Jochen Reiser

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease
    Shafic El Hindi
    Department of Medicine, Division of Nephrology and Hypertension, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA
    Pediatr Nephrol 26:1057-64. 2011
  2. pmc Podocyte GTPases regulate kidney filter dynamics
    Andreas D Kistler
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 81:1053-5. 2012
  3. pmc Establishment of protein delivery systems targeting podocytes
    Wen Chih Chiang
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11837. 2010
  4. doi request reprint Soluble urokinase receptor and focal segmental glomerulosclerosis
    Jochen Reiser
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Curr Opin Nephrol Hypertens 21:428-32. 2012
  5. pmc Specialized roles for cysteine cathepsins in health and disease
    Jochen Reiser
    Department of Medicine, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA
    J Clin Invest 120:3421-31. 2010
  6. pmc Toward the development of podocyte-specific drugs
    Jochen Reiser
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 77:662-8. 2010
  7. pmc CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
    Suma Yaddanapudi
    Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Clin Invest 121:3965-80. 2011
  8. pmc Leptin deficiency-induced obesity affects the density of mast cells in abdominal fat depots and lymph nodes in mice
    Mehmet M Altintas
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA
    Lipids Health Dis 11:21. 2012
  9. ncbi request reprint Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008
  10. pmc Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease
    Sanja Sever
    Department of Medicine, Nephrology Division and Program in Glomerular Disease, Massachusetts General Hospital MGH and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 117:2095-104. 2007

Detail Information

Publications41

  1. pmc TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease
    Shafic El Hindi
    Department of Medicine, Division of Nephrology and Hypertension, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA
    Pediatr Nephrol 26:1057-64. 2011
    ..The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes...
  2. pmc Podocyte GTPases regulate kidney filter dynamics
    Andreas D Kistler
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 81:1053-5. 2012
    ..Wang et al. show that both overactivation and underactivation of RhoA lead to podocyte foot process effacement and proteinuria in vivo. These data suggest that podocyte health requires a well-controlled balance between the two extremes...
  3. pmc Establishment of protein delivery systems targeting podocytes
    Wen Chih Chiang
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11837. 2010
    ..Recent years have made clear that interference with podocyte-specific disease pathways can modulate glomerular function and influence severity and progression of glomerular disease...
  4. doi request reprint Soluble urokinase receptor and focal segmental glomerulosclerosis
    Jochen Reiser
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Curr Opin Nephrol Hypertens 21:428-32. 2012
    ..We discuss recent work on the pathogenetic mechanism of focal segmental glomerulosclerosis (FSGS) and its relationship to soluble urokinase receptor (suPAR)...
  5. pmc Specialized roles for cysteine cathepsins in health and disease
    Jochen Reiser
    Department of Medicine, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA
    J Clin Invest 120:3421-31. 2010
    ..In particular, we highlight the emerging roles of various cathepsin forms in disease, particularly those of the cardiac and renal systems...
  6. pmc Toward the development of podocyte-specific drugs
    Jochen Reiser
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 77:662-8. 2010
    ..This mini-review discusses some of the most recent promising data related to potential drug therapy for proteinuria and kidney disease through direct podocyte targeting...
  7. pmc CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
    Suma Yaddanapudi
    Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Clin Invest 121:3965-80. 2011
    ..Our study identifies CD2AP as the gatekeeper of the podocyte TGF-β response through its regulation of CatL expression and defines a molecular mechanism underlying proteinuric kidney disease...
  8. pmc Leptin deficiency-induced obesity affects the density of mast cells in abdominal fat depots and lymph nodes in mice
    Mehmet M Altintas
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA
    Lipids Health Dis 11:21. 2012
    ..Furthermore, mast cells containing immunoreactive tumor necrosis factor-α (TNF-α), a proinflammatory cytokine involved in obesity-linked insulin resistance, were identified by immunostaining...
  9. ncbi request reprint Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008
    ..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability...
  10. pmc Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease
    Sanja Sever
    Department of Medicine, Nephrology Division and Program in Glomerular Disease, Massachusetts General Hospital MGH and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 117:2095-104. 2007
    ..Our study identifies dynamin as a critical regulator of renal permselectivity that is specifically targeted by proteolysis under pathological conditions...
  11. pmc Podocyte effacement closely links to suPAR levels at time of posttransplantation focal segmental glomerulosclerosis occurrence and improves with therapy
    Nada Alachkar
    1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 2 Department of Medicine, Rush University Medical Center, Chicago, IL 3 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 4 Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 5 Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 6 Department of Medicine, Union Memorial Hospital, Baltimore, MD 7 Address correspondence to Nada Alachkar, M D, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 971, Baltimore, MD 21205 and Jochen Reiser, M D, Ph D, Department of Medicine, Rush University Medical Center, Cohn Research Building, Suite 724, 1735 W Harrison Street, Chicago, IL 60612
    Transplantation 96:649-56. 2013
    ..Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS...
  12. pmc Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis
    Changli Wei
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Med 17:952-60. 2011
    ..Our study identifies serum suPAR as a circulating factor that may cause FSGS...
  13. doi request reprint Sensitizing the Slit Diaphragm with TRPC6 ion channels
    Clemens C Möller
    Department of Medicine, Program in Glomerular Disease and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:950-3. 2009
    ..This article illustrates how recent findings add to emerging concepts in podocyte biology, particularly mechanosensation and signaling at the slit diaphragm...
  14. ncbi request reprint Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:34827-32. 2004
    ..In summary, these data establish that podocyte foot process effacement is a migratory event involving a novel interplay between cathepsin L and alpha(3) integrin...
  15. pmc Apoptosis, mastocytosis, and diminished adipocytokine gene expression accompany reduced epididymal fat mass in long-standing diet-induced obese mice
    Mehmet M Altintas
    Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA
    Lipids Health Dis 10:198. 2011
    ..Moreover, gene and/or protein expression of several adipocytokines (leptin, adiponectin, TNF-α, IL-10, IL-6, MCP-1), F4/80, mMCP6, cleaved caspase-3 were determined...
  16. pmc Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner
    Katsuhiko Asanuma
    Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA
    J Clin Invest 115:1188-98. 2005
    ..In concert, synaptopodin regulates the actin-bundling activity of alpha-actinin in highly dynamic cell compartments, such as podocyte FPs and the dendritic spine apparatus...
  17. pmc Direct dynamin-actin interactions regulate the actin cytoskeleton
    Changkyu Gu
    Nephrology Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Charlestown, MA 02129, USA
    EMBO J 29:3593-606. 2010
    ..Together, our results support a model in which assembled dynamin, generated through interactions with short actin filaments, promotes actin polymerization via displacement of actin-CPs...
  18. ncbi request reprint Proteinuria: an enzymatic disease of the podocyte?
    Peter Mundel
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 77:571-80. 2010
    ..Finally, we describe signaling pathways controlling the podocyte actin cytoskeleton and motility and how these pathways can be manipulated for therapeutic benefit...
  19. ncbi request reprint The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
    Christian Faul
    Department of Medicine, University of Miami Miller School of Medicine, 1600 Northwest Tenth Avenue, Miami, Florida 33136, USA
    Nat Med 14:931-8. 2008
    ..Novel calcineurin substrates such as synaptopodin may provide promising starting points for antiproteinuric drugs that avoid the serious side effects of long-term CsA treatment...
  20. pmc Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice
    Natalia Papeta
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 120:4055-64. 2010
    ..These findings implicate mtDNA damage in the development of ADR toxicity and identify Prkdc as a MDDS modifier gene and a component of the mitochondrial genome maintenance pathway...
  21. pmc Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease
    Andreas D Kistler
    From the Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136
    J Biol Chem 288:36598-609. 2013
    ..Together, these data suggest a dual and context dependent role of TRPC6 in podocytes where acute activation protects from complement-mediated damage, but chronic overactivation leads to focal segmental glomerulosclerosis. ..
  22. pmc Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy
    Nadine Norton
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136 1015, USA
    Am J Hum Genet 88:273-82. 2011
    ..Knockdown of bag3 in a zebrafish model recapitulated DCM and heart failure. We conclude that new comprehensive genomic approaches have identified rare variants in BAG3 as causative of DCM...
  23. pmc TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
    Jochen Reiser
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Genet 37:739-44. 2005
    ..Two of the TRPC6 mutants had increased current amplitudes. These data show that TRPC6 channel activity at the slit diaphragm is essential for proper regulation of podocyte structure and function...
  24. pmc Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerio
    Steve Mangos
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 27:4314-22. 2012
    ..These data indicate conservation of the FGF23-αklotho system across species and suggest a likely role for αklotho in the proximal and distal tubules...
  25. pmc Podocyte biology and pathogenesis of kidney disease
    Jochen Reiser
    Department of Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA
    Annu Rev Med 64:357-66. 2013
    ..Loss of these actin-driven membrane extensions is tightly connected to the presence of protein in the urine, podocyte loss, development of CKD, and ultimately renal failure...
  26. pmc Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis
    Alessia Fornoni
    Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Sci Transl Med 3:85ra46. 2011
    ..Our study suggests that treatment of high-risk patients with rituximab at time of kidney transplant might prevent recurrent FSGS by modulating podocyte function in an SMPDL-3b-dependent manner...
  27. ncbi request reprint Induction of TRPC6 channel in acquired forms of proteinuric kidney disease
    Clemens C Möller
    Department of Medicine, Nephrology Division, Massachusetts General Hospital and Harvard Medical School, MGH East, 149 13th Street, Boston, MA 02129, USA
    J Am Soc Nephrol 18:29-36. 2007
    ..These studies suggest the involvement of TRPC6 in the pathology of nongenetic forms of proteinuric disease...
  28. pmc In vivo imaging of kidney glomeruli transplanted into the anterior chamber of the mouse eye
    Andreas D Kistler
    1 Department of Medicine, Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida, USA 2 Division of Nephrology, University Hospital Zurich, Zurich, Switzerland
    Sci Rep 4:3872. 2014
    ..Our findings demonstrate functionality and long-term survival of glomeruli devoid of Bowman's capsule and provide a novel approach for non-invasive longitudinal in vivo study of glomerular physiology and pathophysiology...
  29. ncbi request reprint The genetic basis of human glomerular disease
    Clemens C Möller
    Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Adv Chronic Kidney Dis 13:166-73. 2006
    ....
  30. doi request reprint Maximal 'CD80-uria' with minimal change
    Andreas D Kistler
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 78:236-8. 2010
    ..Thus, CD80 expression on podocytes, which was initially described in mouse models of foot process effacement and human lupus nephritis, is now brought toward clinical application for use as a diagnostic biomarker...
  31. pmc Circulating suPAR in two cohorts of primary FSGS
    Changli Wei
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Soc Nephrol 23:2051-9. 2012
    ..The associations between a change in circulating suPAR with different therapeutic regimens and with remission support the role of suPAR in the pathogenesis of FSGS...
  32. pmc In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations
    Pirouz Daftarian
    Department of Microbiology and Immunology, University of Miami, Miami, Florida, USA
    Hybridoma (Larchmt) 30:409-18. 2011
    ..Using this process, upon two vaccinations via in vivo electroporation (and final boost), monoclonal antibodies against nucleus and cytoplasmic and transmembrane proteins were achieved...
  33. pmc Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release
    Alessia Fornoni
    Diabetes Research Institute, University of Miami L Miller School of Medicine, Miami, Florida, USA
    Diabetes 59:190-9. 2010
    ..The aim of this study was to investigate whether diabetes modulates nephrin expression in human pancreatic islets and to explore the role of nephrin in beta-cell function...
  34. doi request reprint Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease
    Dony Maiguel
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miami, FL 33136, USA
    Sci Signal 4:ra57. 2011
    ..Thus, we propose that pharmacological activation of CD11b/CD18 offers an alternative therapeutic approach for inflammatory diseases...
  35. pmc Expression of trpC1 and trpC6 orthologs in zebrafish
    Clemens C Möller
    Nephrology Division and Program in Glomerular Disease, Massachusetts General Hospital and Harvard Medical School, Suite 8214, CNY 149 13th Street, Boston, MA 02129, USA
    Gene Expr Patterns 8:291-6. 2008
    ..Our results point to roles of TRPC channels in several tissues during zebrafish development, and suggest that the zebrafish may be a suitable model system to study the pathophysiology of TRPC1 and TRPC6 in specific cell types...
  36. ncbi request reprint Dual effects of RAS blockade on blood pressure and podocyte function
    Jochen Reiser
    Division of Nephrology, Program in Glomerular Disease, Massachusetts General Hospital and Harvard Medical School, CNY 149, 13th Street, Suite 8214, Boston, MA 02129, USA
    Curr Hypertens Rep 9:403-8. 2007
    ..Here we review the dual effects of RAS blockade on BP and on podocyte function and emphasize BP-dependent and BP-independent effects of this regimen...
  37. ncbi request reprint Signal transduction in podocytes-spotlight on receptor tyrosine kinases
    Jochen Reiser
    Department of Medicine, Rush University Medical Center, 1735 West Harrison Street, Cohn Building, Suite 724, Chicago, IL 60612, USA
    Nat Rev Nephrol 10:104-15. 2014
    ..The identification of pathological RTK-mediated signal transduction pathways in podocytes could provide a starting point for the development of novel therapies for glomerular disorders. ..
  38. pmc Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice
    Mehmet M Altintas
    Department of Medicine, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA
    J Lipid Res 52:480-8. 2011
    ..The increase in mast cells in visceral fat of obese mice suggests their role in the pathogenesis of obesity and insulin resistance...
  39. ncbi request reprint CD80 and suPAR in patients with minimal change disease and focal segmental glomerulosclerosis: diagnostic and pathogenic significance
    Gabriel Cara-Fuentes
    Division of Pediatric Nephrology, Department of Pediatrics, University of Florida, 1600 SW Archer Rd HD214, Gainesville, FL, 32610, USA
    Pediatr Nephrol 29:1363-71. 2014
    ..The aim of the study was to assess whether the simultaneous measurement of urinary CD80 and serum suPAR helps differentiate MCD and FSGS...
  40. doi request reprint Proteinuria: abate or applaud abatacept in proteinuric kidney disease?
    Jochen Reiser
    Department of Medicine, Rush University Medical Center, 1735 West Harrison Street, Cohn Building, Suite 724, Chicago, IL 60612, USA
    Nat Rev Nephrol 10:128-30. 2014
    ..A study now suggests abatacept efficacy in focal and segmental glomerulosclerosis. Small patient numbers and concurrent treatment regimens call for more definitive studies regarding this therapeutic strategy...
  41. pmc Induction of B7-1 in podocytes is associated with nephrotic syndrome
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 113:1390-7. 2004
    ..Our findings suggest a novel function for B7-1 in danger signaling by nonimmune cells...

Research Grants6