Research Topics
| Alnawaz RehemtullaSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Overcoming intratumor heterogeneity of polygenic cancer drug resistance with improved biomarker integrationAlnawaz Rehemtulla
Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
Neoplasia 14:1278-89. 2012....- The interconnectedness of cancer cell signalingAlnawaz Rehemtulla
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
Neoplasia 13:1183-93. 2011..This article reflects on historical advances and the role of innovation in the competitive world of grant-sponsored research... - Novel molecular imaging platform for monitoring oncological kinasesShyam Nyati
Department of Radiation Oncology, University of Michigan, Ann Arbor MI 48109 USA
Cancer Cell Int 10:23. 2010..Such reporter system provides unique insights into the pharmacokinetics and pharmacodynamics of drugs that modulate kinase signaling and have a huge potential in drug discovery, validation, and drug-target interactions... 
Bioluminescence detection of cells having stabilized p53 in response to a genotoxic eventAlnawaz Rehemtulla
Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor 48109, USA
Mol Imaging 3:63-8. 2004..It could also be used to study p53 stabilization as a result of inactivating p53 mutations. Such studies will further our understanding of p53's role as the "guardian of the genome" and its function in tumorigenesis...- Extracellular expression of cytosine deaminase results in increased 5-FU production for enhanced enzyme/prodrug therapyAlnawaz Rehemtulla
The Department of Radiation Oncology, The University of Michigan Medical Center, Ann Arbor, MI 48109 0582, USA
Anticancer Res 24:1393-9. 2004.... - The War on Cancer rages onAlnawaz Rehemtulla
Department of Radiation Oncology and Radiology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Neoplasia 11:1252-63. 2009..This article briefly looks back at the progress that has been made in cancer research and compares progress made in other areas of human affliction. While progress has indeed been made, the battle continues to rage on... - A caspase-resistant form of Bcl-X(L), but not wild type Bcl-X(L), promotes clonogenic survival after ionizing radiationA Rehemtulla
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor 48109, USA
Neoplasia 1:63-70. 1999..These results provide a molecular basis for the observation that expression of Bcl-2 or Bcl-X(L) is not a prognostic marker of tumor response to cancer therapy... - Dinosaurs and ancient civilizations: reflections on the treatment of cancerAlnawaz Rehemtulla
Department of Radiation Oncology and Radiology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Neoplasia 12:957-68. 2010..This article reflects on the history of cancer and the progress made following the initiation of the "era of cancer chemotherapy.".. - Neoplasia: the second decadeAlnawaz Rehemtulla
University of Michigan, Ann Arbor, MI 48109 2200, USA
Neoplasia 10:1314-24. 2008..This past year, Neoplasia received a record number of articles for review and has had a 21% increase in the number of published articles... - A review of the past, present, and future directions of neoplasiaAlnawaz Rehemtulla
University of Michigan Medical Center, Ann Arbor, MI 48109-0582, USA
Neoplasia 7:1039-46. 2005 - A transgenic mouse for imaging caspase-dependent apoptosis within the skinDivya Khanna
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
J Invest Dermatol 130:1797-806. 2010..This reporter and transgenic mouse could serve as a unique tool for the study of apoptosis in living cells and animals, especially in the context of skin biology... - Molecular imaging of gene expression and efficacy following adenoviral-mediated brain tumor gene therapyAlnawaz Rehemtulla
University of Michigan School of Medicine, USA
Mol Imaging 1:43-55. 2002.... - Vascular targeted nanoparticles for imaging and treatment of brain tumorsG Ramachandra Reddy
Molecular Therapeutics, Inc, Ann Arbor, MI 48109, USA
Clin Cancer Res 12:6677-86. 2006..CONCLUSIONS: This study reveals the versatility and efficacy of the multifunctional nanoparticle for the targeted detection and treatment of cancer... - Sodium and proton diffusion MRI as biomarkers for early therapeutic response in subcutaneous tumorsVictor D Schepkin
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109 0503, USA
Magn Reson Imaging 24:273-8. 2006..The results of this study support the continued clinical testing of diffusion MRI for evaluation of early tumor treatment response and demonstrate the complementary insights of sodium MRI for oncology applications... - Parametric response map as an imaging biomarker to distinguish progression from pseudoprogression in high-grade gliomaChristina Tsien
Department of Radiation Oncology, University of Michigan Medical Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
J Clin Oncol 28:2293-9. 2010..To assess whether a new method of quantifying therapy-associated hemodynamic alterations may help to distinguish pseudoprogression from true progression in patients with high-grade glioma... - Molecular imaging of Akt kinase activityLimin Zhang
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Med 13:1114-9. 2007..The results provide unique insights into the pharmacokinetics and pharmacodynamics of agents that modulate Akt activity, revealing the usefulness of this reporter for rapid dose and schedule optimization in the drug development process... - The parametric response map is an imaging biomarker for early cancer treatment outcomeCraig J Galban
Departments of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, USA
Nat Med 15:572-6. 2009..Even when accounting for baseline rCBV, which is prognostic, PRM(rCBV) proved more predictive of overall survival... - Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer modelMing Zhang
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 63:658-63. 2003..Such tumor-specific expression should prove useful in colorectal cancer gene therapy to achieve selective prodrug conversion in tumors... 
DCE and DW-MRI monitoring of vascular disruption following VEGF-Trap treatment of a rat glioma modelBenjamin A Hoff
Department of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, MI 48109, USA
NMR Biomed 25:935-42. 2012..Histological findings were found to support imaging response metrics. In conclusion, kinetic MRI parameters and change in ADC have been found to serve as sensitive and early biomarkers of VEGF-Trap anti-vascular targeted therapy...- The functional diffusion map: an imaging biomarker for the early prediction of cancer treatment outcomeBradford A Moffat
Center for Molecular Imaging, Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109-0648, USA
Neoplasia 8:259-67. 2006..Therefore, The fDM imaging biomarker for early prediction of treatment efficacy can be used in the drug development process... - Functional diffusion map as an early imaging biomarker for high-grade glioma: correlation with conventional radiologic response and overall survivalDaniel A Hamstra
University of Michigan, B2A209 UH 1500 East Medical Center Dr, Ann Arbor, MI 48109 0030, USA
J Clin Oncol 26:3387-94. 2008..Diffusion magnetic resonance imaging (MRI) using a functional diffusion map (fDM) may provide an earlier measure to predict patient survival... - Molecular imaging of N-linked glycosylation suggests glycan biosynthesis is a novel target for cancer therapyJoseph N Contessa
Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan, USA
Clin Cancer Res 16:3205-14. 2010..We therefore investigated the feasibility of blocking NLG in vivo to reduce overexpression of RTKs... - Intravoxel water diffusion heterogeneity imaging of human high-grade gliomasThomas C Kwee
Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
NMR Biomed 23:179-87. 2010..The observed negative correlation between tumor alpha and tumor DDC requires further investigation... - A novel kinase inhibitor of FADD phosphorylation chemosensitizes through the inhibition of NF-κBKatrina A Schinske
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
Mol Cancer Ther 10:1807-17. 2011..In addition, the presented results provide proof-of-principle studies as to the validity of targeting FADD-kinase activity as a novel cancer therapy strategy... - Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomasThomas C Kwee
Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Magn Reson Imaging 31:531-7. 2010..To compare apparent diffusion coefficients (ADCs) with distributed diffusion coefficients (DDCs) in high-grade gliomas... - An imaging biomarker of early treatment response in prostate cancer that has metastasized to the boneKuei C Lee
Department of Radiology, and Center for Molecular Imaging, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Cancer Res 67:3524-8. 2007..Validation of fDM results was accomplished by histologic analysis of excised tissue. Results from this study show the capability of fDM as a biomarker for detection of bone cancer treatment efficacy, thus warranting clinical evaluation... - Evaluation of treatment-associated inflammatory response on diffusion-weighted magnetic resonance imaging and 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging biomarkersCraig J Galban
Center for Molecular Imaging and Departments of Radiology, University of Michigan, School of Medicine, Ann Arbor, Michigan 48109 0220, USA
Clin Cancer Res 16:1542-52. 2010.... - Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-DBradford A Moffat
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, Michigan 48109 0503, USA
Clin Cancer Res 12:1525-32. 2006..The aim of this study was to evaluate the effect of VEGF-A expression on tumor growth, perfusion, and chemotherapeutic efficacy in orthotopic 9L gliosarcomas... - Prospective analysis of parametric response map-derived MRI biomarkers: identification of early and distinct glioma response patterns not predicted by standard radiographic assessmentCraig J Galban
Department of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, Michigan 48109, USA
Clin Cancer Res 17:4751-60. 2011..Our study assessed the effectiveness of the parametric response map (PRM) imaging biomarker to provide for an earlier measure of patient survival prediction... - Dynamic imaging of emerging resistance during cancer therapyKuei C Lee
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Res 66:4687-92. 2006..Overall, this study highlights the ability of diffusion MRI to provide sensitive dynamic assessment of therapy-induced response, allowing early opportunities for optimization of therapeutic protocols... - Pharmacokinetic analysis and phase 1 study of MRX-1024 in patients treated with radiation therapy with or without cisplatinum for head and neck cancerDaniel A Hamstra
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 5010, USA
Clin Cancer Res 16:2666-76. 2010..A previous study reported radiation protection from mucosal injury with D-methionine (D-met) in preclinical evaluation; therefore, the pharmacokinetics, safety, and utility of D-met were evaluated clinically... - The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapiesDaniel A Hamstra
Department of Radiation Oncology, The University of Michigan Medical Center, Ann Arbor 48109 0582, USA
Mol Ther 10:916-28. 2004.... - Noninvasive molecular imaging sheds light on the synergy between 5-fluorouracil and TRAIL/Apo2L for cancer therapyKuei C Lee
Department of Biological Chemistry, The University of Michigan Medical Center, Ann Arbor, MI 48109 0582, USA
Clin Cancer Res 13:1839-46. 2007.... - Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade gliomaDaniel A Hamstra
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109-0648, USA
Proc Natl Acad Sci U S A 102:16759-64. 2005..Further evaluation of this technique is warranted to determine whether it may be useful in the individualization of treatment or evaluation of the response in clinical protocols... - Sodium magnetic resonance imaging of chemotherapeutic response in a rat gliomaVictor D Schepkin
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Kresge II Research Building, R3028, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Magn Reson Med 53:85-92. 2005..This study demonstrates the possibility of Na MRI to function as a biomarker for monitoring early tumor treatment and validates the use of monitoring changes in diffusion MRI values for assessing tumor cellularity... - DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastomaStefanie Galban
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 7:e35857. 2012..DW-MRI provided early changes to radiosensitization treatment warranting evaluation of this imaging biomarker in clinical trials... - A feasibility study evaluating the functional diffusion map as a predictive imaging biomarker for detection of treatment response in a patient with metastatic prostate cancer to the boneKuei C Lee
Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Neoplasia 9:1003-11. 2007..Thus, the fDM imaging biomarker may provide a quantifiable therapeutic endpoint to assess response in patients with metastatic bone cancer... - Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor responseBradford A Moffat
Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 102:5524-9. 2005..Overall, fDM analysis provided an early biomarker for predicting treatment response in brain tumor patients... - Assessment of multiexponential diffusion features as MRI cancer therapy response metricsBenjamin A Hoff
Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Magn Reson Med 64:1499-509. 2010.... - Therapeutic efficacy of DTI-015 using diffusion magnetic resonance imaging as an early surrogate markerDaniel E Hall
University of Michigan, Center for Molecular Imaging and Department of Radiology, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0648, USA
Clin Cancer Res 10:7852-9. 2004.... - Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancerTerence M Williams
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Mol Cancer Ther 11:1193-202. 2012..These results provide rationale for further testing of a treatment regimen in pancreatic cancer that combines MEK inhibition with radiation, optimally in conjunction with Akt inhibition... - Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapyKuei C Lee
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Biomedical Sciences Research Building, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Clin Cancer Res 13:443-50. 2007..In this study, we evaluate the feasibility of using diffusion magnetic resonance imaging (MRI) as a reliable and quantitative measure for the early assessment of response in a breast cancer model... - Enhancing Akt imaging through targeted reporter expressionLimin Zhang
Department of Radiation Oncology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA
Mol Imaging 7:168-74. 2008..Based on these results, we propose that the membrane-associated Akt reporter may be better suited for identification of novel compounds that modulate the Akt pathway by high-throughput screening... - Synthesis and investigation of a radioiodinated F3 peptide analog as a SPECT tumor imaging radioligandMahaveer S Bhojani
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 6:e22418. 2011..These studies demonstrate a potential utility of F3 peptide-based radioligands for tumor imaging with PET or SPECT techniques... - Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor--a pharmacokinetic studyDaniel A Hamstra
The Department of Radiation, The University of Michigan Medical Center, Ann Arbor, MI 48109-0648, USA
J Neurooncol 73:225-38. 2005.... - Voxel-by-voxel functional diffusion mapping for early evaluation of breast cancer treatmentBing Ma
Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA
Inf Process Med Imaging 21:276-87. 2009..Comparison of the experimental results with pathology shows that ADC changes can be used to evaluate early response of breast cancer treatment... - A small-molecule furin inhibitor inhibits cancer cell motility and invasivenessJulia M Coppola
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 10:363-70. 2008..Additionally, this molecule inhibited proMT1-MMP processing, complete MMP-2 maturation, and invasiveness of human fibrosarcoma cells (HT1080)... - Radiosynthesis and evaluation of 5-[125I]iodoindol-3-yl-beta-D-galactopyranoside as a beta-galactosidase imaging radioligandMarcian E Van Dort
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
Mol Imaging 7:187-97. 2008.... - Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imagingDaniel A Hamstra
Department of Radiation Oncology, University of Michigan Medical Center, 1331 East Ann Street, Ann Arbor, MI 48109, USA
Cancer Res 66:7482-9. 2006..In addition, the kinetics of oscillations were altered by pretreatment with radiation-modifying agents. These results show the use of this mouse model in enhancing our understanding of the transcriptional role of p53 in vivo... - A methodology for registration of a histological slide and in vivo MRI volume based on optimizing mutual informationCharles R Meyer
University of Michigan, Ann Arbor, USA
Mol Imaging 5:16-23. 2006..Overall, this approach provides a robust method for coregistration of in vivo images with histological sections and will have broad applications in the field of functional and molecular imaging... - Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cellsJoseph N Contessa
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
Cancer Res 68:3803-9. 2008..This study provides evidence that enzymatic steps regulating N-linked glycosylation are novel targets for developing approaches to sensitize tumor cells to cytotoxic therapies... - Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancerMahaveer S Bhojani
Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0648, USA
Cell Cycle 4:1478-81. 2005..These results suggest that levels of p-FADD may be used as a prognostic biomarker for predicting survival of lung cancer patients... - Diffusion coefficient measurement using a temperature-controlled fluid for quality control in multicenter studiesThomas L Chenevert
Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
J Magn Reson Imaging 34:983-7. 2011..Validating imaging biomarkers through multicenter trials requires calibration and performance testing across sites... - Noninvasive real-time imaging of apoptosisBharathi Laxman
Center for Molecular Imaging, University of Michigan Medical School, 1150 West Medical Center Drive, Medical Sciences Research Building III, Room 9303, Ann Arbor, MI 48109-0648, USA
Proc Natl Acad Sci U S A 99:16551-5. 2002.... - Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small moleculesTomoko Komiyama
Departments of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0606, USA
J Biol Chem 284:15729-38. 2009.... - Diffusion MRI: a new strategy for assessment of cancer therapeutic efficacyThomas L Chenevert
Department of Radiology, Center for Molecular Imaging, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0030, USA
Mol Imaging 1:336-43. 2002.... - Imaging of proteolytic activity using a conditional cell surface receptorMahaveer Swaroop Bhojani
University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Mol Imaging 5:129-37. 2006..This methodology may provide for a multimodal noninvasive real-time imaging of apoptosis and a new opportunity for high-throughput screening of cell-death-modulating therapeutic agents... - A feasibility study of parametric response map analysis of diffusion-weighted magnetic resonance imaging scans of head and neck cancer patients for providing early detection of therapeutic efficacyCraig J Galban
The University of Michigan Medical School, Ann Arbor, MI, USA
Transl Oncol 2:184-90. 2009..Observations from this study have found that diffusion MRI, when assessed by PRM(ADC), has the potential to provide both prognostic and spatial information during NSOPT of head and neck cancer... - A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRIBradford A Moffat
University of Michigan, Ann Arbor, USA
Mol Imaging 2:324-32. 2003..The flexible formulation of these nanoparticles suggests that future modifications could be accomplished allowing for their use as a targeted molecular imaging contrast agent and/or therapeutic platform for multiple indications... - Evaluation of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRIBrian D Ross
Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI 48109, USA
NMR Biomed 16:67-76. 2003.... - Continuous arterial spin labeling using a train of adiabatic inversion pulsesBradford A Moffat
Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
J Magn Reson Imaging 21:290-6. 2005.... - Evaluation of D-methionine as a novel oral radiation protector for prevention of mucositisSaleha B Vuyyuri
Departments of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
Clin Cancer Res 14:2161-70. 2008..D-Methionine (D-Met), the dextro-isomer of the common amino acid l-methionine, has been documented to protect normal tissues from a diverse array of oxidative insults... - Noninvasive imaging of apoptosis and its application in cancer therapeuticsJulia M Coppola
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Clin Cancer Res 14:2492-501. 2008..Noninvasive imaging of apoptosis facilitates optimization of therapeutic protocols regarding dosing and schedule and enables identification of efficacious combination therapies... - Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of gliomaPatrick McConville
MIR Preclinical Services, Inc, Ann Arbor, Michigan, USA
Clin Cancer Res 13:2897-904. 2007..The nestin tv-a (Ntv-a) genetically engineered mouse spontaneously develops glioma when infected with ALV-A expressing platelet-derived growth factor, resulting in autocrine platelet-derived growth factor signaling... - Diffusion-weighted MRI for assessment of early cancer treatment responseStefanie Galban
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
Curr Pharm Biotechnol 11:701-8. 2010..The utility of DW-MRI for assessing therapeutic-induced response is further evaluated on tumors residing in the brain, head and neck and bone... - Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapyYong Eun Lee Koo
University of Michigan, Michigan 48109, USA
Appl Opt 46:1924-30. 2007.... - High and selective expression of yeast cytosine deaminase under a carcinoembryonic antigen promoter-enhancerMukesh K Nyati
Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0010, USA
Cancer Res 62:2337-42. 2002..These findings suggest that the CEA promoter-enhancer strategy confers specificity while preserving activity and is worth exploring in additional animal and, potentially, clinical trials... - AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonistDaniel R Rhodes
Michigan Center for Translational Pathology, Howard Hughes Medical Institute, and Departments of Urology, and Pathology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, MI 48109 5602
Proc Natl Acad Sci U S A 106:10284-9. 2009..Taken together, these observations indicate that marked AGTR1 overexpression defines a subpopulation of ER-positive, ERBB2-negative breast cancer that may benefit from targeted therapy with AGTR1 antagonists, such as losartan... - Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomasGuoan Chen
Departments of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 102:12507-12. 2005.... - In vivo visualization of metastatic prostate cancer and quantitation of disease progression in immunocompromised miceLinda M Kalikin
Department of Urology, Division of Hematology and Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0946, USA
Cancer Biol Ther 2:656-60. 2003..This model provides a controllable biological system for further investigation into the pathogenesis of metastatic prostate cancer and evaluation of new therapies... - Diffusion magnetic resonance imaging: a biomarker for treatment response in oncologyDaniel A Hamstra
Department of Radiation Oncology, The Center for Molecular Imaging, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
J Clin Oncol 25:4104-9. 2007..This review highlights the development of this technique and the state of current clinical understanding of its utility... - Ultraviolet radiation-induced apoptosis is mediated by DaxxShiyong Wu
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neoplasia 4:486-92. 2002..These results suggest that UV-induced JNK activation is not sufficient but required for induction of apoptosis... - Lack of functional pRb results in attenuated recovery of mRNA synthesis and increased apoptosis following UV radiation in human breast cancer cellsChristine A Billecke
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109, USA
Oncogene 21:4481-9. 2002..Inactivation of pRb may contribute to an increased sensitivity to UV radiation by attenuating repair of DNA lesions and recovery of mRNA synthesis following UV radiation... - Brain cancer diagnosis and therapy with nanoplatformsYong-Eun Lee Koo
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
Adv Drug Deliv Rev 58:1556-77. 2006..The advantages of nanoparticle-based delivery and the types of nanoparticle systems under investigation are described, as well as their applications... - Identification of peptides that bind to irradiated pancreatic tumor cellsCanhui Huang
Department of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, MI 48109-0010, USA
Int J Radiat Oncol Biol Phys 62:1497-503. 2005..CONCLUSION: These data suggest that peptides can be identified that target tumors with radiation-induced cell markers and may be clinically useful... - Evaluation of cancer therapy using diffusion magnetic resonance imagingBrian D Ross
University of Michigan Medical School, Ann Arbor, Michigan 48109-0648, USA
Mol Cancer Ther 2:581-7. 2003..This article provides an overview of the use of diffusion magnetic resonance imaging as a surrogate marker for quantitating treatment responsiveness in both preclinical and clinical studies... - Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activityJulia M Coppola
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Anal Biochem 364:19-29. 2007..In conclusion, we describe a customizable noninvasive technology for real-time assessment of Golgi protease activity used to identify inhibitors of furin and BACE... - Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistanceVictor D Schepkin
National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310, USA
NMR Biomed 19:1035-42. 2006..Overall, these experiments demonstrate the sensitivity and applicability of sodium and diffusion MRI as tools for dynamic assessment of tumor response to therapy... - CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculatureZhenhua Miao
ChemoCentryx, Inc, Mountain View, CA 94043, USA
Proc Natl Acad Sci U S A 104:15735-40. 2007..Taken together, these data suggest that CXCR7 has key functions in promoting tumor development and progression... - Development of a hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapyDongfang Wang
Brain Tumor Research Center of the Department of Neurological Surgery, University of California, San Francisco, California 94143-0520, USA
Cancer Gene Ther 12:276-83. 2005..If this construct exhibits antitumor efficacy in vivo, it may have promise as an antitumor agent in humans... - TRAIL and anti-tumor responsesMahaveer Swaroop Bhojani
Center for Molecular Imaging, Departments of Radiology, University of Michigan Ann Arbor, Michigan 48109 0648, USA
Cancer Biol Ther 2:S71-8. 2003..Only time will tell whether the search for the Holy Grail for treatment of cancer will end with TRAIL?.. - Synthesis and characterization of silica-embedded iron oxide nanoparticles for magnetic resonance imagingFei Yan
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA
J Nanosci Nanotechnol 4:72-6. 2004..The design of the nanoparticle is universal and flexible and allows for facile addition or interchange of its active components (i.e., MRI contrast agents and targeting moiety) with photodynamic dyes...
Research Grants
- Molecular Imaging of Phospho-FADD and its role in resistance to therapyAlnawaz Rehemtulla; Fiscal Year: 2007....
- Molecular Imaging of Phospho-FADD and its role in resistance to therapyAlnawaz Rehemtulla; Fiscal Year: 2010....