Research Topics
Genomes and Genes
| Alexander ReinerSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adultsAlex P Reiner
Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
Arterioscler Thromb Vasc Biol 33:158-64. 2013..Despite the well-recognized role of CD14 in inflammation, relatively little is known about the genetic determinants of sCD14 or the relationship of sCD14 to vascular- and aging-related phenotypes...
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American womenAlex P Reiner
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Am J Hum Genet 91:502-12. 2012..The genetic architecture underlying the CRP phenotype in AA women is complex and involves genetic variants shared across populations, as well as variants specific to populations of African descent...
Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) studyA P Reiner
Departments of Epidemiology and Genome Sciences, University of Washington, Seattle, WA 98101 1448, USA
J Thromb Haemost 4:1279-87. 2006..Previous genotype-phenotype association studies of fibrinogen have been limited by incomplete knowledge of genomic sequence variation within and between major ethnic groups in FGB, FGA, and FGG...- Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young womenA P Reiner
Department of Epidemiology, University of Washington, Seattle, WA, USA
J Thromb Haemost 5:42-9. 2007..Associations between common F7 haplotypes, plasma factor VII (FVII) levels, and cardiovascular risk have recently been reported in population studies involving predominantly European men... - Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA StudyAlexander P Reiner
Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195, USA
Hum Genet 121:565-75. 2007..These results demonstrate the potential for confounding of genetic associations with some cardiovascular disease-related traits in large studies involving US African-Americans... - USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studiesAlexander P Reiner
Department of Epidemiology, Box 357236, University of Washington, Seattle, WA 98195, USA
Arterioscler Thromb Vasc Biol 27:2736-42. 2007.... - Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive proteinAlexander P Reiner
University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
Am J Hum Genet 82:1193-201. 2008.... - Polymorphisms of the IL1-receptor antagonist gene (IL1RN) are associated with multiple markers of systemic inflammationAlexander P Reiner
Department of Epidemiology, Box 357236, University of Washington, Seattle, Washington 98195, USA
Arterioscler Thromb Vasc Biol 28:1407-12. 2008..Circulating levels of acute phase reactant proteins such as plasma C-reactive protein (CRP) are likely influenced by multiple genes regulating the innate immune response... - PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health StudyA P Reiner
Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
J Thromb Haemost 6:1625-32. 2008..Genes encoding protein C anticoagulant pathways are candidates for atherothrombotic and other aging-related disorders... - Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health StudyA P Reiner
Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
J Thromb Haemost 7:1499-505. 2009..Additional genetic factors are likely to underlie the etiology of VTE, some of which may become manifest at older ages... - Inflammation and thrombosis biomarkers and incident frailty in postmenopausal womenAlexander P Reiner
Women s Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
Am J Med 122:947-54. 2009.... - Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The CardiovasculaAlexander P Reiner
Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
Circ Cardiovasc Genet 2:244-54. 2009..Common polymorphisms of the HNF-1 alpha gene (HNF1A) were recently associated with plasma C-reactive protein and gamma-glutamyl transferase concentration in middle-aged to older European Americans (EA)... - Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT)Alexander P Reiner
Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
PLoS Genet 7:e1002108. 2011..In summary, the CXCL2, CDK6, and PSMD3-CSF3 regions are associated with WBC count in African American and other populations. We also demonstrate that large inter-chromosomal duplications can result in false positive associations in GWAS... - Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health studyAlexander P Reiner
Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
Atherosclerosis 181:175-83. 2005..These findings suggest that modulators of fibrinolytic activity may have a generalized influence on aging, and merit further investigation in studies of genetic determinants of human longevity... - Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white womenA P Reiner
Department of Medicine, Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
Stroke 32:2580-6. 2001.... - Platelet glycoprotein gene polymorphisms and risk of thrombosis: facts and fanciesA P Reiner
Department of Medicine, University of Washington, Seattle, USA
Rev Clin Exp Hematol 5:262-87; discussion 311-2. 2001..The challenge will be to integrate advances in platelet biology with molecular and genetic epidemiology to enhance our understanding of the genetic determinants of common, but etiologically complex thrombotic diseases... - Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarctionAlexander P Reiner
Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101 1448, USA
Blood 102:25-30. 2003..03). If confirmed, these findings may permit a better assessment of the cardiovascular risks and benefits associated with postmenopausal estrogen therapy... - Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young womenAlexander P Reiner
Department of Medicine, University of Washington, Seattle, USA
Br J Haematol 116:376-82. 2002..The relationship of factor XIIIA polymorphisms to cerebrovascular disease requires further study... - Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesisAlexander P Reiner
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Thromb Haemost 89:142-8. 2003..019). These results suggest the hypothesis that genetic variation of platelet glycoprotein Ia may play a particularly important role during the advanced stages of diabetic retinopathy... - Factor V Leiden, prothrombin G20210A, and risk of sudden coronary death in apparently healthy personsAlexander P Reiner
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
Am J Cardiol 90:66-8. 2002 - Platelet glycoprotein IIb polymorphism, traditional risk factors and non-fatal myocardial infarction in young womenA P Reiner
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Br J Haematol 112:632-6. 2001..Additional studies involving larger numbers of subjects are needed to confirm this preliminary finding... - Proteolytic modulation of thrombopoietin activity: comparison of thrombin, plasmin, and urokinaseA P Reiner
Department of Medicine, University of Washington, Seattle 98195, USA
Thromb Haemost 83:909-14. 2000..These proteolytic events have potential implications for regulation of Tpo activity in vivo... - Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health StudyAlexander P Reiner
Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
Am J Hum Genet 76:463-77. 2005..Complementary methods that identify discrete subgroups on the basis of genetic similarity may help to further characterize the complex biodemographic structure of human populations... - Genetic variants of platelet glycoprotein receptors and risk of stroke in young womenA P Reiner
Departments of Medicine, University of Washington, Seattle, WA 98195 9756, USA
Stroke 31:1628-33. 2000..Data on the association of these genetic susceptibility markers with ischemic stroke are more limited, and their role in hemorrhagic stroke has not been previously examined... - C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and olderBrandon L Pierce
Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
Cancer Causes Control 20:1193-203. 2009..21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation... - Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health StudyCara L Carty
Department of Epidemiology, University of Washington, WA, USA
J Atheroscler Thromb 16:419-30. 2009..Interaction of the SAA genes with genetic variants of their regulators, IL-1, IL-6 and TNF-alpha in influencing CVD was also explored... - Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertensionBruce M Psaty
Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
JAMA 287:1680-9. 2002..Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown... - Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levelsChristopher S Carlson
Department of Genome Sciences, University of Washington, Seattle, WA, USA
Am J Hum Genet 77:64-77. 2005..We also demonstrate the functional importance of these SNPs in vitro... - Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health StudyCara L Carty
Department of Epidemiology, University of Washington, Seattle, USA
Ann Hum Genet 74:1-10. 2010..Although IL-6 responsive binding sites are present in fibrinogen gene promoter regions, we did not find strong evidence of interaction between fibrinogen SNPs and IL6 SNPs or levels influencing CVD... - The association of PAI-1 promoter 4G/5G insertion/deletion polymorphism with myocardial infarction and stroke in young womenLucia A Hindorff
Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
J Cardiovasc Risk 9:131-7. 2002..Whether these results apply to young women is not known... - Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) StudyAlexander P Reiner
Departments of Epidemiology, University of Washington, Seattle, WA 98195, USA
Arterioscler Thromb Vasc Biol 28:1549-55. 2008..To characterize the genetic and clinical correlates of soluble P-selectin, and the relationship of P-selectin to atherosclerotic risk, in young European-American (EA) and African-American (AA) adults... - Effect of VKORC1 haplotypes on transcriptional regulation and warfarin doseMark J Rieder
Department of Genome Sciences, University of Washington, Seattle, USA
N Engl J Med 352:2285-93. 2005..The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin... - Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic strokeJoshua C Bis
Department of Medicine, University of Washington, Seattle, WA 981041, USA
Atherosclerosis 198:166-73. 2008.... - Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health StudyLucia A Hindorff
Department of Epidemiology, University of Washington, Seattle, WA, United States
Atherosclerosis 197:922-30. 2008..If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks... - Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patientsKristin D Marciante
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
Am J Epidemiol 166:19-27. 2007..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke... - Common genetic variation in the prothrombin gene, hormone therapy, and incident nonfatal myocardial infarction in postmenopausal womenLucia A Hindorff
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98101, USA
Am J Epidemiol 163:600-7. 2006..These preliminary results suggest that common genetic variants in the prothrombin gene or other variants in linkage disequilibrium are associated with myocardial infarction in postmenopausal women... - Simple estimates of haplotype relative risks in case-control dataBenjamin French
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98195 7232, USA
Genet Epidemiol 30:485-94. 2006..The potential for phase ambiguity does not necessarily imply uncertainty in imputed diplotypes, especially in large studies of common haplotypes... - Conjugated equine estrogen, esterified estrogen, prothrombotic variants, and the risk of venous thrombosis in postmenopausal womenNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, WA, USA
Arterioscler Thromb Vasc Biol 26:2807-12. 2006..Esterified estrogen (EE), an alternative estrogenic compound, appears not to be associated with increased risk and nothing is known about the joint risk with prothrombotic genetic variants... - Genetic variants of the hemostatic system and development of transplant coronary artery diseaseJian Qing He
Puget Sound Blood Center, Seattle, Washington, USA
J Heart Lung Transplant 21:629-36. 2002..The clinical setting of heart transplantation provides a unique opportunity to examine the relative contribution of circulating (i.e., recipient) vs local vascular (i.e., donor) hemostatic components to the occurrence of CAD... - Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition studyChristina L Wassel Fyr
Department of Epidemiology, University of Minnesota, Minneapolis, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454 1015, USA
Hum Genet 121:615-24. 2007..The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin... - The genetics of human longevityWarren S Browner
California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
Am J Med 117:851-60. 2004..Despite the challenges in study design and analysis that face investigators in this area, the identification of genetic pathways that regulate longevity may suggest potential targets for therapy... - Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health StudyMyriam Fornage
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Stroke 39:1952-9. 2008.... - Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular eventsLeslie A Lange
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
JAMA 296:2703-11. 2006..C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD)...
Research Grants
- Molecular Epidemiology of MI and Stroke in Older AdultsAlexander Reiner; Fiscal Year: 2006....
- Thrombosis Genetics, MI and Stroke in Older AdultsAlexander P Reiner; Fiscal Year: 2010....