Research Topics
Species | Christopher RemboldSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Absence of force suppression in rabbit bladder correlates with low expression of heat shock protein 20Timothy W Batts
Cardiovascular Division, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
BMC Physiol 5:16. 2005..This has been termed force suppression and been found to correlate with ser16-phosphorylation of heat shock protein 20 (HSP20). We tested for the existence of this mechanism in a smooth muscle that is not responsive to nitric oxide...
Combination therapy of dyslipidemia in non-insulin-dependent diabetes mellitus and the metabolic syndromeChristopher M Rembold
Box 801395, Cardiovascular Division, Departments of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
Curr Diab Rep 4:330-4. 2004..These therapies should also be considered to reduce the high cardiovascular risk associated with NIDDM and the metabolic syndrome...- Children with obstructive sleep-disordered breathing generate high-frequency inspiratory sounds during sleepChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
Sleep 27:1154-61. 2004..Our objective was to determine whether HFIS occur in most children with obstructive SDB and adenotonsillar hypertrophy and whether adenotonsillectomy reduces HFIS... - An upper airway resonator model of high-frequency inspiratory sounds in children with sleep-disordered breathingChristopher M Rembold
Box 801395, Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
J Appl Physiol 98:1855-61. 2005..8 +/- 0.4 cm. In conclusion, these data suggest that children generate HFIS when 1) they have a narrowed upper airway and 2) their upper airway acts as a resonating chamber... 
Serine 68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxationChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
J Vasc Res 42:483-91. 2005..Protein kinase A (PKA) is known to phosphorylate PLM on serine 68 (S68), although the functional effect of S68 PLM phosphorylation is unclear. We therefore evaluated S68 PLM phosphorylation in swine carotid arteries...- Number-needed-to-treat analysis of the prevention of myocardial infarction and death by antidyslipidemic therapyC M Rembold
Cardiovascular Division, University of Virginia Health Sciences Center, Charlottesville 22908, USA
J Fam Pract 42:577-86. 1996..Dyslipidemia is one of the risk factors for the development of coronary atherosclerosis. Recent studies suggest that treating dyslipidemia in persons with coronary atherosclerosis may decrease morbidity and mortality... - Longer muscle lengths recapitulate force suppression in swine carotid arteryChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0146, USA
Am J Physiol Heart Circ Physiol 292:H1065-70. 2007..Further research is required to determine this length-dependent mechanism... - To statin or to non-statin in coronary disease--considering absolute risk is the answerChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
Atherosclerosis 195:1-6. 2007..The Mediterranean diet was also beneficial in chronic CAD. These results suggest that both statin and non-statin therapy are important for reducing the sequelae of atherosclerosis... - Force suppression and the crossbridge cycle in swine carotid arteryChristopher M Rembold
Box 800146, Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 0146, USA
Am J Physiol Cell Physiol 293:C1003-9. 2007..These data are most consistent with a model where force suppression involves the inhibition of phosphorylated crossbridge binding to thin filaments... - Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contractionChristopher M Rembold
Cardiovascular Division, Univ of Virginia Health System, PO Box 800146, Charlottesville, VA 22908 0146, USA
Am J Physiol Cell Physiol 293:C993-1002. 2007..Further research is needed to determine whether Y118 paxillin phosphorylation, actin polymerization, and changes in rheology could have a role in arterial smooth muscle contraction... - Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylationChristopher M Rembold
Box 801395, Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 1395, USA
Am J Physiol Cell Physiol 287:C594-602. 2004..This result suggests cooperative mechanisms analogous to skeletal muscle that will require testing... - Tissue length modulates "stimulated actin polymerization," force augmentation, and the rate of swine carotid arterial contractionAnkit D Tejani
Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908 0146, USA
Am J Physiol Cell Physiol 301:C1470-8. 2011..e., force augmentation and, possibly, latch... - cGMP-mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid arteryC M Rembold
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Physiol 524:865-78. 2000..We hypothesize that phosphorylation of HSP20 regulates force independent of MLC phosphorylation via binding of HSP20 to thin filaments and inhibition of cross-bridge cycling... - Selected contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media toneC M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Appl Physiol 91:1460-6. 2001..These data are consistent with the hypothesis that Ser(16)-HSP20 phosphorylation may be a cyclic nucleotide-dependent, yet MRLC phosphorylation-independent, inhibitor of smooth muscle contractile force... - Mechanisms responsible for forskolin-induced relaxation of rat tail arteryC M Rembold
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
Hypertension 31:872-7. 1998..Our data also suggest that forskolin-induced relaxation of intact rat tail artery occurred primarily through repolarization and reductions in the [Ca2+]i sensitivity of force... - Localization of heat shock protein 20 in swine carotid arteryC M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia, Health System Charlottesville, Virginia 22908, USA
BMC Physiol 1:10. 2001..This mechanism, termed relaxation without MRLC dephosphorylation, may be regulated by ser16 phosphorylation of heat shock protein 20 (HSP20)... - Caldesmon and heat shock protein 20 phosphorylation in nitroglycerin- and magnesium-induced relaxation of swine carotid arteryC M Rembold
Cardiovascular Division, Departments of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908, USA
Biochim Biophys Acta 1500:257-64. 2000..However, it is possible that HSP20 phosphorylation may be involved in nitroglycerin-induced relaxation without MRLC dephosphorylation... - Oral L-arginine can reverse digital necrosis in Raynaud's phenomenonChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 0146, USA
Mol Cell Biochem 244:139-41. 2003..They also suggest a potential role for oral L-arginine therapy in Raynaud's phenomenon, especially in Raynaud's phenomenon with digital necrosis... - Heat induced HSP20 phosphorylation without increased cyclic nucleotide levels in swine carotid mediaChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 USA
BMC Physiol 3:3. 2003..e., reduce force with only minimal reduction in ser19-myosin regulatory light chain (MRLC) phosphorylation... - Heat shock protein 20-mediated force suppression in forskolin-relaxed swine carotid arteryMelissa K Meeks
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
Am J Physiol Cell Physiol 288:C633-9. 2005..Our data are more consistent with the second and third hypotheses that force suppression is mediated by full or partial inhibition of local myosin binding at the thin- or thick-filament level... - Heat-induced force suppression and HSP20 phosphorylation in swine carotid mediaChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Appl Physiol 93:484-8. 2002..These processes may bring about a resistance to contractile agonists, which could have clinical significance in conditions such as hyperthermia and/or sepsis with vasodilatory shock... 
Force augmentation and stimulated actin polymerization in swine carotid arteryAnkit D Tejani
Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 0146, USA
Am J Physiol Cell Physiol 298:C182-90. 2010..These data suggest that stimulated actin polymerization may produce a substrate for increased crossbridge mediated force, a process we observe as force augmentation...- Movements during sleep correlate with impaired attention and verbal and memory skills in children with adenotonsillar hypertrophy suspected of having obstructive sleep disordered breathingPaul M Suratt
Department of Internal Medicine, Pulmonary Critical Care Division, Box 800682, University of Virginia School of Medicine, Charlottesville, VA 22908, United States
Sleep Med 12:322-8. 2011..Children with obstructive sleep disordered breathing (OSDB) have both impaired cognitive performance and frequent movements during sleep. It is not known whether movements during sleep are related to cognitive function... - Reduced time in bed and obstructive sleep-disordered breathing in children are associated with cognitive impairmentPaul M Suratt
Pulmonary Critical Care Division, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Pediatrics 119:320-9. 2007.... - Effectiveness of multiple antilipidemic agents on Vertical Auto Profile II guided treatment of dyslipoproteinemiaChristopher M Rembold
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Am J Cardiol 90:887-90. 2002 - The latch-bridge hypothesis of smooth muscle contractionRichard A Murphy
Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Can J Physiol Pharmacol 83:857-64. 2005..The molecular basis for cooperativity is unknown, but may involve thin filament proteins absent in striated muscle... - Increased expression of heat shock protein 20 and decreased contractile stress in obstructed rat bladderTimothy W Batts
Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908-1395, USA
J Urol 176:1679-84. 2006..If confirmed in humans, patients with clinical conditions that result in detrusor hypocontractility could potentially benefit from pharmacological interventions aimed at inhibiting heat shock protein 20... - Usefulness of carotid intimal medial thickness and flow-mediated dilation in a preventive cardiovascular practiceKaren E Rembold
Cardiovascular Division, Departments of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908-1395, USA
Am J Cardiol 91:1475-7, A8. 2003 - Prediction of major adverse cardiovascular events by age-normalized carotid intimal medial thicknessYasmine S Ali
Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Atherosclerosis 187:186-90. 2006..CONCLUSIONS: Age-normalized measurement of carotid bulb and internal carotid IMT may be helpful in determining which individuals would most benefit from aggressive risk-factor modification... - Age predicts cancer incidence better than statin-induced low-density lipoprotein levelChristopher M Rembold
J Am Coll Cardiol 51:90-1; author reply 92. 2008 - Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for VasculaJames H Stein
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
J Am Soc Echocardiogr 21:93-111; quiz 189-90. 2008 - The health benefits of eating salmonChristopher M Rembold
Science 305:475; author reply 475. 2004
Research Grants
- NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLEChristopher Rembold; Fiscal Year: 2004....
- P20-Mediated Suppression of Vascular ForceChristopher Rembold; Fiscal Year: 2004..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..