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Genomes and Genes | Muredach ReillySummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Frequency, risk factors, and clinical outcomes of left ventricular assist device-associated ventricular thrombusM P Reilly
Department of Medicine, University of Pennsylvania Health System, Philadelphia 19014, USA
Am J Cardiol 86:1156-9, A10. 2000..LV cannulation, when using short-term LVADs, may decrease the incidence of LV thrombosis, and early transition to Heartmate-LVAD support may improve outcome...- Higher order lipase gene association with plasma triglyceridesMuredach P Reilly
Cardiovascular Division and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Lipid Res 46:1914-22. 2005.... - Resistin is an inflammatory marker of atherosclerosis in humansMuredach P Reilly
Division of Cardiology, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Circulation 111:932-9. 2005..Given the convergence of adipocyte and macrophage function, resistin may provide unique insight into links between obesity, inflammation, and atherosclerosis in humans... - Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levelsMuredach P Reilly
Cardiovascular Division, Department of Medicine, The Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Investig Med 52:515-22. 2004.... - Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetesMuredach P Reilly
Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
J Clin Endocrinol Metab 89:3872-8. 2004..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored... - Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosisMuredach P Reilly
Cardiovascular Division and Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Circulation 110:803-9. 2004.... - Coronary artery calcification and cardiovascular risk factors: impact of the analytic approachMuredach P Reilly
Cardiovascular Division, Department of Medicine, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19004 6160, USA
Atherosclerosis 173:69-78. 2004..We present analytic approaches that are likely to provide consistent results and recommend the use of at least two distinct multivariable methods... - Plasma cytokines, metabolic syndrome, and atherosclerosis in humansMuredach P Reilly
Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
J Investig Med 55:26-35. 2007..We hypothesized that plasma levels of IL-6 and soluble tumor necrosis factor alpha receptor 2 (sol-TNFR2) would be related to coronary atherosclerosis beyond established risk factors and the metabolic syndrome... - C-reactive protein and coronary artery calcification: The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)Muredach P Reilly
Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, USA
Arterioscler Thromb Vasc Biol 23:1851-6. 2003..In the largest study to date, we examined the association of plasma CRP with coronary artery calcification (CAC) in 914 asymptomatic subjects in the Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)... - Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitusRoshanak Bagheri
Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
Am J Cardiol 99:951-5. 2007.... - Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factorsMegan L Wolfe
Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 815 BRB2/3, Philadelphia, PA 19104, USA
J Cardiovasc Risk 9:369-76. 2002.... 
Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitusRoshanak Bagheri
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Cardiol 106:1118-23. 2010..These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus...
Evaluating the association between all components of the metabolic syndrome and pre-eclampsiaSindhu K Srinivas
Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
J Matern Fetal Neonatal Med 22:501-9. 2009....- Adipokines, insulin resistance, and coronary artery calcificationAtif Qasim
Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Am Coll Cardiol 52:231-6. 2008..In addition, we assessed which biomarkers of adiposity and insulin resistance are the strongest predictors of CAC beyond traditional risk factors, metabolic syndrome, and plasma C-reactive protein (CRP)... - Common variants in HSPB7 and FRMD4B associated with advanced heart failureThomas P Cappola
Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
Circ Cardiovasc Genet 3:147-54. 2010..We tested the hypothesis that inherited variation in genes of known importance to cardiovascular biology would thus contribute to heart failure risk... - Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular diseaseShrita M Patel
Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 94:4776-84. 2009..Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown... - Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whitesSeth S Martin
Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes 58:1887-92. 2009..We investigated the hypothesis that apoB is a superior marker of CAC relative to LDL cholesterol... - Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humansWen Liang Song
Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 283:1179-88. 2008..Niacin increased tetranor PGDM and 2,3-dinor-11beta-PGF(2alpha) in humans coincident with facial flushing. Tetranor PGDM is an abundant metabolite in urine that reflects modulated biosynthesis of PGD(2) in humans and mice... - Atherosclerotic cardiovascular disease risk in the HAART-treated HIV-1 populationNehal Mehta
Cardiovascular Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
HIV Clin Trials 6:5-24. 2005..The objective of this article is to review the mechanisms of atherosclerotic CVD and to discuss risk factors and markers that can be applied in the evaluation and treatment of CVD in the HIV-positive population... - Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgammaL Chastine Bell-Parikh
Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104 6084, USA
J Clin Invest 112:945-55. 2003..15d-PGJ2 is not the endogenous mediator of PPARgamma-dependent adipocyte activation and is unaltered in clinical settings in which PPARgamma activation has been implicated... - The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirinStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
J Am Coll Cardiol 43:985-90. 2004.... - Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variationThomas P Cappola
Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 108:2456-61. 2011..The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis... - Adipose inflammation, insulin resistance, and cardiovascular diseaseArti Shah
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
JPEN J Parenter Enteral Nutr 32:638-44. 2008..Developing therapeutic strategies that target both adipose inflammation and insulin resistance may help to prevent type 2 diabetes and cardiovascular disease in the emerging epidemic of obesity... - Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studiesMuredach P Reilly
Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
Lancet 377:383-92. 2011..We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis... - Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humansAndrew C Edmondson
Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
J Clin Invest 119:1042-50. 2009..Our results establish that loss-of-function mutations in LIPG lead to increased HDL-C levels and support the idea that inhibition of endothelial lipase may be an effective mechanism to raise HDL-C... - Endothelial lipase is increased in vivo by inflammation in humansKaren O Badellino
School of Nursing, and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
Circulation 117:678-85. 2008..Furthermore, we directly tested the hypothesis that plasma EL concentrations would increase with induction of an inflammatory state by low-dose endotoxin in humans... - Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitusNehal N Mehta
Cardiovascular Institute, Philadelphia, Pennsylvania, USA
Am J Cardiol 107:406-11. 2011.... - Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetesLuis H Eraso
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes Care 33:408-10. 2010..Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD)... - Correcting population stratification in genetic association studies using a phylogenetic approachMingyao Li
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Bioinformatics 26:798-806. 2010.... 
Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosisKaren O Badellino
Institute for Translational Medicine and Therapeutics, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
PLoS Med 3:e22. 2006..We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans...- Utility and barriers to performance of the ankle-brachial index in primary care practiceEmile R Mohler
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Vasc Med 9:253-60. 2004..The ABI is a simple peripheral arterial disease detection tool that can be successfully applied in primary care office practices... - HDL proteomics: pot of gold or Pandora's box?Muredach P Reilly
Cardiovascular Institute, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
J Clin Invest 117:595-8. 2007.... - Cardiovascular disease among hispanics and non-hispanics in the chronic renal insufficiency cohort (CRIC) studyAna C Ricardo
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Clin J Am Soc Nephrol 6:2121-31. 2011..Hispanics are the largest minority group in the United States. The leading cause of death in patients with chronic kidney disease (CKD) is cardiovascular disease (CVD), yet little is known about its prevalence among Hispanics with CKD... - Inflammation induces fibrinogen nitration in experimental human endotoxemiaSean P Heffron
Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Free Radic Biol Med 47:1140-6. 2009..Inflammation-induced fibrinogen nitration may be a risk factor for promoting CVD events... - Experimental endotoxemia induces adipose inflammation and insulin resistance in humansNehal N Mehta
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes 59:172-81. 2010..This study sought to explore potential mechanisms of inflammatory-induced IR in humans with a focus on adipose tissue... - Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic CaucasiansAtif N Qasim
Cardiovascular Institute, Institute for Translational Medicine and Therapeutics, and Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Clin Endocrinol (Oxf) 70:698-705. 2009..We hypothesized that the -420C>G putative gain-of-function resistin variant would be associated with inflammatory markers and atherosclerosis but not with metabolic syndrome or adipokines in humans... - Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndromePhilippe O Szapary
Division of General Internal Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Arterioscler Thromb Vasc Biol 26:182-8. 2006..These results suggest that PIO has direct effects on HDL, which may contribute to its antiatherogenic effects... - Innate immunity modulates adipokines in humansPaul D Anderson
Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
J Clin Endocrinol Metab 92:2272-9. 2007..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis... - An inflammatory cascade leading to hyperresistinemia in humansMichael Lehrke
Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS Med 1:e45. 2004..CONCLUSIONS: Inflammation is a hyperresistinemic state in humans, and cytokine induction of resistin may contribute to insulin resistance in endotoxemia, obesity, and other inflammatory states... - The metabolic syndrome: more than the sum of its parts?Muredach P Reilly
Cardiovascular Division, Department of Medicine, the Center for Experimental Therapeutics and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Penn 19104 6160, USA
Circulation 108:1546-51. 2003 - Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studiesBrendan J Keating
The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, USA
PLoS ONE 3:e3583. 2008..These datasets will also facilitate more robust secondary analyses, such as explorations with alternative genetic models, epistasis and gene-environment interactions... - Apolipoprotein E and coronary disease: a puzzling paradoxMuredach Reilly
Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS Med 3:e258. 2006 - Adipocyte modulation of high-density lipoprotein cholesterolYuzhen Zhang
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Circulation 121:1347-55. 2010.... - Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathwayFiona C McGillicuddy
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 284:31936-44. 2009..We demonstrate that IFNgamma attenuates insulin sensitivity and suppresses differentiation in human adipocytes, an effect most likely mediated via sustained JAK-STAT1 pathway activation... - Strong synaptic transmission impact by copy number variations in schizophreniaJoseph T Glessner
Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10584-9. 2010..Our results suggest that novel variations involving the processes of synaptic transmission contribute to the genetic susceptibility of schizophrenia... - Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failureEsther E Vorovich
Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am Heart J 155:992-7. 2008..We tested MMP-9 as a biomarker of remodeling and predictor of outcomes in a systolic heart failure cohort derived from clinical practice and compared its performance to brain natriuretic peptide (BNP)... - CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humansMichael Lehrke
Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Am Coll Cardiol 49:442-9. 2007..This study was designed to determine the association of CXCL16 with inflammation, atherosclerosis, and acute coronary syndromes... - Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitusNehal N Mehta
Cardiovascular Institute, University of Pennsylvania Medical Center, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
Cardiovasc Drugs Ther 23:17-24. 2009..Prior studies demonstrate beneficial effects of PKC beta inhibition on microvascular parameters, but, to date, no study has examined the effect on macrovascular atherosclerotic readouts... - Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular diseaseSeth S Martin
Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
J Am Coll Cardiol 52:1201-10. 2008..Leptin resistance and its interactions with metabolic and inflammatory factors, therefore, represent potential novel diagnostic and therapeutic targets in obesity-related cardiovascular disease... - Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarctionStephen E Kimmel
University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Ann Intern Med 142:157-64. 2005..Cardiovascular effects among the COX-2 inhibitors seem different, but further studies, preferably randomized trials, are needed to fully understand the spectrum of effects of COX-2 inhibitors and potential differences among them... - Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivoYuzhen Zhang
Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Clin Invest 115:2870-4. 2005..These studies demonstrate that hepatic SR-BI expression, despite its inverse effects on steady-state plasma HDL cholesterol concentrations, is an important positive regulator of the rate of macrophage RCT... - A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesisRobert J Brown
Department of Medicine and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
J Lipid Res 50:1910-6. 2009..Thus, this N-terminal variant results in reduced secretion of EL protein, plausibly leading to increased HDL-C levels... - Genetic variants influencing circulating lipid levels and risk of coronary artery diseaseDawn M Waterworth
Genetics Division, GlaxoSmithKline R and D, King of Prussia, PA, USA
Arterioscler Thromb Vasc Biol 30:2264-76. 2010..We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides... - Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studiesThemistocles L Assimes
Department of Medicine, Stanford University School of Medicine, Stanford, California 94304 1334, USA
J Am Coll Cardiol 56:1552-63. 2010..We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD)... - Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trialShrita M Patel
Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 94:2161-6. 2010..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women... - Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with diseaseScot J Matkovich
Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, 660 S Eucliud Avenue, St Louis, Missouri 63110, USA
J Clin Invest 120:280-9. 2010.... - Inflammation impairs reverse cholesterol transport in vivoFiona C McGillicuddy
Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Circulation 119:1135-45. 2009..The present study presents the first integrated functional evidence that inflammation retards numerous components of RCT... - Gene profiling of human adipose tissue during evoked inflammation in vivoRachana Shah
Division of Pediatric Endocrinology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 58:2211-9. 2009..However, few human adipose-secreted proteins are known to mediate these processes. We hypothesized that microarray mRNA profiling of human adipose during evoked inflammation could identify novel adipocytokines... - Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidationWen Liang Song
Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 284:23636-43. 2009..Clustered analysis of F(2)- and F(3)-iPs refines assessment of the oxidant stress response to an inflammatory stimulus in vivo by integrating variability in dietary intake of omega-3/omega-6 PUFAs... - Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancerPeter A Kanetsky
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Nat Genet 41:811-5. 2009..All of the genotypes were associated with both seminoma and nonseminoma TGCT subtypes. These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in TGCT susceptibility... - Atheroprotective lipoprotein effects of a niacin-simvastatin combination compared to low- and high-dose simvastatin monotherapySubha L Airan-Javia
The Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, Philadelphia, PA, USA
Am Heart J 157:687.e1-8. 2009..Niacin has multiple lipoprotein effects that may provide cardiovascular benefit when added to statin monotherapy... - Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetesJulius Gudmundsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:977-83. 2007..Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes... - A variant in CDKAL1 influences insulin response and risk of type 2 diabetesValgerdur Steinthorsdottir
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:770-5. 2007..The insulin response for homozygotes was approximately 20% lower than for heterozygotes or noncarriers, suggesting that this variant confers risk of T2D through reduced insulin secretion... - The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysmAnna Helgadottir
deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
Nat Genet 40:217-24. 2008..These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases... - Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolutionAgnar Helgason
deCODE Genetics, 101 Reykjavik, Iceland
Nat Genet 39:218-25. 2007.... - Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesStruan F A Grant
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 38:320-3. 2006..It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway... - Associations among race/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapyAndrea S Foulkes
School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America
PLoS Med 3:e52. 2006..However, the association of race/ethnicity, or candidate gene effects across race/ethnicity, with plasma lipid levels in HIV-1-infected individuals, has not been reported... - A common variant on chromosome 9p21 affects the risk of myocardial infarctionAnna Helgadottir
deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
Science 316:1491-3. 2007..64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases...
Research Grants
- Genetics of atherosclerosis in renal diseaseMuredach Reilly; Fiscal Year: 2007....
- Inflammation, the metabolic syndrome and atherosclerosisMuredach Reilly; Fiscal Year: 2006..abstract_text> ..
- Mentored Patient-Oriented Research Career Development AwMuredach Reilly; Fiscal Year: 2004..Focussed coursework in patient-oriented research will compliment practical experience obtained during the development of this application. ..
- Genetics of atherosclerosis in renal diseaseMuredach P Reilly; Fiscal Year: 2010....