K Ren

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint An improved method for assessing mechanical allodynia in the rat
    K Ren
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201 1586, USA
    Physiol Behav 67:711-6. 1999
  2. pmc Suckling and sucrose ingestion suppress persistent hyperalgesia and spinal Fos expression after forepaw inflammation in infant rats
    K Ren
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Proc Natl Acad Sci U S A 94:1471-5. 1997
  3. pmc Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla
    S C LaGraize
    University of Maryland Dental School, Department of Neural and Pain, Sciences, Program in Neuroscience, 650 W Baltimore Street, 8 South, Baltimore, MD 21201, USA
    Neuroscience 171:1341-56. 2010
  4. ncbi request reprint Long-term effects of short-lasting early local inflammatory insult
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, 21201, USA
    Neuroreport 12:399-403. 2001
  5. ncbi request reprint Selective upregulation of the flip-flop splice variants of AMPA receptor subunits in the rat spinal cord after hindpaw inflammation
    Q Q Zhou
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, MD 21201-1586, USA
    Brain Res Mol Brain Res 88:186-93. 2001
  6. ncbi request reprint Progesterone attenuates persistent inflammatory hyperalgesia in female rats: involvement of spinal NMDA receptor mechanisms
    K Ren
    Department of Oral and Craniofacial Biological Sciences, Rm 5A26, Dental School, University of Maryland, 666 W Baltimore St, 21201, Baltimore, MD, USA
    Brain Res 865:272-7. 2000
  7. ncbi request reprint Ontogeny of analgesia elicited by non-nutritive suckling in acute and persistent neonatal rat pain models
    V Anseloni
    Department of Biomedical Sciences, Program in Neuroscience, University of Maryland Dental School, 666 West Baltimore Street, Baltimore, MD 21201, USA
    Pain 109:507-13. 2004
  8. ncbi request reprint Inflammation-induced Fos protein expression in the rat spinal cord is enhanced following dorsolateral or ventrolateral funiculus lesions
    F Wei
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Brain Res 782:136-41. 1998
  9. ncbi request reprint Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain
    H Imbe
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, MD, USA
    Cells Tissues Organs 169:238-47. 2001
  10. ncbi request reprint Endogenous mechanisms of sensory modulation
    R Dubner
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Pain . 1999

Collaborators

Detail Information

Publications19

  1. ncbi request reprint An improved method for assessing mechanical allodynia in the rat
    K Ren
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201 1586, USA
    Physiol Behav 67:711-6. 1999
    ..Importantly, this method can also be used in the orofacial region, and will facilitate studies on the mechanisms of persistent orofacial pain in animals...
  2. pmc Suckling and sucrose ingestion suppress persistent hyperalgesia and spinal Fos expression after forepaw inflammation in infant rats
    K Ren
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Proc Natl Acad Sci U S A 94:1471-5. 1997
    ..These findings may provide new clinical approaches for engaging endogenous analgesic mechanisms in infants following tissue injury and inflammation...
  3. pmc Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla
    S C LaGraize
    University of Maryland Dental School, Department of Neural and Pain, Sciences, Program in Neuroscience, 650 W Baltimore Street, 8 South, Baltimore, MD 21201, USA
    Neuroscience 171:1341-56. 2010
    ....
  4. ncbi request reprint Long-term effects of short-lasting early local inflammatory insult
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, 21201, USA
    Neuroreport 12:399-403. 2001
    ..These data suggest that early inflammatory insult may differentially affect the aspects of nociceptive circuitry involved in transient pain sensitivity and in inflammation-induced hyperalgesia...
  5. ncbi request reprint Selective upregulation of the flip-flop splice variants of AMPA receptor subunits in the rat spinal cord after hindpaw inflammation
    Q Q Zhou
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, MD 21201-1586, USA
    Brain Res Mol Brain Res 88:186-93. 2001
    ..Selective changes in the expression of the flip-flop splice variants of the AMPA receptor suggest a reorganization of the composition of the AMPA receptor complex and its involvement in the development of inflammatory hyperalgesia...
  6. ncbi request reprint Progesterone attenuates persistent inflammatory hyperalgesia in female rats: involvement of spinal NMDA receptor mechanisms
    K Ren
    Department of Oral and Craniofacial Biological Sciences, Rm 5A26, Dental School, University of Maryland, 666 W Baltimore St, 21201, Baltimore, MD, USA
    Brain Res 865:272-7. 2000
    ....
  7. ncbi request reprint Ontogeny of analgesia elicited by non-nutritive suckling in acute and persistent neonatal rat pain models
    V Anseloni
    Department of Biomedical Sciences, Program in Neuroscience, University of Maryland Dental School, 666 West Baltimore Street, Baltimore, MD 21201, USA
    Pain 109:507-13. 2004
    ..Orotactile stimulation during suckling effectively reduces transient pain elicited by thermal and mechanical stimuli, as well as persistent hyperalgesia and allodynia caused by inflammation...
  8. ncbi request reprint Inflammation-induced Fos protein expression in the rat spinal cord is enhanced following dorsolateral or ventrolateral funiculus lesions
    F Wei
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Brain Res 782:136-41. 1998
    ....
  9. ncbi request reprint Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain
    H Imbe
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, MD, USA
    Cells Tissues Organs 169:238-47. 2001
    ..Since deep inputs may be more effective in inducing central neuronal excitation than cutaneous inputs, greater sensory disturbances may occur in pain conditions involving deep tissues than in those involving cutaneous tissues...
  10. ncbi request reprint Endogenous mechanisms of sensory modulation
    R Dubner
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Pain . 1999
    ..These parallel brain mechanisms emphasize the saliency of pain experience as an important learned behavior for the survival of the organism, similar to sequential goal-directed behaviors in an operant task...
  11. ncbi request reprint The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation
    R Terayama
    Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore 21201 1586, USA
    Pain 97:171-81. 2002
    ..At early time points, NMDA receptor and NGC activation enhance descending facilitation; as time progresses, the dose-response curve of NMDA shifts to the left and descending inhibition dominates and masks any descending facilitation...
  12. ncbi request reprint Characterization of basal and re-inflammation-associated long-term alteration in pain responsivity following short-lasting neonatal local inflammatory insult
    K Ren
    Department of Biomedical Sciences, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Pain 110:588-96. 2004
    ..These finding provide a framework within which the entire complex of long-term effects of early noxious experience can be understood and examined...
  13. ncbi request reprint Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action
    M O Urban
    Department of Pharmacology and Chemistry, Merck Research Laboratories, San Diego, CA, USA
    J Pharmacol Exp Ther 313:1209-16. 2005
    ..Thus, the stereoselective efficacy of 3-MeGBP, presumably related to alpha(2)delta binding, likely does not completely account for the mechanism of action of GBP...
  14. ncbi request reprint A brainstem substrate for analgesia elicited by intraoral sucrose
    V C Z Anseloni
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Neuroscience 133:231-43. 2005
    ..Intraoral sucrose activates neurons in the periaqueductal gray and nucleus raphe magnus, two key brainstem sites critically involved in descending pain modulation...
  15. ncbi request reprint alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation
    K Ren
    Department of Pharmaceutics, Box 100494, University of Florida, Gainesville, FL 32610, USA
    Neuroscience 145:314-22. 2007
    ....
  16. ncbi request reprint The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice
    K Ren
    Department of Pharmaceutics, 1600 Southwest Archer Drive, Box 100494, University of Florida, Gainesville, FL 32610, USA
    Neuroscience 148:230-7. 2007
    ....
  17. ncbi request reprint A new model of experimental parotitis in rats and its implication for trigeminal nociception
    A Ogawa
    Departments of Dental Anesthesiology, Osaka University, Graduate School, Faculty of Dentistry 1 8, Yamadaoka, 565 0871, Suita Osaka, Japan
    Exp Brain Res 152:307-16. 2003
    ..The model will be useful in developing new strategies to treat chronic orofacial pain...
  18. ncbi request reprint Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections
    H Sun
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Pain 90:105-11. 2001
    ..This neuronal pathway is consistent with the interpretation that tactile allodynia pursuant to peripheral nerve injury is transmitted to the central nervous system by means of large diameter, myelinated fibers...
  19. ncbi request reprint Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation
    Kenji Miki
    Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, 666 W Baltimore St, Baltimore, MD 21201, USA
    J Neurophysiol 87:750-60. 2002
    ..The functional phenotypic switch of RVM neurons provides a novel mechanism underlying activity-dependent plasticity and enhanced net descending inhibition after inflammation...