaha, NE 68198, USA
    Respir Med 107:424-32. 2013
    ..There was an increased number of malignancies in infliximab-treated (5.7%) over placebo-treated (1.3%) patients in a 44-week, phase 2 clinical study of 234 patients with moderate-to-severe chronic obstructive pulmonary disease (COPD)...
  8. doi request reprint Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4
    Joel Michalski
    Department of Internal Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Am J Respir Cell Mol Biol 47:729-37. 2012
    ..These alterations may contribute to COPD pathogenesis and could provide novel therapeutic targets...
  9. pmc Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency
    Woo Jin Kim
    Channing Laboratory and the Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Respir Res 13:16. 2012
    ..We investigated whether SNPs in the chromosome 15q region would be modifiers for lung function and COPD in AAT deficiency...
  10. pmc Systemic inflammatory profile and response to anti-tumor necrosis factor therapy in chronic obstructive pulmonary disease
    Matthew J Loza
    Immunology Biomarkers, Janssen Research and Development, LLC, Malvern, PA, USA
    Respir Res 13:12. 2012
    ..This study sought to evaluate the systemic inflammatory profile associated with COPD and to assess the impact of tumor necrosis factor neutralization on systemic inflammation...
  11. pmc A randomized placebo-controlled trial of varenicline for smoking cessation allowing flexible quit dates
    Stephen Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Nicotine Tob Res 14:343-50. 2012
    ..The objective of this study was to compare varenicline 1 mg twice daily (b.i.d.) with placebo in subjects using a flexible quit date paradigm after starting medication...
  12. pmc Prostaglandin E2 stimulates the production of vascular endothelial growth factor through the E-prostanoid-2 receptor in cultured human lung fibroblasts
    Masanori Nakanishi
    Division of Pulmonary, Critical Care, Sleep and Allergy Medicine, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Am J Respir Cell Mol Biol 46:217-23. 2012
    ..This activity may contribute to the maintenance of pulmonary microvasculature in the alveolar wall...
  13. pmc Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease
    Paul W Jones
    St George s, University of London, London, UK
    Respir Res 12:55. 2011
    ..The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD)...
  14. pmc Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels
    Y Zhu
    University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198-5125, USA
    Respir Res 2:300-5. 2001
    ..01). PGE2 appeared to decrease both MMP production and activation. CONCLUSION: The current study demonstrates that interactions between monocytes and fibroblasts can mediate tissue remodeling...
  15. pmc Sputum neutrophils as a biomarker in COPD: findings from the ECLIPSE study
    Dave Singh
    University of Manchester, Medicines Evaluation Unit, South Manchester University Hospitals Trust, Southmoor Road, Manchester M23 9QZ, UK
    Respir Res 11:77. 2010
    ..We studied the relationships between sputum neutrophils and FEV1, health status, exacerbation rates, systemic inflammation and emphysema, and long term variability at 1 year...
  16. pmc One-year treatment with mometasone furoate in chronic obstructive pulmonary disease
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Liverpool, UK
    Respir Res 9:73. 2008
    ..031). MF-DPI treatment was well tolerated.Once-daily MF-DPI improved lung function and health status in subjects with moderate-to-severe COPD and was comparable to BID MF-DPI...
  17. pmc Characterisation of COPD heterogeneity in the ECLIPSE cohort
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
    Respir Res 11:122. 2010
    ..Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE)...
  18. pmc Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture
    Y Zhu
    University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198-5125, USA
    Respir Res 2:295-9. 2001
    ..CONCLUSION: The current study, therefore, demonstrates that interaction between monocytes and fibroblasts can contract and degrade extracellular matrix in extended culture...
  19. pmc TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels
    Tetsu Kobayashi
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Respir Res 6:141. 2005
    ..Contraction induced by different factors, therefore, may be differentially associated with apoptosis, which may be related to the persistence or resolution of the fibroblasts that accumulate following injury...
  20. pmc Differentiation of embryonic stem cells into fibroblast-like cells in three-dimensional type I collagen gel cultures
    Shinsaku Togo
    Department of Internal Medicine, Pulmonary, Critical Care, Sleep and Allergy Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198 5910, USA
    In Vitro Cell Dev Biol Anim 47:114-24. 2011
    ..This methodology provides a means to investigate and define the mechanisms that regulate fibroblast differentiation...
  21. doi request reprint Lessons from multidisciplinary cross-fertilization: chronic obstructive pulmonary disease, lung cancer, and heart disease
    Stephen I Rennard
    Pulmonary and Critical Care Medicine, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Proc Am Thorac Soc 5:865-8. 2008
    ..Exploration of those relationships promises to advance the understanding of all three diseases and holds the potential to advance the diagnosis and treatment of these common and devastating conditions...
  22. ncbi request reprint Reactive nitrogen species augment fibroblast-mediated collagen gel contraction, mediator production, and chemotaxis
    Hisatoshi Sugiura
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 34:592-9. 2006
    ..01), and neutralizing anti-TGF-beta antibody suppressed peroxynitrite-augmented alpha5beta1 expression (P < 0.01). These results suggest that RNS can affect the tissue repair process by modulating TGF-beta1...
  23. ncbi request reprint Exacerbations and progression of disease in asthma and chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Proc Am Thorac Soc 1:88-92. 2004
    ..Future studies of how exacerbation affects the "natural history" of asthma and COPD will require a better understanding of the heterogeneity of exacerbations but promises to identify new therapeutic strategies to treat these disorders...
  24. ncbi request reprint Antiinflammatory therapies other than corticosteroids
    Stephen I Rennard
    University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198, USA
    Proc Am Thorac Soc 1:282-7. 2004
    ..The complex network of regulatory molecules that controls the inflammatory response, therefore, presents a number of potential therapeutic targets with the promise of altering the disease process in COPD...
  25. ncbi request reprint Clinical approach to patients with chronic obstructive pulmonary disease and cardiovascular disease
    Stephen I Rennard
    Department of Internal Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Proc Am Thorac Soc 2:94-100. 2005
    ..It is plausible that treatment of pulmonary inflammation characteristic of COPD will alter cardiac risk. Such an approach would offer a novel approach for the development of treatments for these common conditions...
  26. ncbi request reprint Challenges and opportunities for combination therapy in chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, 985125 Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Proc Am Thorac Soc 2:391-3; discussion 394-5. 2005
    ..The use of a truly multidimensional outcome parameter promises an entirely novel paradigm for the assessment of novel combinations of therapies...
  27. ncbi request reprint Exacerbation-free COPD: a goal too far?
    Stephen I Rennard
    Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, Nebraska Medical Center, Omaha, USA
    Proc Am Thorac Soc 4:583-5. 2007
    ..The challenge addressed by the participants was whether more effective treatments could be developed that could further eliminate COPD exacerbations...
  28. ncbi request reprint Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4
    Stephen I Rennard
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Chest 129:56-66. 2006
    ..COPD is a relentless, progressive disease. This study evaluated the efficacy of cilomilast, a selective phosphodiesterase (PDE) 4 inhibitor, in the treatment of COPD...
  29. ncbi request reprint COPD: the dangerous underestimate of 15%
    Stephen I Rennard
    University of Nebraska Medical Center, Omaha, NE 68198, USA
    Lancet 367:1216-9. 2006
  30. pmc NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract
    Xiangde Liu
    Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Respir Res 9:66. 2008
    ..Since NF-kappaB is also involved in regulating apoptosis and cell survival, the current study was designed to investigate the role of NF-kappaB in mediating cell survival in response to cigarette smoke exposure in HBECs...
  31. ncbi request reprint A dose-ranging study of indacaterol in obstructive airways disease, with a tiotropium comparison
    Stephen Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, Omaha, Nebraska 68198 5885, USA
    Respir Med 102:1033-44. 2008
    ..Indacaterol demonstrated a good overall safety and tolerability profile...
  32. pmc Efficacy and tolerability of budesonide/formoterol in one hydrofluoroalkane pressurized metered-dose inhaler in patients with chronic obstructive pulmonary disease: results from a 1-year randomized controlled clinical trial
    Stephen I Rennard
    Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
    Drugs 69:549-65. 2009
    ....
  33. pmc Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD
    Stephen I Rennard
    Nebraska Medical Center, Omaha, Nebraska, USA
    Respir Res 12:18. 2011
    ..This led to the question of whether a responsive subset existed that could be investigated further...
  34. ncbi request reprint The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease
    Stephen I Rennard
    University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198, USA
    Am J Respir Crit Care Med 175:926-34. 2007
    ..Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-alpha is overexpressed and has been suggested to play a pathogenic role...
  35. ncbi request reprint Minimal clinically important difference, clinical perspective: an opinion
    Stephen I Rennard
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
    COPD 2:51-5. 2005
    ..The limits of the concept, particularly as it relates to issues of importance to patients, however, needs to be recognized...
  36. pmc Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema
    Stephen I Rennard
    University of Nebraska Medical Center, Pulmonary and Critical Care Medicine, 985125 Nebraska Medical Center, Omaha, NE 98198 5125, USA
    Proc Am Thorac Soc 3:703-8. 2006
    ....
  37. doi request reprint COPD heterogeneity: what this will mean in practice
    Stephen I Rennard
    Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Internal Medicine, University of Nebraska Medical Center Omaha, Omaha Nebraska 68198 5910, USA
    Respir Care 56:1181-7. 2011
    ..The clinical implications of improved understanding of COPD heterogeneity will be better care and outcomes for COPD patients, which will depend on increased diagnostic accuracy and selective administration of treatments...
  38. ncbi request reprint Rationale and emerging approaches for targeting lung repair and regeneration in the treatment of chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary, Critical Care, Sleep and Allergy Section, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Proc Am Thorac Soc 8:368-75. 2011
    ..In contrast to therapy designed to slow the progression of COPD, it may be much easier and less expensive to demonstrate efficacy for a therapy that restores lung function...
  39. ncbi request reprint Chronic obstructive pulmonary disease: linking outcomes and pathobiology of disease modification
    Stephen I Rennard
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68198 5300, USA
    Proc Am Thorac Soc 3:276-80. 2006
    ..The development of biomarkers of lung damage, pulmonary inflammation, and systemic disease will be essential to our further understanding of the natural history of COPD and the discovery of new, effective treatments for its progression...
  40. doi request reprint The efficacy and safety of cilomilast in COPD
    Stephen Rennard
    University of Nebraska Medical Center, Omaha, 68198 5885, USA
    Drugs 68:3-57. 2008
    ..However, subsequent phase III studies failed to definitively confirm the earlier programme results, which led to termination of the development of cilomilast...
  41. ncbi request reprint Inflammation and repair processes in chronic obstructive pulmonary disease
    S I Rennard
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198 5300, USA
    Am J Respir Crit Care Med 160:S12-6. 1999
    ..Rennard SI. Inflammation and repair processes in chronic obstructive pulmonary disease...
  42. ncbi request reprint Evaluation of subclinical respiratory tract inflammation in heavy smokers who switch to a cigarette-like nicotine delivery device that primarily heats tobacco
    Stephen I Rennard
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha 68198, USA
    Nicotine Tob Res 4:467-76. 2002
    ..One individual experienced a transient twofold increase in CO and concurrently experienced transient headaches. Eclipse use may be a strategy to reduce the health risks for heavy smokers unwilling or unable to quit...
  43. ncbi request reprint Impact of COPD in North America and Europe in 2000: subjects' perspective of Confronting COPD International Survey
    S Rennard
    University of Nebraska, Pulmonary and Critical Care Medicine Section, Omaha 68198 5125, USA
    Eur Respir J 20:799-805. 2002
    ..This international survey confirmed the great burden to society and high individual morbidity associated with chronic obstructive pulmonary disease in subjects in North America and Europe...
  44. pmc Natural histories of chronic obstructive pulmonary disease
    Stephen I Rennard
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Proc Am Thorac Soc 5:878-83. 2008
    ..With advances in understanding the clinical features of COPD and with the development of evaluating new tools to assess patients with COPD, longitudinal studies evaluating COPD in novel ways and for longer durations are needed...
  45. ncbi request reprint Overview of causes of COPD. New understanding of pathogenesis and mechanisms can guide future therapy
    Stephen I Rennard
    University of Nebraska Medical Center, 600 S 42nd St, Omaha, NE 68198, USA
    Postgrad Med 111:28-30, 33-4, 37-8. 2002
    ..Moreover, mediators that drive these processes have systemic effects that contribute to the syndromes characteristic of COPD. Understanding these mechanisms has created novel therapeutic approaches to the management of this disorder...
  46. ncbi request reprint New therapeutic drugs in the management of chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary and Critical Care Section, Internal Medicine Department, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Curr Opin Pulm Med 8:106-11. 2002
    ..Therapeutic recommendations will require publication of appropriately designed and adequately powered clinical trials...
  47. ncbi request reprint Treatment of stable chronic obstructive pulmonary disease
    Stephen I Rennard
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Lancet 364:791-802. 2004
    ..Treatment for stable COPD can improve the function and quality of life of many patients, could reduce admissions to hospital, and has been suggested to improve survival...
  48. ncbi request reprint Cigarette smoke in research
    Stephen I Rennard
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 31:479-80. 2004
  49. ncbi request reprint COPD in 2001: a major challenge for medicine, the pharmaceutical industry, and society
    Stephen I Rennard
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Chest 121:113S-115S. 2002
  50. ncbi request reprint COPD: treatments benefit patients
    Stephen I Rennard
    University of Nebraska Medical Center, Omaha, NE 68198, USA
    Lancet 361:444-5. 2003
  51. ncbi request reprint Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
    Drugs 68:1975-2000. 2008
    ..Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patients with COPD...
  52. doi request reprint PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts
    Shinsaku Togo
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Physiol Lung Cell Mol Physiol 296:L959-69. 2009
    ..The present study supports the concept that PDE4 inhibitors may attenuate fibroblast activities that can lead to fibrosis and that PDE4 inhibitors may be particularly effective in the presence of TGF-beta1-induced fibroblast stimulation...
  53. ncbi request reprint Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells
    Xiangde Liu
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1049-56. 2002
    ..These findings suggest that IL-4 and IL-13 may modulate airway tissue remodeling and, therefore, could play a role in the altered airway connective tissue which characterizes asthma...
  54. pmc Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway
    Koichiro Kamio
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 37:113-20. 2007
    ..The ability of prostacyclin to modulate fibroblast function suggests that prostacyclin can contribute to tissue remodeling...
  55. ncbi request reprint Cells derived from the circulation contribute to the repair of lung injury
    Shinji Abe
    University of Nebraska Medical Center, Department of Internal Medicine, Pulmonary and Critical Care Medicine Section 985125, Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Am J Respir Crit Care Med 170:1158-63. 2004
    ..This study demonstrates that stem/progenitor cells in blood contribute to the repair of lung injury in irradiated mice...
  56. ncbi request reprint TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985125 Nebraska Medical Center, Omaha, NE 68198 5125, USA
    J Allergy Clin Immunol 111:1307-18. 2003
    ..T(H)2 and T(H)1 cytokines have opposite effects on many aspects of the inflammatory response...
  57. ncbi request reprint Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cells
    Xiangde Liu
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Osteoporos Int 14:235-42. 2003
    ..The current study demonstrates that cigarette smoke can interfere with the ability of bone cells to participate in repair and remodeling events. Such an effect may be one mechanism leading to the development of osteoporosis...
  58. ncbi request reprint Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells
    Xiangde Liu
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 33:121-9. 2005
    ....
  59. ncbi request reprint PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels
    Tadashi Kohyama
    University of Nebraska Medical Center, Omaha 68198 5125, USA
    Am J Respir Cell Mol Biol 26:694-701. 2002
    ..In summary, these in vitro results suggest that PDE4 inhibitors may be able to suppress fibroblast activity and, thus, have the potential to block the development of progressive fibrosis...
  60. ncbi request reprint Glucocorticoids modulate TGF-beta production by human fetal lung fibroblasts
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Inflammation 27:9-19. 2003
    ..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun...
  61. pmc Reduced miR-146a increases prostaglandin E₂in chronic obstructive pulmonary disease fibroblasts
    Tadashi Sato
    Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5910, USA
    Am J Respir Crit Care Med 182:1020-9. 2010
    ..Overproduction of the inflammatory mediator prostaglandin (PG) E₂ by COPD fibroblasts contributes to reduced repair function...
  62. ncbi request reprint Lysophosphatidic acid in airway function and disease
    Myron L Toews
    Department of Pharmacology, University of Nebraska Medical Center, 986260 Nebraska Medical Center, Omaha, NE 68198 6260, USA
    Biochim Biophys Acta 1582:240-50. 2002
    ....
  63. ncbi request reprint Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Am J Respir Cell Mol Biol 26:484-90. 2002
    ..The ability of these cytokines to modulate TGF-beta release may contribute to both normal airway repair and to the development of subepithelial fibrosis in asthma...
  64. doi request reprint Knowledge and beliefs about genetics and smoking among visitors and staff at a health care facility
    Julia Fisco Houfek
    University of Nebraska Medical Center, College of Nursing, Omaha, Nebraska 98198 5330, USA
    Public Health Nurs 25:77-87. 2008
    ..Because genetics influences smoking, genetic information will likely be used to individualize future cessation treatment...
  65. ncbi request reprint Lung cells transplanted to irradiated recipients generate lymphohematopoietic progeny
    Shinji Abe
    Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 6395, USA
    Am J Respir Cell Mol Biol 30:491-9. 2004
    ..CD45(+) cells in the lung cells have lymphohematopoietic stem/progenitor cell characteristics, and this has implications for cell or gene therapy applications...
  66. ncbi request reprint Activation of protein kinase A accelerates bovine bronchial epithelial cell migration
    John R Spurzem
    Department of Veterans Affairs Medical Center, Omaha, Nebraska 68105, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1108-16. 2002
    ..Augmentation of PKA activity reduced the levels of active Rho and the formation of focal adhesions. These studies suggest that PKA activation modulates Rho activity, migration mechanisms, and thus bronchial epithelial repair mechanisms...
  67. ncbi request reprint Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung fibroblasts
    Tetsu Kobayashi
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Biochem Biophys Res Commun 339:290-5. 2006
    ..Thus, Smad3 mediates TGF-beta1-induced contraction and alpha-SMA induction in human lung fibroblasts. Smad3, therefore, could be a target for blocking contraction of human fibrotic tissue induced by TGF-beta1...
  68. doi request reprint MicroRNA-146a modulates human bronchial epithelial cell survival in response to the cytokine-induced apoptosis
    Xiangde Liu
    Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Internal Medicine, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Biochem Biophys Res Commun 380:177-82. 2009
    ..The MicroRNA-146a mimic appears to modulate HBEC survival through a mechanism of up-regulating Bcl-XL and STAT3 phosphorylation, and by this mechanism it could contribute to tissue repair and remodeling...
  69. ncbi request reprint Prostacyclin analogs inhibit fibroblast migration
    Tadashi Kohyama
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Am J Physiol Lung Cell Mol Physiol 283:L428-32. 2002
    ..Such an effect may contribute to the regulation of fibroblasts in wound healing and could contribute to the pathogenesis of diseases characterized by abnormal tissue repair remodeling...
  70. ncbi request reprint Interferon-gamma reduces interleukin-4- and interleukin-13-augmented transforming growth factor-beta2 production in human bronchial epithelial cells by targeting Smads
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Chest 123:372S-3S. 2003
  71. ncbi request reprint Efficacy of the nicotine inhaler in smoking reduction: A double-blind, randomized trial
    Stephen I Rennard
    Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Nicotine Tob Res 8:555-64. 2006
    ..In conclusion, the nicotine inhaler can help smokers who are unable or unwilling to quit to reduce daily cigarette consumption, which may be a health benefit on its own and may further promote quitting...
  72. doi request reprint Effects of exercise on hematological parameters, circulating side population cells, and cytokines
    Gina G Wardyn
    Department of Internal Medicine, Pulmonary Section, University of Nebraska Medical Center, Omaha, NE 68198 2055, USA
    Exp Hematol 36:216-23. 2008
    ....
  73. ncbi request reprint Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines
    Thomas L Freeman
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Chem Res Toxicol 18:817-24. 2005
    ..These data suggest that cigarette smoke may promote the modification of proteins, like those associated with oxidized low-density lipoprotein, and may contribute to smoking-related disease...
  74. ncbi request reprint Glucocorticoids modulate TGF-beta production
    Fu Qiang Wen
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Inflammation 26:279-90. 2002
    ..Thus, TGF-beta isoforms may stimulate production of various TGF-beta isoforms in the lung. Glucocorticoids then may block TGF-beta production by modulating mRNA levels and c-Jun...
  75. ncbi request reprint Synergetic effect of interleukin-4 and transforming growth factor-beta1 on type I collagen gel contraction and degradation by HFL-1 cells: implication in tissue remodeling
    Xiangde Liu
    University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Chest 123:427S-8S. 2003
  76. ncbi request reprint Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction
    Huijung Kim
    Pulmonary and Critical Care Medicine Section, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Am J Respir Cell Mol Biol 28:111-21. 2003
    ..Taken together, these results demonstrate the ability of ultrafine particles to contribute to altered tissue repair and extend the known mechanisms by which these biologically active particles exert their effects...
  77. ncbi request reprint Pathogenesis of COPD
    John R Spurzem
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985300 Nebraska Medical Center, Omaha, NE 68198 5300, USA
    Semin Respir Crit Care Med 26:142-53. 2005
    ..Advances in understanding the pathogenesis of COPD have the potential for identifying new therapeutic targets that could alter the natural history of this devastating disorder...
  78. ncbi request reprint The CC chemokine ligand 2 (CCL2) mediates fibroblast survival through IL-6
    Xiangde Liu
    University of Nebraska Medical Center, Department of Pulmonary and Critical Care Medicine, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 37:121-8. 2007
    ..These data suggest that CCL2 mediates fibroblast survival by inhibiting apoptosis through IL-6/STAT3 signaling and provides a novel mechanism through which CCL2 may contribute to the development and maintenance of lung fibrosis...
  79. doi request reprint Smoking cessation
    Michael A Chandler
    Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Chest 137:428-35. 2010
    ..As smoking is an etiologic and exacerbating factor for lung diseases, the pulmonary physician should be particularly expert in smoking cessation interventions...
  80. ncbi request reprint Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts
    Tetsu Kobayashi
    University of Nebraska Medical Center, Omaha, NE, USA
    Biochem Biophys Res Commun 327:393-8. 2005
    ..These result suggest that TGF-beta1 stimulation of VEGF production by fibroblasts is regulated by Smad3 but not by Smad2 signaling...
  81. ncbi request reprint Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation
    Hisatoshi Sugiura
    University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Cell Physiol 210:99-110. 2007
    ..Through such a mechanism, PGE(2) may alter survival of cells in the smoke-exposed lungs, thus affecting the pathogenesis of cigarette smoke-induced disease...
  82. pmc Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms
    Shinsaku Togo
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Crit Care Med 178:248-60. 2008
    ..Alterations in fibroblast functional capacity, therefore, could play a role in the pathogenesis of pulmonary emphysema, which is characterized by inadequate maintenance of tissue structure...
  83. ncbi request reprint Conference report - 9th Annual Meeting of the Society for Research on Nicotine and Tobacco
    Stephen I Rennard
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    MedGenMed 5:36. 2003
  84. ncbi request reprint Cigarette smoke stimulates MMP-1 production by human lung fibroblasts through the ERK1/2 pathway
    Huijung Kim
    Pulmonary and Critical Care Medicine Section, University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, Nebraska 68198, USA
    COPD 1:13-23. 2004
    ..By inducing MMP-1, cigarette smoke may result in excess tissue destruction and contribute to the development of emphysema...
  85. doi request reprint Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease?
    Rose A Maciewicz
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Proc Am Thorac Soc 6:614-7. 2009
    ....
  86. ncbi request reprint Smad3 mediates the TGF-beta-induced contraction of type I collagen gels by mouse embryo fibroblasts
    Xiangde Liu
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5125, USA
    Cell Motil Cytoskeleton 54:248-53. 2003
    ..Thus, the Smad3 gene could be a target for blocking contraction of fibrotic tissue induced by TGF-beta...
  87. ncbi request reprint Inhalation of tobacco smoke induces increased proliferation of urinary bladder epithelium and endothelium in female C57BL/6 mice
    Takamasa Ohnishi
    Department of Pathology and Microbiology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 3135, United States
    Toxicology 241:58-65. 2007
    ..The increased urothelial proliferation appeared to be due to superficial cell cytotoxicity with consequent regeneration...
  88. pmc Prostaglandin E₂ inhibits human lung fibroblast chemotaxis through disparate actions on different E-prostanoid receptors
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Am J Respir Cell Mol Biol 44:99-107. 2011
    ..Alterations in EP receptor expression may have the potential to alter PGE(2) action. Targeting specific EP receptors may offer therapeutic opportunities in conditions characterized by abnormal tissue repair and remodeling...
  89. doi request reprint Statins inhibit matrix metalloproteinase release from human lung fibroblasts
    K Kamio
    University of Nebraska Medical Center, Omaha, NE 68198 5910, USA
    Eur Respir J 35:637-46. 2010
    ..The current data suggest that statins may modulate remodelling processes mediated by fibroblasts by inhibiting MMP release...
  90. ncbi request reprint Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Japan
    Am J Respir Cell Mol Biol 27:487-94. 2002
    ..These results suggest that cilomilast may be a potentially effective therapeutic agent in diseases characterized by excessive tissue destruction, such as emphysema...
  91. ncbi request reprint Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease
    Bipen D Patel
    Department of Medicine, University of Cambridge, Cambridge, UK
    Am J Respir Crit Care Med 178:500-5. 2008
    ..It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families...
  92. ncbi request reprint Reversible cigarette smoke extract-induced DNA damage in human lung fibroblasts
    Huijung Kim
    Department of Internal Medicine, Seoul Adventist Hospital and WonKwang University Sanbon Medical Center, Korea
    Am J Respir Cell Mol Biol 31:483-90. 2004
    ..Moreover, this DNA damage is reversible, with cells surviving and TUNEL positivity reversing when CSE is removed within 24 h...
  93. ncbi request reprint Cytokines modulate cilomilast response in lung fibroblasts
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
    Clin Immunol 111:297-302. 2004
    ..In summary, the inhibitory effect of cilomilast on fibroblast migration and collagen gel contraction is modulated by IL-1beta and IL-4 through regulation of PGE(2) production...
  94. ncbi request reprint IL-4 and IL-13 induce chemotaxis of human foreskin fibroblasts, but not human fetal lung fibroblasts
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
    Inflammation 28:33-7. 2004
    ..Therefore, the role of specific cytokines in mediating fibrotic responses might vary depending on local mesenchymal cell responses...
  95. pmc Platelets stimulate fibroblast-mediated contraction of collagen gels
    Ulrika Zagai
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Respir Res 4:13. 2003
    ..We also sought to determine to what extent platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) contribute to this effect...
  96. ncbi request reprint Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  97. ncbi request reprint Nerve growth factor stimulates fibronectin-induced fibroblast migration
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Japan
    J Lab Clin Med 140:329-35. 2002
    ....
  98. ncbi request reprint Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell density
    Hangjun Wang
    Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Am J Physiol Lung Cell Mol Physiol 284:L205-13. 2003
    ..These effects may help explain the varied pathologies associated with exposure to cigarette smoke...
  99. ncbi request reprint PGD(2) modulates fibroblast-mediated native collagen gel contraction
    Tadashi Kohyama
    Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
    Am J Respir Cell Mol Biol 27:375-81. 2002
    ....
  100. ncbi request reprint Proposal for a multidimensional staging system for chronic obstructive pulmonary disease
    Bartolome R Celli
    Department of Pulmonary and Critical Care Medicine, Tufts University, Boston, MA 02135, USA
    Respir Med 99:1546-54. 2005
    ..Although the staging boundaries were based on existing literature, they have proven useful in predicting survival. We conclude that a multidimensional grading system is useful to assess the impact of COPD...