Jacqueline D Reeves

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry
    Andre J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 79:7121-34. 2005
  2. ncbi request reprint Emerging drug targets for antiretroviral therapy
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Drugs 65:1747-66. 2005
  3. pmc Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope protein
    Wei Huang
    Monogram Biosciences, 345 Oyster Point Blvd, South San Francisco, CA 94080, USA
    J Virol 82:5584-93. 2008
  4. pmc Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 79:4991-9. 2005
  5. ncbi request reprint Human immunodeficiency virus type 2
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 301 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Gen Virol 83:1253-65. 2002
  6. pmc Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:16249-54. 2002
  7. pmc Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 78:5476-85. 2004
  8. ncbi request reprint Functional impact of HIV coreceptor-binding site mutations
    Mark J Biscone
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Virology 351:226-36. 2006
  9. ncbi request reprint A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo
    Stefan Pohlmann
    University of Pennsylvania, Department of Microbiology, Philadelphia, PA 19104, USA
    Virology 360:275-85. 2007
  10. pmc Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors
    Stefan Pohlmann
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 78:3223-32. 2004

Collaborators

Detail Information

Publications22

  1. pmc Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entry
    Andre J Marozsan
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    J Virol 79:7121-34. 2005
    ..This increased avidity of an HIV-1 isolate for its cell receptors may be a significant factor influencing overall replicative capacity or fitness...
  2. ncbi request reprint Emerging drug targets for antiretroviral therapy
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Drugs 65:1747-66. 2005
    ..Furthermore, the development of microbicides targeting HIV holds promise for reducing HIV transmission events...
  3. pmc Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope protein
    Wei Huang
    Monogram Biosciences, 345 Oyster Point Blvd, South San Francisco, CA 94080, USA
    J Virol 82:5584-93. 2008
    ..We hypothesize that the latter plays an important role in the transition from CCR5 to CXCR4 coreceptor use...
  4. pmc Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 79:4991-9. 2005
    ..Resistance to other entry inhibitors was not observed...
  5. ncbi request reprint Human immunodeficiency virus type 2
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 301 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Gen Virol 83:1253-65. 2002
  6. pmc Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:16249-54. 2002
    ....
  7. pmc Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 78:5476-85. 2004
    ....
  8. ncbi request reprint Functional impact of HIV coreceptor-binding site mutations
    Mark J Biscone
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Virology 351:226-36. 2006
    ..Thus, mutations that reduce coreceptor binding and enhance susceptibility to coreceptor inhibitors can affect fusion and enfuvirtide susceptibility in an Env context-dependent manner...
  9. ncbi request reprint A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo
    Stefan Pohlmann
    University of Pennsylvania, Department of Microbiology, Philadelphia, PA 19104, USA
    Virology 360:275-85. 2007
    ..Thus, changes in the V3 loop that diminished CCR5 usage and altered Env interactions with CCR5 reduced the pathogenic potential of SIVmac in rhesus macaques but did not abolish it entirely...
  10. pmc Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors
    Stefan Pohlmann
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 78:3223-32. 2004
    ..In summary, we found that a single amino acid at position 324 in the SIV Env V3 loop can modulate both the efficiency and the types of coreceptors engaged by Env and allow for CD4-independent fusion in some cases...
  11. pmc Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein
    Terri G Edwards
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:2683-91. 2002
    ....
  12. pmc Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
    Graham Simmons
    Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:11876-81. 2005
    ..The requirement for cathepsin L proteolysis identifies a previously uncharacterized class of inhibitor for SARS-CoV infection...
  13. pmc Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
    Graham Simmons
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:4240-5. 2004
    ..Together, these studies describe important tools that can be used to study SARS-CoV S glycoprotein structure and function, including approaches that can be used to identify inhibitors of the entry of SARS-CoV into target cells...
  14. pmc Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switching
    Cristina Pastore
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 81:8165-79. 2007
    ..Decreased CCR5 and increased CD4 binding appear to be common features of coreceptor switch intermediates...
  15. pmc Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion
    Stephen A Gallo
    Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD, USA
    Retrovirology 3:90. 2006
    ..We address this issue by comparing the kinetics HIV-1IIIB Env with those mediated by HIV-2 from two strains with different affinities for CD4 and CXCR4...
  16. ncbi request reprint Human Leydig cells are productively infected by some HIV-2 and SIV strains but not by HIV-1
    Samantha Willey
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, UK
    AIDS 17:183-8. 2003
    ..However, the testis has been largely ignored despite representing a pharmacologic sanctuary which could act as a viral reservoir...
  17. ncbi request reprint Cellular entry of HIV: Evaluation of therapeutic targets
    Stefan Pohlmann
    Institute for Clinical and molecular Virology and Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Curr Pharm Des 12:1963-73. 2006
    ..Both, cellular receptors and structures in Env associated with membrane fusion are targets for therapeutic intervention. Here, we will discuss how HIV-1 enters cells and introduce strategies how this process can be inhibited...
  18. pmc Identification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cells
    Samantha J Willey
    Center for AIDS Research, Program in Molecular Medicine, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01605, USA
    J Virol 77:6138-52. 2003
    ..This AMD3100-resistant replication was also sensitive to vMIP-I inhibition. The nature and potential role of this alternative coreceptor(s) in HIV infection in vivo is discussed...
  19. ncbi request reprint Evolution of coreceptor use and CD4-independence in envelope clones derived from SIVsm-infected macaques
    Dalma Vödrös
    Department of Medical Microbiology, Dermatology and Infection, Lund University, Lund, Sweden
    Virology 316:17-28. 2003
    ..Therefore, interplay between receptor tropism and neutralization may shape viral evolution and SIV pathogenesis...
  20. pmc Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection
    Ronald S Veazey
    Joan and Sanford I Weill Medical College of Cornell University, Dept of Microbiology and Immunology, 1300 York Ave, W 805, New York, NY 10021, USA
    J Exp Med 198:1551-62. 2003
    ..These findings support the development of small molecule CCR5 inhibitors as antiviral therapies, and possibly as components of a topical microbicide to prevent HIV-1 sexual transmission...
  21. pmc Modulation of Env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivity
    Eloisa Yuste
    New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
    J Virol 78:6775-85. 2004
    ....
  22. ncbi request reprint Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host
    Jeffrey M Milush
    University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 179:3047-56. 2007
    ....