Louis F Reichardt

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Neurotrophin-regulated signalling pathways
    Louis F Reichardt
    Neuroscience Program, Department of Physiology and Howard Hughes Medical Institute, University of California San Francisco, 1550 Fourth Street, Rock Hall 284a, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 361:1545-64. 2006
  2. pmc Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development
    Jyothi Arikkath
    Department of Physiology, Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 29:5435-42. 2009
  3. pmc Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
    Amanda K Wiggins
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 167:257-67. 2004
  4. pmc Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse
    Zhen Huang
    Department of Physiology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:11208-19. 2006
  5. pmc Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin
    Seung Hye Lee
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 183:893-908. 2008
  6. pmc Vascular development of the brain requires beta8 integrin expression in the neuroepithelium
    John M Proctor
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:9940-8. 2005
  7. pmc BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions
    Shernaz X Bamji
    Neuroscience Program, Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 174:289-99. 2006
  8. pmc Control of axonal branching and synapse formation by focal adhesion kinase
    Beatriz Rico
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 7:1059-69. 2004
  9. pmc Retinal TrkB receptors regulate neural development in the inner, but not outer, retina
    Ruslan N Grishanin
    Neuroscience Program, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Mol Cell Neurosci 38:431-43. 2008
  10. pmc p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins
    Lisa P Elia
    Howard Hughes Medical Institute and Department of Physiology, 1550 Fourth Street, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 51:43-56. 2006

Research Grants

  1. PREDOCTORAL TRAINING IN NEUROBIOLOGY
    Louis Reichardt; Fiscal Year: 2007
  2. CORE--TRANSGENIC MICE
    Louis Reichardt; Fiscal Year: 2007

Detail Information

Publications61

  1. pmc Neurotrophin-regulated signalling pathways
    Louis F Reichardt
    Neuroscience Program, Department of Physiology and Howard Hughes Medical Institute, University of California San Francisco, 1550 Fourth Street, Rock Hall 284a, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 361:1545-64. 2006
    ....
  2. pmc Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development
    Jyothi Arikkath
    Department of Physiology, Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 29:5435-42. 2009
    ....
  3. pmc Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
    Amanda K Wiggins
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 167:257-67. 2004
    ..Together, these data indicate that HIPK2, through regulation of Brn3a-dependent gene expression, is a critical component in the transcriptional machinery that controls sensory neuron survival...
  4. pmc Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse
    Zhen Huang
    Department of Physiology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:11208-19. 2006
    ....
  5. pmc Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin
    Seung Hye Lee
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 183:893-908. 2008
    ..Our results indicate that a presynaptic signaling pathway through p120ctn, Fer, SHP-2, and beta-catenin promotes excitatory synapse development and function...
  6. pmc Vascular development of the brain requires beta8 integrin expression in the neuroepithelium
    John M Proctor
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:9940-8. 2005
    ....
  7. pmc BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactions
    Shernaz X Bamji
    Neuroscience Program, Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 174:289-99. 2006
    ..Together, this data demonstrates that the disruption of cadherin-beta-catenin complexes is an important molecular event through which BDNF increases synapse density in cultured hippocampal neurons...
  8. pmc Control of axonal branching and synapse formation by focal adhesion kinase
    Beatriz Rico
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 7:1059-69. 2004
    ..Thus, FAK functions as a negative regulator of axonal branching and synapse formation, and it seems to exert its actions, in part, through Rho family GTPases...
  9. pmc Retinal TrkB receptors regulate neural development in the inner, but not outer, retina
    Ruslan N Grishanin
    Neuroscience Program, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Mol Cell Neurosci 38:431-43. 2008
    ..We conclude that retinal BDNF/TrkB signaling has its primary role in the development of inner retinal neuronal circuits, and that this action is not a secondary effect due to the loss of visual signaling in the outer retina...
  10. pmc p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins
    Lisa P Elia
    Howard Hughes Medical Institute and Department of Physiology, 1550 Fourth Street, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 51:43-56. 2006
    ..Thus, p120ctn acts as a signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during spine and synapse development...
  11. pmc FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies
    Hilary E Beggs
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143, USA
    Neuron 40:501-14. 2003
    ..In addition, FAK is required within neurons during development because neuron-specific fak deletion alters dendritic morphology in the absence of lamination defects...
  12. pmc p120 catenin is required for normal renal tubulogenesis and glomerulogenesis
    DENISE K MARCIANO
    Department of Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:2099-109. 2011
    ..Taken together, our data show that p120ctn is required for early tubule and glomerular morphogenesis, as well as control of luminal diameter, probably through regulation of cadherins...
  13. pmc Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development
    Ainara Vallejo-Illarramendi
    Department of Physiology, UCSF, San Francisco, California 94158 2611, USA
    J Clin Invest 119:2218-30. 2009
    ..Our results indicate that FAK plays an essential role in cardiac outflow tract development by promoting the activation of molecules such as Crkl and Erk1/2...
  14. pmc Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior
    M Sloan Warren
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA
    J Neurosci 32:2824-34. 2012
    ....
  15. pmc The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression
    James M Linton
    Department of Physiology, 1550 Fourth Street, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 134:2501-9. 2007
    ..Our results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development...
  16. pmc Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
    Rickmer Braren
    The Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, Howard Hughes Medical Institute, San Francisco, CA 94143, USA
    J Cell Biol 172:151-62. 2006
    ..This study reveals that FAK is crucial for vascular morphogenesis and the regulation of EC survival and morphology...
  17. pmc Erbin controls dendritic morphogenesis by regulating localization of delta-catenin
    Jyothi Arikkath
    Department of Physiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 28:7047-56. 2008
    ..Knockdown of erbin results in alterations in localization of delta-catenin. These results suggest a critical role for erbin in regulating dendritic morphogenesis by maintaining appropriate localization of delta-catenin...
  18. pmc Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly
    Agnieszka Niewmierzycka
    Department of Pathology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:7022-31. 2005
    ..This study demonstrates a critical role for Ilk in cortical lamination and suggests that Ilk-associated pathways are involved in the pathogenesis of cobblestone lissencephalies...
  19. pmc TrkB (tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex
    Albert I Chen
    Department of Physiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 31:2769-80. 2011
    ..Thus, our findings demonstrate that TrkB controls the assembly and maintenance of GABAergic synapses and suggest that TrkB functions, in part, through promoting synaptic adhesion...
  20. pmc Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency
    Ania L Gheyara
    Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
    Am J Pathol 171:1966-77. 2007
    ..These findings resemble those seen in humans and mice lacking the alpha 7-integrin subunit and suggest that Ilk may act as a cytoplasmic effector of alpha 7 beta1-integrin in the pathogenesis of these deficiencies...
  21. pmc Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus
    Gerard M J Beaudoin
    Department of Physiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 32:99-110. 2012
    ..The remaining synapses appeared to function normally. Thus, afadin is a key intracellular signaling molecule for cadherin recruitment and is necessary for spine and synapse formation in vivo...
  22. doi request reprint Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex
    Gerard M J Beaudoin
    Department of Physiology, University of California San Francisco UCSF, San Francisco, California, USA
    Nat Protoc 7:1741-54. 2012
    ..The preparation of the glass substrate must begin 5 d before the culture. The dissection and plating out of neurons takes 3-4 h and neurons can be maintained in culture for up to 4 weeks...
  23. pmc Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β
    Thomas D Arnold
    Department of Pediatrics, VA Medical Center, University of California, San Francisco, San Francisco, California 95158, USA
    J Neurosci 32:1197-206. 2012
    ..Of special interest, the retinal vascular phenotypes observed in each mutant are remarkably similar to those of others following inhibition of neuropilin-1, a receptor previously implicated in TGFβ activation and signaling...
  24. pmc Brain-derived neurotrophic factor and TrkB modulate visual experience-dependent refinement of neuronal pathways in retina
    Xiaorong Liu
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:7256-67. 2007
    ..These experiments reveal a previously unrecognized action of BDNF and TrkB in controlling cell-specific, experience-dependent remodeling of neuronal structures in the visual system...
  25. pmc TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells
    Ursula Funfschilling
    Program in Neuroscience, Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143 0723, USA
    J Comp Neurol 480:392-414. 2004
    ..Many types of nonneuronal cells affiliated with hair follicles and blood vessels also express TrkC-reporter but lack immunodetectable TrkC...
  26. pmc Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity
    Jyothi Arikkath
    Department of Physiology, University of California San Francisco, Rock Hall, Room 284A, Mission Bay, 1550 Fourth Street, San Francisco, CA 94158 2611, USA
    Trends Neurosci 31:487-94. 2008
    ..These exciting discoveries provide insights into novel functional roles of the complex beyond regulating cell adhesion...
  27. pmc Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
    Baoji Xu
    Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    Nat Neurosci 6:736-42. 2003
    ..These results show that MC4R signaling controls BDNF expression in the VMH and support the hypothesis that BDNF is an important effector through which MC4R signaling controls energy balance...
  28. pmc Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice
    Mark A Travis
    Lung Biology Center, Department of Medicine, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA
    Nature 449:361-5. 2007
    ....
  29. pmc N- and C-terminal domains of beta-catenin, respectively, are required to initiate and shape axon arbors of retinal ganglion cells in vivo
    Tamira M Elul
    Department of Physiology, University of California San Francisco, San Francisco, California 94143, USA
    J Neurosci 23:6567-75. 2003
    ....
  30. pmc Transcriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis Via TGF-β-TAK1-Dependent Mechanism
    Yulei Shang
    Department of Pathology, University of California San Francisco, San Francisco, California, United States of America Pathology Service 113B, VA Medical Center, San Francisco, California, United States of America
    PLoS Biol 11:e1001527. 2013
    ..Our results reveal a previously unrecognized role of HIPK proteins in connecting TGF-β signaling pathway with the transcriptional programs critical for angiogenesis in early embryonic development...
  31. pmc Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
    Shernaz X Bamji
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:719-31. 2003
    ..This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion...
  32. pmc TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum
    Beatriz Rico
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, California 94143, USA
    Nat Neurosci 5:225-33. 2002
    ..Thus, TrkB is essential to the development of GABAergic neurons and regulates synapse formation in addition to its role in the development of axon terminals...
  33. pmc A novel method that improves sensitivity of protein detection in PAGE and Western blot
    Ainara Vallejo-Illarramendi
    Department of Physiology, University of California, San Francisco, CA, USA
    Electrophoresis 34:1148-50. 2013
    ..As a result, less protein is required for loading and signal detection. Our protocol is a straightforward modification of a standard experimental technique, and is especially useful when only limited sample quantities are available...
  34. ncbi request reprint Going the distance, or not, with neurotrophin signals
    Louis F Reichardt
    Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, 1550 Fourth Street, Room 284A, San Francisco, CA 94143, USA
    Cell 118:141-3. 2004
    ..In this issue of Cell, the difference is explained as the ability of NGF, but not NT-3, to induce internalization and retrograde transport of activated TrkA...
  35. ncbi request reprint Trk receptors: roles in neuronal signal transduction
    Eric J Huang
    Department of Pathology, University of California Veterans Administration Medical Center, San Francisco, California 94143, USA
    Annu Rev Biochem 72:609-42. 2003
    ..p75NTR also influences the conformations of Trk receptors; this modifies ligand-binding specificity and affinity with important developmental consequences...
  36. pmc The origin recognition core complex regulates dendrite and spine development in postmitotic neurons
    Zhen Huang
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 170:527-35. 2005
    ..Expression of ORC ATPase motif mutants enhanced the branching of dendritic arbors. The ORC core complex thus appears to have a novel role in regulating dendrite and dendritic spine development in postmitotic neurons...
  37. pmc Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons
    Phu V Tran
    Department of Physiology, University of California, San Francisco, 94143 0444, USA
    Mol Cell Neurosci 22:441-53. 2003
    ..Our findings demonstrate that SF-1 is required for terminal differentiation of the VMN and suggest that transcriptional targets of SF-1 mediate normal circuitry between the hypothalamus and limbic structures in the telencephalon...
  38. pmc Methods for identifying novel integrin ligands
    DENISE K MARCIANO
    Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, California, USA
    Methods Enzymol 426:223-37. 2007
    ..These methods are applicable for studies on a variety of integrins, and may be extended to other cell surface receptors as well...
  39. pmc Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration
    Matthias Hebrok
    Diabetes Center and Department of Medicine, University of California, San Francisco, USA
    Trends Cell Biol 14:153-5. 2004
    ..Data also indicate that alpha3beta1 mediates HGF-stimulated cell migration on netrin-coated substrata. These results indicate that netrins might have much broader functions than previously suspected...
  40. pmc beta8 integrins are required for vascular morphogenesis in mouse embryos
    Jiangwen Zhu
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 129:2891-903. 2002
    ..This study thus identifies a molecule crucial for vascular patterning in embryonic yolk sac and brain...
  41. pmc Cre-mediated recombination in rhombic lip derivatives
    Ursula Funfschilling
    Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, California 94141 0723, USA
    Genesis 33:160-9. 2002
    ..No recombination occurred in any of the interneurons in the cerebellum (stellate cells, basket cells, and Golgi cells), consistent with the hypothesis that they are not derived from the same embryonic tissue as the granule cells...
  42. pmc Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons
    M Laura Feltri
    Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Cell Biol 156:199-209. 2002
    ....
  43. pmc Trafficking of TrkA-green fluorescent protein chimerae during nerve growth factor-induced differentiation
    Jerome Jullien
    Differentiation and Cell Cycle Group, Laboratoire de Biologie Moleculaire et Cellulaire, UMR 5665 CNRS, Ecole Normale Superieure de Lyon, France
    J Biol Chem 278:8706-16. 2003
    ..This approach and the fidelity of the biochemical properties of the TrkA-GFP demonstrate that real-time visualization of trafficking of tyrosine kinase receptors in the presence or absence of the ligand is feasible...
  44. ncbi request reprint Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance
    Bernd Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Prog Brain Res 146:265-78. 2004
    ..Indeed, BDNF may be one of the earliest genes expressed selectively in hair cells and it appears to be regulated somewhat independently of the genes needed for hair cell differentiation...
  45. pmc Beta1-integrins are critical for cerebellar granule cell precursor proliferation
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:3402-12. 2004
    ....
  46. pmc Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate
    Aziz Moqrich
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Neurosci 7:812-8. 2004
    ..The surviving presumptive TrkA-expressing neurons adopted a proprioceptive phenotype, indicating that neurotrophin signaling can specify sensory neuron subtypes...
  47. pmc Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction
    Guofa Liu
    Department of Anatomy, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    Nat Neurosci 7:1222-32. 2004
    ..Our results show the biochemical and functional links between netrin, a prototypical neuronal guidance cue, and FAK, a central player in intracellular signaling that is crucial for cell migration...
  48. pmc Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics
    Markus Schober
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 176:667-80. 2007
    ..We show that, together, these FAK-dependent activities are critical to control the turnover of focal adhesions, which is perturbed in the absence of FAK...
  49. pmc Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment
    Zeenat S Hakim
    Department of Pathology and Carolina Cardiovascular Biology Center, 501 Brinkhous Bullitt Bldg CB 7525, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 27:5352-64. 2007
    ..Future studies will be necessary to determine the precise contributions of the additional nkx2-5-derived lineages to the phenotypes observed...
  50. pmc NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes
    Jonah R Chan
    Department of Neurobiology, Stanford University School of Medicine, Fairchild Science Building D235, CA 94305, USA
    Neuron 43:183-91. 2004
    ..These findings indicate a novel role for growth factors in regulating the receptivity of axons to myelination and reveal that different axonal signals control central and peripheral myelination...
  51. ncbi request reprint Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells
    Robert W Tilghman
    Department of Microbiology, University of Virginia Health System, Charlottesville, 22908, USA
    J Cell Sci 118:2613-23. 2005
    ..These data are consistent with a role for FAK in regulating the formation of a leading edge during cell migration by coordinating integrin signaling to direct the correct spatial activation of membrane protrusion...
  52. ncbi request reprint EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation
    Michael L Moeller
    Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521, USA
    J Biol Chem 281:1587-98. 2006
    ..These data suggest that EphB receptors are upstream regulators of FAK in dendritic filopodia and that FAK-mediated RhoA activation contributes to assembly of actin filaments in dendritic spines...
  53. pmc Functionally intact glutamate-mediated signaling in bipolar cells of the TRKB knockout mouse retina
    Baerbel Rohrer
    Department of Ophthalmology, Medical University of South Carolina, Charlston, SC 29425, USA
    Vis Neurosci 21:703-13. 2004
    ..These data indicate that there does not appear to be evidence for postsynaptic deficits in glutamatergic signaling in the ON and OFF bipolar cells of mice lacking trkB...
  54. pmc Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy
    Laura A DiMichele
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Circ Res 99:636-45. 2006
    ....
  55. pmc Studies on integrins in the nervous system
    Sumiko Denda
    Shiseido Research Center 2, Kanazawa Ku, Yokohama, Japan
    Methods Enzymol 426:203-21. 2007
    ..2006). In this chapter, we describe methods used in our laboratory to characterize neuronal responses to extracellular matrix proteins, and procedures for assessing integrin roles in neuronal cell attachment and differentiation...
  56. pmc Molecular kinetics of nerve growth factor receptor trafficking and activation
    Jerome Jullien
    Differentiation and Cell Cycle Group, Laboratoire de Biologie Moleculaire et Cellulaire, CNRS UMR 5665, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Biol Chem 277:38700-8. 2002
    ..Together, these data show that the primary effect of NGF treatment is a p75(NTR)-modulated decrease in TrkA transit time at the cell surface...
  57. pmc Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development
    Julia Mills
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
    J Neurosci 26:830-40. 2006
    ..Together, these results implicate ILK as a critical effector in a signaling pathway necessary for granule cell proliferation and cerebellar development...
  58. pmc Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation
    Sujata Lakhe-Reddy
    Department of Medicine, Case Western Reserve University School of Medicine, Rammelkamp Center for Education and Research, MetroHealth Medical Center, Cleveland, Ohio 44109, USA
    J Biol Chem 281:19688-99. 2006
    ....
  59. ncbi request reprint Neurobiology: signals that make waves
    Louis F Reichardt
    Nature 426:25-6. 2003
  60. pmc Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cells
    Laurens W J Bosman
    Institut für Neurowissenschaften, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802, Munchen, Germany
    Brain Cell Biol 35:87-101. 2006
    ..Thus, our results demonstrate an involvement of TrkB receptors in synapse elimination and reveal a new role for receptor tyrosine kinases in the brain...
  61. pmc Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC
    Katharine M Cronk
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Development 129:3739-50. 2002
    ..Therefore, truncated trkC plays a more important role in the development of this innervation than kinase forms of trkA or trkC or of NT3, the only known ligand for trkC receptors...

Research Grants2

  1. PREDOCTORAL TRAINING IN NEUROBIOLOGY
    Louis Reichardt; Fiscal Year: 2007
    ..Our goal is to facilitate the intellectual growth and development of scientific skills of new investigators committed to solving major problems in Neuroscience and to making positive contributions to education in the 21st Century. ..
  2. CORE--TRANSGENIC MICE
    Louis Reichardt; Fiscal Year: 2007
    ..The Reichardt laboratory will provide the supervision and expertise for setting up and managing this facility under the overall guidance of the Principal Investigator. ..