Dejian Ren

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Sodium leak channels in neuronal excitability and rhythmic behaviors
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 72:899-911. 2011
  2. ncbi Calcium signaling in sperm: help from prostasomes
    Dejian Ren
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Sci Signal 4:pe27. 2011
  3. ncbi Calcium signaling through CatSper channels in mammalian fertilization
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Physiology (Bethesda) 25:165-75. 2010
  4. ncbi Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex
    Boxun Lu
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 68:488-99. 2010
  5. ncbi Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80
    Boxun Lu
    Department of Biology, University of Pennsylvania, 415 S University Avenue, Philadelphia, Pennsylvania 19104, USA
    Nature 457:741-4. 2009
  6. ncbi The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, 415 S University Ave, Philadelphia, Pennsylvania 19104, USA
    Reprod Biol Endocrinol 7:119. 2009
  7. ncbi CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 77:551-9. 2007
  8. ncbi A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 81:539-44. 2009
  9. ncbi Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 80:1092-8. 2009
  10. ncbi UNC80 functions as a scaffold for Src kinases in NALCN channel function
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Channels (Austin) 3:161-3. 2009

Research Grants

  1. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2007
  2. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2009
  3. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2010
  4. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2009
  5. The Protein Complex of a Sperm Ion Channel
    Dejian Ren; Fiscal Year: 2006
  6. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2010

Collaborators

  • Yan Wang
  • Qi Zhang
  • Manabu Nakayama
  • David E Clapham
  • Jingsheng Xia
  • Haikun Wang
  • Boxun Lu
  • Jin Liu
  • Chunlei Cang
  • Sudipto Das
  • Yanhua Su
  • Kwang Hyun Cho
  • Shyuefang Battaglia-Hsu
  • Kimberly Aranda
  • Young Jun Seo
  • Yandong Zhou
  • Betsy Navarro
  • Lucy Shi
  • Itzhak Nissim
  • David Reigada
  • Kwang-Hyun Cho
  • Claire H Mitchell

Detail Information

Publications13

  1. ncbi Sodium leak channels in neuronal excitability and rhythmic behaviors
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 72:899-911. 2011
    ..This review discusses the properties of the NALCN complex, its regulation, and its contribution to neuronal function and animal behavior...
  2. ncbi Calcium signaling in sperm: help from prostasomes
    Dejian Ren
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Sci Signal 4:pe27. 2011
    ..Just before encountering the female reproductive tract, sperm acquire some of the key molecules for Ca2+ signaling from the male reproductive tract itself: prostasomes secreted by the prostate gland...
  3. ncbi Calcium signaling through CatSper channels in mammalian fertilization
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Physiology (Bethesda) 25:165-75. 2010
    ..We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought...
  4. ncbi Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex
    Boxun Lu
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 68:488-99. 2010
    ..Therefore, extracellular Ca(2+) influences neuronal excitability through the UNC79-UNC80-NALCN complex in a G protein-dependent fashion...
  5. ncbi Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80
    Boxun Lu
    Department of Biology, University of Pennsylvania, 415 S University Avenue, Philadelphia, Pennsylvania 19104, USA
    Nature 457:741-4. 2009
    ..These findings identify NALCN as the cation channel activated by substance P receptor, and suggest that UNC-80 and Src family kinases, rather than a G protein, are involved in the coupling from receptor to channel...
  6. ncbi The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, 415 S University Ave, Philadelphia, Pennsylvania 19104, USA
    Reprod Biol Endocrinol 7:119. 2009
    ..Both of these processes require extracellular calcium, but how calcium enters sperm during capacitation is not well understood...
  7. ncbi CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 77:551-9. 2007
    ....
  8. ncbi A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 81:539-44. 2009
    ....
  9. ncbi Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 80:1092-8. 2009
    ..Furthermore, the ZP-induced [Ca(2+)](i) increase starts from the sperm tail and propagates toward the head...
  10. ncbi UNC80 functions as a scaffold for Src kinases in NALCN channel function
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Channels (Austin) 3:161-3. 2009
    ..This finding is consistent with the known requirement for Src kinases in the activation of NALCN, and may lead to new insights into the molecular mechanisms underlying G-protein-independent activation of the channel...
  11. ncbi CatSperbeta, a novel transmembrane protein in the CatSper channel complex
    Jin Liu
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:18945-52. 2007
    ..CatSperbeta protein is absent in CatSper1(-/-) sperm, suggesting that it is required for trafficking or formation of a stable channel complex. CatSperbeta is the first identified auxiliary protein to the CatSper channel...
  12. ncbi The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm
    Boxun Lu
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell 129:371-83. 2007
    ..Thus, NALCN, a nonselective cation channel, forms the background Na(+) leak conductance and controls neuronal excitability...
  13. ncbi mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state
    Chunlei Cang
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Cell 152:778-90. 2013
    ..Thus, TPCs make up an ion channel family that couples the cell's metabolic state to endolysosomal function and are crucial for physical endurance during food restriction...

Research Grants13

  1. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2007
    ..Results from this study will allow us to understand the ion mechanism underlying sperm motility and may lay the foundation for the future development of drugs for infertility treatment and for male contraceptives. ..
  2. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2009
    ..They may also reveal how the function of the protein can influence neuronal excitabilities in physiological and pathophysiological conditions such as paralysis, seizure and epilepsy. ..
  3. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2010
    ..They may also reveal how the function of the protein can influence neuronal excitabilities in physiological and pathophysiological conditions such as paralysis, seizure and epilepsy. ..
  4. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2009
    ..They may also reveal how the function of the protein can influence neuronal excitabilities in physiological and pathophysiological conditions such as paralysis, seizure and epilepsy. ..
  5. The Protein Complex of a Sperm Ion Channel
    Dejian Ren; Fiscal Year: 2006
    ..Such an expression system will allow us to study the regulation of sperm function by ion channels at the molecular level. It may also lead to the development of a safe and efficient male contraceptive. ..
  6. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2010
    ..Results from this study will allow us to understand the ion mechanism underlying sperm motility and may lay the foundation for the future development of drugs for infertility treatment and for male contraceptives. ..