Alexander Reiner

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
  2. pmc Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults
    Alex P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
    Arterioscler Thromb Vasc Biol 33:158-64. 2013
  3. pmc Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women
    Alex P Reiner
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 91:502-12. 2012
  4. pmc PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study
    A P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    J Thromb Haemost 6:1625-32. 2008
  5. ncbi Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    A P Reiner
    Departments of Epidemiology and Genome Sciences, University of Washington, Seattle, WA 98101 1448, USA
    J Thromb Haemost 4:1279-87. 2006
  6. ncbi Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women
    A P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Thromb Haemost 5:42-9. 2007
  7. pmc Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascula
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Circ Cardiovasc Genet 2:244-54. 2009
  8. ncbi Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA Study
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195, USA
    Hum Genet 121:565-75. 2007
  9. ncbi USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studies
    Alexander P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 27:2736-42. 2007
  10. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008

Research Grants

Detail Information

Publications44

  1. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
    ..African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...
  2. pmc Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults
    Alex P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
    Arterioscler Thromb Vasc Biol 33:158-64. 2013
    ..Despite the well-recognized role of CD14 in inflammation, relatively little is known about the genetic determinants of sCD14 or the relationship of sCD14 to vascular- and aging-related phenotypes...
  3. pmc Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women
    Alex P Reiner
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 91:502-12. 2012
    ..The genetic architecture underlying the CRP phenotype in AA women is complex and involves genetic variants shared across populations, as well as variants specific to populations of African descent...
  4. pmc PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study
    A P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    J Thromb Haemost 6:1625-32. 2008
    ..Genes encoding protein C anticoagulant pathways are candidates for atherothrombotic and other aging-related disorders...
  5. ncbi Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    A P Reiner
    Departments of Epidemiology and Genome Sciences, University of Washington, Seattle, WA 98101 1448, USA
    J Thromb Haemost 4:1279-87. 2006
    ..Previous genotype-phenotype association studies of fibrinogen have been limited by incomplete knowledge of genomic sequence variation within and between major ethnic groups in FGB, FGA, and FGG...
  6. ncbi Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women
    A P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Thromb Haemost 5:42-9. 2007
    ..Associations between common F7 haplotypes, plasma factor VII (FVII) levels, and cardiovascular risk have recently been reported in population studies involving predominantly European men...
  7. pmc Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascula
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Circ Cardiovasc Genet 2:244-54. 2009
    ..Common polymorphisms of the HNF-1 alpha gene (HNF1A) were recently associated with plasma C-reactive protein and gamma-glutamyl transferase concentration in middle-aged to older European Americans (EA)...
  8. ncbi Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA Study
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195, USA
    Hum Genet 121:565-75. 2007
    ..These results demonstrate the potential for confounding of genetic associations with some cardiovascular disease-related traits in large studies involving US African-Americans...
  9. ncbi USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studies
    Alexander P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 27:2736-42. 2007
    ....
  10. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008
    ....
  11. pmc Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammation
    Alexander P Reiner
    Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
    Arterioscler Thromb Vasc Biol 28:1407-12. 2008
    ..Circulating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the innate immune response...
  12. pmc Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study
    A P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
    J Thromb Haemost 7:1499-505. 2009
    ..Additional genetic factors are likely to underlie the etiology of VTE, some of which may become manifest at older ages...
  13. pmc Inflammation and thrombosis biomarkers and incident frailty in postmenopausal women
    Alexander P Reiner
    Women s Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Med 122:947-54. 2009
    ....
  14. pmc Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 7:e1002108. 2011
    ..In summary, the CXCL2, CDK6, and PSMD3-CSF3 regions are associated with WBC count in African American and other populations. We also demonstrate that large inter-chromosomal duplications can result in false positive associations in GWAS...
  15. ncbi Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
    Atherosclerosis 181:175-83. 2005
    ..These findings suggest that modulators of fibrinolytic activity may have a generalized influence on aging, and merit further investigation in studies of genetic determinants of human longevity...
  16. ncbi Genetic variants of platelet glycoprotein receptors and risk of stroke in young women
    A P Reiner
    Departments of Medicine, University of Washington, Seattle, WA 98195 9756, USA
    Stroke 31:1628-33. 2000
    ..Data on the association of these genetic susceptibility markers with ischemic stroke are more limited, and their role in hemorrhagic stroke has not been previously examined...
  17. ncbi Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young women
    Alexander P Reiner
    Department of Medicine, University of Washington, Seattle, USA
    Br J Haematol 116:376-82. 2002
    ..The relationship of factor XIIIA polymorphisms to cerebrovascular disease requires further study...
  18. ncbi Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy persons
    Alexander P Reiner
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 90:66-8. 2002
  19. ncbi Platelet glycoprotein gene polymorphisms and risk of thrombosis: facts and fancies
    A P Reiner
    Department of Medicine, University of Washington, Seattle, USA
    Rev Clin Exp Hematol 5:262-87; discussion 311-2. 2001
    ..The challenge will be to integrate advances in platelet biology with molecular and genetic epidemiology to enhance our understanding of the genetic determinants of common, but etiologically complex thrombotic diseases...
  20. ncbi Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction
    Alexander P Reiner
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101 1448, USA
    Blood 102:25-30. 2003
    ..03). If confirmed, these findings may permit a better assessment of the cardiovascular risks and benefits associated with postmenopausal estrogen therapy...
  21. ncbi Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Thromb Haemost 89:142-8. 2003
    ..019). These results suggest the hypothesis that genetic variation of platelet glycoprotein Ia may play a particularly important role during the advanced stages of diabetic retinopathy...
  22. ncbi Platelet glycoprotein IIb polymorphism, traditional risk factors and non-fatal myocardial infarction in young women
    A P Reiner
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Br J Haematol 112:632-6. 2001
    ..Additional studies involving larger numbers of subjects are needed to confirm this preliminary finding...
  23. ncbi Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white women
    A P Reiner
    Department of Medicine, Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
    Stroke 32:2580-6. 2001
    ....
  24. pmc Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
    Am J Hum Genet 76:463-77. 2005
    ..Complementary methods that identify discrete subgroups on the basis of genetic similarity may help to further characterize the complex biodemographic structure of human populations...
  25. ncbi Proteolytic modulation of thrombopoietin activity: comparison of thrombin, plasmin, and urokinase
    A P Reiner
    Department of Medicine, University of Washington, Seattle 98195, USA
    Thromb Haemost 83:909-14. 2000
    ..These proteolytic events have potential implications for regulation of Tpo activity in vivo...
  26. pmc C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older
    Brandon L Pierce
    Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
    Cancer Causes Control 20:1193-203. 2009
    ..21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation...
  27. pmc Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study
    Cara L Carty
    Department of Epidemiology, University of Washington, WA, USA
    J Atheroscler Thromb 16:419-30. 2009
    ..Interaction of the SAA genes with genetic variants of their regulators, IL-1, IL-6 and TNF-alpha in influencing CVD was also explored...
  28. ncbi Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension
    Bruce M Psaty
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    JAMA 287:1680-9. 2002
    ..Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown...
  29. pmc Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, WA, United States
    Atherosclerosis 197:922-30. 2008
    ..If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks...
  30. pmc Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study
    Cara L Carty
    Department of Epidemiology, University of Washington, Seattle, USA
    Ann Hum Genet 74:1-10. 2010
    ..Although IL-6 responsive binding sites are present in fibrinogen gene promoter regions, we did not find strong evidence of interaction between fibrinogen SNPs and IL6 SNPs or levels influencing CVD...
  31. doi Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
    Alexander P Reiner
    Departments of Epidemiology, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 28:1549-55. 2008
    ..To characterize the genetic and clinical correlates of soluble P-selectin, and the relationship of P-selectin to atherosclerotic risk, in young European-American (EA) and African-American (AA) adults...
  32. ncbi The association of PAI-1 promoter 4G/5G insertion/deletion polymorphism with myocardial infarction and stroke in young women
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
    J Cardiovasc Risk 9:131-7. 2002
    ..Whether these results apply to young women is not known...
  33. ncbi Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose
    Mark J Rieder
    Department of Genome Sciences, University of Washington, Seattle, USA
    N Engl J Med 352:2285-93. 2005
    ..The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin...
  34. pmc Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke
    Joshua C Bis
    Department of Medicine, University of Washington, Seattle, WA 981041, USA
    Atherosclerosis 198:166-73. 2008
    ....
  35. pmc Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Am J Hum Genet 77:64-77. 2005
    ..We also demonstrate the functional importance of these SNPs in vitro...
  36. ncbi Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients
    Kristin D Marciante
    Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
    Am J Epidemiol 166:19-27. 2007
    ..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke...
  37. ncbi Common genetic variation in the prothrombin gene, hormone therapy, and incident nonfatal myocardial infarction in postmenopausal women
    Lucia A Hindorff
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98101, USA
    Am J Epidemiol 163:600-7. 2006
    ..These preliminary results suggest that common genetic variants in the prothrombin gene or other variants in linkage disequilibrium are associated with myocardial infarction in postmenopausal women...
  38. ncbi Conjugated equine estrogen, esterified estrogen, prothrombotic variants, and the risk of venous thrombosis in postmenopausal women
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Arterioscler Thromb Vasc Biol 26:2807-12. 2006
    ..Esterified estrogen (EE), an alternative estrogenic compound, appears not to be associated with increased risk and nothing is known about the joint risk with prothrombotic genetic variants...
  39. ncbi Simple estimates of haplotype relative risks in case-control data
    Benjamin French
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98195 7232, USA
    Genet Epidemiol 30:485-94. 2006
    ..The potential for phase ambiguity does not necessarily imply uncertainty in imputed diplotypes, especially in large studies of common haplotypes...
  40. ncbi Genetic variants of the hemostatic system and development of transplant coronary artery disease
    Jian Qing He
    Puget Sound Blood Center, Seattle, Washington, USA
    J Heart Lung Transplant 21:629-36. 2002
    ..The clinical setting of heart transplantation provides a unique opportunity to examine the relative contribution of circulating (i.e., recipient) vs local vascular (i.e., donor) hemostatic components to the occurrence of CAD...
  41. ncbi Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition study
    Christina L Wassel Fyr
    Department of Epidemiology, University of Minnesota, Minneapolis, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454 1015, USA
    Hum Genet 121:615-24. 2007
    ..The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin...
  42. ncbi The genetics of human longevity
    Warren S Browner
    California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
    Am J Med 117:851-60. 2004
    ..Despite the challenges in study design and analysis that face investigators in this area, the identification of genetic pathways that regulate longevity may suggest potential targets for therapy...
  43. ncbi Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events
    Leslie A Lange
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    JAMA 296:2703-11. 2006
    ..C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD)...
  44. pmc Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 39:1952-9. 2008
    ....

Research Grants6

  1. Molecular Epidemiology of MI and Stroke in Older Adults
    Alexander Reiner; Fiscal Year: 2003
    ....
  2. Molecular Epidemiology of MI and Stroke in Older Adults
    Alexander Reiner; Fiscal Year: 2004
    ....
  3. Molecular Epidemiology of MI and Stroke in Older Adults
    Alexander Reiner; Fiscal Year: 2005
    ....
  4. Molecular Epidemiology of MI and Stroke in Older Adults
    Alexander Reiner; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  5. Thrombosis Genetics, MI and Stroke in Older Adults
    Alexander Reiner; Fiscal Year: 2009
    ....
  6. Thrombosis Genetics, MI and Stroke in Older Adults
    Alexander P Reiner; Fiscal Year: 2010
    ....