Affiliation: University of Virginia
Rembold C, Garvey S, Tejani A. Slack length reduces the contractile phenotype of the Swine carotid artery. J Vasc Res. 2013;50:221-7 pubmed publisher
..These data suggest that (1) slack length treatment significantly alters the contractile phenotype of arterial tissue, and (2) slack length treatment is a model to study acute phenotypic modulation of intact arterial smooth muscle. ..
Rembold C, Wardle R, Wingard C, Batts T, Etter E, Murphy R. Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylation. Am J Physiol Cell Physiol. 2004;287:C594-602 pubmed
..This result suggests cooperative mechanisms analogous to skeletal muscle that will require testing. ..
Rembold C. Force suppression and the crossbridge cycle in swine carotid artery. Am J Physiol Cell Physiol. 2007;293:C1003-9 pubmed
..These data are most consistent with a model where force suppression involves the inhibition of phosphorylated crossbridge binding to thin filaments. ..
Rembold C, Tejani A, Ripley M, Han S. Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contraction. Am J Physiol Cell Physiol. 2007;293:C993-1002 pubmed
..Further research is needed to determine whether Y118 paxillin phosphorylation, actin polymerization, and changes in rheology could have a role in arterial smooth muscle contraction. ..
Rembold C, O Connor M, Clarkson M, Wardle R, Murphy R. Selected contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media tone. J Appl Physiol (1985). 2001;91:1460-6 pubmed
..These data are consistent with the hypothesis that Ser(16)-HSP20 phosphorylation may be a cyclic nucleotide-dependent, yet MRLC phosphorylation-independent, inhibitor of smooth muscle contractile force...
Rembold C, Ripley M, Meeks M, Geddis L, Kutchai H, Marassi F, et al
. Serine 68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxation. J Vasc Res. 2005;42:483-91 pubmed
..Agents that increase [cAMP], but not agents that increase [cGMP], increased S68 PLM phosphorylation. S68 PLM phosphorylation may be involved in cAMP-dependent regulation of smooth muscle force. ..
Rembold C. Coenzyme Q10 Supplementation in Orthostatic Hypotension and Multiple-System Atrophy: A Report on 7 Cases. Am J Med. 2018;131:444-446 pubmed publisher
..These data suggest that orthostatic hypotension could improve with coenzyme Q10 administration and that a randomized clinical trial to test this hypothesis should be begun. ..