Muredach Reilly

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
  2. ncbi request reprint Frequency, risk factors, and clinical outcomes of left ventricular assist device-associated ventricular thrombus
    M P Reilly
    Department of Medicine, University of Pennsylvania Health System, Philadelphia 19014, USA
    Am J Cardiol 86:1156-9, A10. 2000
  3. ncbi request reprint Resistin is an inflammatory marker of atherosclerosis in humans
    Muredach P Reilly
    Division of Cardiology, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 111:932-9. 2005
  4. ncbi request reprint Plasma cytokines, metabolic syndrome, and atherosclerosis in humans
    Muredach P Reilly
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    J Investig Med 55:26-35. 2007
  5. ncbi request reprint Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, The Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Investig Med 52:515-22. 2004
  6. ncbi request reprint Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
  7. ncbi request reprint Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis
    Muredach P Reilly
    Cardiovascular Division and Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 110:803-9. 2004
  8. ncbi request reprint Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19004 6160, USA
    Atherosclerosis 173:69-78. 2004
  9. ncbi request reprint C-reactive protein and coronary artery calcification: The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)
    Muredach P Reilly
    Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    Arterioscler Thromb Vasc Biol 23:1851-6. 2003
  10. ncbi request reprint Higher order lipase gene association with plasma triglycerides
    Muredach P Reilly
    Cardiovascular Division and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Lipid Res 46:1914-22. 2005

Detail Information

Publications69

  1. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
    ..This study sought to explore potential mechanisms of inflammatory-induced IR in humans with a focus on adipose tissue...
  2. ncbi request reprint Frequency, risk factors, and clinical outcomes of left ventricular assist device-associated ventricular thrombus
    M P Reilly
    Department of Medicine, University of Pennsylvania Health System, Philadelphia 19014, USA
    Am J Cardiol 86:1156-9, A10. 2000
    ..LV cannulation, when using short-term LVADs, may decrease the incidence of LV thrombosis, and early transition to Heartmate-LVAD support may improve outcome...
  3. ncbi request reprint Resistin is an inflammatory marker of atherosclerosis in humans
    Muredach P Reilly
    Division of Cardiology, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 111:932-9. 2005
    ..Given the convergence of adipocyte and macrophage function, resistin may provide unique insight into links between obesity, inflammation, and atherosclerosis in humans...
  4. ncbi request reprint Plasma cytokines, metabolic syndrome, and atherosclerosis in humans
    Muredach P Reilly
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    J Investig Med 55:26-35. 2007
    ..We hypothesized that plasma levels of IL-6 and soluble tumor necrosis factor alpha receptor 2 (sol-TNFR2) would be related to coronary atherosclerosis beyond established risk factors and the metabolic syndrome...
  5. ncbi request reprint Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, The Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Investig Med 52:515-22. 2004
    ....
  6. ncbi request reprint Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
    ..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored...
  7. ncbi request reprint Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis
    Muredach P Reilly
    Cardiovascular Division and Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 110:803-9. 2004
    ....
  8. ncbi request reprint Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19004 6160, USA
    Atherosclerosis 173:69-78. 2004
    ..We present analytic approaches that are likely to provide consistent results and recommend the use of at least two distinct multivariable methods...
  9. ncbi request reprint C-reactive protein and coronary artery calcification: The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)
    Muredach P Reilly
    Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    Arterioscler Thromb Vasc Biol 23:1851-6. 2003
    ..In the largest study to date, we examined the association of plasma CRP with coronary artery calcification (CAC) in 914 asymptomatic subjects in the Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)...
  10. ncbi request reprint Higher order lipase gene association with plasma triglycerides
    Muredach P Reilly
    Cardiovascular Division and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Lipid Res 46:1914-22. 2005
    ....
  11. ncbi request reprint Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factors
    Megan L Wolfe
    Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 815 BRB2 3, Philadelphia, PA 19104, USA
    J Cardiovasc Risk 9:369-76. 2002
    ..We hypothesized that the presence and extent of CAC would be greater in asymptomatic type 2 diabetics than in non-diabetics independent of traditional risk factors...
  12. ncbi request reprint Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Cardiol 99:951-5. 2007
    ....
  13. pmc Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 106:1118-23. 2010
    ..These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus...
  14. doi request reprint Evaluating the association between all components of the metabolic syndrome and pre-eclampsia
    Sindhu K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    J Matern Fetal Neonatal Med 22:501-9. 2009
    ....
  15. pmc Adipokines, insulin resistance, and coronary artery calcification
    Atif Qasim
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 52:231-6. 2008
    ..In addition, we assessed which biomarkers of adiposity and insulin resistance are the strongest predictors of CAC beyond traditional risk factors, metabolic syndrome, and plasma C-reactive protein (CRP)...
  16. pmc Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC
    Jayanta Gupta
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin J Am Soc Nephrol 7:1938-46. 2012
    ..Increased risk of mortality in patients with CKD has been attributed to inflammation. However, the association between kidney function, albuminuria, and biomarkers of inflammation has not been examined in a large cohort of CKD patients...
  17. pmc Common variants in HSPB7 and FRMD4B associated with advanced heart failure
    Thomas P Cappola
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Circ Cardiovasc Genet 3:147-54. 2010
    ..We tested the hypothesis that inherited variation in genes of known importance to cardiovascular biology would thus contribute to heart failure risk...
  18. pmc Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites
    Seth S Martin
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 58:1887-92. 2009
    ..We investigated the hypothesis that apoB is a superior marker of CAC relative to LDL cholesterol...
  19. pmc Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:4776-84. 2009
    ..Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown...
  20. ncbi request reprint Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans
    Wen Liang Song
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 283:1179-88. 2008
    ..Niacin increased tetranor PGDM and 2,3-dinor-11beta-PGF(2alpha) in humans coincident with facial flushing. Tetranor PGDM is an abundant metabolite in urine that reflects modulated biosynthesis of PGD(2) in humans and mice...
  21. ncbi request reprint Atherosclerotic cardiovascular disease risk in the HAART-treated HIV-1 population
    Nehal Mehta
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    HIV Clin Trials 6:5-24. 2005
    ..The objective of this article is to review the mechanisms of atherosclerotic CVD and to discuss risk factors and markers that can be applied in the evaluation and treatment of CVD in the HIV-positive population...
  22. pmc Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma
    L Chastine Bell-Parikh
    Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104 6084, USA
    J Clin Invest 112:945-55. 2003
    ..15d-PGJ2 is not the endogenous mediator of PPARgamma-dependent adipocyte activation and is unaltered in clinical settings in which PPARgamma activation has been implicated...
  23. ncbi request reprint The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Am Coll Cardiol 43:985-90. 2004
    ....
  24. pmc Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation
    Thomas P Cappola
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:2456-61. 2011
    ..The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis...
  25. pmc Adipose inflammation, insulin resistance, and cardiovascular disease
    Arti Shah
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    JPEN J Parenter Enteral Nutr 32:638-44. 2008
    ..Developing therapeutic strategies that target both adipose inflammation and insulin resistance may help to prevent type 2 diabetes and cardiovascular disease in the emerging epidemic of obesity...
  26. pmc Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
    Karen O Badellino
    Institute for Translational Medicine and Therapeutics, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Med 3:e22. 2006
    ..We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans...
  27. pmc Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes
    Luis H Eraso
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 33:408-10. 2010
    ..Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD)...
  28. ncbi request reprint Utility and barriers to performance of the ankle-brachial index in primary care practice
    Emile R Mohler
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vasc Med 9:253-60. 2004
    ..The ABI is a simple peripheral arterial disease detection tool that can be successfully applied in primary care office practices...
  29. doi request reprint Endothelial lipase is increased in vivo by inflammation in humans
    Karen O Badellino
    School of Nursing, and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 117:678-85. 2008
    ..Furthermore, we directly tested the hypothesis that plasma EL concentrations would increase with induction of an inflammatory state by low-dose endotoxin in humans...
  30. pmc Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, Philadelphia, Pennsylvania, USA
    Am J Cardiol 107:406-11. 2011
    ....
  31. pmc HDL proteomics: pot of gold or Pandora's box?
    Muredach P Reilly
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Invest 117:595-8. 2007
    ....
  32. pmc Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 119:1042-50. 2009
    ..Our results establish that loss-of-function mutations in LIPG lead to increased HDL-C levels and support the idea that inhibition of endothelial lipase may be an effective mechanism to raise HDL-C...
  33. pmc Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
    Muredach P Reilly
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Lancet 377:383-92. 2011
    ..We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis...
  34. pmc Correcting population stratification in genetic association studies using a phylogenetic approach
    Mingyao Li
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Bioinformatics 26:798-806. 2010
    ....
  35. pmc Cardiovascular disease among hispanics and non-hispanics in the chronic renal insufficiency cohort (CRIC) study
    Ana C Ricardo
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Clin J Am Soc Nephrol 6:2121-31. 2011
    ..Hispanics are the largest minority group in the United States. The leading cause of death in patients with chronic kidney disease (CKD) is cardiovascular disease (CVD), yet little is known about its prevalence among Hispanics with CKD...
  36. ncbi request reprint Innate immunity modulates adipokines in humans
    Paul D Anderson
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Endocrinol Metab 92:2272-9. 2007
    ..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...
  37. pmc Inflammation induces fibrinogen nitration in experimental human endotoxemia
    Sean P Heffron
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Free Radic Biol Med 47:1140-6. 2009
    ..Inflammation-induced fibrinogen nitration may be a risk factor for promoting CVD events...
  38. pmc Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians
    Atif N Qasim
    Cardiovascular Institute, Institute for Translational Medicine and Therapeutics, and Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Clin Endocrinol (Oxf) 70:698-705. 2009
    ..We hypothesized that the -420C>G putative gain-of-function resistin variant would be associated with inflammatory markers and atherosclerosis but not with metabolic syndrome or adipokines in humans...
  39. pmc An inflammatory cascade leading to hyperresistinemia in humans
    Michael Lehrke
    Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Med 1:e45. 2004
    ..Adipocyte-derived resistin is a circulating protein implicated in insulin resistance in rodents, but the role of human resistin is uncertain because it is produced largely by macrophages...
  40. ncbi request reprint Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome
    Philippe O Szapary
    Division of General Internal Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:182-8. 2006
    ..The purpose of this research was to evaluate the short-term effects of pioglitazone (PIO) on high-density lipoprotein cholesterol (HDL-C) and other metabolic parameters in nondiabetic patients with metabolic syndrome (MetSyn)...
  41. ncbi request reprint The metabolic syndrome: more than the sum of its parts?
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, the Center for Experimental Therapeutics and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Penn 19104 6160, USA
    Circulation 108:1546-51. 2003
  42. pmc Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies
    Brendan J Keating
    The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, USA
    PLoS ONE 3:e3583. 2008
    ..These datasets will also facilitate more robust secondary analyses, such as explorations with alternative genetic models, epistasis and gene-environment interactions...
  43. pmc Apolipoprotein E and coronary disease: a puzzling paradox
    Muredach Reilly
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Med 3:e258. 2006
  44. pmc Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    Fiona C McGillicuddy
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:31936-44. 2009
    ..We demonstrate that IFNgamma attenuates insulin sensitivity and suppresses differentiation in human adipocytes, an effect most likely mediated via sustained JAK-STAT1 pathway activation...
  45. pmc Adipocyte modulation of high-density lipoprotein cholesterol
    Yuzhen Zhang
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Circulation 121:1347-55. 2010
    ....
  46. pmc Strong synaptic transmission impact by copy number variations in schizophrenia
    Joseph T Glessner
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10584-9. 2010
    ..Our results suggest that novel variations involving the processes of synaptic transmission contribute to the genetic susceptibility of schizophrenia...
  47. pmc Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure
    Esther E Vorovich
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am Heart J 155:992-7. 2008
    ..We tested MMP-9 as a biomarker of remodeling and predictor of outcomes in a systolic heart failure cohort derived from clinical practice and compared its performance to brain natriuretic peptide (BNP)...
  48. doi request reprint Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease
    Seth S Martin
    Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Am Coll Cardiol 52:1201-10. 2008
    ..Leptin resistance and its interactions with metabolic and inflammatory factors, therefore, represent potential novel diagnostic and therapeutic targets in obesity-related cardiovascular disease...
  49. ncbi request reprint CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans
    Michael Lehrke
    Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 49:442-9. 2007
    ..This study was designed to determine the association of CXCL16 with inflammation, atherosclerosis, and acute coronary syndromes...
  50. pmc Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania Medical Center, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Cardiovasc Drugs Ther 23:17-24. 2009
    ..Prior studies demonstrate beneficial effects of PKC beta inhibition on microvascular parameters, but, to date, no study has examined the effect on macrovascular atherosclerotic readouts...
  51. pmc Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
    Yuzhen Zhang
    Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 115:2870-4. 2005
    ..These studies demonstrate that hepatic SR-BI expression, despite its inverse effects on steady-state plasma HDL cholesterol concentrations, is an important positive regulator of the rate of macrophage RCT...
  52. ncbi request reprint Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction
    Stephen E Kimmel
    University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Ann Intern Med 142:157-64. 2005
    ..Some of these mechanisms could increase risk (for example, inhibition of prostacyclin production), and some could decrease risk (for example, inhibition of inflammation)...
  53. pmc Genetic variants influencing circulating lipid levels and risk of coronary artery disease
    Dawn M Waterworth
    Genetics Division, GlaxoSmithKline R and D, King of Prussia, PA, USA
    Arterioscler Thromb Vasc Biol 30:2264-76. 2010
    ..We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides...
  54. pmc A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis
    Robert J Brown
    Department of Medicine and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
    J Lipid Res 50:1910-6. 2009
    ..Thus, this N-terminal variant results in reduced secretion of EL protein, plausibly leading to increased HDL-C levels...
  55. pmc Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
    Themistocles L Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
    J Am Coll Cardiol 56:1552-63. 2010
    ..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)...
  56. pmc Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 94:2161-6. 2010
    ..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women...
  57. pmc Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nat Genet 41:811-5. 2009
    ..All of the genotypes were associated with both seminoma and nonseminoma TGCT subtypes. These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in TGCT susceptibility...
  58. pmc Atheroprotective lipoprotein effects of a niacin-simvastatin combination compared to low- and high-dose simvastatin monotherapy
    Subha L Airan-Javia
    The Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, Philadelphia, PA, USA
    Am Heart J 157:687.e1-8. 2009
    ..Niacin has multiple lipoprotein effects that may provide cardiovascular benefit when added to statin monotherapy...
  59. pmc Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease
    Scot J Matkovich
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, 660 S Eucliud Avenue, St Louis, Missouri 63110, USA
    J Clin Invest 120:280-9. 2010
    ....
  60. ncbi request reprint Inflammation impairs reverse cholesterol transport in vivo
    Fiona C McGillicuddy
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 119:1135-45. 2009
    ..The present study presents the first integrated functional evidence that inflammation retards numerous components of RCT...
  61. pmc Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation
    Wen Liang Song
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:23636-43. 2009
    ..Clustered analysis of F(2)- and F(3)-iPs refines assessment of the oxidant stress response to an inflammatory stimulus in vivo by integrating variability in dietary intake of omega-3/omega-6 PUFAs...
  62. pmc Gene profiling of human adipose tissue during evoked inflammation in vivo
    Rachana Shah
    Division of Pediatric Endocrinology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2211-9. 2009
    ..However, few human adipose-secreted proteins are known to mediate these processes. We hypothesized that microarray mRNA profiling of human adipose during evoked inflammation could identify novel adipocytokines...
  63. ncbi request reprint Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    Struan F A Grant
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 38:320-3. 2006
    ..It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway...
  64. pmc Associations among race/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapy
    Andrea S Foulkes
    School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS Med 3:e52. 2006
    ..However, the association of race/ethnicity, or candidate gene effects across race/ethnicity, with plasma lipid levels in HIV-1-infected individuals, has not been reported...
  65. doi request reprint The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 40:217-24. 2008
    ..These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases...
  66. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....
  67. ncbi request reprint A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    Valgerdur Steinthorsdottir
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:770-5. 2007
    ..The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion...
  68. ncbi request reprint A common variant on chromosome 9p21 affects the risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Science 316:1491-3. 2007
    ..64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases...
  69. ncbi request reprint Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
    ..Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes...

Research Grants13

  1. Inflammation, the metabolic syndrome and atherosclerosis
    Muredach Reilly; Fiscal Year: 2005
    ..abstract_text> ..
  2. Inflammation, the metabolic syndrome and atherosclerosis
    Muredach Reilly; Fiscal Year: 2003
    ..abstract_text> ..
  3. Mentored Patient-Oriented Research Career Development Aw
    Muredach Reilly; Fiscal Year: 2003
    ..Focussed coursework in patient-oriented research will compliment practical experience obtained during the development of this application. ..
  4. Inflammation, the metabolic syndrome and atherosclerosis
    Muredach Reilly; Fiscal Year: 2004
    ..abstract_text> ..
  5. Genetics of atherosclerosis in renal disease
    Muredach Reilly; Fiscal Year: 2007
    ....
  6. Genetics of atherosclerosis in renal disease
    Muredach Reilly; Fiscal Year: 2006
    ....
  7. Inflammation, the metabolic syndrome and atherosclerosis
    Muredach Reilly; Fiscal Year: 2006
    ..abstract_text> ..
  8. Mentored Patient-Oriented Research Career Development Aw
    Muredach Reilly; Fiscal Year: 2001
    ..Focussed coursework in patient-oriented research will compliment practical experience obtained during the development of this application. ..
  9. Mentored Patient-Oriented Research Career Development Aw
    Muredach Reilly; Fiscal Year: 2004
    ..Focussed coursework in patient-oriented research will compliment practical experience obtained during the development of this application. ..
  10. Mentored Patient-Oriented Research Career Development Aw
    Muredach Reilly; Fiscal Year: 2002
    ..Focussed coursework in patient-oriented research will compliment practical experience obtained during the development of this application. ..
  11. Genetics of atherosclerosis in renal disease
    Muredach Reilly; Fiscal Year: 2009
    ....
  12. Genetics of atherosclerosis in renal disease
    Muredach P Reilly; Fiscal Year: 2010
    ....