Research Topics
| William F RegineSummaryAffiliation: University of Maryland Country: USA Publications
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Detail Information
Publications
Recursive partitioning analysis classifications I and II: applicability evaluated in a randomized trial for resected single brain metastasesWilliam F Regine
Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA
Am J Clin Oncol 27:505-9. 2004..An analysis of a previously published randomized trial was performed to determine the applicability of these RPA prognostic classes in the setting of resection of single metastases to the brain...
Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trialWilliam F Regine
Department of Radiation Oncology, University of Maryland Medical Center, Baltimore 21030, USA
JAMA 299:1019-26. 2008..Among patients with locally advanced metastatic pancreatic adenocarcinoma, gemcitabine has been shown to improve outcomes compared with fluorouracil...- Adjuvant therapy for pancreatic cancer: current status, future directionsWilliam F Regine
Department of Radiation Oncology, University of Maryland Medical Center, Baltimore MD 21201, USA
Semin Oncol 33:S10-3. 2006..Just cause for optimism exists, but much work remains to be done. New adjuvant therapies need to be developed and tested, in carefully designed, well-executed, efficient clinical trials... - Low-dose radiotherapy as a chemopotentiator of gemcitabine in tumors of the pancreas or small bowel: a phase I study exploring a new treatment paradigmWilliam F Regine
Department of Radiation Oncology, University of Maryland, Baltimore, MD, USA
Int J Radiat Oncol Biol Phys 68:172-7. 2007..To determine the maximum tolerated dose of upper abdominal low-dose fractionated radiotherapy (<1.0 Gy per fraction) given in combination with, and as a chemopotentiator for, gemcitabine... 
Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U.S. Intergroup/RTOG 9704 phase III trialWilliam F Regine
Department of Radiation Oncology, University of Maryland, Baltimore, MD, USA
Ann Surg Oncol 18:1319-26. 2011..The impact of the addition of gemcitabine to 5-fluorouracil (5-FU) chemoradiation (CRT) on 5-year overall survival (OS) in resected pancreatic adenocarcinoma are presented with updated results of a phase III trial...- Long-term results of hyperfractionated radiation and high-dose intraarterial cisplatin for unresectable oropharyngeal carcinomaPaul M Spring
Division of Otolaryngology Head and Neck Surgery, University of Kentucky Chandler Medical Center, Lexington, Kentucky, USA
Cancer 104:1765-71. 2005.... - Failure to adhere to protocol specified radiation therapy guidelines was associated with decreased survival in RTOG 9704--a phase III trial of adjuvant chemotherapy and chemoradiotherapy for patients with resected adenocarcinoma of the pancreasRoss A Abrams
Department of Radiation Oncology, Rush University Medical Center, Chicago, IL 60612, USA
Int J Radiat Oncol Biol Phys 82:809-16. 2012..5FU-RT treatment was preceded and followed by randomly assigned chemotherapy, either 5-FU or gemcitabine. This analysis explored whether failure to adhere to specified RT guidelines influenced survival and/or toxicity... - A phase II study of concomitant hyperfractionated radiation therapy and double dose intra-arterial cisplatin for squamous cell carcinoma of the head and neckWilliam F Regine
University of Kentucky, Department of Radiation Medicine, 800 Rose Street, Lexington, KY 40536 0293, USA
Technol Cancer Res Treat 1:133-40. 2002..Future investigation of this novel treatment strategy utilizing modern angiographic catheter/microcatherter technology will involve a single dose of IA cisplatin with HFX-RT and dose intensification using neoadjuvant therapy... - Long-term survival in patients with synchronous, solitary brain metastasis from non-small-cell lung cancer treated with radiosurgeryTodd W Flannery
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Int J Radiat Oncol Biol Phys 72:19-23. 2008..To report the outcome of patients with synchronous, solitary brain metastasis from non-small-cell lung cancer (NSCLC) treated with gamma knife stereotactic radiosurgery (GKSRS)... - Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411Christopher H Crane
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 27:4096-102. 2009..Secondary end points were toxicity, progression-free survival (PFS), and response rate (RR)... - The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704Timothy N Showalter
Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
Int J Radiat Oncol Biol Phys 81:1328-35. 2011.... - Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trialsChristopher G Willett
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 56:31-7. 2003..This report summarizes current and future Radiation Therapy Oncology Group clinical trials in the treatment of patients with localized pancreatic cancer... - Analysis of local control in patients receiving IMRT for resected pancreatic cancersSusannah Yovino
Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Int J Radiat Oncol Biol Phys 83:916-20. 2012..A concern regarding this technique is the potential for geographic miss and decreased local control. We analyzed patterns of first failure among patients treated with IMRT for resected pancreatic cancer... - Comparative analysis of the post-lumpectomy target volume versus the use of pre-lumpectomy tumor volume for early-stage breast cancer: implications for the futureElizabeth M Nichols
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Int J Radiat Oncol Biol Phys 77:197-202. 2010..Use of PTVs based on the pre-LPC might also result in greater patient eligibility for APBI-3D-CRT... - Stereotatic radiosurgery of 468 brain metastases < or =2 cm: implications for SRS dose and whole brain radiation therapyMichael K Shehata
Department of Radiation Medicine, University of Kentucky, Lexington, KY, USA
Int J Radiat Oncol Biol Phys 59:87-93. 2004..Second, SRS doses >20 Gy resulted in no obvious improvement in local control and appeared to be associated with a greater rate of complications... - Spatially fractionated GRID radiation treatment of advanced neck disease associated with head and neck cancerJeniffer L Huhn
University of Kentucky, 800 Rose St N15, Lexington, KY 40536, USA
Technol Cancer Res Treat 5:607-12. 2006..It may improve pathologic complete response rates in those patients who undergo planned neck dissection, possibly leading to improved survival. In patients with inoperable bulky disease, addition of GRID enhances local-regional control... - High-dose spatially fractionated GRID radiation therapy (SFGRT): a comparison of treatment outcomes with Cerrobend vs. MLC SFGRTGeoffrey Neuner
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA
Int J Radiat Oncol Biol Phys 82:1642-9. 2012..The clinical efficacy of our own multileaf collimator (MLC) technique is unknown. We undertook a retrospective analysis to compare clinical response rates attained using these two techniques... - Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell linesSwatee Dey
Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
Clin Cancer Res 9:1557-65. 2003..These findings strongly suggest that LDFRT (at these doses, HRS phenomenon is observed) can be used in combination with Paclitaxel to overcome the antiapoptotic effects of BCL-2 and nuclear factor kappa B... - The use of gated and 4D CT imaging in planning for stereotactic body radiation therapyWARREN D D'SOUZA
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA
Med Dosim 32:92-101. 2007..Our results show that patient-specific target definition using gated or 4D CT scans lead to improved normal tissue sparing... - Effects of tumor motion in GRID therapyShahid A Naqvi
Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Med Phys 35:4435-42. 2008.... - Intensity-modulated radiation therapy significantly improves acute gastrointestinal toxicity in pancreatic and ampullary cancersSusannah Yovino
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Int J Radiat Oncol Biol Phys 79:158-62. 2011..Whether these improved dose distributions are associated with decreased toxicity when compared with conventional three-dimensional treatment remains a subject of investigation... - Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trialRoy A Patchell
Department of Surgery Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
Lancet 366:643-8. 2005..The standard treatment for spinal cord compression caused by metastatic cancer is corticosteroids and radiotherapy. The role of surgery has not been established. We assessed the efficacy of direct decompressive surgery... - The evolving role of postoperative adjuvant radiation therapy for pancreatic cancerMichael C Garofalo
Department of Radiation Oncology, University of Maryland at Baltimore, 22 South Green Street, Baltimore, MD 21201, USA
Surg Oncol Clin N Am 13:589-604, viii. 2004..Implications of the recently completed intergroup study are discussed, modern radiation therapy delivery techniques are reviewed, and suggestions for future trials are made... - Oral/pharyngeal squamous carcinoma: treatment strategiesDaniel E Kenady
Department of Surgery, University of Kentucky College of Medicine, Markey Cancer Center, Lexington, Kentucky, USA
J Ky Med Assoc 100:488-94. 2002..In advanced disease neither surgery nor radiation therapy can be used as a primary modality, and often combined treatment is necessary. Chemotherapy has a less well-defined role, but is increasing control rates in advanced tumors... - Neurologic complications of bladder carcinoma: a review of 359 casesThomas S Anderson
Department of Surgery, Neurosurgery Division, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
Cancer 97:2267-72. 2003.... - Factors impacting volumetric white matter changes following whole brain radiation therapyNicholas Szerlip
Department of Neurosurgery, University of Maryland Medical Center, Baltimore, MD, USA
J Neurooncol 103:111-9. 2011..This has significant clinical impact by clearly identifying hyperglycemia, steroid-induced hyperglycemia, and other vascular risk factors as targets for intervention to decrease WMC in patients receiving WBRT... - A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastasesPenny K Sneed
Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
Int J Radiat Oncol Biol Phys 53:519-26. 2002..Data collected from 10 institutions were reviewed to compare survival probabilities of patients with newly diagnosed brain metastases managed initially with radiosurgery (RS) alone vs. RS + whole brain radiotherapy (WBRT)... - Concurrent infusional gemcitabine and radiation in the treatment of advanced unresectable GI malignancy: a phase I studyMohammed Mohiuddin
Department of Radiation Medicine, University of Kentucky, Lexington 40536-0293, USA
Cancer J 8:255-62. 2002..Further evaluation of gemcitabine at 100 mg/m2 is being undertaken in preparation for a confirmatory multi-institutional phase II study... - The impact of TNF-alpha induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiationSabapathi Sathishkumar
University of Kentucky, Department of Radiation Medicine, 800 Rose Street, Lexington, KY 40536-0293, USA
Technol Cancer Res Treat 1:141-7. 2002..Complete tumor response strongly correlated with the induction of TNF-alpha levels in the serum... - The radiation oncologist's perspective on stereotactic radiosurgeryWilliam F Regine
University of Kentucky, Department of Radiation Medicine, 800 Rose Street, Lexington KY 40536 0293, USA
Technol Cancer Res Treat 1:43-9. 2002..Details of these studies, along with others, will be reviewed and implications with regards to the complementary role of WBRT in patients undergoing SRS for brain metastases will be discussed... - Feasibility of delivering grid therapy using a multileaf collimatorJonathan K Ha
Radiation Oncology, University of Maryland, Baltimore, Maryland 21201, USA
Med Phys 33:76-82. 2006..The results clearly showed that MLCs can be used to provide grid treatments with at least as good dosimetric properties as those of the Cerrobend grid blocks, though the former would in general require a longer delivery time... - Concomitant GRID boost for Gamma Knife radiosurgeryLijun Ma
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland 21210, USA
Med Phys 32:3419-23. 2005..e., the near region) were decreased for the GRID boost technique. In conclusion, we demonstrated a new technique for Gamma Knife radiosurgery that can escalate the dose to the target while sparing the adjacent normal brain tissue... - Gamma knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancerTodd W Flannery
Department of Radiation Oncology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
Lung Cancer 42:327-33. 2003..This study adds to the growing body of literature that supports the use of SRS in the management of this patient population... - Cancer caregiving and subjective stress: a multi-site, multi-dimensional analysisJoseph E Gaugler
Department of Behavioral Science, College of Medicine, The University of Kentucky, Lexington, KY 40536, USA
Psychooncology 14:771-85. 2005..The findings offer a number of recommendations for future research and practice focused on informal cancer care... - The rationale for adjuvant whole brain radiation therapy with radiosurgery in the treatment of single brain metastasesRoy A Patchell
Neurosurgery Division, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
Technol Cancer Res Treat 2:111-5. 2003..This paper examines the scientific evidence and the arguments, pro and con, concerning the use of adjuvant WBRT in association with stereotactic radiosurgery or conventional surgery... - Spinal cord and peripheral nerve injury: current management and investigationsWilliam H St Clair
Department of Radiation Medicine, University of Kentucky, Lexington, KY, USA
Semin Radiat Oncol 13:322-32. 2003..This review presents current management and investigations associated with these modality-related injuries... - Long-term outcomes of Gamma Knife radiosurgery for classic trigeminal neuralgia: implications of treatment and critical review of the literature. Clinical articleAnil A Dhople
Department of Radiation Oncology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, Maryland 21201, USA
J Neurosurg 111:351-8. 2009..The authors report their long-term experience with the use of GKS in a previously reported cohort of patients with TN that has now been followed since 1996... - Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomasSteven J DiBiase
Department of Radiation Oncology, Cooper University Hospital, Camden, NJ 08103, USA
Int J Radiat Oncol Biol Phys 60:1515-9. 2004..To determine the long-term outcomes and prognostic factors in benign intracranial meningiomas treated with gamma knife stereotactic radiosurgery (GK-SRS)... - Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implicationsWilliam F Regine
Department of Radiation Medicine, University of Kentucky, Lexington, KY 40536 0084, USA
Int J Radiat Oncol Biol Phys 52:333-8. 2002.... - A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancerNeil E Martin
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Clin Cancer Res 10:5447-54. 2004..CONCLUSIONS: The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed... - Stereotactic radiosurgery for meningiomasLawrence S Chin
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Neurosurg Focus 14:e6. 2003..Radiosurgery is an excellent treatment for asymptomatic, small- to moderate-sized meningiomas. It is also ideal for patients with incompletely resected meningiomas, recurrent meningiomas, and risk factors precluding conventional surgery... - Investigation of motion sickness and inertial stability on a moving couch for intra-fraction motion compensationWARREN D D'SOUZA
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA
Acta Oncol 48:1198-203. 2009..Our results show that patients do not suffer motion sickness or external surface instability on a moving couch... - Interval pathologic assessments in patients treated with concurrent hyperfractionated radiation and intraarterial cisplatin (HYPERRADPLAT)Joseph Valentino
Division of Otolaryngology, University of Kentucky, Chandler Medical Center, Veterans Administration Hospital, Lexington, Kentucky 40536 0293, USA
Head Neck 24:539-44. 2002..These assumptions regarding head and neck cancer in patients treated with concurrent hyperfractionated radiation therapy and intraarterial supradose cisplatin (HYPERRADPLAT) have never been evaluated... - Feasibility of neurocognitive outcome evaluations in patients with brain metastases in a multi-institutional cooperative group setting: results of Radiation Therapy Oncology Group trial BR-0018William F Regine
Department of Radiation Oncology, University of Maryland Medical System, Baltimore, MD 21201, USA
Int J Radiat Oncol Biol Phys 58:1346-52. 2004.... - Gamma knife surgery for trigeminal neuralgia: outcome, imaging, and brainstem correlatesAlice V Cheuk
University of Maryland School of Medicine, Baltimore, MD, USA
Int J Radiat Oncol Biol Phys 60:537-41. 2004..Treatment response and the development of facial numbness do not correlate with MRI imaging quality, presence of nerve compression, or radiation dose to the brainstem... - ACR Appropriateness Criteria on resectable rectal cancer: expert panel on radiation oncology--rectal/anal cancerW Warren Suh
Department of Radiation Oncology, Dana Farber Cancer Institute Brigham and Women s Hospital, Boston, MA 02459, USA
Int J Radiat Oncol Biol Phys 70:1427-30. 2008..A summary of the major randomized clinical trials spanning the past several decades is provided... - Optimal adjuvant therapy for resected pancreatic cancer: chemotherapy or chemoradiotherapy?Michael C Garofalo
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD
Gastrointest Cancer Res 1:182-7. 2007..It is suggested that (1) patients do benefit from adjuvant therapy, and (2) optimal adjuvant therapy should include gemcitabine-based chemoradiotherapy for select patient subgroups... - Complete resolution of laryngeal amyloidosis with radiation treatmentGeoffrey A Neuner
Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland, USA
Head Neck 34:748-52. 2012..Localized amyloidosis of the larynx is a rare entity of unclear etiology. Surgical debulking is the primary treatment modality but often is not curative... - Radiation therapy alone for spinal cord compression: time to improve upon a relatively ineffective status quoYoung Kwok
J Clin Oncol 23:3308-10. 2005 - On statistical reanalysis, the EORTC trial is a positive trial for adjuvant chemoradiation in pancreatic cancerMichael C Garofalo
Ann Surg 244:332-3; author reply 333. 2006 - Low-dose fractionated radiation as a chemopotentiator of neoadjuvant paclitaxel and carboplatin for locally advanced squamous cell carcinoma of the head and neck: results of a new treatment paradigmSusanne M Arnold
Department of Medicine, University of Kentucky Markey Cancer Center, Lexington 40536, USA
Int J Radiat Oncol Biol Phys 58:1411-7. 2004..On the basis of the demonstrated synergy between chemotherapy and low-dose fractionated RT, a novel neoadjuvant therapy was designed using low-dose fractionated RT as a chemopotentiator for locally advanced SCCHN... - Radiosurgery plus whole-brain radiation therapy for brain metastasesRoy A Patchell
JAMA 296:2089-90; author reply 2090-1. 2006 - Brain injury: current management and investigationsAndrew E Sloan
Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
Semin Radiat Oncol 13:309-21. 2003..This review presents current management and investigations associated with these modality-related injuries... - A phase I trial of continuously infused intratumoral bleomycin for the treatment of recurrent glioblastoma multiformeRoy A Patchell
Department of Neurology, University of Kentucky Medical Center, Lexington 40536, USA
J Neurooncol 60:37-42. 2002..Neurologic toxicity occurred only at doses above 16 U/wk. We conclude that continuously infused IT bleomycin is well tolerated; the MTD (and recommended dose for a phase II efficacy trial) of IT bleomycin is 16 U/wk... - Comments about the prospective randomized trial by Aoyama et alRoy A Patchell
Surg Neurol 66:459-60. 2006