Jeremy F Reiter

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Vertebrate Smoothened functions at the primary cilium
    Kevin C Corbit
    Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
    Nature 437:1018-21. 2005
  2. pmc Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition
    Jeremy F Reiter
    Developmental and Stem Cell Biology Program, and Diabetes Center, University of California, San Francisco, 94143 0525, USA
    Genes Dev 20:22-7. 2006
  3. pmc The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
    Pia Aanstad
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
    Curr Biol 19:1034-9. 2009
  4. pmc Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages
    Andrew Kodani
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158 9001, USA
    EMBO J 32:597-607. 2013
  5. pmc Disruption of a ciliary B9 protein complex causes Meckel syndrome
    William E Dowdle
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 94158, USA
    Am J Hum Genet 89:94-110. 2011
  6. pmc Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis
    Victoria M Wu
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, School of Pharmacy, University of California, San Francisco, CA 95158, USA
    Proc Natl Acad Sci U S A 109:13644-9. 2012
  7. pmc The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells
    Julie Hunkapiller
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA
    Stem Cells Dev 20:831-41. 2011
  8. pmc Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access
    Francesc R Garcia-Gonzalo
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 197:697-709. 2012
  9. pmc Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis
    Sunny Y Wong
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco UCSF, San Francisco, California, USA
    Nat Med 15:1055-61. 2009
  10. pmc A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition
    Francesc R Garcia-Gonzalo
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 43:776-84. 2011

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Vertebrate Smoothened functions at the primary cilium
    Kevin C Corbit
    Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
    Nature 437:1018-21. 2005
    ..Thus, Hh-dependent translocation to cilia is essential for Smo activity, suggesting that Smo acts at the primary cilium...
  2. pmc Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition
    Jeremy F Reiter
    Developmental and Stem Cell Biology Program, and Diabetes Center, University of California, San Francisco, 94143 0525, USA
    Genes Dev 20:22-7. 2006
    ..Interestingly, characterization of Tectonic Shh and Tectonic Smo double mutants indicates that Tectonic plays an additional role in repressing Hh pathway activity...
  3. pmc The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
    Pia Aanstad
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
    Curr Biol 19:1034-9. 2009
    ..These data indicate that the ECD, previously thought to be dispensable for vertebrate Smo function, both regulates Smo ciliary localization and is essential for high-level Hh signaling...
  4. pmc Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages
    Andrew Kodani
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158 9001, USA
    EMBO J 32:597-607. 2013
    ..Thus, in addition to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres...
  5. pmc Disruption of a ciliary B9 protein complex causes Meckel syndrome
    William E Dowdle
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 94158, USA
    Am J Hum Genet 89:94-110. 2011
    ..Our data indicate that B9d1 is required for normal Hh signaling, ciliogenesis, and ciliary protein localization and that B9d1 and B9d2 are essential components of a B9 protein complex, disruption of which causes MKS...
  6. pmc Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis
    Victoria M Wu
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, School of Pharmacy, University of California, San Francisco, CA 95158, USA
    Proc Natl Acad Sci U S A 109:13644-9. 2012
    ..The SA compounds may provide alternative means of inhibiting pathogenic Hh signaling, and our study reveals that different pools of Smo move into cilia through distinct mechanisms...
  7. pmc The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells
    Julie Hunkapiller
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA
    Stem Cells Dev 20:831-41. 2011
    ..Thus, loss of Ofd1 affects ES cell interpretation of developmental cues and reveals that EBs model some aspects of ciliopathies, providing insights into the developmental origins of OFD1 syndrome and functions of cilia...
  8. pmc Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access
    Francesc R Garcia-Gonzalo
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 197:697-709. 2012
    ..These diseases are caused by defects in ciliogenesis or ciliary function. The signaling functions of cilia require regulation of ciliary composition, which depends on the control of protein traffic into and out of cilia...
  9. pmc Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis
    Sunny Y Wong
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco UCSF, San Francisco, California, USA
    Nat Med 15:1055-61. 2009
    ..Our findings demonstrate that cilia function as unique signaling organelles that can either mediate or suppress tumorigenesis depending on the nature of the oncogenic initiating event...
  10. pmc A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition
    Francesc R Garcia-Gonzalo
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 43:776-84. 2011
    ..Thus, a transition zone complex of Meckel and Joubert syndrome proteins regulates ciliary assembly and trafficking, suggesting that transition zone dysfunction is the cause of these ciliopathies...
  11. pmc Floxin, a resource for genetically engineering mouse ESCs
    Veena Singla
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA
    Nat Methods 7:50-2. 2010
    ..Floxin technology is applicable to the existing collection of 24,149 compatible gene trap cell lines, which should enable high-throughput modification of many genes in mouse ESCs...
  12. pmc Ofd1, a human disease gene, regulates the length and distal structure of centrioles
    Veena Singla
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2324, USA
    Dev Cell 18:410-24. 2010
    ..Our results indicate that Ofd1 acts at the distal centriole to build distal appendages, recruit Ift88, and stabilize centriolar microtubules at a defined length...
  13. ncbi request reprint The primary cilium as the cell's antenna: signaling at a sensory organelle
    Veena Singla
    Program in Developmental and Stem Cell Biology, and Diabetes Center, University of California, San Francisco, CA 94143 0525, USA
    Science 313:629-33. 2006
    ....
  14. ncbi request reprint Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
    Kevin C Corbit
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158 2324, USA
    Nat Cell Biol 10:70-6. 2008
    ..More generally, these findings reveal that, in contrast to its role in promoting Hedgehog (Hh) signalling, the cilium restrains canonical Wnt signalling...
  15. pmc Wounding mobilizes hair follicle stem cells to form tumors
    Sunny Y Wong
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:4093-8. 2011
    ..These findings demonstrate that BCC-like tumors can originate from follicular stem cells and provide an explanation for the association between wounding and tumorigenesis...
  16. pmc Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells
    Danislav S Spassov
    Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Res 73:1168-79. 2013
    ..Together our results establish a tumor-suppressing function in Trask that restricts epithelial cell growth to the anchored state...
  17. pmc Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal
    Julie Hunkapiller
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 8:e1002576. 2012
    ..Thus, Pcl3 is a component of PRC2 critical for ESC self-renewal, histone methylation, and recruitment of PRC2 to a subset of its genomic sites...
  18. pmc The primary cilium at the crossroads of mammalian hedgehog signaling
    Sunny Y Wong
    Department of Biochemistry, Cardiovascular Research Institute, University of California, San Francisco, California, USA
    Curr Top Dev Biol 85:225-60. 2008
    ..Together, these findings have shed light on one mechanism by which primary cilia transduce signals critical for both development and disease...
  19. doi request reprint A cilium is not a cilium is not a cilium: signaling contributes to ciliary morphological diversity
    Jeremy F Reiter
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 2324, USA
    Dev Cell 14:635-6. 2008
    ..elegans affects its structure. The finding that this cilium is modified in response to the cues it transduces suggests that cilia may not be static antennae, but organelles whose functions are shaped by their signaling activities...
  20. pmc Building it up and taking it down: the regulation of vertebrate ciliogenesis
    Nicole Santos
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158 2324, USA
    Dev Dyn 237:1972-81. 2008
    ..Additionally, identification of the genes underlying diverse ciliopathies in human patients is shedding light on the regulation of the formation of this complex organelle...
  21. pmc Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelle
    Jeremy F Reiter
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 103:18383-4. 2006
  22. pmc A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity
    Nicole Santos
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 2324, USA
    J Cell Sci 127:1500-10. 2014
    ..The identification of a domain essential for both ciliary localization and transcriptional activity suggests that ciliary localization of Gli2 is required for its activation...
  23. pmc The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization
    Jeremy F Reiter
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 555 Mission Bay Blvd South, California 94158, USA
    EMBO Rep 13:608-18. 2012
    ..Together with a recently described septin ring diffusion barrier at the ciliary base, the transition fibres and transition zone deserve attention for their varied roles in forming functional ciliary compartments...
  24. pmc Vive la science! Vive le hérisson!
    Jeremy F Reiter
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    EMBO Rep 11:566-8. 2010
    ....
  25. doi request reprint Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells
    Julie Gaulden
    Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2324, USA
    Hum Mol Genet 17:R60-6. 2008
    ..Conversely, insights into the mechanisms by which ES cells adopt neural fates may provide an improved understanding of neural induction in the early embryo...
  26. ncbi request reprint Notch signaling can regulate endoderm formation in zebrafish
    Yutaka Kikuchi
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Dev Dyn 229:756-62. 2004
    ..Altogether, these results suggest that Notch signaling plays a role in the formation of the endoderm, possibly in its segregation from the mesoderm...

Research Grants3

  1. Semaphorin-plexin signaling & vertebrate cell movement
    Jeremy Reiter; Fiscal Year: 2003
    ..By illuminating the role of plexin signaling in development, these studies may provide understanding into congenital disease as well as how cell movement is co-opted by pathologic processes such as tumor invasion and tumor angiogenesis. ..
  2. Embryonic Stem Cell Formation of Definitive Endoderm
    Jeremy Reiter; Fiscal Year: 2005
    ..Ultimately, this approach seeks to provide novel insights how ES cell differentiation into definitive endoderm is regulated, and by extension, how the definitive endoderm arises and develops in vivo. ..
  3. Hedgehog signaling at the cell's antenna: Smoothened and the primary cilium
    Jeremy Reiter; Fiscal Year: 2007
    ..Taken together, these studies will provide a biochemical and cell biological understanding of how Smoothened and the primary cilium regulate Hedgehog signal transduction both in development and in disease. ..