Research Topics
Genomes and Genes
| Jeremy F ReiterSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Vertebrate Smoothened functions at the primary ciliumKevin C Corbit
Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
Nature 437:1018-21. 2005..Thus, Hh-dependent translocation to cilia is essential for Smo activity, suggesting that Smo acts at the primary cilium...
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibitionJeremy F Reiter
Developmental and Stem Cell Biology Program, and Diabetes Center, University of California, San Francisco, 94143 0525, USA
Genes Dev 20:22-7. 2006..Interestingly, characterization of Tectonic Shh and Tectonic Smo double mutants indicates that Tectonic plays an additional role in repressing Hh pathway activity...- The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signalingPia Aanstad
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
Curr Biol 19:1034-9. 2009..These data indicate that the ECD, previously thought to be dispensable for vertebrate Smo function, both regulates Smo ciliary localization and is essential for high-level Hh signaling... - Disruption of a ciliary B9 protein complex causes Meckel syndromeWilliam E Dowdle
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 94158, USA
Am J Hum Genet 89:94-110. 2011..Our data indicate that B9d1 is required for normal Hh signaling, ciliogenesis, and ciliary protein localization and that B9d1 and B9d2 are essential components of a B9 protein complex, disruption of which causes MKS... - Small molecule inhibitors of Smoothened ciliary localization and ciliogenesisVictoria M Wu
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, School of Pharmacy, University of California, San Francisco, CA 95158, USA
Proc Natl Acad Sci U S A 109:13644-9. 2012..The SA compounds may provide alternative means of inhibiting pathogenic Hh signaling, and our study reveals that different pools of Smo move into cilia through distinct mechanisms... - The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cellsJulie Hunkapiller
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA
Stem Cells Dev 20:831-41. 2011..Thus, loss of Ofd1 affects ES cell interpretation of developmental cues and reveals that EBs model some aspects of ciliopathies, providing insights into the developmental origins of OFD1 syndrome and functions of cilia... - Scoring a backstage pass: mechanisms of ciliogenesis and ciliary accessFrancesc R Garcia-Gonzalo
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA
J Cell Biol 197:697-709. 2012..These diseases are caused by defects in ciliogenesis or ciliary function. The signaling functions of cilia require regulation of ciliary composition, which depends on the control of protein traffic into and out of cilia... - Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesisSunny Y Wong
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco UCSF, San Francisco, California, USA
Nat Med 15:1055-61. 2009..Our findings demonstrate that cilia function as unique signaling organelles that can either mediate or suppress tumorigenesis depending on the nature of the oncogenic initiating event... - A transition zone complex regulates mammalian ciliogenesis and ciliary membrane compositionFrancesc R Garcia-Gonzalo
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
Nat Genet 43:776-84. 2011..Thus, a transition zone complex of Meckel and Joubert syndrome proteins regulates ciliary assembly and trafficking, suggesting that transition zone dysfunction is the cause of these ciliopathies... - Ofd1, a human disease gene, regulates the length and distal structure of centriolesVeena Singla
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2324, USA
Dev Cell 18:410-24. 2010..Our results indicate that Ofd1 acts at the distal centriole to build distal appendages, recruit Ift88, and stabilize centriolar microtubules at a defined length... - Floxin, a resource for genetically engineering mouse ESCsVeena Singla
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA
Nat Methods 7:50-2. 2010..Floxin technology is applicable to the existing collection of 24,149 compatible gene trap cell lines, which should enable high-throughput modification of many genes in mouse ESCs... - The primary cilium as the cell's antenna: signaling at a sensory organelleVeena Singla
Program in Developmental and Stem Cell Biology, and Diabetes Center, University of California, San Francisco, CA 94143 0525, USA
Science 313:629-33. 2006.... - Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanismsKevin C Corbit
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158 2324, USA
Nat Cell Biol 10:70-6. 2008..More generally, these findings reveal that, in contrast to its role in promoting Hedgehog (Hh) signalling, the cilium restrains canonical Wnt signalling... - Wounding mobilizes hair follicle stem cells to form tumorsSunny Y Wong
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:4093-8. 2011..These findings demonstrate that BCC-like tumors can originate from follicular stem cells and provide an explanation for the association between wounding and tumorigenesis... - Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewalJulie Hunkapiller
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
PLoS Genet 8:e1002576. 2012..Thus, Pcl3 is a component of PRC2 critical for ESC self-renewal, histone methylation, and recruitment of PRC2 to a subset of its genomic sites... 
A cilium is not a cilium is not a cilium: signaling contributes to ciliary morphological diversityJeremy F Reiter
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 2324, USA
Dev Cell 14:635-6. 2008..elegans affects its structure. The finding that this cilium is modified in response to the cues it transduces suggests that cilia may not be static antennae, but organelles whose functions are shaped by their signaling activities...- Building it up and taking it down: the regulation of vertebrate ciliogenesisNicole Santos
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158 2324, USA
Dev Dyn 237:1972-81. 2008..Additionally, identification of the genes underlying diverse ciliopathies in human patients is shedding light on the regulation of the formation of this complex organelle... - Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelleJeremy F Reiter
Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 103:18383-4. 2006 - The primary cilium at the crossroads of mammalian hedgehog signalingSunny Y Wong
Department of Biochemistry, Cardiovascular Research Institute, University of California, San Francisco, California, USA
Curr Top Dev Biol 85:225-60. 2008..Together, these findings have shed light on one mechanism by which primary cilia transduce signals critical for both development and disease... - Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cellsDanislav S Spassov
Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
Cancer Res 73:1168-79. 2013..Together our results establish a tumor-suppressing function in Trask that restricts epithelial cell growth to the anchored state... - Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendagesAndrew Kodani
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158 9001, USA
EMBO J 32:597-607. 2013..Thus, in addition to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres... - The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalizationJeremy F Reiter
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 555 Mission Bay Blvd South, California 94158, USA
EMBO Rep 13:608-18. 2012..Together with a recently described septin ring diffusion barrier at the ciliary base, the transition fibres and transition zone deserve attention for their varied roles in forming functional ciliary compartments... - Vive la science! Vive le hérisson!Jeremy F Reiter
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA, USA
EMBO Rep 11:566-8. 2010.... - Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cellsJulie Gaulden
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2324, USA
Hum Mol Genet 17:R60-6. 2008..Conversely, insights into the mechanisms by which ES cells adopt neural fates may provide an improved understanding of neural induction in the early embryo... - Notch signaling can regulate endoderm formation in zebrafishYutaka Kikuchi
Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
Dev Dyn 229:756-62. 2004..Altogether, these results suggest that Notch signaling plays a role in the formation of the endoderm, possibly in its segregation from the mesoderm...
Research Grants
- Semaphorin-plexin signaling & vertebrate cell movementJeremy Reiter; Fiscal Year: 2003..By illuminating the role of plexin signaling in development, these studies may provide understanding into congenital disease as well as how cell movement is co-opted by pathologic processes such as tumor invasion and tumor angiogenesis. ..
- Embryonic Stem Cell Formation of Definitive EndodermJeremy Reiter; Fiscal Year: 2005..Ultimately, this approach seeks to provide novel insights how ES cell differentiation into definitive endoderm is regulated, and by extension, how the definitive endoderm arises and develops in vivo. ..
- Hedgehog signaling at the cell's antenna: Smoothened and the primary ciliumJeremy Reiter; Fiscal Year: 2007..Taken together, these studies will provide a biochemical and cell biological understanding of how Smoothened and the primary cilium regulate Hedgehog signal transduction both in development and in disease. ..