Russell J Reiter

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann N Y Acad Sci 959:238-50. 2002
  2. ncbi request reprint Antioxidant activity of melatonin in Chinese hamster ovarian cells: changes in cellular proliferation and differentiation
    Rosa M Sainz
    Department of Cellular and Structural Biology, Mail Code 7762, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biochem Biophys Res Commun 302:625-34. 2003
  3. ncbi request reprint Melatonin as a naturally occurring co-substrate of quinone reductase-2, the putative MT3 melatonin membrane receptor: hypothesis and significance
    Dun Xian Tan
    Department of Cellular and Structural Biology, University of Texas, Health Science Center, San Antonio, TX 78229 3900, USA
    J Pineal Res 43:317-20. 2007
  4. ncbi request reprint Melatonin in the biliary tract and liver: health implications
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA
    Curr Pharm Des 20:4788-801. 2014
  5. pmc Melatonin combats molecular terrorism at the mitochondrial level
    Russel J Reiter
    The University of Texas Health Science Center, Department of Cellular and Structural Biology, San Antonio, Texas, USA
    Interdiscip Toxicol 1:137-49. 2008
  6. pmc Neurotoxins: free radical mechanisms and melatonin protection
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas
    Curr Neuropharmacol 8:194-210. 2010
  7. pmc Significance of high levels of endogenous melatonin in Mammalian cerebrospinal fluid and in the central nervous system
    Dun Xian Tan
    Department of Cellular and Structural Biology, University of Texas, Health Science Center, at San Antonio, 7703 Floyd Curl, San Antonio, TX, 78229, USA
    Curr Neuropharmacol 8:162-7. 2010
  8. pmc A walnut-enriched diet reduces the growth of LNCaP human prostate cancer xenografts in nude mice
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Invest 31:365-73. 2013
  9. pmc Peripheral reproductive organ health and melatonin: ready for prime time
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Int J Mol Sci 14:7231-72. 2013
  10. ncbi request reprint The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA
    Mini Rev Med Chem 13:373-84. 2013

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann N Y Acad Sci 959:238-50. 2002
    ..As of this writing there is no definitive evidence to prove that melatonin alters the rate of aging, although data relating to melatonin deferring some age-related degenerative conditions is accumulating rapidly...
  2. ncbi request reprint Antioxidant activity of melatonin in Chinese hamster ovarian cells: changes in cellular proliferation and differentiation
    Rosa M Sainz
    Department of Cellular and Structural Biology, Mail Code 7762, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Biochem Biophys Res Commun 302:625-34. 2003
    ..We conclude that the cellular redox state may be involved in cellular transformation caused by antioxidants such as melatonin and trolox...
  3. ncbi request reprint Melatonin as a naturally occurring co-substrate of quinone reductase-2, the putative MT3 melatonin membrane receptor: hypothesis and significance
    Dun Xian Tan
    Department of Cellular and Structural Biology, University of Texas, Health Science Center, San Antonio, TX 78229 3900, USA
    J Pineal Res 43:317-20. 2007
    ..As a result, these alterations in melatonin production under physiological or pathological conditions would probably influence the activity of QR2...
  4. ncbi request reprint Melatonin in the biliary tract and liver: health implications
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA
    Curr Pharm Des 20:4788-801. 2014
    ....
  5. pmc Melatonin combats molecular terrorism at the mitochondrial level
    Russel J Reiter
    The University of Texas Health Science Center, Department of Cellular and Structural Biology, San Antonio, Texas, USA
    Interdiscip Toxicol 1:137-49. 2008
    ..Thus, the molecular terrorism meted out by reactive oxygen and nitrogen species is held in check by melatonin and its derivatives...
  6. pmc Neurotoxins: free radical mechanisms and melatonin protection
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas
    Curr Neuropharmacol 8:194-210. 2010
    ..The studies summarized in this review indicate that this is indeed the case, an action that is obviously assisted by the fact that melatonin readily crosses the blood brain barrier...
  7. pmc Significance of high levels of endogenous melatonin in Mammalian cerebrospinal fluid and in the central nervous system
    Dun Xian Tan
    Department of Cellular and Structural Biology, University of Texas, Health Science Center, at San Antonio, 7703 Floyd Curl, San Antonio, TX, 78229, USA
    Curr Neuropharmacol 8:162-7. 2010
    ..It seems that long term melatonin administration which elevates CSF melatonin concentrations will retard the progression of neurodegenerative disorders, for example, Alzheimer disease...
  8. pmc A walnut-enriched diet reduces the growth of LNCaP human prostate cancer xenografts in nude mice
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Invest 31:365-73. 2013
    ..The final average tumor size in the walnut-diet animals was roughly one-fourth the average size of the prostate tumors in the mice that ate the control diet. ..
  9. pmc Peripheral reproductive organ health and melatonin: ready for prime time
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Int J Mol Sci 14:7231-72. 2013
    ..In general, the direct actions of melatonin on the gonads and adnexa of mammals indicate it is an important agent for maintaining optimal reproductive physiology...
  10. ncbi request reprint The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA
    Mini Rev Med Chem 13:373-84. 2013
    ....
  11. ncbi request reprint Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA
    Ann Med 44:564-77. 2012
    ..The implication is that if these problems were corrected with life-style changes, body-weight could possibly be more easily controlled...
  12. ncbi request reprint Medical implications of melatonin: receptor-mediated and receptor-independent actions
    R J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Adv Med Sci 52:11-28. 2007
    ..Clearly, the intent of the drugs is to take advantage of some of melatonin's numerous beneficial effects...
  13. ncbi request reprint Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage
    R J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Physiol Pharmacol 58:5-22. 2007
    ..These, however, are not the only age-associated neurodegenerative states where melatonin has been found to be protective...
  14. ncbi request reprint Light at night, chronodisruption, melatonin suppression, and cancer risk: a review
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Crit Rev Oncog 13:303-28. 2007
    ..In addition to cancer, there may be other diseases that result from the chronic suppression of melatonin by light at night...
  15. ncbi request reprint Biogenic amines in the reduction of oxidative stress: melatonin and its metabolites
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Neuro Endocrinol Lett 29:391-8. 2008
    ..The outlook for the use of melatonin in clinical trials looks encouraging given its low toxicity and high efficacy...
  16. ncbi request reprint Melatonin therapy in fibromyalgia
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Curr Pain Headache Rep 11:339-42. 2007
    ..Although melatonin is commonly known as a sleep aid (sleep/wake problems are common in FM sufferers), it has a variety of other beneficial effects that may account for its potential benefits in the treatment of FM...
  17. ncbi request reprint Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio 78229 3900, USA
    Acta Biochim Pol 54:1-9. 2007
    ..Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism...
  18. ncbi request reprint Melatonin in edible plants (phytomelatonin): Identification, concentrations, bioavailability and proposed functions
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    World Rev Nutr Diet 97:211-30. 2007
  19. ncbi request reprint Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of blood
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas, USA
    Nutrition 21:920-4. 2005
    ..We investigated whether melatonin is present in walnuts (Juglans regia L.) and, if so, tested whether eating walnuts influences melatonin levels and the total antioxidant status of the blood...
  20. ncbi request reprint Clinical aspects of melatonin
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas, USA
    Saudi Med J 29:1537-47. 2008
    ..Finally, melatonin may be a treatment for hypertension. Melatonin's high efficacy, its high safety profile, and its virtual lack of toxicity make it of interest in clinical medicine...
  21. ncbi request reprint Melatonin relieves the neural oxidative burden that contributes to dementias
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, 78229 3900, USA
    Ann N Y Acad Sci 1035:179-96. 2004
    ..The report concludes with the suggestion that melatonin, alone or in combination with other antioxidants, be considered for routine usage to potentially combat some of the neural ravages of aging...
  22. ncbi request reprint When melatonin gets on your nerves: its beneficial actions in experimental models of stroke
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7762, San Antonio, TX 78229 3900, USA
    Exp Biol Med (Maywood) 230:104-17. 2005
    ....
  23. ncbi request reprint Melatonin: detoxification of oxygen and nitrogen-based toxic reactants
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Adv Exp Med Biol 527:539-48. 2003
    ....
  24. doi request reprint Melatonin in relation to the "strong" and "weak" versions of the free radical theory of aging
    R J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Adv Med Sci 53:119-29. 2008
    ..It is now imperative that similar studies be conducted using humans whose quality of life may benefit from treatment with melatonin...
  25. ncbi request reprint Melatonin reduces oxidative/nitrosative stress due to drugs, toxins, metals, and herbicides
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas, USA
    Neuro Endocrinol Lett 29:609-13. 2008
    ..Concisely reviewed in this report are the protective effects of melatonin against toxic prescription drugs, neural toxins, herbicides and metals. The findings have clear implications for the utility of melatonin in toxicology...
  26. ncbi request reprint Melatonin: new applications in clinical and veterinary medicine, plant physiology and industry
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX, USA
    Neuro Endocrinol Lett 32:575-87. 2011
    ..Finally, the described application of melatonin's use as a chemical reductant in industry could well serve as a stimulus to further define the utility of this versatile molecule in new industrial applications...
  27. ncbi request reprint The photoperiod, circadian regulation and chronodisruption: the requisite interplay between the suprachiasmatic nuclei and the pineal and gut melatonin
    R J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center San Antonio, Texas, USA
    J Physiol Pharmacol 62:269-74. 2011
    ..The consequences of the altered melatonin cycle with the chronodisruption as well as the alterations of GIT melatonin that have been linked to a variety of pathologies, including those of the gastrointestinal tract...
  28. ncbi request reprint Drug-mediated ototoxicity and tinnitus: alleviation with melatonin
    R J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Physiol Pharmacol 62:151-7. 2011
    ..Melatonin's low cost and minimal toxicity profile supports its use to protect the inner ear from drug-mediated damage...
  29. ncbi request reprint Respiratory distress syndrome in the newborn: role of oxidative stress
    E Gitto
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Intensive Care Med 27:1116-23. 2001
    ..The results discussed in this brief review suggest rigorous clinical tests with antioxidants which may help to define the mechanisms associated with RDS and which could lead to new treatment strategies...
  30. ncbi request reprint Cardiac hypertrophy and remodelling: pathophysiological consequences and protective effects of melatonin
    Russel J Reiter
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, USA
    J Hypertens 28:S7-12. 2010
    ..This is not unexpected considering the now well documented potent antioxidative actions of both melatonin and its metabolites. In general, melatonin improves cardiovascular physiology and heart function...
  31. ncbi request reprint Melatonin: a multitasking molecule
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    Prog Brain Res 181:127-51. 2010
    ..In view of this and its virtual absence of toxicity, melatonin may well find applications in both human and veterinary medicine...
  32. ncbi request reprint Beneficial effects of melatonin in cardiovascular disease
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA
    Ann Med 42:276-85. 2010
    ..Taken together, the findings from human and animal studies support the consideration of melatonin as a cardioprotective agent...
  33. doi request reprint Light-mediated perturbations of circadian timing and cancer risk: a mechanistic analysis
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Integr Cancer Ther 8:354-60. 2009
    ..Finally, if cancer is a consequence of excessive nighttime light, it is likely that other diseases/conditions may also be exaggerated by the widespread use of light after darkness onset...
  34. ncbi request reprint Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA
    Crit Rev Biochem Mol Biol 44:175-200. 2009
    ..While increasing life span will not necessarily be a goal of these investigative efforts, improving health and the quality of life in the aged should be an aim of this research...
  35. ncbi request reprint The circadian melatonin rhythm and its modulation: possible impact on hypertension
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA
    J Hypertens Suppl 27:S17-20. 2009
    ..The implication of these findings is that melatonin may have utility as an antihypertensive agent...
  36. ncbi request reprint Melatonin and reproduction revisited
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA
    Biol Reprod 81:445-56. 2009
    ..The information in this article has applicability to human and veterinary medicine...
  37. ncbi request reprint Pharmacological utility of melatonin in reducing oxidative cellular and molecular damage
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7762 San Antonio, TX 78229 3900, USA
    Pol J Pharmacol 56:159-70. 2004
    ..e. ischemia-reperfusion and ionizing radiation, where free radicals are generally conceded as being responsible for much of the resulting tissue destruction...
  38. ncbi request reprint Neurally-mediated and neurally-independent beneficial actions of melatonin in the gastrointestinal tract
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Physiol Pharmacol 54:113-25. 2003
    ..All indications are that melatonin has a variety of beneficial effects in the gastrointestinal tract. It is likely, however, that additional actions of melatonin on the digestive system will be uncovered...
  39. ncbi request reprint Oxidative damage in the central nervous system: protection by melatonin
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284 7762, USA
    Prog Neurobiol 56:359-84. 1998
    ..Since endogenous melatonin levels fal 1 markedly in advanced age, the implication of these findings is that the loss of this antioxidant may contribute to the incidence or severity of some age-associated neurodegenerative diseases...
  40. ncbi request reprint Melatonin: reducing the toxicity and increasing the efficacy of drugs
    Russel J Reiter
    University of Texas Health Science Center, Department of Cellular and Structural Biology, MC 7762, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Pharm Pharmacol 54:1299-321. 2002
    ..Considering the low toxicity of melatonin and its ability to reduce the side effects and increase the efficacy of these drugs, its use as a combination therapy with these agents seems important and worthy of pursuit...
  41. ncbi request reprint Potential biological consequences of excessive light exposure: melatonin suppression, DNA damage, cancer and neurodegenerative diseases
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Neuro Endocrinol Lett 23:9-13. 2002
    ..Further research should be conducted to more accurately define the potential negative impact of light at abnormal times on animal and human pathophysiology...
  42. ncbi request reprint Melatonin and tryptophan derivatives as free radical scavengers and antioxidants
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284, USA
    Adv Exp Med Biol 467:379-87. 1999
    ..Furthermore, melatonin crosses all morphophysiological barriers and enters equally well all cells in the organism...
  43. ncbi request reprint Melatonin: an antioxidant in edible plants
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann N Y Acad Sci 957:341-4. 2002
    ..Since melatonin concentrations in the blood correlate with the total antioxidant status of this fluid, it is likely that dietary melatonin could be important in protecting against oxidative damage...
  44. ncbi request reprint Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, Mail Code 7762, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Mech Ageing Dev 123:1007-19. 2002
    ..This combination of actions assists melatonin in protecting cells from the degenerative changes normally associated with aging and age-related diseases...
  45. ncbi request reprint Melatonin and human reproduction
    R J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 78284 7762, USA
    Ann Med 30:103-8. 1998
    ..While correlations between melatonin and the status of the reproductive system in humans have been noted, whether they are functionally related remains to be determined...
  46. ncbi request reprint Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence
    R J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio 78299 3900, USA
    Cell Biochem Biophys 34:237-56. 2001
    ....
  47. ncbi request reprint Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system
    R J Reiter
    Department of Cellular and Structural Biology, Mail Code 7762, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Ann N Y Acad Sci 939:200-15. 2001
    ..These multiple actions make melatonin a potentially useful agent in the treatment of neurological disorders that have oxidative damage as part of their etiological basis...
  48. ncbi request reprint Melatonin and its relation to the immune system and inflammation
    R J Reiter
    Department of Cellular and Structural Biology, Mail Code 7762, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Ann N Y Acad Sci 917:376-86. 2000
    ..By this means melatonin attenuates transendothelial cell migration and edema, which contribute to tissue damage...
  49. ncbi request reprint Actions of melatonin in the reduction of oxidative stress. A review
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Biomed Sci 7:444-58. 2000
    ..Melatonin has been widely used as a protective agent against a wide variety of processes and agents that damage tissues via free radical mechanisms...
  50. ncbi request reprint Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington's disease, Alzheimer's disease and parkinsonism
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78229 3900, USA
    Ann N Y Acad Sci 890:471-85. 1999
    ..This combination of actions makes melatonin a highly effective pharmacological agent against free radical damage. The role of physiological levels of melatonin in forestalling oxidative damage in the brain is currently being tested...
  51. ncbi request reprint Augmentation of indices of oxidative damage in life-long melatonin-deficient rats
    R J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio 78284 7762, USA
    Mech Ageing Dev 110:157-73. 1999
    ..On the other hand, other pineal secretory products that were reduced as a consequence of pineal removal may have also been responsible for some of the observed changes...
  52. ncbi request reprint Suppression of oxygen toxicity by melatonin
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284 7762, USA
    Zhongguo Yao Li Xue Bao 19:575-81. 1998
    ..These findings have implications for disease processes, eg, neurodegenerative and cardiovascular diseases, which involve free radicals and for aging itself, which also is believed to be related to accumulated oxidative damage...
  53. ncbi request reprint Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284 7762, USA
    Ann N Y Acad Sci 854:410-24. 1998
    ..In humans, the total antioxidative capacity of serum is related to melatonin levels. Thus, the reduction in melatonin with age may be a factor in increased oxidative damage in the elderly...
  54. ncbi request reprint Role of CSF in the transport of melatonin
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, Mail Code 7762, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA E mail
    J Pineal Res 33:61. 2002
  55. ncbi request reprint Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke
    Russell J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78229, USA
    Ann N Y Acad Sci 993:35-47; discussion 48-53. 2003
    ..The primary action to explain melatonin's protective effects may relate to its ubiquitous direct and indirect antioxidative actions, although other beneficial functions of melatonin are not precluded...
  56. ncbi request reprint Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Cardiovasc Res 58:10-9. 2003
    ..The results of these investigations would help to clarify the potential importance of the use of melatonin in situations of oxidative damage to the heart in humans...
  57. ncbi request reprint Melatonin, longevity and health in the aged: an assessment
    Russel J Reiter
    Department of Cellular and Structural Biology, MC 7762, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Free Radic Res 36:1323-9. 2002
    ....
  58. ncbi request reprint Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, U S A
    Acta Biochim Pol 50:1129-46. 2003
    ..Furthermore, clinical tests utilizing melatonin have proven highly successful; because of the positive outcomes of these studies, melatonin's use in disease states and processes where free radical damage is involved should be increased...
  59. ncbi request reprint Melatonin: clinical relevance
    Russel J Reiter
    Department of Cellular and Structural Biology, Mail Code 7762, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Best Pract Res Clin Endocrinol Metab 17:273-85. 2003
    ....
  60. ncbi request reprint Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Pineal Res 34:249-59. 2003
    ..This unique cascade action of melatonin, in terms of scavenging, increases its efficiency to neutralized ABTSb+; this contrasts with the effects of the classic antioxidants...
  61. ncbi request reprint Melatonin as pharmacologic support in burn patients: a proposed solution to thermal injury-related lymphocytopenia and oxidative damage
    Maria Dolores Maldonado
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Crit Care Med 35:1177-85. 2007
    ....
  62. ncbi request reprint Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants
    Juan C Mayo
    Department of Cellular and Structural Biology, School of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Free Radic Res 37:543-53. 2003
    ..Results shown here demonstrate that alkyl peroxyl radicals inactivate catalase and reduce the effectiveness of cells to defend against free radical damage; the damage to catalase can be prevented by antioxidants, especially melatonin...
  63. doi request reprint Role of melatonin in the epigenetic regulation of breast cancer
    Ahmet Korkmaz
    Department of Physiology, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Breast Cancer Res Treat 115:13-27. 2009
    ..e., light at night) with the subsequent deregulation of PER2 which acts as a tumor suppressor gene...
  64. ncbi request reprint Melatonin: from basic research to cancer treatment clinics
    - Vijayalaxmi
    Departments of Radiation Oncology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Clin Oncol 20:2575-601. 2002
    ..This study also provides rationale for the design of larger translational research-based clinical trials...
  65. ncbi request reprint Melatonin as a radioprotective agent: a review
    - Vijayalaxmi
    Department of Radiation Oncology, The University of Texas Health Science Center, San Antonio, 78229, USA
    Int J Radiat Oncol Biol Phys 59:639-53. 2004
    ..The potential use of melatonin for protecting individuals from radiation terrorism is also considered...
  66. ncbi request reprint Melatonin: reducing molecular pathology and dysfunction due to free radicals and associated reactants
    Russel J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Neuro Endocrinol Lett 23:3-8. 2002
    ..g., ischemia/reperfusion injury, toxin exposure, lipopolysaccharide exposure, etc., where free radical damage is a component of the condition...
  67. ncbi request reprint Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage
    Debashis Bandyopadhyay
    Indian Institute of Chemical Biology, Jadavpur, Kolkata, India, Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA
    J Pineal Res 33:1-7. 2002
    ..The findings raise the possibility of melatonin being considered as an effective gastroprotective agent individually or as a cotreatment with either ranitidine and omeprazole...
  68. ncbi request reprint Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger
    Dun Xian Tan
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78229 3900, USA
    Curr Top Med Chem 2:181-97. 2002
    ....
  69. ncbi request reprint Melatonin and mitochondrial function
    Josefa Leon
    Department of Cellular and Structural Biology, University of Texas Health Science Center, Mail Code 7762, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Life Sci 75:765-90. 2004
    ..Via these actions, melatonin preserves the integrity of the mitochondria and helps to maintain cell functions and survival...
  70. ncbi request reprint Cardiovascular diseases: protective effects of melatonin
    Sandra Tengattini
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA
    J Pineal Res 44:16-25. 2008
    ..The results described herein help to clarify the beneficial effects of melatonin against these conditions and define the potential clinical applicability of melatonin in cardiovascular diseases...
  71. ncbi request reprint Melatonin mitigates mitochondrial malfunction
    Josefa Leon
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Pineal Res 38:1-9. 2005
    ..In addition, a reported direct action of melatonin in the control of currents through the MTP opens a new perspective in the understanding of the regulation of apoptotic cell death by the indoleamine...
  72. ncbi request reprint Melatonin protects against oxidative stress caused by delta-aminolevulinic acid: implications for cancer reduction
    Małgorzata Karbownik
    Department of Cellular and Structural Biology, University of Texas Health Science Center, Mail Code 7762, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Cancer Invest 20:276-86. 2002
    ....
  73. ncbi request reprint Reactive oxygen species and the hypomotility of the gall bladder as targets for the treatment of gallstones with melatonin: a review
    Sreedevi Koppisetti
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Dig Dis Sci 53:2592-603. 2008
    ....
  74. ncbi request reprint Protective effects of melatonin in experimental free radical-related ocular diseases
    Andrew W Siu
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA
    J Pineal Res 40:101-9. 2006
    ..It may benefit many individuals worldwide, especially in countries where access to medical facilities is limited...
  75. ncbi request reprint Novel rhythms of N1-acetyl-N2-formyl-5-methoxykynuramine and its precursor melatonin in water hyacinth: importance for phytoremediation
    Dun Xian Tan
    Department of Cellular Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    FASEB J 21:1724-9. 2007
    ..These novel findings could lead to improvements in the phytoremediative capacity of plants by either stimulating endogenous melatonin synthesis or by adding melatonin to water/soil in which they are grown...
  76. ncbi request reprint Inhibitory effect of melatonin on homocysteine-induced lipid peroxidation in rat brain homogenates
    Carmen Osuna
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio 78229 3900, USA
    Pharmacol Toxicol 90:32-7. 2002
    ....
  77. ncbi request reprint Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Pineal Res 34:75-8. 2003
    ..It seems likely that melatonin initially evolved as an antioxidant, becoming a vitamin in the food chain, and in multicellular organisms, where it is produced, it has acquired autocoid, paracoid and hormonal properties...
  78. ncbi request reprint Melatonin and the ovary: physiological and pathophysiological implications
    Hiroshi Tamura
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Fertil Steril 92:328-43. 2009
    ..To summarize the role of melatonin in the physiology and pathophysiology of the ovary...
  79. doi request reprint Melatonin and pregnancy in the human
    Hiroshi Tamura
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Reprod Toxicol 25:291-303. 2008
    ..The scientific evidence supporting a role for melatonin in human pregnancy is summarized...
  80. ncbi request reprint One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas, Health Science Center, San Antonio, TX 78229, USA
    J Pineal Res 42:28-42. 2007
    ..It has been reported that the higher the oxidative state, the more AFMK is produced. The ratio of AFMK and another melatonin metabolite, cyclic 3-hydroxymelatonin, may serve as an indicator of the level of oxidative stress in organisms...
  81. doi request reprint Phytomelatonin: a review
    Sergio D Paredes
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Exp Bot 60:57-69. 2009
    ....
  82. ncbi request reprint The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness
    Dun Xian Tan
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Biol Rev Camb Philos Soc 85:607-23. 2010
    ..The changing biological roles of melatonin seem to have evolved from its primary function as an antioxidant...
  83. ncbi request reprint Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin
    Dun Xian Tan
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Pineal Res 39:185-94. 2005
    ..Recycling of NADH by melatonin might improve the efficiency of NADH as an energy carrier and as an antioxidant. Interactions between melatonin and NADH may be implicated in mitochondrial metabolism...
  84. ncbi request reprint Physiological ischemia/reperfusion phenomena and their relation to endogenous melatonin production: a hypothesis
    Dun Xian Tan
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Endocrine 27:149-58. 2005
    ..e., as a member of antioxidant defense system, to protect against the potential oxidative injury induced by the physiological ischemia/reperfusion...
  85. ncbi request reprint Causes of oxidative stress in the pre- and perinatal period
    Eloisa Gitto
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio 78229 3900, USA
    Biol Neonate 81:146-57. 2002
    ..Thus, increased oxidative stress accompanied by reduced endogenous defences may play a role in the pathogenesis of a number of diseases in the newborn...