Research Topics
| Jacqueline D ReevesSummaryAffiliation: University of Pennsylvania Country: USA Publications
| Collaborators
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Detail Information
Publications
Differences in the fitness of two diverse wild-type human immunodeficiency virus type 1 isolates are related to the efficiency of cell binding and entryAndre J Marozsan
Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
J Virol 79:7121-34. 2005..This increased avidity of an HIV-1 isolate for its cell receptors may be a significant factor influencing overall replicative capacity or fitness...
Emerging drug targets for antiretroviral therapyJacqueline D Reeves
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Drugs 65:1747-66. 2005..Furthermore, the development of microbicides targeting HIV holds promise for reducing HIV transmission events...- Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope proteinWei Huang
Monogram Biosciences, 345 Oyster Point Blvd, South San Francisco, CA 94080, USA
J Virol 82:5584-93. 2008..We hypothesize that the latter plays an important role in the transition from CCR5 to CXCR4 coreceptor use... - Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralizationJacqueline D Reeves
Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
J Virol 79:4991-9. 2005..Resistance to other entry inhibitors was not observed... - Human immunodeficiency virus type 2Jacqueline D Reeves
Department of Microbiology, University of Pennsylvania, 301 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
J Gen Virol 83:1253-65. 2002 - Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kineticsJacqueline D Reeves
Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 99:16249-54. 2002.... - Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivityJacqueline D Reeves
Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
J Virol 78:5476-85. 2004.... - Functional impact of HIV coreceptor-binding site mutationsMark J Biscone
Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
Virology 351:226-36. 2006..Thus, mutations that reduce coreceptor binding and enhance susceptibility to coreceptor inhibitors can affect fusion and enfuvirtide susceptibility in an Env context-dependent manner... - Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptorsStefan Pohlmann
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Virol 78:3223-32. 2004..In summary, we found that a single amino acid at position 324 in the SIV Env V3 loop can modulate both the efficiency and the types of coreceptors engaged by Env and allow for CD4-independent fusion in some cases... - A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivoStefan Pohlmann
University of Pennsylvania, Department of Microbiology, Philadelphia, PA 19104, USA
Virology 360:275-85. 2007..Thus, changes in the V3 loop that diminished CCR5 usage and altered Env interactions with CCR5 reduced the pathogenic potential of SIVmac in rhesus macaques but did not abolish it entirely... - Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope proteinTerri G Edwards
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Virol 76:2683-91. 2002.... - Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entryGraham Simmons
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:11876-81. 2005..The requirement for cathepsin L proteolysis identifies a previously uncharacterized class of inhibitor for SARS-CoV infection... - Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entryGraham Simmons
Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:4240-5. 2004..Together, these studies describe important tools that can be used to study SARS-CoV S glycoprotein structure and function, including approaches that can be used to identify inhibitors of the entry of SARS-CoV into target cells... - Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switchingCristina Pastore
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Virol 81:8165-79. 2007..Decreased CCR5 and increased CD4 binding appear to be common features of coreceptor switch intermediates... 
Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusionStephen A Gallo
Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD, USA
Retrovirology 3:90. 2006..We address this issue by comparing the kinetics HIV-1IIIB Env with those mediated by HIV-2 from two strains with different affinities for CD4 and CXCR4...- Human Leydig cells are productively infected by some HIV-2 and SIV strains but not by HIV-1Samantha Willey
Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, UK
AIDS 17:183-8. 2003..In contrast, Leydig cells support HIV-2 and SIV infection and thus represent a potential target for infection. Receptor use and significance of HIV-2/SIV infection of Leydig cells remain to be determined... - Cellular entry of HIV: Evaluation of therapeutic targetsStefan Pohlmann
Institute for Clinical and molecular Virology and Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
Curr Pharm Des 12:1963-73. 2006..Both, cellular receptors and structures in Env associated with membrane fusion are targets for therapeutic intervention. Here, we will discuss how HIV-1 enters cells and introduce strategies how this process can be inhibited... - Identification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cellsSamantha J Willey
Center for AIDS Research, Program in Molecular Medicine, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01605, USA
J Virol 77:6138-52. 2003..This AMD3100-resistant replication was also sensitive to vMIP-I inhibition. The nature and potential role of this alternative coreceptor(s) in HIV infection in vivo is discussed... - Evolution of coreceptor use and CD4-independence in envelope clones derived from SIVsm-infected macaquesDalma Vödrös
Department of Medical Microbiology, Dermatology and Infection, Lund University, Lund, Sweden
Virology 316:17-28. 2003..Therefore, interplay between receptor tropism and neutralization may shape viral evolution and SIV pathogenesis... - Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infectionRonald S Veazey
Joan and Sanford I. Weill Medical College of Cornell University, Dept. of Microbiology and Immunology, 1300 York Ave, W-805, New York, NY 10021, USA
J Exp Med 198:1551-62. 2003..These findings support the development of small molecule CCR5 inhibitors as antiviral therapies, and possibly as components of a topical microbicide to prevent HIV-1 sexual transmission... - Modulation of Env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivityEloisa Yuste
New England Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
J Virol 78:6775-85. 2004.... - Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural hostJeffrey M Milush
University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Immunol 179:3047-56. 2007....