Dejian Ren

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 77:551-9. 2007
  2. doi request reprint Calcium signaling through CatSper channels in mammalian fertilization
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Physiology (Bethesda) 25:165-75. 2010
  3. pmc Sodium leak channels in neuronal excitability and rhythmic behaviors
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 72:899-911. 2011
  4. doi request reprint Calcium signaling in sperm: help from prostasomes
    Dejian Ren
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Sci Signal 4:pe27. 2011
  5. pmc Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex
    Boxun Lu
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 68:488-99. 2010
  6. pmc Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80
    Boxun Lu
    Department of Biology, University of Pennsylvania, 415 S University Avenue, Philadelphia, Pennsylvania 19104, USA
    Nature 457:741-4. 2009
  7. pmc The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, 415 S University Ave, Philadelphia, Pennsylvania 19104, USA
    Reprod Biol Endocrinol 7:119. 2009
  8. pmc A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 81:539-44. 2009
  9. pmc Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 80:1092-8. 2009
  10. doi request reprint The voltage-gated sodium channel TPC1 confers endolysosomal excitability
    Chunlei Cang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Chem Biol 10:463-9. 2014

Research Grants

Collaborators

Detail Information

Publications16

  1. ncbi request reprint CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 77:551-9. 2007
    ....
  2. doi request reprint Calcium signaling through CatSper channels in mammalian fertilization
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Physiology (Bethesda) 25:165-75. 2010
    ..We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought...
  3. pmc Sodium leak channels in neuronal excitability and rhythmic behaviors
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 72:899-911. 2011
    ..This review discusses the properties of the NALCN complex, its regulation, and its contribution to neuronal function and animal behavior...
  4. doi request reprint Calcium signaling in sperm: help from prostasomes
    Dejian Ren
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Sci Signal 4:pe27. 2011
    ..Just before encountering the female reproductive tract, sperm acquire some of the key molecules for Ca2+ signaling from the male reproductive tract itself: prostasomes secreted by the prostate gland...
  5. pmc Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex
    Boxun Lu
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 68:488-99. 2010
    ..Therefore, extracellular Ca(2+) influences neuronal excitability through the UNC79-UNC80-NALCN complex in a G protein-dependent fashion...
  6. pmc Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80
    Boxun Lu
    Department of Biology, University of Pennsylvania, 415 S University Avenue, Philadelphia, Pennsylvania 19104, USA
    Nature 457:741-4. 2009
    ..These findings identify NALCN as the cation channel activated by substance P receptor, and suggest that UNC-80 and Src family kinases, rather than a G protein, are involved in the coupling from receptor to channel...
  7. pmc The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, 415 S University Ave, Philadelphia, Pennsylvania 19104, USA
    Reprod Biol Endocrinol 7:119. 2009
    ..Both of these processes require extracellular calcium, but how calcium enters sperm during capacitation is not well understood...
  8. pmc A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 81:539-44. 2009
    ....
  9. pmc Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 80:1092-8. 2009
    ..Furthermore, the ZP-induced [Ca(2+)](i) increase starts from the sperm tail and propagates toward the head...
  10. doi request reprint The voltage-gated sodium channel TPC1 confers endolysosomal excitability
    Chunlei Cang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Chem Biol 10:463-9. 2014
    ..Thus, TPC1 is a member of a new family of voltage-gated Na(+) channels that senses pH changes and confers electrical excitability to organelles. ..
  11. pmc UNC80 functions as a scaffold for Src kinases in NALCN channel function
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Channels (Austin) 3:161-3. 2009
    ..This finding is consistent with the known requirement for Src kinases in the activation of NALCN, and may lead to new insights into the molecular mechanisms underlying G-protein-independent activation of the channel...
  12. pmc mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state
    Chunlei Cang
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Cell 152:778-90. 2013
    ..Thus, TPCs make up an ion channel family that couples the cell's metabolic state to endolysosomal function and are crucial for physical endurance during food restriction...
  13. doi request reprint TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function
    Chunlei Cang
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Cell 162:1101-12. 2015
    ..Thus, TMEM175 comprises a K(+) channel that underlies the molecular mechanism of lysosomal K(+) permeability...
  14. ncbi request reprint CatSperbeta, a novel transmembrane protein in the CatSper channel complex
    Jin Liu
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:18945-52. 2007
    ..CatSperbeta protein is absent in CatSper1(-/-) sperm, suggesting that it is required for trafficking or formation of a stable channel complex. CatSperbeta is the first identified auxiliary protein to the CatSper channel...
  15. pmc A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability
    Chunlei Cang
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, Pennsylvania 19104, USA
    Nat Commun 5:5015. 2014
    ..TPC3 homologues are present in plants and animals, and they may be important for cellular processes and behaviours associated with prolonged membrane depolarization. ..
  16. ncbi request reprint The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm
    Boxun Lu
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 129:371-83. 2007
    ..Thus, NALCN, a nonselective cation channel, forms the background Na(+) leak conductance and controls neuronal excitability...

Research Grants2

  1. The Protein Complex of a Sperm Ion Channel
    Dejian Ren; Fiscal Year: 2006
    ..Such an expression system will allow us to study the regulation of sperm function by ion channels at the molecular level. It may also lead to the development of a safe and efficient male contraceptive. ..
  2. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2010
    ..Results from this study will allow us to understand the ion mechanism underlying sperm motility and may lay the foundation for the future development of drugs for infertility treatment and for male contraceptives. ..