Christopher Rembold

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi Slack length reduces the contractile phenotype of the Swine carotid artery
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 0146, USA
    J Vasc Res 50:221-7. 2013
  2. pmc Absence of force suppression in rabbit bladder correlates with low expression of heat shock protein 20
    Timothy W Batts
    Cardiovascular Division, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    BMC Physiol 5:16. 2005
  3. ncbi Children with obstructive sleep-disordered breathing generate high-frequency inspiratory sounds during sleep
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Sleep 27:1154-61. 2004
  4. ncbi An upper airway resonator model of high-frequency inspiratory sounds in children with sleep-disordered breathing
    Christopher M Rembold
    Box 801395, Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
    J Appl Physiol 98:1855-61. 2005
  5. pmc Serine 68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxation
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Vasc Res 42:483-91. 2005
  6. pmc Longer muscle lengths recapitulate force suppression in swine carotid artery
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0146, USA
    Am J Physiol Heart Circ Physiol 292:H1065-70. 2007
  7. ncbi To statin or to non-statin in coronary disease--considering absolute risk is the answer
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Atherosclerosis 195:1-6. 2007
  8. pmc Force suppression and the crossbridge cycle in swine carotid artery
    Christopher M Rembold
    Box 800146, Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 0146, USA
    Am J Physiol Cell Physiol 293:C1003-9. 2007
  9. pmc Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contraction
    Christopher M Rembold
    Cardiovascular Division, Univ of Virginia Health System, PO Box 800146, Charlottesville, VA 22908 0146, USA
    Am J Physiol Cell Physiol 293:C993-1002. 2007
  10. pmc Tissue length modulates "stimulated actin polymerization," force augmentation, and the rate of swine carotid arterial contraction
    Ankit D Tejani
    Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908 0146, USA
    Am J Physiol Cell Physiol 301:C1470-8. 2011

Research Grants

  1. NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLE
    Christopher Rembold; Fiscal Year: 2004
  2. P20-Mediated Suppression of Vascular Force
    Christopher Rembold; Fiscal Year: 2004

Collaborators

Detail Information

Publications33

  1. doi Slack length reduces the contractile phenotype of the Swine carotid artery
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 0146, USA
    J Vasc Res 50:221-7. 2013
    ..These data suggest that (1) slack length treatment significantly alters the contractile phenotype of arterial tissue, and (2) slack length treatment is a model to study acute phenotypic modulation of intact arterial smooth muscle. ..
  2. pmc Absence of force suppression in rabbit bladder correlates with low expression of heat shock protein 20
    Timothy W Batts
    Cardiovascular Division, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    BMC Physiol 5:16. 2005
    ..This has been termed force suppression and been found to correlate with ser16-phosphorylation of heat shock protein 20 (HSP20). We tested for the existence of this mechanism in a smooth muscle that is not responsive to nitric oxide...
  3. ncbi Children with obstructive sleep-disordered breathing generate high-frequency inspiratory sounds during sleep
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Sleep 27:1154-61. 2004
    ..Our objective was to determine whether HFIS occur in most children with obstructive SDB and adenotonsillar hypertrophy and whether adenotonsillectomy reduces HFIS...
  4. ncbi An upper airway resonator model of high-frequency inspiratory sounds in children with sleep-disordered breathing
    Christopher M Rembold
    Box 801395, Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
    J Appl Physiol 98:1855-61. 2005
    ..8 +/- 0.4 cm. In conclusion, these data suggest that children generate HFIS when 1) they have a narrowed upper airway and 2) their upper airway acts as a resonating chamber...
  5. pmc Serine 68 phospholemman phosphorylation during forskolin-induced swine carotid artery relaxation
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Vasc Res 42:483-91. 2005
    ..Protein kinase A (PKA) is known to phosphorylate PLM on serine 68 (S68), although the functional effect of S68 PLM phosphorylation is unclear. We therefore evaluated S68 PLM phosphorylation in swine carotid arteries...
  6. pmc Longer muscle lengths recapitulate force suppression in swine carotid artery
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0146, USA
    Am J Physiol Heart Circ Physiol 292:H1065-70. 2007
    ..Further research is required to determine this length-dependent mechanism...
  7. ncbi To statin or to non-statin in coronary disease--considering absolute risk is the answer
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Atherosclerosis 195:1-6. 2007
    ..The Mediterranean diet was also beneficial in chronic CAD. These results suggest that both statin and non-statin therapy are important for reducing the sequelae of atherosclerosis...
  8. pmc Force suppression and the crossbridge cycle in swine carotid artery
    Christopher M Rembold
    Box 800146, Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 0146, USA
    Am J Physiol Cell Physiol 293:C1003-9. 2007
    ..These data are most consistent with a model where force suppression involves the inhibition of phosphorylated crossbridge binding to thin filaments...
  9. pmc Paxillin phosphorylation, actin polymerization, noise temperature, and the sustained phase of swine carotid artery contraction
    Christopher M Rembold
    Cardiovascular Division, Univ of Virginia Health System, PO Box 800146, Charlottesville, VA 22908 0146, USA
    Am J Physiol Cell Physiol 293:C993-1002. 2007
    ..Further research is needed to determine whether Y118 paxillin phosphorylation, actin polymerization, and changes in rheology could have a role in arterial smooth muscle contraction...
  10. pmc Tissue length modulates "stimulated actin polymerization," force augmentation, and the rate of swine carotid arterial contraction
    Ankit D Tejani
    Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908 0146, USA
    Am J Physiol Cell Physiol 301:C1470-8. 2011
    ..e., force augmentation and, possibly, latch...
  11. ncbi Combination therapy of dyslipidemia in non-insulin-dependent diabetes mellitus and the metabolic syndrome
    Christopher M Rembold
    Box 801395, Cardiovascular Division, Departments of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Curr Diab Rep 4:330-4. 2004
    ..These therapies should also be considered to reduce the high cardiovascular risk associated with NIDDM and the metabolic syndrome...
  12. ncbi Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylation
    Christopher M Rembold
    Box 801395, Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Am J Physiol Cell Physiol 287:C594-602. 2004
    ..This result suggests cooperative mechanisms analogous to skeletal muscle that will require testing...
  13. ncbi Number-needed-to-treat analysis of the prevention of myocardial infarction and death by antidyslipidemic therapy
    C M Rembold
    Cardiovascular Division, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Fam Pract 42:577-86. 1996
    ..Dyslipidemia is one of the risk factors for the development of coronary atherosclerosis. Recent studies suggest that treating dyslipidemia in persons with coronary atherosclerosis may decrease morbidity and mortality...
  14. ncbi Mechanisms responsible for forskolin-induced relaxation of rat tail artery
    C M Rembold
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Hypertension 31:872-7. 1998
    ..Our data also suggest that forskolin-induced relaxation of intact rat tail artery occurred primarily through repolarization and reductions in the [Ca2+]i sensitivity of force...
  15. ncbi Caldesmon and heat shock protein 20 phosphorylation in nitroglycerin- and magnesium-induced relaxation of swine carotid artery
    C M Rembold
    Cardiovascular Division, Departments of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Biochim Biophys Acta 1500:257-64. 2000
    ..However, it is possible that HSP20 phosphorylation may be involved in nitroglycerin-induced relaxation without MRLC dephosphorylation...
  16. pmc cGMP-mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery
    C M Rembold
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Physiol 524:865-78. 2000
    ..We hypothesize that phosphorylation of HSP20 regulates force independent of MLC phosphorylation via binding of HSP20 to thin filaments and inhibition of cross-bridge cycling...
  17. ncbi Selected contribution: HSP20 phosphorylation in nitroglycerin- and forskolin-induced sustained reductions in swine carotid media tone
    C M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Appl Physiol 91:1460-6. 2001
    ..These data are consistent with the hypothesis that Ser(16)-HSP20 phosphorylation may be a cyclic nucleotide-dependent, yet MRLC phosphorylation-independent, inhibitor of smooth muscle contractile force...
  18. pmc Localization of heat shock protein 20 in swine carotid artery
    C M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia, Health System Charlottesville, Virginia 22908, USA
    BMC Physiol 1:10. 2001
    ..This mechanism, termed relaxation without MRLC dephosphorylation, may be regulated by ser16 phosphorylation of heat shock protein 20 (HSP20)...
  19. pmc Heat induced HSP20 phosphorylation without increased cyclic nucleotide levels in swine carotid media
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 USA
    BMC Physiol 3:3. 2003
    ..e., reduce force with only minimal reduction in ser19-myosin regulatory light chain (MRLC) phosphorylation...
  20. ncbi Oral L-arginine can reverse digital necrosis in Raynaud's phenomenon
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 0146, USA
    Mol Cell Biochem 244:139-41. 2003
    ..They also suggest a potential role for oral L-arginine therapy in Raynaud's phenomenon, especially in Raynaud's phenomenon with digital necrosis...
  21. ncbi Heat shock protein 20-mediated force suppression in forskolin-relaxed swine carotid artery
    Melissa K Meeks
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Am J Physiol Cell Physiol 288:C633-9. 2005
    ..Our data are more consistent with the second and third hypotheses that force suppression is mediated by full or partial inhibition of local myosin binding at the thin- or thick-filament level...
  22. ncbi Heat-induced force suppression and HSP20 phosphorylation in swine carotid media
    Matthew J O'Connor
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Appl Physiol 93:484-8. 2002
    ..These processes may bring about a resistance to contractile agonists, which could have clinical significance in conditions such as hyperthermia and/or sepsis with vasodilatory shock...
  23. doi Force augmentation and stimulated actin polymerization in swine carotid artery
    Ankit D Tejani
    Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 0146, USA
    Am J Physiol Cell Physiol 298:C182-90. 2010
    ..These data suggest that stimulated actin polymerization may produce a substrate for increased crossbridge mediated force, a process we observe as force augmentation...
  24. doi Movements during sleep correlate with impaired attention and verbal and memory skills in children with adenotonsillar hypertrophy suspected of having obstructive sleep disordered breathing
    Paul M Suratt
    Department of Internal Medicine, Pulmonary Critical Care Division, Box 800682, University of Virginia School of Medicine, Charlottesville, VA 22908, United States
    Sleep Med 12:322-8. 2011
    ..Children with obstructive sleep disordered breathing (OSDB) have both impaired cognitive performance and frequent movements during sleep. It is not known whether movements during sleep are related to cognitive function...
  25. ncbi Reduced time in bed and obstructive sleep-disordered breathing in children are associated with cognitive impairment
    Paul M Suratt
    Pulmonary Critical Care Division, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Pediatrics 119:320-9. 2007
    ....
  26. pmc The latch-bridge hypothesis of smooth muscle contraction
    Richard A Murphy
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Can J Physiol Pharmacol 83:857-64. 2005
    ..The molecular basis for cooperativity is unknown, but may involve thin filament proteins absent in striated muscle...
  27. ncbi Effectiveness of multiple antilipidemic agents on Vertical Auto Profile II guided treatment of dyslipoproteinemia
    Christopher M Rembold
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Cardiol 90:887-90. 2002
  28. ncbi Increased expression of heat shock protein 20 and decreased contractile stress in obstructed rat bladder
    Timothy W Batts
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908 1395, USA
    J Urol 176:1679-84. 2006
    ..Heat shock protein 20 is the proposed mediator of force suppression in vascular smooth muscle. We investigated whether heat shock protein 20 could also mediate the decreased contractility observed in partially obstructed rat bladders...
  29. ncbi Usefulness of carotid intimal medial thickness and flow-mediated dilation in a preventive cardiovascular practice
    Karen E Rembold
    Cardiovascular Division, Departments of Internal Medicine and Physiology, University of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Am J Cardiol 91:1475-7, A8. 2003
  30. ncbi Prediction of major adverse cardiovascular events by age-normalized carotid intimal medial thickness
    Yasmine S Ali
    Cardiovascular Division, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Atherosclerosis 187:186-90. 2006
    ..We investigated the value of age-normalized carotid IMT measurements in predicting major adverse cardiovascular events in a population of patients referred for carotid IMT measurement...
  31. doi Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascula
    James H Stein
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Am Soc Echocardiogr 21:93-111; quiz 189-90. 2008
  32. doi Age predicts cancer incidence better than statin-induced low-density lipoprotein level
    Christopher M Rembold
    J Am Coll Cardiol 51:90-1; author reply 92. 2008
  33. ncbi The health benefits of eating salmon
    Christopher M Rembold
    Science 305:475; author reply 475. 2004

Research Grants4

  1. NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLE
    Christopher Rembold; Fiscal Year: 2004
    ....
  2. P20-Mediated Suppression of Vascular Force
    Christopher Rembold; Fiscal Year: 2004
    ..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..