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Bowman B, Sebolt K, Hoff B, Boes J, Daniels D, Heist K, et al. Phosphorylation of FADD by the kinase CK1Î± promotes KRASG12D-induced lung cancer. Sci Signal. 2015;8:ra9 pubmed publisher
..This interaction was decreased in cells treated with a CKI-7, a CK1Î± inhibitor. Therefore, as the kinase that phosphorylates FADD downstream of RAS, CK1Î± may be a therapeutic target for KRAS-driven lung cancer. ..